DE3278365D1 - Expression vectors - Google Patents

Expression vectors

Info

Publication number
DE3278365D1
DE3278365D1 DE8282304460T DE3278365T DE3278365D1 DE 3278365 D1 DE3278365 D1 DE 3278365D1 DE 8282304460 T DE8282304460 T DE 8282304460T DE 3278365 T DE3278365 T DE 3278365T DE 3278365 D1 DE3278365 D1 DE 3278365D1
Authority
DE
Germany
Prior art keywords
expression vectors
vectors
expression
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8282304460T
Other languages
English (en)
Inventor
Alan John Kingsman
Susan Mary Kingsman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vernalis R&D Ltd
Original Assignee
Celltech R&D Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27261280&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE3278365(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Celltech R&D Ltd filed Critical Celltech R&D Ltd
Application granted granted Critical
Publication of DE3278365D1 publication Critical patent/DE3278365D1/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/56—IFN-alpha
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/14—Lymphokine; related peptides
    • Y10S930/142—Interferon

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Mycology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Toxicology (AREA)
  • Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Plant Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Peptides Or Proteins (AREA)
DE8282304460T 1981-08-25 1982-08-24 Expression vectors Expired DE3278365D1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB8125934 1981-08-25
GB8208422 1982-03-23
GB8217496 1982-06-16

Publications (1)

Publication Number Publication Date
DE3278365D1 true DE3278365D1 (en) 1988-05-26

Family

ID=27261280

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8282304460T Expired DE3278365D1 (en) 1981-08-25 1982-08-24 Expression vectors

Country Status (9)

Country Link
US (1) US4615974A (de)
EP (1) EP0073635B2 (de)
JP (1) JP2666800B2 (de)
AU (1) AU560472B2 (de)
CA (1) CA1263942A (de)
DE (1) DE3278365D1 (de)
DK (1) DK368882A (de)
ES (1) ES8308361A1 (de)
IE (1) IE54046B1 (de)

