IL69849A - Ortho substituted dihydroxy-2(1h)quinazolinone-1-alkanoic acids,their preparation and pharmaceutical compositions containing them - Google Patents

Ortho substituted dihydroxy-2(1h)quinazolinone-1-alkanoic acids,their preparation and pharmaceutical compositions containing them

Info

Publication number
IL69849A
IL69849A IL69849A IL6984983A IL69849A IL 69849 A IL69849 A IL 69849A IL 69849 A IL69849 A IL 69849A IL 6984983 A IL6984983 A IL 6984983A IL 69849 A IL69849 A IL 69849A
Authority
IL
Israel
Prior art keywords
alkyl
salts
quinazolinone
preparation
pharmaceutical compositions
Prior art date
Application number
IL69849A
Other versions
IL69849A0 (en
Original Assignee
Ortho Pharma Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/430,552 external-priority patent/US4490374A/en
Application filed by Ortho Pharma Corp filed Critical Ortho Pharma Corp
Priority to IL7924483A priority Critical patent/IL79244A/en
Publication of IL69849A0 publication Critical patent/IL69849A0/en
Priority to IL7309784A priority patent/IL73097A/en
Priority to IL79244A priority patent/IL79244A0/en
Publication of IL69849A publication Critical patent/IL69849A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
    • C07D239/80—Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cosmetics (AREA)
  • Manufacture Of Tobacco Products (AREA)

Abstract

Cpds. of formula (I) and their quat. salts with alkyl halides, alkali (ne earth) metal salts and the amine salt, aminoalcohol salts and aminoacid salts are new. In (I) R1 is H, NH2 or N02; R2 is H, alkyl, cycloalkyl, cycloalkylalkyl, haloalkyl or bicycloalkyl; R3 and R4 are H, lower alkyl, or aryl (opt. substd. by alkyl, lower alkoxy or OH); R5 is H, lower alkyl, or opt. substd. benzyl, provided that when R5 is other than H, the cpd. is a quat. salt; X is benzyl, COOH, alkoxycarbonyl, CN, CONH2, methane sulphonyl, formyl, alkanoyl, aroyl, heteroaroyl or heteroaryl; and Y and Z are H or OH, at least one being OH and when both are OH, they are in the 5,6- or 6,7- posn. Intermediates of formula (II) are also new. (R6 is lower alkyl; and R7 is H or is absent). Cpds. (I) are renal vasodilators and cardiovascular agents, and some intermediates in their prepn. are cardiotonic agents. Dose is 15-300 mg/kg.
IL69849A 1982-09-30 1983-09-28 Ortho substituted dihydroxy-2(1h)quinazolinone-1-alkanoic acids,their preparation and pharmaceutical compositions containing them IL69849A (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
IL7924483A IL79244A (en) 1982-09-30 1983-09-28 5,6-dialkoxy-2(1h)quinazolinone derivatives
IL7309784A IL73097A (en) 1983-09-28 1984-09-26 Substituted 2(1h)-quinazolinone-1-propionic acids and esters and their preparation
IL79244A IL79244A0 (en) 1982-09-30 1986-06-26 5,6-dialkoxy-2(1h)quinazolinone derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/430,552 US4490374A (en) 1982-09-30 1982-09-30 5,6-Dialkoxy-3,4-optionally substituted-2(1H)quinazolinones, composition and method of use

Publications (2)

Publication Number Publication Date
IL69849A0 IL69849A0 (en) 1983-12-30
IL69849A true IL69849A (en) 1987-11-30

Family

ID=23708017

Family Applications (1)

Application Number Title Priority Date Filing Date
IL69849A IL69849A (en) 1982-09-30 1983-09-28 Ortho substituted dihydroxy-2(1h)quinazolinone-1-alkanoic acids,their preparation and pharmaceutical compositions containing them

Country Status (13)

Country Link
KR (1) KR840006218A (en)
AT (2) ATE34979T1 (en)
DE (2) DE3376978D1 (en)
ES (4) ES8503671A1 (en)
HU (1) HU192242B (en)
IL (1) IL69849A (en)
NO (1) NO833541L (en)
NZ (1) NZ205685A (en)
PH (2) PH19508A (en)
RO (2) RO87466B (en)
SG (1) SG31887G (en)
YU (2) YU196983A (en)
ZW (1) ZW20883A1 (en)

Also Published As

Publication number Publication date
ES532920A0 (en) 1985-09-01
ES8507510A1 (en) 1985-09-01
YU196983A (en) 1987-02-28
KR840006218A (en) 1984-11-22
ES526133A0 (en) 1985-03-16
ES8507512A1 (en) 1985-09-01
ES8507511A1 (en) 1985-09-01
PH19508A (en) 1986-05-14
IL69849A0 (en) 1983-12-30
RO87466A (en) 1985-08-31
RO89787A (en) 1986-07-30
NO833541L (en) 1984-04-02
ES8503671A1 (en) 1985-03-16
YU192285A (en) 1987-12-31
NZ205685A (en) 1987-03-31
ES532918A0 (en) 1985-09-01
DE3382013D1 (en) 1991-01-03
RO87466B (en) 1985-08-31
ATE58531T1 (en) 1990-12-15
DE3376978D1 (en) 1988-07-14
SG31887G (en) 1987-07-17
ATE34979T1 (en) 1988-06-15
ZW20883A1 (en) 1985-05-01
HU192242B (en) 1988-10-28
ES532919A0 (en) 1985-09-01
PH21757A (en) 1988-02-18

Similar Documents

Publication Publication Date Title
MY111814A (en) Watersoluble azole antifungals
ES8503666A1 (en) 1-Aryloxy-2,3,4,5-tetrahydro-3-benzazepines, a process for preparing the same and their use as medicaments.
ES8403466A1 (en) Hydroxyalkynyl-azolyl derivatives, process for their preparation and their use as fungicides.
GB1435755A (en) 2-phenoxy alkyl sulphonalides
IL69849A0 (en) Ortho substituted dihydroxy-2(1h)quinazolinone-1-alkanoic acids,their preparation and pharmaceutical compositions containing them
MY103910A (en) 4-oxo-3-quinolinecarboxylic acids useful as antibacterial agents and preparation thereof
TW339325B (en) Novel azepane derivatives, process for the preparation thereof and pharmaceutical composition containing the same
US4111941A (en) Thienyl pyrazole thioamides
GB1320484A (en) 2,6-diaminobenzoic acid derivatives
EA200000116A1 (en) ANTI-FIBROUS CONNECTIONS BASED ON 2,4,4-triple-substituted 1,3-DIOXOLANES
ES428673A1 (en) Substituted nitrobenzophenone derivatives
ES8103082A1 (en) Pyrido[3,4-e]-as-triazines
ES8106147A1 (en) 1,2,4-Triazole-3-thiols as antisecretory agents
GB1256931A (en)
GB1437799A (en) Benzimidazolinone compounds
GB1135947A (en) Novel biologically active derivatives of phenanthridone
ES8705454A1 (en) Imidazoalkylcarboxylic-acid derivatives, process for their preparation and their use in the preparation of pharmaceutically active compounds.
ES8506014A1 (en) Acridanone derivatives.
GB1106965A (en) 4-arylpiperidines, their acid addition salts, and processes for the preparation thereof
GB1439485A (en) Dinitro-2-thiophenamine derivatives methods for their preparation and compositions containing them
DE3467297D1 (en) Benzobicyclononane amino derivatives with anticonvulsive properties
ES8701716A1 (en) New N,N'-di:phenyl-malon-bis:amide derivs.
GB1042210A (en) N-substituted pyridobenzodiazepine derivatives