JPS5480406A - Preparation of urokinase for injection - Google Patents

Preparation of urokinase for injection

Info

Publication number
JPS5480406A
JPS5480406A JP14834377A JP14834377A JPS5480406A JP S5480406 A JPS5480406 A JP S5480406A JP 14834377 A JP14834377 A JP 14834377A JP 14834377 A JP14834377 A JP 14834377A JP S5480406 A JPS5480406 A JP S5480406A
Authority
JP
Japan
Prior art keywords
urokinase
molecular weight
preparation
solution
mixture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP14834377A
Other languages
Japanese (ja)
Other versions
JPS629092B2 (en
Inventor
Kiyoshi Harada
Yoshiyuki Hirakawa
Seiichi Morisono
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tanabe Seiyaku Co Ltd
Original Assignee
Tanabe Seiyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tanabe Seiyaku Co Ltd filed Critical Tanabe Seiyaku Co Ltd
Priority to JP14834377A priority Critical patent/JPS5480406A/en
Publication of JPS5480406A publication Critical patent/JPS5480406A/en
Publication of JPS629092B2 publication Critical patent/JPS629092B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

PURPOSE: To prepare stable urokinase for injection use by adding gelatine having specific average molecular weight to an aqueous urokinase solution, and purifying the mixture by ultra-filtration.
CONSTITUTION: Urokinase for injection use is prepared by adding 0.05-2 W/W% of gelatine having an average molecular weight of 10,000-50,000, pref. molecular weight range of 10,000-50,000, to an aqueous solution of urokinase, and filtering the mixture with a membrane filter having pore sizes of usulally 0.22-0.45μ, under a pressure of 0.3-5 kg/cm2. Addition of 0.1-5 W/W% of D-mannit or glycine to the urokinase solution remarkably improves the solubility of the freeze-dried urokinase preparation.
COPYRIGHT: (C)1979,JPO&Japio
JP14834377A 1977-12-09 1977-12-09 Preparation of urokinase for injection Granted JPS5480406A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP14834377A JPS5480406A (en) 1977-12-09 1977-12-09 Preparation of urokinase for injection

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP14834377A JPS5480406A (en) 1977-12-09 1977-12-09 Preparation of urokinase for injection

Publications (2)

Publication Number Publication Date
JPS5480406A true JPS5480406A (en) 1979-06-27
JPS629092B2 JPS629092B2 (en) 1987-02-26

Family

ID=15450638

Family Applications (1)

Application Number Title Priority Date Filing Date
JP14834377A Granted JPS5480406A (en) 1977-12-09 1977-12-09 Preparation of urokinase for injection

Country Status (1)

Country Link
JP (1) JPS5480406A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06315379A (en) * 1980-04-03 1994-11-15 Abbott Lab Thrombolytic agent
JP2006219500A (en) * 1994-04-26 2006-08-24 Genetics Inst Llc Formulation for factor ix
WO2011149016A1 (en) * 2010-05-26 2011-12-01 公立大学法人奈良県立医科大学 Complex containing thrombolytic enzyme

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06315379A (en) * 1980-04-03 1994-11-15 Abbott Lab Thrombolytic agent
JP2006219500A (en) * 1994-04-26 2006-08-24 Genetics Inst Llc Formulation for factor ix
WO2011149016A1 (en) * 2010-05-26 2011-12-01 公立大学法人奈良県立医科大学 Complex containing thrombolytic enzyme

Also Published As

Publication number Publication date
JPS629092B2 (en) 1987-02-26

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