Families Citing this family (118)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ199722A (en) * 1981-02-25 1985-12-13 Genentech Inc Dna transfer vector for expression of exogenous polypeptide in yeast;transformed yeast strain
JPS58146281A (ja) * 1981-10-19 1983-08-31 Suntory Ltd 酵母細胞の形質転換法
US4775622A (en) * 1982-03-08 1988-10-04 Genentech, Inc. Expression, processing and secretion of heterologous protein by yeast
US4657857A (en) * 1982-05-19 1987-04-14 Internationale Octrooi Maatschappij "Octropa" B.V. Yeast of the genus kluyveromyces modified for the expression of preprothaumatin or its various allelic and modified forms or their maturation forms, and the proteins obtained by that expression
GB2125047B (en) * 1982-08-09 1986-02-19 Ciba Geigy Ag Yeast hybrid vectors and their use for the production of polypeptides
AU577259B2 (en) * 1982-08-13 1988-09-22 Zymogenetics Inc. Glycolytic promters for regulated protein expression protease inhibitor
JPS5931799A (ja) * 1982-08-16 1984-02-20 Science & Tech Agency Ｂ型肝炎ウイルス遺伝子を組込んだ組換えプラスミド
US4977092A (en) * 1985-06-26 1990-12-11 Amgen Expression of exogenous polypeptides and polypeptide products including hepatitis B surface antigen in yeast cells
EP0116201B1 (de) * 1983-01-12 1992-04-22 Chiron Corporation Sekretorische Expression in Eukaryoten
US4876197A (en) * 1983-02-22 1989-10-24 Chiron Corporation Eukaryotic regulatable transcription
US5089398A (en) * 1983-02-22 1992-02-18 Chiron Corporation Enhanced yeast transcription employing hybrid GAPDH promoter region constructs
JPS60501140A (ja) * 1983-04-22 1985-07-25 アムジエン 酵母による外因性ポリペプチドの分泌
WO1984004539A1 (fr) * 1983-05-19 1984-11-22 Transgene Sa Production de la catechol 2,3-oxygenase par des levures, plasmide pour sa mise en oeuvre et application
EP0129268B1 (de) * 1983-05-19 1989-10-04 Unilever N.V. Verbesserungen in der Expression von neu eingeführten Genen in Hefezellen
FR2561662B2 (fr) * 1984-03-22 1986-08-22 Transgene Sa Bloc d'expression de la catechol 2,3-oxygenase dans les levures et souche marquee par ce bloc d'expression
GB8314961D0 (en) * 1983-05-31 1983-07-06 Kingsman A J Dna sequence
US4870008A (en) * 1983-08-12 1989-09-26 Chiron Corporation Secretory expression in eukaryotes
GB8325043D0 (en) * 1983-09-19 1983-10-19 Kingsman A J Vector
FR2562090B2 (fr) * 1984-03-27 1988-04-08 Transgene Sa Proteine antigenique de la rage glycosylee
EP0140762A1 (de) * 1983-10-03 1985-05-08 Transgene S.A. Vektoren zur Expression eines antigenischen Tollwutproteins in eukaryotischen Zellen und ihre Verwendung zur Herstellung eines Vakzins
FR2552776B1 (fr) * 1983-10-03 1986-05-09 Transgene Sa Vecteurs d'expression d'une proteine antigenique de la rage dans les cellules eucaryotes et leur application a la preparation d'un vaccin
GB8334261D0 (en) * 1983-12-22 1984-02-01 Bass Plc Fermentation processes
AU587176B2 (en) * 1984-02-14 1989-08-10 Mycogen Plant Science, Inc. Transfer vector
FR2559782B1 (fr) * 1984-02-16 1986-07-18 Transgene Sa Vecteur d'expression dans les levures de l'interleukine-2, levures transformees et procede de preparation de l'interleukine-2
FI841500A0 (fi) * 1984-04-13 1984-04-13 Valtion Teknillinen Foerfarande foer uppbygnande av cellulolytiska jaeststammar.
FR2564106B1 (fr) * 1984-05-09 1988-04-22 Transgene Sa Vecteurs d'expression du facteur ix, cellules transformees par ces vecteurs et procede de preparation du facteur ix.
US4880734A (en) * 1984-05-11 1989-11-14 Chiron Corporation Eukaryotic regulatable transcription
DK58285D0 (da) * 1984-05-30 1985-02-08 Novo Industri As Peptider samt fremstilling og anvendelse deraf
