DE3175100D1 - Novel prodrugs of biologically active agents containing mercapto groups, process for preparing and therapeutically effective composition containing the same - Google Patents

Novel prodrugs of biologically active agents containing mercapto groups, process for preparing and therapeutically effective composition containing the same

Info

Publication number
DE3175100D1
DE3175100D1 DE8181102940T DE3175100T DE3175100D1 DE 3175100 D1 DE3175100 D1 DE 3175100D1 DE 8181102940 T DE8181102940 T DE 8181102940T DE 3175100 T DE3175100 T DE 3175100T DE 3175100 D1 DE3175100 D1 DE 3175100D1
Authority
DE
Germany
Prior art keywords
carbon atoms
residue
alkyl
amino acid
image
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8181102940T
Other languages
German (de)
English (en)
Inventor
Nicholas S Bodor
Kenneth B Sloan
Stefano A Pogany
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Application granted granted Critical
Publication of DE3175100D1 publication Critical patent/DE3175100D1/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • A61P5/12—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH for decreasing, blocking or antagonising the activity of the posterior pituitary hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/84—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/38—One sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • C07D307/88—Benzo [c] furans; Hydrogenated benzo [c] furans with one oxygen atom directly attached in position 1 or 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/36—Sulfur atom
    • C07D473/38—Sulfur atom attached in position 6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Toxicology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Furan Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Manufacturing Of Electrical Connectors (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE8181102940T 1980-04-21 1981-04-16 Novel prodrugs of biologically active agents containing mercapto groups, process for preparing and therapeutically effective composition containing the same Expired DE3175100D1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US14198180A 1980-04-21 1980-04-21

Publications (1)

Publication Number Publication Date
DE3175100D1 true DE3175100D1 (en) 1986-09-18

Family

ID=22498074

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8181102940T Expired DE3175100D1 (en) 1980-04-21 1981-04-16 Novel prodrugs of biologically active agents containing mercapto groups, process for preparing and therapeutically effective composition containing the same

Country Status (10)

Country Link
US (1) US4443435A (enExample)
EP (1) EP0038541B1 (enExample)
JP (1) JPS572252A (enExample)
AT (1) ATE21388T1 (enExample)
DE (1) DE3175100D1 (enExample)
DK (1) DK172081A (enExample)
ES (1) ES8301197A1 (enExample)
GR (1) GR75219B (enExample)
IE (1) IE52017B1 (enExample)
PT (1) PT72877B (enExample)

