YU192285A - Process for obtaining orto substituted dihydroxi-2(1h)-hynazolinone-1-alcane acids - Google Patents

Process for obtaining orto substituted dihydroxi-2(1h)-hynazolinone-1-alcane acids

Info

Publication number
YU192285A
YU192285A YU01922/85A YU192285A YU192285A YU 192285 A YU192285 A YU 192285A YU 01922/85 A YU01922/85 A YU 01922/85A YU 192285 A YU192285 A YU 192285A YU 192285 A YU192285 A YU 192285A
Authority
YU
Yugoslavia
Prior art keywords
alkyl
salts
hynazolinone
dihydroxi
alcane
Prior art date
Application number
YU01922/85A
Inventor
V T Bandurco
S D Levine
D M Mulvey
A J Tobia
Original Assignee
Ortho Pharma Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/430,552 external-priority patent/US4490374A/en
Application filed by Ortho Pharma Corp filed Critical Ortho Pharma Corp
Publication of YU192285A publication Critical patent/YU192285A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72Quinazolines; Hydrogenated quinazolines
    • C07D239/78Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
    • C07D239/80Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cosmetics (AREA)
  • Manufacture Of Tobacco Products (AREA)

Abstract

Cpds. of formula (I) and their quat. salts with alkyl halides, alkali (ne earth) metal salts and the amine salt, aminoalcohol salts and aminoacid salts are new. In (I) R1 is H, NH2 or N02; R2 is H, alkyl, cycloalkyl, cycloalkylalkyl, haloalkyl or bicycloalkyl; R3 and R4 are H, lower alkyl, or aryl (opt. substd. by alkyl, lower alkoxy or OH); R5 is H, lower alkyl, or opt. substd. benzyl, provided that when R5 is other than H, the cpd. is a quat. salt; X is benzyl, COOH, alkoxycarbonyl, CN, CONH2, methane sulphonyl, formyl, alkanoyl, aroyl, heteroaroyl or heteroaryl; and Y and Z are H or OH, at least one being OH and when both are OH, they are in the 5,6- or 6,7- posn. Intermediates of formula (II) are also new. (R6 is lower alkyl; and R7 is H or is absent). Cpds. (I) are renal vasodilators and cardiovascular agents, and some intermediates in their prepn. are cardiotonic agents. Dose is 15-300 mg/kg.
YU01922/85A 1982-09-30 1985-12-11 Process for obtaining orto substituted dihydroxi-2(1h)-hynazolinone-1-alcane acids YU192285A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/430,552 US4490374A (en) 1982-09-30 1982-09-30 5,6-Dialkoxy-3,4-optionally substituted-2(1H)quinazolinones, composition and method of use

Publications (1)

Publication Number Publication Date
YU192285A true YU192285A (en) 1987-12-31

Family

ID=23708017

Family Applications (2)

Application Number Title Priority Date Filing Date
YU01969/83A YU196983A (en) 1982-09-30 1983-09-30 Process for making new derivatives of hinazolinone
YU01922/85A YU192285A (en) 1982-09-30 1985-12-11 Process for obtaining orto substituted dihydroxi-2(1h)-hynazolinone-1-alcane acids

Family Applications Before (1)

Application Number Title Priority Date Filing Date
YU01969/83A YU196983A (en) 1982-09-30 1983-09-30 Process for making new derivatives of hinazolinone

Country Status (13)

Country Link
KR (1) KR840006218A (en)
AT (2) ATE34979T1 (en)
DE (2) DE3382013D1 (en)
ES (4) ES526133A0 (en)
HU (1) HU192242B (en)
IL (1) IL69849A (en)
NO (1) NO833541L (en)
NZ (1) NZ205685A (en)
PH (2) PH19508A (en)
RO (2) RO87466B (en)
SG (1) SG31887G (en)
YU (2) YU196983A (en)
ZW (1) ZW20883A1 (en)

Also Published As

Publication number Publication date
ZW20883A1 (en) 1985-05-01
DE3382013D1 (en) 1991-01-03
HU192242B (en) 1988-10-28
ATE58531T1 (en) 1990-12-15
PH21757A (en) 1988-02-18
RO87466A (en) 1985-08-31
NO833541L (en) 1984-04-02
ATE34979T1 (en) 1988-06-15
YU196983A (en) 1987-02-28
ES8507510A1 (en) 1985-09-01
RO89787A (en) 1986-07-30
ES8507512A1 (en) 1985-09-01
ES532920A0 (en) 1985-09-01
NZ205685A (en) 1987-03-31
ES8503671A1 (en) 1985-03-16
ES532918A0 (en) 1985-09-01
ES8507511A1 (en) 1985-09-01
ES532919A0 (en) 1985-09-01
PH19508A (en) 1986-05-14
IL69849A0 (en) 1983-12-30
ES526133A0 (en) 1985-03-16
SG31887G (en) 1987-07-17
DE3376978D1 (en) 1988-07-14
IL69849A (en) 1987-11-30
RO87466B (en) 1985-08-31
KR840006218A (en) 1984-11-22

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