DE3177260D1 - Fuer plasminogen-aktivator kodierende rekombinante desoxyribonukleinsaeure und verfahren zur herstellung von plasminogen-aktivator-protein daraus. - Google Patents

Fuer plasminogen-aktivator kodierende rekombinante desoxyribonukleinsaeure und verfahren zur herstellung von plasminogen-aktivator-protein daraus.

Info

Publication number
DE3177260D1
DE3177260D1 DE8181301323T DE3177260T DE3177260D1 DE 3177260 D1 DE3177260 D1 DE 3177260D1 DE 8181301323 T DE8181301323 T DE 8181301323T DE 3177260 T DE3177260 T DE 3177260T DE 3177260 D1 DE3177260 D1 DE 3177260D1
Authority
DE
Germany
Prior art keywords
plasminogen activator
recombinant
producing
coding
protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE8181301323T
Other languages
English (en)
Inventor
Paul Porwen Hung
Shaw-Guang Lee
Ranajit Roychoudhury
Barry Joseph Ratzkin
Michael Cheng-Yien Chen
Willi Jurgen Schrenk
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22475512&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE3177260(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Application granted granted Critical
Publication of DE3177260D1 publication Critical patent/DE3177260D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6462—Plasminogen activators u-Plasminogen activator (3.4.21.73), i.e. urokinase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21073—Serine endopeptidases (3.4.21) u-Plasminogen activator (3.4.21.73), i.e. urokinase
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/808—Materials and products related to genetic engineering or hybrid or fused cell technology, e.g. hybridoma, monoclonal products

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
DE8181301323T 1980-04-03 1981-03-27 Fuer plasminogen-aktivator kodierende rekombinante desoxyribonukleinsaeure und verfahren zur herstellung von plasminogen-aktivator-protein daraus. Expired - Lifetime DE3177260D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/137,032 US4370417A (en) 1980-04-03 1980-04-03 Recombinant deoxyribonucleic acid which codes for plasminogen activator

Publications (1)

Publication Number Publication Date
DE3177260D1 true DE3177260D1 (de) 1991-11-21

Family

ID=22475512

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8181301323T Expired - Lifetime DE3177260D1 (de) 1980-04-03 1981-03-27 Fuer plasminogen-aktivator kodierende rekombinante desoxyribonukleinsaeure und verfahren zur herstellung von plasminogen-aktivator-protein daraus.

Country Status (5)

