IE820075L - 4-amino-chloroquinolines - Google Patents

4-amino-chloroquinolines

Info

Publication number
IE820075L
IE820075L IE820075A IE7582A IE820075L IE 820075 L IE820075 L IE 820075L IE 820075 A IE820075 A IE 820075A IE 7582 A IE7582 A IE 7582A IE 820075 L IE820075 L IE 820075L
Authority
IE
Ireland
Prior art keywords
amino
formula
image
optionally substituted
carbon atoms
Prior art date
Application number
IE820075A
Other versions
IE51957B1 (en
Original Assignee
Rhone Poulenc Sante
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Sante filed Critical Rhone Poulenc Sante
Publication of IE820075L publication Critical patent/IE820075L/en
Publication of IE51957B1 publication Critical patent/IE51957B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/42—Nitrogen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/233—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/42—Nitrogen atoms attached in position 4
    • C07D215/46—Nitrogen atoms attached in position 4 with hydrocarbon radicals, substituted by nitrogen atoms, attached to said nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Quinoline Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

4-Amino-chloroquinolines of the formula: <IMAGE> in which R1 represents a hydrogen atom or an alkyl radical (1 to 5 carbon atoms), and R2 represents an alkyl radical (1 to 5 carbon atoms) optionally substituted by a dialkylamino group, or a phenyl radical optionally substituted by one or more carboxy and hydroxy radicals and alkyl radicals (1 to 4 carbon atoms) optionally substituted by a dialkylamino group, are prepared by the condensation of an amine of the formula: <IMAGE> with a chloro-1,2,3,4-tetrahydroquinolin-4-one of the formula: <IMAGE> with aromatization of the tetrahydroquinoline, the reaction being carried out in the presence of a ruthenium based catalyst on a support. The 4-amino-chloroquinoline products are useful as pharmaceuticals.
IE75/82A 1981-01-16 1982-01-15 Process for the preparation of 4-amino-chloroquinolines IE51957B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8100765A FR2498187A1 (en) 1981-01-16 1981-01-16 PROCESS FOR THE PREPARATION OF AMINO-4 CHLORO-7 QUINOLINES

Publications (2)

Publication Number Publication Date
IE820075L true IE820075L (en) 1982-07-16
IE51957B1 IE51957B1 (en) 1987-04-29

Family

ID=9254223

Family Applications (1)

Application Number Title Priority Date Filing Date
IE75/82A IE51957B1 (en) 1981-01-16 1982-01-15 Process for the preparation of 4-amino-chloroquinolines

Country Status (13)

