DK172081A - Mercaptoforbindelse og fremgangsmaade til fremstilling deraf - Google Patents

Mercaptoforbindelse og fremgangsmaade til fremstilling deraf

Info

Publication number
DK172081A
DK172081A DK172081A DK172081A DK172081A DK 172081 A DK172081 A DK 172081A DK 172081 A DK172081 A DK 172081A DK 172081 A DK172081 A DK 172081A DK 172081 A DK172081 A DK 172081A
Authority
DK
Denmark
Prior art keywords
carbon atoms
residue
alkyl
amino acid
image
Prior art date
Application number
DK172081A
Other languages
English (en)
Inventor
N S Bodor
K B Sloan
S A Pogany
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of DK172081A publication Critical patent/DK172081A/da

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32One oxygen, sulfur or nitrogen atom
    • C07D239/42One nitrogen atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00General protective or antinoxious agents
    • A61P39/02Antidotes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/10Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • A61P5/12Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH for decreasing, blocking or antagonising the activity of the posterior pituitary hormones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D207/00Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/84Sulfur atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32One oxygen, sulfur or nitrogen atom
    • C07D239/38One sulfur atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87Benzo [c] furans; Hydrogenated benzo [c] furans
    • C07D307/88Benzo [c] furans; Hydrogenated benzo [c] furans with one oxygen atom directly attached in position 1 or 3
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D473/00Heterocyclic compounds containing purine ring systems
    • C07D473/26Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/36Sulfur atom
    • C07D473/38Sulfur atom attached in position 6
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16Purine radicals
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
DK172081A 1980-04-21 1981-04-15 Mercaptoforbindelse og fremgangsmaade til fremstilling deraf DK172081A (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US14198180A 1980-04-21 1980-04-21

Publications (1)

Publication Number Publication Date
DK172081A true DK172081A (da) 1981-10-22

Family

ID=22498074

Family Applications (1)

Application Number Title Priority Date Filing Date
DK172081A DK172081A (da) 1980-04-21 1981-04-15 Mercaptoforbindelse og fremgangsmaade til fremstilling deraf

Country Status (10)