Country Link
US (1) US4370417A (de)
EP (1) EP0037687B1 (de)
JP (5) JPH0653070B2 (de)
DE (1) DE3177260D1 (de)
ES (1) ES8205263A1 (de)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4370417A (en) * 1980-04-03 1983-01-25 Abbott Laboratories Recombinant deoxyribonucleic acid which codes for plasminogen activator
NL8003402A (nl) * 1980-06-11 1982-01-04 Leuven Res & Dev Vzw Nieuwe plasminogeen-activator en farmaceutisch preparaat met trombolytische werking.
US5525484A (en) * 1981-01-16 1996-06-11 Genome Therapeutics Corp. Recombinant DNA means and method for producing rennin, prorenin and pre-prorennin
JPS58148899A (ja) * 1982-02-27 1983-09-05 Green Cross Corp:The ウロキナ−ゼ様蛋白質をコ−ドするｍＲＮＡ及びその製造法
US4775622A (en) * 1982-03-08 1988-10-04 Genentech, Inc. Expression, processing and secretion of heterologous protein by yeast
FI88932C (fi) * 1982-04-15 1993-07-26 Genentech Inc Framstaellning av funktionellt maenskligt urokinasprotein
US5112755A (en) * 1982-04-15 1992-05-12 Genentech, Inc. Preparation of functional human urokinase proteins
FI831484L (fi) 1982-05-05 1983-11-06 Genentech Inc Plasminogen aktivator foer maenskovaevnad
GT198302091A (es) * 1982-05-05 1984-10-25 Activador de plasminogeno de tejido humano a),b),c).
US4766075A (en) * 1982-07-14 1988-08-23 Genentech, Inc. Human tissue plasminogen activator
IL68561A (en) * 1982-05-05 1991-01-31 Genentech Inc Preparation of polypeptide with human tissue plasminogen activator function,processes for making it,and dna and transformed cell intermediates thereof
US5185259A (en) * 1982-05-05 1993-02-09 Genentech, Inc. Truncated human tissue plasminogen activator
DE3348289C2 (de) * 1982-05-05 1994-05-05 Genentech Inc Verfahren zur Herstellung von Human-Gewebe-Plasminogen-Aktivator
US4530904A (en) * 1982-09-03 1985-07-23 Eli Lilly And Company Method for conferring bacteriophage resistance to bacteria
WO1984001786A1 (en) * 1982-10-28 1984-05-10 Beecham Group Plc Enzyme derivatives and their use in the treatment of thrombosis
US5010002A (en) * 1983-01-19 1991-04-23 Genentech, Inc. Human t-PA production using vectors coding DHFR protein
US5011795A (en) * 1983-01-19 1991-04-30 Genentech, Inc. Human tPA production using vectors coding for DHFR protein
IE56716B1 (en) * 1983-01-19 1991-11-20 Genentech Inc Method for producing human tpa and expression vectors therefor
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
AU561372B2 (en) * 1983-10-10 1987-05-07 Board Of Regents Of The University Of Oklahoma, The Streptokinase-coding recombinant vectors
JPS60180591A (ja) * 1984-02-27 1985-09-14 Green Cross Corp:The ヒトウロキナ−ゼのｄνａ配列，プラスミド，宿主
DE3585097D1 (de) * 1984-02-27 1992-02-20 Green Cross Corp Herstellung menschlicher urokinase.
US4753879A (en) * 1984-08-27 1988-06-28 Biogen N.V. Modified tissue plasminogen activators
EP0174835A1 (de) * 1984-09-11 1986-03-19 The Upjohn Company Menschlicher Gewebeplasminogenaktivator und rekombinante DNA-Zusammensetzungen
NO175158C (no) * 1984-10-01 1994-09-07 Genzyme Corp Fremstilling av human livmorsvevplasminogenaktivator med rekombinant-DNA
DE3680838D1 (de) * 1985-01-25 1991-09-19 Sagami Chem Res Stabilisierte menschliche prourokinase.
US5219569A (en) * 1985-04-22 1993-06-15 Genentech, Inc. Protease resistant urokinase
MY103358A (en) * 1987-04-15 1993-06-30 Novartis Ag Process for the production of protiens.
EP0330700B1 (de) * 1987-08-19 1993-12-22 Sagami Chemical Research Center Menschlicher Prourokinase ähnliches Polypeptid
US4920051A (en) * 1988-02-03 1990-04-24 Damon Biotech, Inc. Recovery of urokinase compounds
IE901849A1 (en) * 1989-07-19 1991-06-19 Gruenenthal Gmbh Plasmids, their preparation and their use in the manufacture¹of a plasminogen activator
US6605712B1 (en) * 1990-12-20 2003-08-12 Arch Development Corporation Gene transcription and ionizing radiation: methods and compositions
US20030113271A1 (en) * 1997-01-29 2003-06-19 University Technology Corporation Formulations for pulmonary delivery
US6794184B1 (en) 1998-01-19 2004-09-21 Ulrich Mohr Culturing device and method for culturing cells or tissue components
US20040242523A1 (en) * 2003-03-06 2004-12-02 Ana-Farber Cancer Institue And The Univiersity Of Chicago Chemo-inducible cancer gene therapy
US8034791B2 (en) 2001-04-06 2011-10-11 The University Of Chicago Activation of Egr-1 promoter by DNA damaging chemotherapeutics
ES2380007T3 (es) * 2001-04-06 2012-05-07 The University Of Chicago Inducción por agentes quimioterapéuticos de la actividad del promotor Egr-1 en la terapia génica
US20030170678A1 (en) * 2001-10-25 2003-09-11 Neurogenetics, Inc. Genetic markers for Alzheimer's disease and methods using the same
US20030224380A1 (en) * 2001-10-25 2003-12-04 The General Hospital Corporation Genes and polymorphisms on chromosome 10 associated with Alzheimer's disease and other neurodegenerative diseases
AU2002364945A1 (en) * 2001-10-25 2003-07-09 Neurogenetics, Inc. Genes and polymorphisms on chromosome 10 associated with alzheimer's disease and other neurodegenerative diseases

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3256158A (en) * 1963-03-22 1966-06-14 Abbott Lab Purification of urokinase
US3355361A (en) * 1964-10-15 1967-11-28 Sterling Drug Inc Recovery and purification of urokinase
US3755083A (en) * 1971-08-30 1973-08-28 Rand Labor Inc Method for recovering urokinase from urine containing the same
JPS519782A (en) * 1974-07-15 1976-01-26 Eiken Chemical Urokinaazeno seiseiho
JPS5122876A (en) * 1974-08-21 1976-02-23 Fujiwa Kako Kk Hotai c1 esuteraazeno noshukuseiseiho
US4237224A (en) * 1974-11-04 1980-12-02 Board Of Trustees Of The Leland Stanford Jr. University Process for producing biologically functional molecular chimeras
US3957582A (en) * 1974-11-20 1976-05-18 Abbott Laboratories Purification of urokinase
US4190495A (en) * 1976-09-27 1980-02-26 Research Corporation Modified microorganisms and method of preparing and using same
DE2720704C2 (de) * 1977-05-07 1986-09-25 Behringwerke Ag, 3550 Marburg Neues Glycoprotein, Verfahren zu seiner Herstellung und seine Verwendung
NZ187300A (en) * 1977-05-27 1982-08-17 Univ California Dna transfer vector and micro-organism modified to contain a nucleotide sequence equivalent to the gene of a higher organism
JPS5411219A (en) * 1977-06-25 1979-01-27 Green Cross Corp:The Thrombolytic agent and its preparation
JPS5480406A (en) * 1977-12-09 1979-06-27 Tanabe Seiyaku Co Ltd Preparation of urokinase for injection
JPS54107511A (en) * 1978-02-10 1979-08-23 Asahi Chem Ind Co Ltd Preparation of bio-active substance
JPS6043116B2 (ja) * 1978-02-21 1985-09-26 株式会社ミドリ十字 ウロキナ−ゼ誘導体
JPS5526878A (en) * 1978-08-17 1980-02-26 Kowa Co Enzyme activating plasminogen and its preparation
JPS5537129A (en) * 1978-09-06 1980-03-15 Nippon Soda Co Ltd Urokinase adsorbent, and preparation of high purity urokinase using the same
US4342832A (en) * 1979-07-05 1982-08-03 Genentech, Inc. Method of constructing a replicable cloning vehicle having quasi-synthetic genes
US4370417A (en) * 1980-04-03 1983-01-25 Abbott Laboratories Recombinant deoxyribonucleic acid which codes for plasminogen activator
JPS57101911A (en) * 1980-12-18 1982-06-24 Toshiba Corp Feed water control device
JPS58129605A (ja) * 1982-01-29 1983-08-02 Toshiba Corp 運転台数制御方法
FI88932C (fi) * 1982-04-15 1993-07-26 Genentech Inc Framstaellning av funktionellt maenskligt urokinasprotein
JPS61181377A (ja) * 1985-01-25 1986-08-14 Sagami Chem Res Center ヒトウロキナ−ゼ遺伝子
JPS6287633A (ja) * 1985-10-14 1987-04-22 Kobe Steel Ltd 建設機械のエンスト防止方法
JP2724820B2 (ja) * 1986-12-18 1998-03-09 株式会社小松製作所 可変容量型油圧ポンプの制御装置
JPH01149054U (de) * 1988-04-07 1989-10-16

Also Published As

Publication number Publication date
JP2873536B2 (ja) 1999-03-24
JPH0276823A (ja) 1990-03-16
JPH0284186A (ja) 1990-03-26
JPH06315379A (ja) 1994-11-15
EP0037687B1 (de) 1991-10-16
JP2964439B2 (ja) 1999-10-18
EP0037687A2 (de) 1981-10-14
ES501018A0 (es) 1982-06-01
JPH0653072B2 (ja) 1994-07-20
US4370417A (en) 1983-01-25
JPH07132085A (ja) 1995-05-23
EP0037687A3 (en) 1982-02-17
JPH0653070B2 (ja) 1994-07-20
JPS56158799A (en) 1981-12-07
ES8205263A1 (es) 1982-06-01

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Legal Events

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8363 Opposition against the patent