Country Link
US (1) US4421920A (en)
EP (1) EP0056766B1 (en)
JP (1) JPS57171973A (en)
KR (1) KR870001921B1 (en)
AT (1) ATE7492T1 (en)
CA (1) CA1171861A (en)
DE (1) DE3260150D1 (en)
DK (1) DK148805C (en)
FR (1) FR2498187A1 (en)
HU (1) HU184985B (en)
IE (1) IE51957B1 (en)
IN (1) IN158327B (en)
ZA (1) ZA82277B (en)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2892298A (en) * 1957-08-05 1959-06-30 Earl J Chaney Pickup device
GB8426584D0 (en) * 1984-10-19 1984-11-28 Beecham Group Plc Compounds
WO1986006718A1 (en) * 1985-05-17 1986-11-20 The Australian National University Antimalarial compounds
US4789678A (en) * 1986-08-25 1988-12-06 Hoechst-Roussel Pharmaceuticals, Inc. Memory enhancing α-alkyl-4-amino-3-quinolinemethanols and 1-(4-aralkylamino-3-quinolinyl)alkanones and related compounds
CA1340821C (en) * 1988-10-06 1999-11-16 Nobuyuki Fukazawa Heterocyclic compounds and anticancer-drug reinforcing agents containing them as effective components
PT100905A (en) * 1991-09-30 1994-02-28 Eisai Co Ltd BICYCLE HYGIENEOUS HETEROCYCLIC COMPOUNDS CONTAINING BENZENE, CYCLOHEXAN OR PYRIDINE AND PYRIMIDINE, PYRIDINE OR IMIDAZOLE SUBSTITUTES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
CA2133620A1 (en) * 1993-10-28 1995-04-29 Werner Hofheinz Aminoquinoline derivatives
AU6168296A (en) * 1995-06-07 1996-12-30 The Administrators Of The Tulane Eductional Fund Chloroquine analogs and methods of preventing and treating p lasmodial disease
CN1116286C (en) 1996-03-05 2003-07-30 曾尼卡有限公司 4-anilinoquinazoline derivatives
ATE300521T1 (en) * 1996-09-25 2005-08-15 Astrazeneca Ab QUINOLINE DERIVATIVES THAT DELAY THE EFFECT OF GROWTH FACTORS LIKE VEGF
GB9910579D0 (en) 1999-05-08 1999-07-07 Zeneca Ltd Chemical compounds
GB9910580D0 (en) 1999-05-08 1999-07-07 Zeneca Ltd Chemical compounds
US20040229908A1 (en) * 1999-07-13 2004-11-18 Jodi Nelson Compositions and methods for the treatment of Parkinson's disease and tardive dyskinesias
US6417177B1 (en) 1999-07-13 2002-07-09 Alpha Research Group, Llc Chloroquine derivatives for the treatment of Parkinson's disease
EP1274692B1 (en) * 2000-04-07 2006-08-02 AstraZeneca AB Quinazoline compounds
AU2002210714A1 (en) * 2000-11-02 2002-06-11 Astrazeneca Ab Substituted quinolines as antitumor agents
EP1337513A1 (en) * 2000-11-02 2003-08-27 AstraZeneca AB 4-substituted quinolines as antitumor agents
US7084157B2 (en) * 2002-05-17 2006-08-01 Rajeev Raut Ophthalmic pharmaceutical compositions and methods for treating ocular inflammation
US20040002451A1 (en) * 2002-06-20 2004-01-01 Bruce Kerwin Compositions of pegylated soluble tumor necrosis factor receptors and methods of preparing
GB0215823D0 (en) * 2002-07-09 2002-08-14 Astrazeneca Ab Quinazoline derivatives
GB0225579D0 (en) * 2002-11-02 2002-12-11 Astrazeneca Ab Chemical compounds
US7108992B2 (en) * 2002-11-27 2006-09-19 St. Jude Children's Research Hospital ATM kinase compositions and methods
US6916627B2 (en) * 2002-11-27 2005-07-12 St. Jude Children's Research Hospital ATM kinase compositions and methods
CN1984660B (en) 2003-07-03 2010-12-15 美瑞德生物工程公司 4-arylamino-quinazolines as activators of aspartic acid specificity cysteine protease and inducers of apoptosis
US8309562B2 (en) * 2003-07-03 2012-11-13 Myrexis, Inc. Compounds and therapeutical use thereof
MXPA06007242A (en) * 2003-12-23 2006-08-18 Pfizer Novel quinoline derivatives.
ES2237332B1 (en) 2004-01-14 2006-11-01 Consejo Sup. Investig. Cientificas DERIVATIVES OF PIRIDINIO AND QUINOLINIO.
US8586613B2 (en) 2004-01-14 2013-11-19 Universidad De Granada Pyridinium and quinolinium derivatives
EP1833482A4 (en) 2005-01-03 2011-02-16 Myriad Genetics Inc Compounds and therapeutical use thereof
US8258145B2 (en) * 2005-01-03 2012-09-04 Myrexis, Inc. Method of treating brain cancer
US8440695B2 (en) * 2005-11-09 2013-05-14 St Jude Children's Research Hospital Use of chloroquine to treat metabolic syndrome
CN105693606B (en) * 2016-03-09 2017-12-05 西安科技大学 A kind of method of asymmetric synthesis of optical voidness (R)/(S) HCQ
CN105693605B (en) * 2016-03-09 2017-12-22 西安科技大学 A kind of method of asymmetric synthesis of optical voidness (R)/(S) chloroquine
EP4251746A1 (en) 2020-11-30 2023-10-04 Cellectis SA Use of aminoquinoline compounds for higher gene integration

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2653940A (en) * 1951-01-27 1953-09-29 William S Johnson Process for preparing 4-quinolyl secondary amines

Also Published As

Publication number Publication date
KR830009038A (en) 1983-12-17
IE51957B1 (en) 1987-04-29
ZA82277B (en) 1982-11-24
FR2498187A1 (en) 1982-07-23
FR2498187B1 (en) 1983-09-30
EP0056766A1 (en) 1982-07-28
JPS57171973A (en) 1982-10-22
ATE7492T1 (en) 1984-06-15
DE3260150D1 (en) 1984-06-20
HU184985B (en) 1984-11-28
DK16582A (en) 1982-07-17
DK148805C (en) 1986-04-01
KR870001921B1 (en) 1987-10-22
US4421920A (en) 1983-12-20
CA1171861A (en) 1984-07-31
EP0056766B1 (en) 1984-05-16
IN158327B (en) 1986-10-18
DK148805B (en) 1985-10-07

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