ES8503671A1 - 2(1H)-Quinazolinone-1-propionic acids and analogues - Google Patents
2(1H)-Quinazolinone-1-propionic acids and analoguesInfo
- Publication number
- ES8503671A1 ES8503671A1 ES526133A ES526133A ES8503671A1 ES 8503671 A1 ES8503671 A1 ES 8503671A1 ES 526133 A ES526133 A ES 526133A ES 526133 A ES526133 A ES 526133A ES 8503671 A1 ES8503671 A1 ES 8503671A1
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- salts
- lower alkyl
- substd
- quat
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
- C07D239/80—Oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
- Manufacture Of Tobacco Products (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Cpds. of formula (I) and their quat. salts with alkyl halides, alkali (ne earth) metal salts and the amine salt, aminoalcohol salts and aminoacid salts are new. In (I) R1 is H, NH2 or N02 R2 is H, alkyl, cycloalkyl, cycloalkylalkyl, haloalkyl or bicycloalkyl R3 and R4 are H, lower alkyl, or aryl (opt. substd. by alkyl, lower alkoxy or OH) R5 is H, lower alkyl, or opt. substd. benzyl, provided that when R5 is other than H, the cpd. is a quat. salt X is benzyl, COOH, alkoxycarbonyl, CN, CONH2, methane sulphonyl, formyl, alkanoyl, aroyl, heteroaroyl or heteroaryl and Y and Z are H or OH, at least one being OH and when both are OH, they are in the 5,6- or 6,7- posn. Intermediates of formula (II) are also new. (R6 is lower alkyl and R7 is H or is absent). Cpds. (I) are renal vasodilators and cardiovascular agents, and some intermediates in their prepn. are cardiotonic agents. Dose is 15-300 mg/kg.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/430,552 US4490374A (en) | 1982-09-30 | 1982-09-30 | 5,6-Dialkoxy-3,4-optionally substituted-2(1H)quinazolinones, composition and method of use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8503671A1 true ES8503671A1 (en) | 1985-03-16 |
| ES526133A0 ES526133A0 (en) | 1985-03-16 |
Family
ID=23708017
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES526133A Granted ES526133A0 (en) | 1982-09-30 | 1983-09-29 | SUBSTITUTED QUINAZOLINONES |
| ES532920A Expired ES8507512A1 (en) | 1982-09-30 | 1984-05-29 | 2(1H)-Quinazolinone-1-propionic acids and analogues |
| ES532918A Expired ES8507510A1 (en) | 1982-09-30 | 1984-05-29 | 2(1H)-Quinazolinone-1-propionic acids and analogues |
| ES532919A Expired ES8507511A1 (en) | 1982-09-30 | 1984-05-29 | 2(1H)-Quinazolinone-1-propionic acids and analogues |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES532920A Expired ES8507512A1 (en) | 1982-09-30 | 1984-05-29 | 2(1H)-Quinazolinone-1-propionic acids and analogues |
| ES532918A Expired ES8507510A1 (en) | 1982-09-30 | 1984-05-29 | 2(1H)-Quinazolinone-1-propionic acids and analogues |
| ES532919A Expired ES8507511A1 (en) | 1982-09-30 | 1984-05-29 | 2(1H)-Quinazolinone-1-propionic acids and analogues |
Country Status (13)
| Country | Link |
|---|---|
| KR (1) | KR840006218A (en) |
| AT (2) | ATE58531T1 (en) |
| DE (2) | DE3376978D1 (en) |
| ES (4) | ES526133A0 (en) |
| HU (1) | HU192242B (en) |
| IL (1) | IL69849A (en) |
| NO (1) | NO833541L (en) |
| NZ (1) | NZ205685A (en) |
| PH (2) | PH19508A (en) |
| RO (2) | RO87466A (en) |
| SG (1) | SG31887G (en) |
| YU (2) | YU196983A (en) |
| ZW (1) | ZW20883A1 (en) |
-
1983
- 1983-09-21 NZ NZ205685A patent/NZ205685A/en unknown
- 1983-09-28 PH PH29609A patent/PH19508A/en unknown
- 1983-09-28 IL IL69849A patent/IL69849A/en unknown
- 1983-09-29 RO RO83112200A patent/RO87466A/en unknown
- 1983-09-29 ZW ZW208/83A patent/ZW20883A1/en unknown
- 1983-09-29 AT AT86201912T patent/ATE58531T1/en not_active IP Right Cessation
- 1983-09-29 ES ES526133A patent/ES526133A0/en active Granted
- 1983-09-29 NO NO833541A patent/NO833541L/en unknown
- 1983-09-29 DE DE8383305895T patent/DE3376978D1/en not_active Expired
- 1983-09-29 DE DE8686201912T patent/DE3382013D1/en not_active Expired - Lifetime
- 1983-09-29 RO RO83116473A patent/RO89787A/en unknown
- 1983-09-29 HU HU833392A patent/HU192242B/en unknown
- 1983-09-29 AT AT83305895T patent/ATE34979T1/en active
- 1983-09-30 YU YU01969/83A patent/YU196983A/en unknown
- 1983-09-30 KR KR1019830004638A patent/KR840006218A/en not_active Application Discontinuation
-
1984
- 1984-05-29 ES ES532920A patent/ES8507512A1/en not_active Expired
- 1984-05-29 ES ES532918A patent/ES8507510A1/en not_active Expired
- 1984-05-29 ES ES532919A patent/ES8507511A1/en not_active Expired
-
1985
- 1985-05-24 PH PH32313A patent/PH21757A/en unknown
- 1985-12-11 YU YU01922/85A patent/YU192285A/en unknown
-
1987
- 1987-03-31 SG SG318/87A patent/SG31887G/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| RO89787A (en) | 1986-07-30 |
| PH19508A (en) | 1986-05-14 |
| PH21757A (en) | 1988-02-18 |
| IL69849A0 (en) | 1983-12-30 |
| DE3376978D1 (en) | 1988-07-14 |
| ATE34979T1 (en) | 1988-06-15 |
| NO833541L (en) | 1984-04-02 |
| YU196983A (en) | 1987-02-28 |
| ZW20883A1 (en) | 1985-05-01 |
| SG31887G (en) | 1987-07-17 |
| ES532920A0 (en) | 1985-09-01 |
| RO87466B (en) | 1985-08-31 |
| ES532919A0 (en) | 1985-09-01 |
| YU192285A (en) | 1987-12-31 |
| ES532918A0 (en) | 1985-09-01 |
| KR840006218A (en) | 1984-11-22 |
| ES526133A0 (en) | 1985-03-16 |
| ES8507510A1 (en) | 1985-09-01 |
| HU192242B (en) | 1988-10-28 |
| ES8507511A1 (en) | 1985-09-01 |
| IL69849A (en) | 1987-11-30 |
| RO87466A (en) | 1985-08-31 |
| ATE58531T1 (en) | 1990-12-15 |
| NZ205685A (en) | 1987-03-31 |
| DE3382013D1 (en) | 1991-01-03 |
| ES8507512A1 (en) | 1985-09-01 |
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