SU1364343A1 (ru) * 1984-07-13 1988-01-07 Всесоюзный научно-исследовательский институт генетики и селекции промышленных микроорганизмов Способ получени человеческого лейкоцитарного интерферона альфа-2
US4762786A (en) * 1984-09-27 1988-08-09 Eli Lilly And Company Vectors and conditions which allow genetic transformation of cephalosporium
US4855231A (en) * 1984-10-30 1989-08-08 Phillips Petroleum Company Regulatory region for heterologous gene expression in yeast
US4885242A (en) * 1984-10-30 1989-12-05 Phillips Petroleum Company Genes from pichia histidine pathway and uses thereof
US7273695B1 (en) 1984-10-31 2007-09-25 Novartis Vaccines And Diagnostics, Inc. HIV immunoassays using synthetic envelope polypeptides
CA1341423C (en) 1984-10-31 2003-03-04 Paul A. Luciw Recombinant proteins of viruses associated with lymphadenopathy syndrome and/or acquired immune deficiency syndrome
US7285271B1 (en) 1984-10-31 2007-10-23 Novartis Vaccines And Diagnostics, Inc. Antigenic composition comprising an HIV gag or env polypeptide
JPS61268184A (ja) * 1984-11-05 1986-11-27 Green Cross Corp:The 組換えプラスミド及び当該プラスミドによる形質転換株
US4990446A (en) * 1984-12-06 1991-02-05 Labofina, S.A. Promoters for the expression of foreign genes in yeast, plasmids comprising them, and use thereof for the production of polypeptides
JPS61141890A (ja) * 1984-12-15 1986-06-28 Suntory Ltd アルコ−ルの製造法
GB8513645D0 (en) * 1985-05-30 1985-07-03 Kingsman A J Expression vector
US4882282A (en) * 1985-08-16 1989-11-21 Immunex Corporation DNA sequences encoding bovine interleukin-2
EP0240550A4 (de) * 1985-09-26 1989-09-19 Genetics Inst Lungen-oberflachenaktive proteine.
US5104795A (en) * 1985-11-13 1992-04-14 Zoma Corporation Shortened phosphoglycerate kinase promoter
EP0245479B1 (de) * 1985-11-13 1993-02-17 Xoma Corporation Verkürzter phosphoglycerat-kinase-promotor
GB8620926D0 (en) * 1986-08-29 1986-10-08 Delta Biotechnology Ltd Yeast promoter
DE3635867A1 (de) * 1986-10-22 1988-05-11 Boehringer Ingelheim Int Neue hefeexpressionsvektoren fuer ifn-omega, verfahren zu ihrer herstellung und deren verwendung
US5378603A (en) * 1987-03-30 1995-01-03 Board Of Regents, The University Of Texas System Method and composition for identifying substances which activate transcription of the LDL receptor gene
JPS6463395A (en) 1987-05-04 1989-03-09 Oncogen Oncostatin m and novel composition having antitumor activity
US4966841A (en) * 1987-05-22 1990-10-30 The Board Of Regents Of The University Of Washington Enhanced vector production and expression of recombinant DNA products
EP0712928A2 (de) 1987-06-23 1996-05-22 The Board Of Trustees Of The Leland Stanford Junior University T-Zellen Antigen Rezeptor
WO1988010308A1 (en) * 1987-06-24 1988-12-29 Whitehead Institute For Biomedical Research Pheromone-inducible yeast promoter
US5063154A (en) * 1987-06-24 1991-11-05 Whitehead Institute For Biomedical Research Pheromone - inducible yeast promoter
US5591603A (en) * 1987-08-28 1997-01-07 Novo Nordisk A/S Process for preparing aprotinin and aprotinin analogs in yeast cells
US5049493A (en) * 1987-10-23 1991-09-17 California Institute Of Technology Enhancement of cell growth by expression of a cloned hemoglobin gene
US7442525B1 (en) 1987-12-24 2008-10-28 Novartis Vaccines And Diagnostics, Inc. Method for expressing HIV polypeptides
FR2628750B1 (fr) * 1988-03-21 1991-11-08 Pasteur Institut Vecteur modifie par une sequence codant pour une sequence d'acides amines contenue dans une proteine de mammifere ayant une activite biologique de recepteur membranaire
US5258502A (en) * 1989-01-30 1993-11-02 Massachusetts Institute Of Technology Immobilization and purification of fusion proteins using chitin-binding ability