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DK302883D0 (da) * 1983-06-30 1983-06-30 Hans Bundgaard Allopurinol prodrugs
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US4713123A (en) 1985-02-22 1987-12-15 Kawasaki Steel Corporation Method of producing extra-low iron loss grain oriented silicon steel sheets
US5203928A (en) * 1986-03-25 1993-04-20 Kawasaki Steel Corporation Method of producing low iron loss grain oriented silicon steel thin sheets having excellent surface properties
JPH0615694B2 (ja) * 1987-04-17 1994-03-02 川崎製鉄株式会社 方向性けい素鋼板の鉄損低減方法
DE3889600T2 (de) * 1987-08-01 1994-09-01 Kawasaki Steel Co Kornorientierte Elektrobleche mit sehr geringen Eisenverlusten und Verfahren zum Herstellen dieser Bleche.
US5120740A (en) * 1989-11-03 1992-06-09 Wisconsin Alumni Research Foundation Prodrugs of 6-mercaptopurine and 6-thioguanine
JPH0723511B2 (ja) * 1989-12-07 1995-03-15 新日本製鐵株式会社 一方向性電磁鋼帯の処理装置
EP0606884B1 (en) * 1993-01-12 1999-08-18 Nippon Steel Corporation Grain-oriented electrical steel sheet with very low core loss and method of producing the same
US5823679A (en) * 1993-09-17 1998-10-20 Omega Engineering, Inc. Method and apparatus for measuring temperature including aiming light
FR2773213B1 (fr) 1996-12-11 2001-08-24 Omega Engineering Procede et dispositif pour la mesure par infrarouge de la temperature d'une surface
DE69810852T2 (de) * 1997-07-17 2003-06-05 Kawasaki Steel Corp., Kobe Kornorientiertes Elektrostahlblech mit ausgezeichneten magnetischen Eigenschaften und dessen Herstellungsverfahren
CN1321215C (zh) 2001-07-16 2007-06-13 新日本制铁株式会社 高磁场铁损和涂层特性优异的超高磁通密度单取向电工钢板及其制造方法
US8188067B2 (en) 2004-04-01 2012-05-29 Teva Pharmaceutical Industries Ltd. Formulations of 6-mercaptopurine
AU2005232583B2 (en) * 2004-04-01 2009-03-12 Teva Pharmaceutical Industries Ltd. Delayed release formulations of 6-mercaptopurine
EP2096185B1 (en) 2006-11-22 2014-08-13 Nippon Steel & Sumitomo Metal Corporation Unidirectionally grain oriented electromagnetic steel sheet having excellent film adhesion, and method for manufacturing the same
JP2010513326A (ja) 2006-12-19 2010-04-30 メシルジーン インコーポレイテッド ヒストンデアセチラーゼの阻害薬及びそのプロドラッグ
EP2110130A1 (en) * 2008-04-18 2009-10-21 Teva Pharmaceutical Industries Ltd. Pharmaceutical use of 6-mercaptopurine
JP5927754B2 (ja) 2010-06-29 2016-06-01 Ｊｆｅスチール株式会社 方向性電磁鋼板およびその製造方法
JP5923879B2 (ja) 2010-06-29 2016-05-25 Ｊｆｅスチール株式会社 方向性電磁鋼板およびその製造方法
JP5998424B2 (ja) 2010-08-06 2016-09-28 Ｊｆｅスチール株式会社 方向性電磁鋼板
JP5853352B2 (ja) 2010-08-06 2016-02-09 Ｊｆｅスチール株式会社 方向性電磁鋼板およびその製造方法
JP5593942B2 (ja) 2010-08-06 2014-09-24 Ｊｆｅスチール株式会社 方向性電磁鋼板およびその製造方法
US9330839B2 (en) 2010-08-06 2016-05-03 Jfe Steel Corporation Grain oriented electrical steel sheet and method for manufacturing the same
EP2799576B1 (en) 2011-12-26 2018-08-01 JFE Steel Corporation Grain-oriented electrical steel sheet
RU2570250C1 (ru) 2011-12-27 2015-12-10 ДжФЕ СТИЛ КОРПОРЕЙШН Текстурированный лист из электротехнической стали
US10745773B2 (en) 2011-12-27 2020-08-18 Jfe Steel Corporation Device to improve iron loss properties of grain-oriented electrical steel sheet
KR101570018B1 (ko) 2011-12-28 2015-11-17 제이에프이 스틸 가부시키가이샤 방향성 전기 강판 및 그 철손 개선 방법
US10804015B2 (en) 2011-12-29 2020-10-13 Posco Electrical steel sheet and method for manufacturing the same
KR101636191B1 (ko) 2012-04-26 2016-07-04 제이에프이 스틸 가부시키가이샤 방향성 전기 강판 및 그 제조 방법
JP5971157B2 (ja) 2013-03-11 2016-08-17 Ｊｆｅスチール株式会社 塗布装置および塗布方法
JP5668795B2 (ja) 2013-06-19 2015-02-12 Ｊｆｅスチール株式会社 方向性電磁鋼板およびそれを用いた変圧器鉄心
CN105555984B (zh) 2013-09-19 2017-07-07 杰富意钢铁株式会社 方向性电磁钢板及其制造方法
JP6215673B2 (ja) 2013-11-29 2017-10-18 東芝産業機器システム株式会社 ベクトル磁気特性制御材、および、鉄心
KR101639920B1 (ko) 2014-12-26 2016-07-15 주식회사 포스코 방향성 전기강판의 자구미세화 장치 및 그 방법
EP3362053A4 (en) 2015-10-16 2019-04-17 Hadasit Medical Research Services and Development Ltd. TREATMENT OF NON-ALCOHOLIC FATTYLENE OR NON-ALCOHOLIC STEATOHEPATITIS WITH 6-MERCAPTOPURIN WITH DELAYED RELEASE
CN110352255B (zh) 2017-02-28 2021-09-21 杰富意钢铁株式会社 方向性电磁钢板及其制造方法
KR102890792B1 (ko) 2020-08-27 2025-11-24 제이에프이 스틸 가부시키가이샤 방향성 전자 강판의 제조 방법
WO2022113517A1 (ja) 2020-11-27 2022-06-02 Ｊｆｅスチール株式会社 方向性電磁鋼板およびその製造方法
CN115724824B (zh) * 2021-09-01 2024-03-15 四川大学 3-(酰胺烷硫基)苯酞类化合物、其制备方法和用途
US20250075300A1 (en) 2022-01-06 2025-03-06 Jfe Steel Corporation Grain-oriented electrical steel sheet
CN119836484A (zh) 2022-09-09 2025-04-15 杰富意钢铁株式会社 取向性电磁钢板

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NZ196349A (en) * 1980-03-07 1984-08-24 Interx Research Corp Enhancement of absorption rate of orally administered polar bioactive agents
GR75219B (enExample) * 1980-04-21 1984-07-13 Merck & Co Inc

Also Published As

Publication number Publication date
ES501496A0 (es) 1982-12-01
PT72877B (en) 1983-03-29
IE52017B1 (en) 1987-05-27
EP0038541B1 (en) 1986-08-13
GR75219B (enExample) 1984-07-13
JPH0226630B2 (enExample) 1990-06-12
US4443435A (en) 1984-04-17
JPS572252A (en) 1982-01-07
IE810869L (en) 1982-10-21
EP0038541A1 (en) 1981-10-28
ATE21388T1 (de) 1986-08-15
PT72877A (en) 1981-05-01
DK172081A (da) 1981-10-22
ES8301197A1 (es) 1982-12-01

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