ES532918A0 - A PROCEDURE FOR THE PREPARATION OF SUBSTITUTED QUINAZOLINONES - Google Patents
A PROCEDURE FOR THE PREPARATION OF SUBSTITUTED QUINAZOLINONESInfo
- Publication number
- ES532918A0 ES532918A0 ES532918A ES532918A ES532918A0 ES 532918 A0 ES532918 A0 ES 532918A0 ES 532918 A ES532918 A ES 532918A ES 532918 A ES532918 A ES 532918A ES 532918 A0 ES532918 A0 ES 532918A0
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- salts
- lower alkyl
- substd
- quat
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
- C07D239/80—Oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
- Manufacture Of Tobacco Products (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Cpds. of formula (I) and their quat. salts with alkyl halides, alkali (ne earth) metal salts and the amine salt, aminoalcohol salts and aminoacid salts are new. In (I) R1 is H, NH2 or N02; R2 is H, alkyl, cycloalkyl, cycloalkylalkyl, haloalkyl or bicycloalkyl; R3 and R4 are H, lower alkyl, or aryl (opt. substd. by alkyl, lower alkoxy or OH); R5 is H, lower alkyl, or opt. substd. benzyl, provided that when R5 is other than H, the cpd. is a quat. salt; X is benzyl, COOH, alkoxycarbonyl, CN, CONH2, methane sulphonyl, formyl, alkanoyl, aroyl, heteroaroyl or heteroaryl; and Y and Z are H or OH, at least one being OH and when both are OH, they are in the 5,6- or 6,7- posn. Intermediates of formula (II) are also new. (R6 is lower alkyl; and R7 is H or is absent). Cpds. (I) are renal vasodilators and cardiovascular agents, and some intermediates in their prepn. are cardiotonic agents. Dose is 15-300 mg/kg.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/430,552 US4490374A (en) | 1982-09-30 | 1982-09-30 | 5,6-Dialkoxy-3,4-optionally substituted-2(1H)quinazolinones, composition and method of use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES532918A0 true ES532918A0 (en) | 1985-09-01 |
| ES8507510A1 ES8507510A1 (en) | 1985-09-01 |
Family
ID=23708017
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES526133A Expired ES8503671A1 (en) | 1982-09-30 | 1983-09-29 | 2(1H)-Quinazolinone-1-propionic acids and analogues |
| ES532918A Expired ES8507510A1 (en) | 1982-09-30 | 1984-05-29 | 2(1H)-Quinazolinone-1-propionic acids and analogues |
| ES532919A Granted ES532919A0 (en) | 1982-09-30 | 1984-05-29 | A PROCEDURE FOR THE PREPARATION OF SUBSTITUTED QUINAZOLINONES |
| ES532920A Granted ES532920A0 (en) | 1982-09-30 | 1984-05-29 | A PROCEDURE FOR THE PREPARATION OF SUBSTITUTED QUINAZOLINONES |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES526133A Expired ES8503671A1 (en) | 1982-09-30 | 1983-09-29 | 2(1H)-Quinazolinone-1-propionic acids and analogues |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES532919A Granted ES532919A0 (en) | 1982-09-30 | 1984-05-29 | A PROCEDURE FOR THE PREPARATION OF SUBSTITUTED QUINAZOLINONES |
| ES532920A Granted ES532920A0 (en) | 1982-09-30 | 1984-05-29 | A PROCEDURE FOR THE PREPARATION OF SUBSTITUTED QUINAZOLINONES |
Country Status (13)
| Country | Link |
|---|---|
| KR (1) | KR840006218A (en) |
| AT (2) | ATE58531T1 (en) |
| DE (2) | DE3382013D1 (en) |
| ES (4) | ES8503671A1 (en) |
| HU (1) | HU192242B (en) |
| IL (1) | IL69849A (en) |
| NO (1) | NO833541L (en) |
| NZ (1) | NZ205685A (en) |
| PH (2) | PH19508A (en) |
| RO (2) | RO87466B (en) |
| SG (1) | SG31887G (en) |
| YU (2) | YU196983A (en) |
| ZW (1) | ZW20883A1 (en) |
-
1983
- 1983-09-21 NZ NZ205685A patent/NZ205685A/en unknown
- 1983-09-28 PH PH29609A patent/PH19508A/en unknown
- 1983-09-28 IL IL69849A patent/IL69849A/en unknown
- 1983-09-29 ES ES526133A patent/ES8503671A1/en not_active Expired
- 1983-09-29 RO RO112200A patent/RO87466B/en unknown
- 1983-09-29 AT AT86201912T patent/ATE58531T1/en not_active IP Right Cessation
- 1983-09-29 RO RO83116473A patent/RO89787A/en unknown
- 1983-09-29 DE DE8686201912T patent/DE3382013D1/en not_active Expired - Lifetime
- 1983-09-29 AT AT83305895T patent/ATE34979T1/en active
- 1983-09-29 NO NO833541A patent/NO833541L/en unknown
- 1983-09-29 DE DE8383305895T patent/DE3376978D1/en not_active Expired
- 1983-09-29 ZW ZW208/83A patent/ZW20883A1/en unknown
- 1983-09-29 HU HU833392A patent/HU192242B/en unknown
- 1983-09-30 YU YU01969/83A patent/YU196983A/en unknown
- 1983-09-30 KR KR1019830004638A patent/KR840006218A/en not_active Application Discontinuation
-
1984
- 1984-05-29 ES ES532918A patent/ES8507510A1/en not_active Expired
- 1984-05-29 ES ES532919A patent/ES532919A0/en active Granted
- 1984-05-29 ES ES532920A patent/ES532920A0/en active Granted
-
1985
- 1985-05-24 PH PH32313A patent/PH21757A/en unknown
- 1985-12-11 YU YU01922/85A patent/YU192285A/en unknown
-
1987
- 1987-03-31 SG SG318/87A patent/SG31887G/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NZ205685A (en) | 1987-03-31 |
| HU192242B (en) | 1988-10-28 |
| SG31887G (en) | 1987-07-17 |
| RO89787A (en) | 1986-07-30 |
| ES8507511A1 (en) | 1985-09-01 |
| ATE34979T1 (en) | 1988-06-15 |
| ES526133A0 (en) | 1985-03-16 |
| YU196983A (en) | 1987-02-28 |
| PH19508A (en) | 1986-05-14 |
| DE3376978D1 (en) | 1988-07-14 |
| KR840006218A (en) | 1984-11-22 |
| IL69849A0 (en) | 1983-12-30 |
| ES8503671A1 (en) | 1985-03-16 |
| ES8507512A1 (en) | 1985-09-01 |
| ZW20883A1 (en) | 1985-05-01 |
| ES8507510A1 (en) | 1985-09-01 |
| PH21757A (en) | 1988-02-18 |
| ES532920A0 (en) | 1985-09-01 |
| NO833541L (en) | 1984-04-02 |
| RO87466A (en) | 1985-08-31 |
| IL69849A (en) | 1987-11-30 |
| ES532919A0 (en) | 1985-09-01 |
| RO87466B (en) | 1985-08-31 |
| YU192285A (en) | 1987-12-31 |
| DE3382013D1 (en) | 1991-01-03 |
| ATE58531T1 (en) | 1990-12-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Patent lapsed |
Effective date: 19960506 |