US6172039B1 (en) 1990-04-16 2001-01-09 Apex Bioscience, Inc. Expression of recombinant hemoglobin and hemoglobin variants in yeast
US5206153A (en) * 1990-06-27 1993-04-27 Snow Brand Milk Products Co., Ltd. Method of producing human α-fetoprotein and product produced thereby
WO1992005244A1 (en) 1990-09-13 1992-04-02 Duke University Expression of g protein coupled receptors in yeast
EP0506945B1 (de) * 1990-10-25 1998-07-29 HODGSON, Clague Pitman Methode des gentransfers mittels retrotransposons
US6027722A (en) * 1990-10-25 2000-02-22 Nature Technology Corporation Vectors for gene transfer
SG84484A1 (en) * 1991-02-25 2001-11-20 Ciba Geigy Ag Improved yeast vectors
US20100267023A1 (en) * 1992-09-24 2010-10-21 Keygene N.V. Selective restriction fragment amplification: fingerprinting
US5422254A (en) * 1992-02-14 1995-06-06 Oy Alko Ab Method to increase the trehalose content of organisms by transforming them with the structural genes for the short and long chains of yeast trehalose synthase
AU699706C (en) 1993-03-12 2000-01-13 Creighton University Improved vectors for gene therapy
US20030190753A1 (en) * 1995-11-09 2003-10-09 Nature Technology Corporation Vectors for gene transfer
US5989866A (en) 1996-10-16 1999-11-23 Zymogenetics, Inc. FGF homologs
US6017694A (en) * 1997-12-19 2000-01-25 American Cyanamid Company Methods of screening for modulators of respiratory syncytial virus matrix protein interaction
HUP0103593A2 (hu) 1998-09-23 2002-01-28 Zymogenetics, Inc. Zalpha11 citokin receptor
DK1137773T3 (da) 1998-12-07 2008-12-08 Zymogenetics Inc Væsktfaktorhomolog ZVEGF3
ATE249517T1 (de) 1999-01-07 2003-09-15 Zymogenetics Inc Lösliche rezeptoren br43x2 und verfahren zu deren therapeutischen verwendung
US7833529B1 (en) 1999-01-07 2010-11-16 Zymogenetics, Inc. Methods for inhibiting B lymphocyte proliferation with soluble ztnf4 receptor
IL145288A0 (en) 1999-03-09 2002-06-30 Zymogenetics Inc Novel cytokin zalpha11 ligand
EP1190056B1 (de) 1999-07-07 2007-04-25 ZymoGenetics, Inc. Menschlicher cytokinrezeptor
ATE459716T1 (de) 1999-12-23 2010-03-15 Zymogenetics Inc Zytokin zcyt018
WO2001087933A2 (en) 2000-05-11 2001-11-22 Zymogenetics, Inc. Zsig33-like peptides
AU2001273032A1 (en) 2000-06-26 2002-01-08 Zymogenetics Inc. Cytokine receptor zcytor17
RU2292394C2 (ru) 2000-06-30 2007-01-27 ЗАЙМОДЖЕНЕТИКС, Инк., Интерферон-подобный белок zcyto21
EP1736545A3 (de) 2000-08-08 2007-03-28 ZymoGenetics, Inc. Lösliche Zcyctor 11 Cytokinrezeptoren
JP2004533997A (ja) 2001-02-20 2004-11-11 ザイモジェネティクス，インコーポレイティド Ｂｃｍａ及びｔａｃｉの両者を結合する抗体
FR2821625B1 (fr) * 2001-03-01 2003-05-16 Genodyssee Nouveaux polynucleotides comportant un polymorphisme de type snp fonctionnel dans la sequence nucleotidique du gene ifn-alpha-2 ainsi que de nouveaux polypeptides codes par ces polynucleotides et leurs utilisations therapeutiques
FR2823220B1 (fr) * 2001-04-04 2003-12-12 Genodyssee Nouveaux polynucleotides et polypeptides de l'erythropoietine (epo)
SI2116259T1 (sl) 2001-05-24 2012-11-30 Zymogenetics Inc Taci imunoglobulin fuzijski proteini
US6645739B2 (en) 2001-07-26 2003-11-11 Phoenix Pharmacologies, Inc. Yeast expression systems, methods of producing polypeptides in yeast, and compositions relating to same
WO2003023015A2 (en) 2001-09-13 2003-03-20 California Institute Of Technology Method for expression of small antiviral rna molecules within a cell
WO2003022228A2 (en) 2001-09-13 2003-03-20 California Institute Of Technology Method for producing transgenic birds and fish
CA2465156C (en) 2001-11-05 2011-10-18 Zymogenetics, Inc. Il-21 antagonists
US7064186B2 (en) 2002-01-18 2006-06-20 Zymogenetics, Inc. Cytokine zcytor17 ligand
US7494804B2 (en) 2002-01-18 2009-02-24 Zymogenetics, Inc. Polynucleotide encoding cytokine receptor zcytor17 multimer
CN101676728A (zh) 2002-04-19 2010-03-24 津莫吉尼蒂克斯公司 细胞因子受体
EP2251353B1 (de) 2003-08-07 2013-03-06 ZymoGenetics, Inc. Homogene Präparate von IL-29
WO2005087810A2 (en) 2004-03-08 2005-09-22 Zymogenetics, Inc. Dimeric fusion proteins and materials and methods for producing them
EP1793845A2 (de) 2004-07-29 2007-06-13 ZymoGenetics, Inc. Verwendung von il-28 und il-29 zur krebsbehandlung
EP2166103B1 (de) 2004-08-02 2013-05-22 BASF Plant Science GmbH Verfahren zur Isolierung von Transkriptionsabschlusssequenzen
EP2192132A3 (de) 2005-02-08 2010-08-18 ZymoGenetics, Inc. Anti-il-20-, Anti-il-22- und Anti-il-22ra-Antikörper und Bindungspartner sowie Verwendungsverfahren bei Entzündungen
EP3214095B1 (de) 2005-05-12 2019-12-11 ZymoGenetics, Inc. Zusammensetzungen und verfahren zur modulation von immunsystemreaktionen
AR059025A1 (es) 2005-08-09 2008-03-12 Zymogenetics Inc Metodos para el tratamiento y prevencion de proliferacion de celulas anormales utilizando moleculas de fusion taci
US7842292B2 (en) * 2005-08-09 2010-11-30 Ares Trading S.A. Methods for treating B-cell malignancies using a TACI-Ig fusion molecule
JP2009537563A (ja) * 2006-05-15 2009-10-29 アレス トレーディング ソシエテ アノニム Ｔａｃｉ融合分子を使用する自己免疫疾患を治療するための方法
US20100240597A1 (en) 2007-06-15 2010-09-23 Arkansas State University Methods of delivery of molecules to cells using a ricin subunit and compositions relating to same
AU2008328371B2 (en) 2007-11-21 2011-08-11 Roskilde Universitet Polypeptides comprising an ice-binding activity
CN101952309A (zh) * 2007-12-21 2011-01-19 Ifxa有限公司 蛋白酶抑制剂
BRPI0907640A2 (pt) * 2008-01-25 2015-11-03 Univ Aarhus inibição exosítio-seletiva da atividade de papp-a contra igfbp-4
DK2274008T3 (da) 2008-03-27 2014-05-12 Zymogenetics Inc Sammensætninger og fremgangsmåder til hæmning af PDGFRBETA og VEGF-A
JP2011526154A (ja) 2008-06-27 2011-10-06 ザイモジェネティクス， インコーポレイテッド 可溶性ハイブリッドＦｃγレセプターおよび関連する方法
BR112012031329A2 (pt) 2010-06-09 2016-10-11 Zymogenetics Inc proteínas de fusão diméricas vstm3 e composições e métodos relacionados
US9771576B2 (en) 2012-02-01 2017-09-26 Synthetic Genomics, Inc. Materials and methods for the synthesis of error-minimized nucleic acid molecules
WO2014202089A2 (en) 2013-06-18 2014-12-24 Roskilde Universitet Variants of anti-freeze polypeptides
CA2997263C (en) 2015-09-08 2022-10-04 Theripion, Inc. Apoa-1 fusion polypeptides and related compositions and methods
WO2018136163A2 (en) 2016-12-09 2018-07-26 Theripion, Inc. Tandem apoa-1 fusion polypeptides
JP7369113B2 (ja) 2017-07-20 2023-10-25 アプティーボ リサーチ アンド デベロップメント エルエルシー 癌胎児性抗原結合タンパク質、関連する化合物および方法
DK3710484T3 (da) 2017-12-20 2023-11-27 Harbour Biomed Shanghai Co Ltd Ctla-4-bindende antistoffer og anvendelser deraf
US10150801B1 (en) 2017-12-27 2018-12-11 Imunami Laboratories Pte. Ltd. Recombinant polypeptides and methods of use thereof
EP3732190A1 (de) 2017-12-27 2020-11-04 Imunami Laboratories Pte. Ltd. Rekombinante polypeptide und verfahren zur verwendung davon
WO2021040610A1 (en) 2019-08-26 2021-03-04 Imunami Laboratories Pte. Ltd. Recombinant polypeptides and methods of use thereof
US10675332B1 (en) 2019-08-26 2020-06-09 Imunami Laboratories Pte. Ltd. Recombinant polypeptides and methods of use thereof
CA3182917A1 (en) 2020-06-22 2021-12-30 Ya-Huei Chen Recombinant polypeptides and combinations for use in the treatment of cancer
AU2022223409A1 (en) 2021-02-19 2023-09-21 Theripion, Inc. Dnase fusion polypeptides and related compositions and methods

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2441659A1 (fr) * 1978-11-14 1980-06-13 Anvar Nouveaux plasmides hybrides et microorganismes les contenant
GB2068969B (en) * 1980-02-05 1983-07-27 Upjohn Co Gene expression
US4666847A (en) * 1981-01-16 1987-05-19 Collaborative Research, Inc. Recombinant DNA means and method
NZ201705A (en) * 1981-08-31 1986-03-14 Genentech Inc Recombinant dna method for production of hepatitis b surface antigen in yeast

Also Published As

Publication number Publication date
DK368882A (da) 1983-02-26
JP2666800B2 (ja) 1997-10-22
AU560472B2 (en) 1987-04-09
AU8723882A (en) 1983-03-24
EP0073635A2 (de) 1983-03-09
IE821985L (en) 1983-02-25
IE54046B1 (en) 1989-05-24
ES515241A0 (es) 1983-08-16
CA1263942A (en) 1989-12-19
EP0073635A3 (en) 1984-05-16
EP0073635B1 (de) 1988-04-20
EP0073635B2 (de) 1992-09-30
ES8308361A1 (es) 1983-08-16
US4615974A (en) 1986-10-07
JPS5877896A (ja) 1983-05-11

Similar Documents

Publication Publication Date Title
DE3278365D1 (en) Expression vectors
GB2102186B (en) Disc-accommodating case
CS144682A2 (en) Pletaci stroj
CS82782A2 (en) Zpusob odstranovani kyslicnikovych okuji z povrchu kovovych predmetu
DE3277194D1 (en) Wingsail arrangement
GB2104901B (en) Expression vectors
JPS57180973A (en) Case
BG48180A1 (en) Stereocomparator
ZA825959B (en) Expression vectors
GB8529127D0 (en) Expression vectors
JPS57115208A (en) Handbag
KR820001471Y1 (en) Handbags
CA48729S (en) Infiltrometer
CA47741S (en) Walking-board
CA48859S (en) Hairslide
CS755981A1 (en) Zpusob vyroby zpevnenych texturovanych odlitku z termoplastu
CS272681A1 (en) Dvojplastova plocha strecha z drevenych stresnych dielcov
IE812624L (en) Plasmid vectors
CS173583A2 (en) Zpusob vyroby l1 arylcyklobutyl palkylaminu
JPS57133834A (en) Case
CS51483A2 (en) Zpusob vyroby heterocyklickych derivatu guanidinu
CS132781A1 (en) Zpusob vyroby priskoveho dratu
AU85813S (en) woodstove
AU85050S (en) roller-ski
AU83569S (en) key-blank

Legal Events

Date Code Title Description
8363 Opposition against the patent
8366 Restricted maintained after opposition proceedings
8327 Change in the person/name/address of the patent owner

Owner name: BRITISH BIOTECH PHARMACEUTICALS LTD., OXFORD, GB

8339 Ceased/non-payment of the annual fee