JPS5480406A - Preparation of urokinase for injection - Google Patents
Preparation of urokinase for injectionInfo
- Publication number
- JPS5480406A JPS5480406A JP14834377A JP14834377A JPS5480406A JP S5480406 A JPS5480406 A JP S5480406A JP 14834377 A JP14834377 A JP 14834377A JP 14834377 A JP14834377 A JP 14834377A JP S5480406 A JPS5480406 A JP S5480406A
- Authority
- JP
- Japan
- Prior art keywords
- urokinase
- molecular weight
- preparation
- solution
- mixture
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
PURPOSE: To prepare stable urokinase for injection use by adding gelatine having specific average molecular weight to an aqueous urokinase solution, and purifying the mixture by ultra-filtration.
CONSTITUTION: Urokinase for injection use is prepared by adding 0.05-2 W/W% of gelatine having an average molecular weight of 10,000-50,000, pref. molecular weight range of 10,000-50,000, to an aqueous solution of urokinase, and filtering the mixture with a membrane filter having pore sizes of usulally 0.22-0.45μ, under a pressure of 0.3-5 kg/cm2. Addition of 0.1-5 W/W% of D-mannit or glycine to the urokinase solution remarkably improves the solubility of the freeze-dried urokinase preparation.
COPYRIGHT: (C)1979,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP14834377A JPS5480406A (en) | 1977-12-09 | 1977-12-09 | Preparation of urokinase for injection |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP14834377A JPS5480406A (en) | 1977-12-09 | 1977-12-09 | Preparation of urokinase for injection |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5480406A true JPS5480406A (en) | 1979-06-27 |
JPS629092B2 JPS629092B2 (en) | 1987-02-26 |
Family
ID=15450638
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP14834377A Granted JPS5480406A (en) | 1977-12-09 | 1977-12-09 | Preparation of urokinase for injection |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5480406A (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH06315379A (en) * | 1980-04-03 | 1994-11-15 | Abbott Lab | Thrombolytic agent |
JP2006219500A (en) * | 1994-04-26 | 2006-08-24 | Genetics Inst Llc | Formulation for factor ix |
WO2011149016A1 (en) * | 2010-05-26 | 2011-12-01 | 公立大学法人奈良県立医科大学 | Complex containing thrombolytic enzyme |
-
1977
- 1977-12-09 JP JP14834377A patent/JPS5480406A/en active Granted
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH06315379A (en) * | 1980-04-03 | 1994-11-15 | Abbott Lab | Thrombolytic agent |
JP2006219500A (en) * | 1994-04-26 | 2006-08-24 | Genetics Inst Llc | Formulation for factor ix |
WO2011149016A1 (en) * | 2010-05-26 | 2011-12-01 | 公立大学法人奈良県立医科大学 | Complex containing thrombolytic enzyme |
Also Published As
Publication number | Publication date |
---|---|
JPS629092B2 (en) | 1987-02-26 |
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