CO5271679A1 - PROTEASA INHIBITORS 7-14 MEMBERS - Google Patents

PROTEASA INHIBITORS 7-14 MEMBERS

Info

Publication number
CO5271679A1
CO5271679A1 CO00011383A CO00011383A CO5271679A1 CO 5271679 A1 CO5271679 A1 CO 5271679A1 CO 00011383 A CO00011383 A CO 00011383A CO 00011383 A CO00011383 A CO 00011383A CO 5271679 A1 CO5271679 A1 CO 5271679A1
Authority
CO
Colombia
Prior art keywords
alkyl
het
group
nr2h
cycloalkyl
Prior art date
Application number
CO00011383A
Other languages
Spanish (es)
Inventor
Marquis Robert Wells Jr
Daniel Frank Veber
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of CO5271679A1 publication Critical patent/CO5271679A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
    • C07D313/16—Eight-membered rings
    • C07D313/18—Eight-membered rings not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Un compuesto de Fórmula I:<EMI FILE="00011383_1" ID="1" IMF=JPEG >en la que: A es C(O) o CH(OH); R1 es <EMI FILE="00011383_2" ID="2" IMF=JPEG >R´ es seleccionado del grupo que consiste en H, alquilo C1-6, Ar-alquilo C0-6 o Het alquilo C0-6; R" es seleccionado del grupo que consiste en H, alquilo C1-6, Ar-alquilo C0-6 o Het alquilo C0-6; R"AND#39 es seleccionado del grupo que consiste en H, alquilo C1-6, cicloalquilo C3-6-alquilo C0-6, Ar-alquilo C0-6 o Het-alquilo C0-6; R2 es seleccionado del grupo que consiste en H, alquenilo C2-6, alquinilo C2-6, Het. Ar o alquilo C1-6 opcionalmente sustituido con 0R6, SR6, NR62, R6NC(O)OR5, CO2R6, CO2NR62, N(C=NH)NH2, Het o Ar; R3 es seleccionado del grupo que consiste en H, alquilo C1-6, cicloalquil C3-6-alquilo C0-6, Ar-alquilo C0-6, Het-alquilo C0-6, R4C(O)-, R4C(S)-, R4SO2-, R4OC(O)-, R4R7NC(O)-, R4R7NC(S)-, R7HNCH(R7)C(O)-, o R4OC(O)NR7CH(R7)C(O)-; R4 es seleccionado del grupo que consiste en alquilo C1-6, cicloalquil C3-6-alquilo C0-6, Ar-alquilo C0-6 o Het-alquilo C0-6; R5 es seleccionado del grupo que consiste en H, alquilo C1-6, Ar-alquilo C0-6 o Het-alquilo C0-6;R6 y R7 son seleccionados del grupo que consiste en H, alquilo C1-6, Ar-alquilo C0-6 o Het-alquilo C0-6;M es seleccionado del grupo que consiste en: HC = CH, H2C-CH2, H(OR2)C-C(OR2)H, H(OR2)C-CH2, H(NR2H)C-C(NR2H)H, o H(OR2)C-C(NR2H)H, o H(NR2H)C-CH2; n es 1-7; L es 0-1;o sales, hidratos y solvatos farmacéuticamente aceptables de los mismos.A compound of Formula I: <EMI FILE = "00011383_1" ID = "1" MFI = JPEG> in which: A is C (O) or CH (OH); R1 is <EMI FILE = "00011383_2" ID = "2" IMF = JPEG> R 'is selected from the group consisting of H, C1-6 alkyl, Ar-C0-6 alkyl or Het C0-6 alkyl; R "is selected from the group consisting of H, C1-6 alkyl, Ar-C0-6 alkyl or Het C0-6 alkyl; R" AND # 39 is selected from the group consisting of H, C1-6 alkyl, C3 cycloalkyl -6-C0-6 alkyl, Ar-C0-6 alkyl or Het-C0-6 alkyl; R2 is selected from the group consisting of H, C2-6 alkenyl, C2-6 alkynyl, Het. Ar or C1-6 alkyl optionally substituted with 0R6, SR6, NR62, R6NC (O) OR5, CO2R6, CO2NR62, N (C = NH) NH2, Het or Ar; R3 is selected from the group consisting of H, C1-6 alkyl, C3-6 cycloalkyl-C0-6 alkyl, Ar-C0-6 alkyl, Het-C0-6 alkyl, R4C (O) -, R4C (S) - , R4SO2-, R4OC (O) -, R4R7NC (O) -, R4R7NC (S) -, R7HNCH (R7) C (O) -, or R4OC (O) NR7CH (R7) C (O) -; R4 is selected from the group consisting of C1-6 alkyl, C3-6 cycloalkyl-C0-6 alkyl, Ar-C0-6 alkyl or Het-C0-6 alkyl; R5 is selected from the group consisting of H, C1-6 alkyl, Ar-C0-6 alkyl or Het-C0-6 alkyl; R6 and R7 are selected from the group consisting of H, C1-6 alkyl, Ar-C0 alkyl -6 or Het-C0-6 alkyl; M is selected from the group consisting of: HC = CH, H2C-CH2, H (OR2) CC (OR2) H, H (OR2) C-CH2, H (NR2H) CC (NR2H) H, or H (OR2) CC (NR2H) H, or H (NR2H) C-CH2; n is 1-7; L is 0-1; or pharmaceutically acceptable salts, hydrates and solvates thereof.

