ATE58531T1 - SUBSTITUTED CHINAZOLINONES. - Google Patents
SUBSTITUTED CHINAZOLINONES.Info
- Publication number
- ATE58531T1 ATE58531T1 AT86201912T AT86201912T ATE58531T1 AT E58531 T1 ATE58531 T1 AT E58531T1 AT 86201912 T AT86201912 T AT 86201912T AT 86201912 T AT86201912 T AT 86201912T AT E58531 T1 ATE58531 T1 AT E58531T1
- Authority
- AT
- Austria
- Prior art keywords
- alkyl
- salts
- lower alkyl
- substd
- quat
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
- C07D239/80—Oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Cosmetics (AREA)
- Manufacture Of Tobacco Products (AREA)
Abstract
Cpds. of formula (I) and their quat. salts with alkyl halides, alkali (ne earth) metal salts and the amine salt, aminoalcohol salts and aminoacid salts are new. In (I) R1 is H, NH2 or N02; R2 is H, alkyl, cycloalkyl, cycloalkylalkyl, haloalkyl or bicycloalkyl; R3 and R4 are H, lower alkyl, or aryl (opt. substd. by alkyl, lower alkoxy or OH); R5 is H, lower alkyl, or opt. substd. benzyl, provided that when R5 is other than H, the cpd. is a quat. salt; X is benzyl, COOH, alkoxycarbonyl, CN, CONH2, methane sulphonyl, formyl, alkanoyl, aroyl, heteroaroyl or heteroaryl; and Y and Z are H or OH, at least one being OH and when both are OH, they are in the 5,6- or 6,7- posn. Intermediates of formula (II) are also new. (R6 is lower alkyl; and R7 is H or is absent). Cpds. (I) are renal vasodilators and cardiovascular agents, and some intermediates in their prepn. are cardiotonic agents. Dose is 15-300 mg/kg.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/430,552 US4490374A (en) | 1982-09-30 | 1982-09-30 | 5,6-Dialkoxy-3,4-optionally substituted-2(1H)quinazolinones, composition and method of use |
| EP86201912A EP0220786B1 (en) | 1982-09-30 | 1983-09-29 | Substituted quinazolinones |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE58531T1 true ATE58531T1 (en) | 1990-12-15 |
Family
ID=23708017
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT83305895T ATE34979T1 (en) | 1982-09-30 | 1983-09-29 | ORTHOSUBSTITUTED DIHYDROXY-2(1H)QUINAZOLINONE-1-ALKANOIC ACIDS. |
| AT86201912T ATE58531T1 (en) | 1982-09-30 | 1983-09-29 | SUBSTITUTED CHINAZOLINONES. |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT83305895T ATE34979T1 (en) | 1982-09-30 | 1983-09-29 | ORTHOSUBSTITUTED DIHYDROXY-2(1H)QUINAZOLINONE-1-ALKANOIC ACIDS. |
Country Status (13)
| Country | Link |
|---|---|
| KR (1) | KR840006218A (en) |
| AT (2) | ATE34979T1 (en) |
| DE (2) | DE3382013D1 (en) |
| ES (4) | ES526133A0 (en) |
| HU (1) | HU192242B (en) |
| IL (1) | IL69849A (en) |
| NO (1) | NO833541L (en) |
| NZ (1) | NZ205685A (en) |
| PH (2) | PH19508A (en) |
| RO (2) | RO87466B (en) |
| SG (1) | SG31887G (en) |
| YU (2) | YU196983A (en) |
| ZW (1) | ZW20883A1 (en) |
-
1983
- 1983-09-21 NZ NZ205685A patent/NZ205685A/en unknown
- 1983-09-28 IL IL69849A patent/IL69849A/en unknown
- 1983-09-28 PH PH29609A patent/PH19508A/en unknown
- 1983-09-29 HU HU833392A patent/HU192242B/en unknown
- 1983-09-29 RO RO112200A patent/RO87466B/en unknown
- 1983-09-29 DE DE8686201912T patent/DE3382013D1/en not_active Expired - Lifetime
- 1983-09-29 AT AT83305895T patent/ATE34979T1/en active
- 1983-09-29 AT AT86201912T patent/ATE58531T1/en not_active IP Right Cessation
- 1983-09-29 ZW ZW208/83A patent/ZW20883A1/en unknown
- 1983-09-29 ES ES526133A patent/ES526133A0/en active Granted
- 1983-09-29 DE DE8383305895T patent/DE3376978D1/en not_active Expired
- 1983-09-29 RO RO83116473A patent/RO89787A/en unknown
- 1983-09-29 NO NO833541A patent/NO833541L/en unknown
- 1983-09-30 KR KR1019830004638A patent/KR840006218A/en not_active Application Discontinuation
- 1983-09-30 YU YU01969/83A patent/YU196983A/en unknown
-
1984
- 1984-05-29 ES ES532920A patent/ES532920A0/en active Granted
- 1984-05-29 ES ES532919A patent/ES532919A0/en active Granted
- 1984-05-29 ES ES532918A patent/ES532918A0/en active Granted
-
1985
- 1985-05-24 PH PH32313A patent/PH21757A/en unknown
- 1985-12-11 YU YU01922/85A patent/YU192285A/en unknown
-
1987
- 1987-03-31 SG SG318/87A patent/SG31887G/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ZW20883A1 (en) | 1985-05-01 |
| DE3382013D1 (en) | 1991-01-03 |
| HU192242B (en) | 1988-10-28 |
| PH21757A (en) | 1988-02-18 |
| RO87466A (en) | 1985-08-31 |
| NO833541L (en) | 1984-04-02 |
| ATE34979T1 (en) | 1988-06-15 |
| YU196983A (en) | 1987-02-28 |
| ES8507510A1 (en) | 1985-09-01 |
| RO89787A (en) | 1986-07-30 |
| ES8507512A1 (en) | 1985-09-01 |
| ES532920A0 (en) | 1985-09-01 |
| NZ205685A (en) | 1987-03-31 |
| ES8503671A1 (en) | 1985-03-16 |
| ES532918A0 (en) | 1985-09-01 |
| ES8507511A1 (en) | 1985-09-01 |
| ES532919A0 (en) | 1985-09-01 |
| PH19508A (en) | 1986-05-14 |
| IL69849A0 (en) | 1983-12-30 |
| ES526133A0 (en) | 1985-03-16 |
| SG31887G (en) | 1987-07-17 |
| DE3376978D1 (en) | 1988-07-14 |
| IL69849A (en) | 1987-11-30 |
| RO87466B (en) | 1985-08-31 |
| YU192285A (en) | 1987-12-31 |
| KR840006218A (en) | 1984-11-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |