DE3260150D1 - Process for the preparation of 4-amino-chloroquinolines - Google Patents
Process for the preparation of 4-amino-chloroquinolinesInfo
- Publication number
- DE3260150D1 DE3260150D1 DE8282400080T DE3260150T DE3260150D1 DE 3260150 D1 DE3260150 D1 DE 3260150D1 DE 8282400080 T DE8282400080 T DE 8282400080T DE 3260150 T DE3260150 T DE 3260150T DE 3260150 D1 DE3260150 D1 DE 3260150D1
- Authority
- DE
- Germany
- Prior art keywords
- amino
- formula
- image
- optionally substituted
- carbon atoms
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- QVCRGJALYOLXDC-UHFFFAOYSA-N 2-chloroquinolin-4-amine Chemical class C1=CC=C2C(N)=CC(Cl)=NC2=C1 QVCRGJALYOLXDC-UHFFFAOYSA-N 0.000 title abstract 3
- 125000004432 carbon atom Chemical group C* 0.000 abstract 3
- LBUJPTNKIBCYBY-UHFFFAOYSA-N 1,2,3,4-tetrahydroquinoline Chemical compound C1=CC=C2CCCNC2=C1 LBUJPTNKIBCYBY-UHFFFAOYSA-N 0.000 abstract 2
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 2
- QRJMFMFNPROMBS-UHFFFAOYSA-N 1-chloro-2,3-dihydroquinolin-4-one Chemical compound C1=CC=C2N(Cl)CCC(=O)C2=C1 QRJMFMFNPROMBS-UHFFFAOYSA-N 0.000 abstract 1
- KJTLSVCANCCWHF-UHFFFAOYSA-N Ruthenium Chemical compound [Ru] KJTLSVCANCCWHF-UHFFFAOYSA-N 0.000 abstract 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical compound [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 238000005899 aromatization reaction Methods 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 239000003054 catalyst Substances 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 230000005494 condensation Effects 0.000 abstract 1
- 238000009833 condensation Methods 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 229910052707 ruthenium Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
- C07D215/42—Nitrogen atoms attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/233—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
- C07D215/42—Nitrogen atoms attached in position 4
- C07D215/46—Nitrogen atoms attached in position 4 with hydrocarbon radicals, substituted by nitrogen atoms, attached to said nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Quinoline Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Catalysts (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8100765A FR2498187A1 (fr) | 1981-01-16 | 1981-01-16 | Procede de preparation d'amino-4 chloro-7 quinoleines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE3260150D1 true DE3260150D1 (en) | 1984-06-20 |
Family
ID=9254223
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE8282400080T Expired DE3260150D1 (en) | 1981-01-16 | 1982-01-15 | Process for the preparation of 4-amino-chloroquinolines |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US4421920A (enExample) |
| EP (1) | EP0056766B1 (enExample) |
| JP (1) | JPS57171973A (enExample) |
| KR (1) | KR870001921B1 (enExample) |
| AT (1) | ATE7492T1 (enExample) |
| CA (1) | CA1171861A (enExample) |
| DE (1) | DE3260150D1 (enExample) |
| DK (1) | DK148805C (enExample) |
| FR (1) | FR2498187A1 (enExample) |
| HU (1) | HU184985B (enExample) |
| IE (1) | IE51957B1 (enExample) |
| IN (1) | IN158327B (enExample) |
| ZA (1) | ZA82277B (enExample) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2892298A (en) * | 1957-08-05 | 1959-06-30 | Earl J Chaney | Pickup device |
| GB8426584D0 (en) * | 1984-10-19 | 1984-11-28 | Beecham Group Plc | Compounds |
| EP0222839A4 (en) * | 1985-05-17 | 1988-11-09 | Univ Australian | ANTI-MALARIA COMPOUNDS. |
| US4789678A (en) * | 1986-08-25 | 1988-12-06 | Hoechst-Roussel Pharmaceuticals, Inc. | Memory enhancing α-alkyl-4-amino-3-quinolinemethanols and 1-(4-aralkylamino-3-quinolinyl)alkanones and related compounds |
| CA1340821C (en) * | 1988-10-06 | 1999-11-16 | Nobuyuki Fukazawa | Heterocyclic compounds and anticancer-drug reinforcing agents containing them as effective components |
| PT100905A (pt) * | 1991-09-30 | 1994-02-28 | Eisai Co Ltd | Compostos heterociclicos azotados biciclicos contendo aneis de benzeno, ciclo-hexano ou piridina e de pirimidina, piridina ou imidazol substituidos e composicoes farmaceuticas que os contem |
| CA2133620A1 (en) * | 1993-10-28 | 1995-04-29 | Werner Hofheinz | Aminoquinoline derivatives |
| AU6168296A (en) * | 1995-06-07 | 1996-12-30 | The Administrators Of The Tulane Eductional Fund | Chloroquine analogs and methods of preventing and treating p lasmodial disease |
| KR100489174B1 (ko) | 1996-03-05 | 2005-09-30 | 제네카-파마 소시에떼아노님 | 4-아닐리노퀴나졸린유도체 |
| IL128994A (en) * | 1996-09-25 | 2004-12-15 | Zeneca Ltd | History of quinoline and naphthyridine and their salts, processes for their preparation, pharmaceutical preparations containing them and their use as medicines |
| GB9910579D0 (en) | 1999-05-08 | 1999-07-07 | Zeneca Ltd | Chemical compounds |
| GB9910580D0 (en) | 1999-05-08 | 1999-07-07 | Zeneca Ltd | Chemical compounds |
| US6417177B1 (en) | 1999-07-13 | 2002-07-09 | Alpha Research Group, Llc | Chloroquine derivatives for the treatment of Parkinson's disease |
| US20040229908A1 (en) * | 1999-07-13 | 2004-11-18 | Jodi Nelson | Compositions and methods for the treatment of Parkinson's disease and tardive dyskinesias |
| PT1274692E (pt) * | 2000-04-07 | 2006-11-30 | Astrazeneca Ab | Compostos de quinazolina |
| EP1337524A1 (en) * | 2000-11-02 | 2003-08-27 | AstraZeneca AB | Substituted quinolines as antitumor agents |
| JP2004517059A (ja) * | 2000-11-02 | 2004-06-10 | アストラゼネカ アクチボラグ | 抗腫瘍剤用の４−置換キノリン類 |
| US7084157B2 (en) * | 2002-05-17 | 2006-08-01 | Rajeev Raut | Ophthalmic pharmaceutical compositions and methods for treating ocular inflammation |
| US20040002451A1 (en) * | 2002-06-20 | 2004-01-01 | Bruce Kerwin | Compositions of pegylated soluble tumor necrosis factor receptors and methods of preparing |
| GB0215823D0 (en) * | 2002-07-09 | 2002-08-14 | Astrazeneca Ab | Quinazoline derivatives |
| GB0225579D0 (en) * | 2002-11-02 | 2002-12-11 | Astrazeneca Ab | Chemical compounds |
| US6916627B2 (en) * | 2002-11-27 | 2005-07-12 | St. Jude Children's Research Hospital | ATM kinase compositions and methods |
| US7108992B2 (en) * | 2002-11-27 | 2006-09-19 | St. Jude Children's Research Hospital | ATM kinase compositions and methods |
| US8309562B2 (en) * | 2003-07-03 | 2012-11-13 | Myrexis, Inc. | Compounds and therapeutical use thereof |
| KR101218213B1 (ko) | 2003-07-03 | 2013-01-04 | 시토비아 인크. | 카스파제의 활성인자 및 세포자멸사의 유도인자로서의4-아릴아미노-퀴나졸린 |
| GEP20084572B (en) * | 2003-12-23 | 2008-12-25 | Pfizer | Novel quinoline derivatives |
| ES2237332B1 (es) | 2004-01-14 | 2006-11-01 | Consejo Sup. Investig. Cientificas | Derivados de piridinio y quinolinio. |
| US8586613B2 (en) | 2004-01-14 | 2013-11-19 | Universidad De Granada | Pyridinium and quinolinium derivatives |
| EP1833482A4 (en) | 2005-01-03 | 2011-02-16 | Myriad Genetics Inc | COMPOUNDS AND ITS THERAPEUTIC USE |
| US8258145B2 (en) * | 2005-01-03 | 2012-09-04 | Myrexis, Inc. | Method of treating brain cancer |
| WO2007059372A2 (en) * | 2005-11-09 | 2007-05-24 | St. Jude Children's Research Hospital | Use of chloroquine to treat metabolic syndrome |
| CN105693605B (zh) * | 2016-03-09 | 2017-12-22 | 西安科技大学 | 一种光学纯(r)/(s)‑氯喹的不对称合成方法 |
| CN105693606B (zh) * | 2016-03-09 | 2017-12-05 | 西安科技大学 | 一种光学纯(r)/(s)‑羟氯喹的不对称合成方法 |
| EP4251746A1 (en) | 2020-11-30 | 2023-10-04 | Cellectis SA | Use of aminoquinoline compounds for higher gene integration |
| CN115947684B (zh) * | 2023-01-18 | 2025-01-17 | 贵州医科大学 | 一种钯和铜协同催化氧化芳构化制备4-胺基喹啉类衍生物的方法 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2653940A (en) * | 1951-01-27 | 1953-09-29 | William S Johnson | Process for preparing 4-quinolyl secondary amines |
-
1981
- 1981-01-16 FR FR8100765A patent/FR2498187A1/fr active Granted
-
1982
- 1982-01-14 JP JP57003535A patent/JPS57171973A/ja active Pending
- 1982-01-15 KR KR8200161A patent/KR870001921B1/ko not_active Expired
- 1982-01-15 HU HU82121A patent/HU184985B/hu not_active IP Right Cessation
- 1982-01-15 AT AT82400080T patent/ATE7492T1/de active
- 1982-01-15 EP EP82400080A patent/EP0056766B1/fr not_active Expired
- 1982-01-15 CA CA000394273A patent/CA1171861A/fr not_active Expired
- 1982-01-15 IN IN36/DEL/82A patent/IN158327B/en unknown
- 1982-01-15 ZA ZA82277A patent/ZA82277B/xx unknown
- 1982-01-15 US US06/339,722 patent/US4421920A/en not_active Expired - Fee Related
- 1982-01-15 DK DK16582A patent/DK148805C/da not_active IP Right Cessation
- 1982-01-15 DE DE8282400080T patent/DE3260150D1/de not_active Expired
- 1982-01-15 IE IE75/82A patent/IE51957B1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ZA82277B (en) | 1982-11-24 |
| HU184985B (en) | 1984-11-28 |
| EP0056766A1 (fr) | 1982-07-28 |
| FR2498187A1 (fr) | 1982-07-23 |
| CA1171861A (fr) | 1984-07-31 |
| FR2498187B1 (enExample) | 1983-09-30 |
| IN158327B (enExample) | 1986-10-18 |
| DK16582A (da) | 1982-07-17 |
| IE51957B1 (en) | 1987-04-29 |
| KR870001921B1 (ko) | 1987-10-22 |
| IE820075L (en) | 1982-07-16 |
| ATE7492T1 (de) | 1984-06-15 |
| KR830009038A (ko) | 1983-12-17 |
| DK148805C (da) | 1986-04-01 |
| US4421920A (en) | 1983-12-20 |
| DK148805B (da) | 1985-10-07 |
| JPS57171973A (en) | 1982-10-22 |
| EP0056766B1 (fr) | 1984-05-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE3260150D1 (en) | Process for the preparation of 4-amino-chloroquinolines | |
| EP0110814A3 (en) | Beta-carbolines, process for their preparation and pharmaceutical compositions containing them | |
| ES8604544A1 (es) | Procedimiento para preparar nuevos derivados de acidos feni-laceticos | |
| GB2185252B (en) | Triazole derivatives | |
| HUT68166A (en) | Process for preparing substituted piperidines | |
| ZA858169B (en) | New adamantanamine derivatives,processes for their preparation and drugs in which they are present | |
| ES8101550A1 (es) | Un procedimiento para la preparacion de nuevos derivados de 2-pirrolidin-metanol. | |
| PT74470A (de) | Chemische verbindungen verfahren zu ihrer herstellung und ihre verwendungen als antigene oder immunadsorbentien | |
| FI873443A7 (fi) | Norfloxacinmellanprodukt. | |
| AU568064B2 (en) | 4-acylamino-1-aza-adamantanes | |
| RO87991A (ro) | Procedeu pentru prepararea unor esteri tiazolidinici substituiti ai unor acizi minerali | |
| PT79724A (en) | Chemical synthesis | |
| FR2498607B1 (enExample) | ||
| ES481486A1 (es) | Procedimientos para preparar derivados de acidos 1-pirrol- carboxilixos | |
| DE3267690D1 (en) | Process for the preparation of 3-alkyl-6-methyl-beta-resorcylic-acid esters | |
| IE810260L (en) | Benzylidene derivatives. | |
| IL65666A (en) | Derivatives of 4-aminomethyl-5-acyl-1,3-dihydro-2h-imidazol-2-ones and process for their preparation | |
| JPS6483032A (en) | Manufacture of diene-1-ol, 9-hydroxydodecene- (10)-yl-1 tertiary butyl ether and use | |
| DE3464237D1 (en) | Tetra-alkyl-2,2,5,5-cyclohexanon-4-ol-1 and its sulfonated derivatives, process and intermediates for its preparation and its use in the synthesis of cis-cyclopropanlactones | |
| IL65667A (en) | 4-(4-phenyl-1-piperidinyl)methyl-5-benzoyl-1,3-dihydro-2h-imidazol-2-one derivatives and process for their preparation | |
| ES8305732A1 (es) | Procedimiento para preparar derivados de imidazol. | |
| IN161663B (enExample) | ||
| JPS56110693A (en) | Allylcarboxylic acid derivative | |
| GB8721373D0 (en) | Chemical process | |
| DK242483A (da) | Fremgangsmaade til fremstilling af oximderivater af 7-aminothiazolylacetamidocephalosporansyre |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8339 | Ceased/non-payment of the annual fee |