CO00011383A 1999-02-19 2000-02-18 PROTEASA INHIBITORS 7-14 MEMBERS CO5271679A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US12069999P 1999-02-19 1999-02-19

Publications (1)

Publication Number Publication Date
CO5271679A1 true CO5271679A1 (en) 2003-04-30

Family

ID=22392011

Family Applications (1)

Application Number Title Priority Date Filing Date
CO00011383A CO5271679A1 (en) 1999-02-19 2000-02-18 PROTEASA INHIBITORS 7-14 MEMBERS

Country Status (8)

Country Link
EP (1) EP1153022A4 (en)
JP (1) JP2002537297A (en)
AU (1) AU3235100A (en)
CO (1) CO5271679A1 (en)
DZ (1) DZ3083A1 (en)
HK (1) HK1042695A1 (en)
PE (1) PE20001486A1 (en)
WO (1) WO2000049011A1 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7168084B1 (en) 1992-12-09 2007-01-23 Sedna Patent Services, Llc Method and apparatus for targeting virtual objects
US20030144175A1 (en) 1998-12-23 2003-07-31 Smithkline Beecham Corporation Protease inhibitors
WO2001034599A1 (en) 1999-11-10 2001-05-17 Smithkline Beecham Corporation Protease inhibitors
EP1229914A4 (en) 1999-11-10 2004-06-23 Smithkline Beecham Corp Protease inhibitors
WO2001034600A1 (en) 1999-11-10 2001-05-17 Smithkline Beecham Corporation Protease inhibitors
NZ520588A (en) 2000-03-21 2004-06-25 Smithkline Beecham Corp Protease inhibitors
JP2004513942A (en) * 2000-11-17 2004-05-13 メディヴァー　ユーケイ　リミテッド Cysteine protease inhibitor
JP2004520439A (en) * 2000-11-17 2004-07-08 メディヴィル・アクチボラグ Cysteine protease inhibitor
DE502004001386D1 (en) * 2003-05-27 2006-10-19 Merck Patent Gmbh Pyranderivative with exocyclic double bond
ATE340836T1 (en) 2003-05-27 2006-10-15 Merck Patent Gmbh PYRAND DERIVATIVES
EP1757284A1 (en) * 2005-08-25 2007-02-28 Santhera Pharmaceuticals (Schweiz) AG Use of N-(dibenz(b,f)oxepin-10ylmethyl)-N-methyl-N-prop-2-ynylamine (omigapil) for the prophylaxis and/or treatment of muscular dystrophy

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5021432A (en) * 1988-04-26 1991-06-04 Yoshitomi Pharmaceutical Industries, Ltd. Benzopyran compound and its pharmaceutical use
CA2157412A1 (en) * 1993-03-03 1994-09-15 Julia Marie Heerding Balanoids
US5612370A (en) * 1995-06-07 1997-03-18 Bristol-Myers Squibb Company Phenylglycine and phenylalaninen amido benzopyran derivatives
AR013079A1 (en) * 1997-05-06 2000-12-13 Smithkline Beecham Corp SUBSTITUTED DERIVATIVES OF TETRAHIDROFURANO-3-ONAS, TETRAHIDROPIRANO-3- ONAS AND TETRAHIDROTIOFEN-3-ONAS, A PROCEDURE FOR THE PREPARATION OF A PHARMACEUTICAL COMPOSITION OF A MEDICINAL PRODUCT USEFUL AS INTERMEDIATE PROTEIN INHIBITORS

Also Published As

Publication number Publication date
JP2002537297A (en) 2002-11-05
EP1153022A1 (en) 2001-11-14
AU3235100A (en) 2000-09-04
WO2000049011A1 (en) 2000-08-24
DZ3083A1 (en) 2004-06-02
EP1153022A4 (en) 2002-03-27
HK1042695A1 (en) 2002-08-23
PE20001486A1 (en) 2001-02-08

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