Country Link
US (1) US4443435A (da)
EP (1) EP0038541B1 (da)
JP (1) JPS572252A (da)
AT (1) ATE21388T1 (da)
DE (1) DE3175100D1 (da)
DK (1) DK172081A (da)
ES (1) ES8301197A1 (da)
GR (1) GR75219B (da)
IE (1) IE52017B1 (da)
PT (1) PT72877B (da)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR75219B (da) * 1980-04-21 1984-07-13 Merck & Co Inc
JPS57183778A (en) * 1981-04-30 1982-11-12 Nippon Synthetic Chem Ind Co Ltd:The S-(3-phthalidyl)-l-cysteine and its preparation
US4454065A (en) * 1982-05-18 1984-06-12 Smithkline Beckman Corporation Oligopeptide prodrugs
DK302883D0 (da) * 1983-06-30 1983-06-30 Hans Bundgaard Allopurinol prodrugs
CS249576B1 (en) * 1984-12-22 1987-04-16 Antonin Cerny 6-purinyl n-(2-chlorethyl)carbamate and thiocarbamate and method of their production
US4713123A (en) 1985-02-22 1987-12-15 Kawasaki Steel Corporation Method of producing extra-low iron loss grain oriented silicon steel sheets
US5203928A (en) * 1986-03-25 1993-04-20 Kawasaki Steel Corporation Method of producing low iron loss grain oriented silicon steel thin sheets having excellent surface properties
JPH0615694B2 (ja) * 1987-04-17 1994-03-02 川崎製鉄株式会社 方向性けい素鋼板の鉄損低減方法
EP0302639B1 (en) * 1987-08-01 1994-05-18 Kawasaki Steel Corporation Grain oriented electromagnetic steel sheets having a very low iron loss and method of producing the same
US5120740A (en) * 1989-11-03 1992-06-09 Wisconsin Alumni Research Foundation Prodrugs of 6-mercaptopurine and 6-thioguanine
JPH0723511B2 (ja) * 1989-12-07 1995-03-15 新日本製鐵株式会社 一方向性電磁鋼帯の処理装置
EP0606884B1 (en) * 1993-01-12 1999-08-18 Nippon Steel Corporation Grain-oriented electrical steel sheet with very low core loss and method of producing the same
US5823679A (en) * 1993-09-17 1998-10-20 Omega Engineering, Inc. Method and apparatus for measuring temperature including aiming light
FR2773213B1 (fr) 1996-12-11 2001-08-24 Omega Engineering Procede et dispositif pour la mesure par infrarouge de la temperature d'une surface
DE69810852T2 (de) * 1997-07-17 2003-06-05 Kawasaki Steel Co Kornorientiertes Elektrostahlblech mit ausgezeichneten magnetischen Eigenschaften und dessen Herstellungsverfahren
CN1321215C (zh) 2001-07-16 2007-06-13 新日本制铁株式会社 高磁场铁损和涂层特性优异的超高磁通密度单取向电工钢板及其制造方法
TW200602061A (en) * 2004-04-01 2006-01-16 Teva Pharma Delayed release formulations of 6-mercaptopurine
US8188067B2 (en) * 2004-04-01 2012-05-29 Teva Pharmaceutical Industries Ltd. Formulations of 6-mercaptopurine
KR101165430B1 (ko) 2006-11-22 2012-07-12 신닛뽄세이테쯔 카부시키카이샤 피막 밀착성이 우수한 일방향성 전자 강판 및 그 제조법
KR20090094383A (ko) 2006-12-19 2009-09-04 메틸진 인크. 히스톤 탈아세틸화효소의 억제제 및 이의 프로드럭
US20090263482A1 (en) * 2008-04-18 2009-10-22 Vered Rosenberger Treatment of inflammatory bowel disease with 6-mercaptopurine
JP5923879B2 (ja) 2010-06-29 2016-05-25 Jfeスチール株式会社 方向性電磁鋼板およびその製造方法
JP5927754B2 (ja) 2010-06-29 2016-06-01 Jfeスチール株式会社 方向性電磁鋼板およびその製造方法
JP5998424B2 (ja) 2010-08-06 2016-09-28 Jfeスチール株式会社 方向性電磁鋼板
JP5593942B2 (ja) 2010-08-06 2014-09-24 Jfeスチール株式会社 方向性電磁鋼板およびその製造方法
JP5853352B2 (ja) 2010-08-06 2016-02-09 Jfeスチール株式会社 方向性電磁鋼板およびその製造方法
US9330839B2 (en) 2010-08-06 2016-05-03 Jfe Steel Corporation Grain oriented electrical steel sheet and method for manufacturing the same
RU2576355C1 (ru) 2011-12-26 2016-02-27 ДжФЕ СТИЛ КОРПОРЕЙШН Текстурированный лист электротехнической стали
WO2013099258A1 (ja) 2011-12-27 2013-07-04 Jfeスチール株式会社 方向性電磁鋼板
JP5871013B2 (ja) 2011-12-27 2016-03-01 Jfeスチール株式会社 方向性電磁鋼板の鉄損改善装置
WO2013099274A1 (ja) 2011-12-28 2013-07-04 Jfeスチール株式会社 方向性電磁鋼板およびその鉄損改善方法
US10804015B2 (en) 2011-12-29 2020-10-13 Posco Electrical steel sheet and method for manufacturing the same
EP2843069B1 (en) 2012-04-26 2019-06-05 JFE Steel Corporation Grain-oriented electrical steel sheet and method for manufacturing same
JP5971157B2 (ja) 2013-03-11 2016-08-17 Jfeスチール株式会社 塗布装置および塗布方法
JP5668795B2 (ja) 2013-06-19 2015-02-12 Jfeスチール株式会社 方向性電磁鋼板およびそれを用いた変圧器鉄心
JP5884944B2 (ja) 2013-09-19 2016-03-15 Jfeスチール株式会社 方向性電磁鋼板およびその製造方法
JP6215673B2 (ja) 2013-11-29 2017-10-18 東芝産業機器システム株式会社 ベクトル磁気特性制御材、および、鉄心
KR101639920B1 (ko) 2014-12-26 2016-07-15 주식회사 포스코 방향성 전기강판의 자구미세화 장치 및 그 방법
EP3362053A4 (en) 2015-10-16 2019-04-17 Hadasit Medical Research Services and Development Ltd. TREATMENT OF NON-ALCOHOLIC FATTYLENE OR NON-ALCOHOLIC STEATOHEPATITIS WITH 6-MERCAPTOPURIN WITH DELAYED RELEASE
US11387025B2 (en) 2017-02-28 2022-07-12 Jfe Steel Corporation Grain-oriented electrical steel sheet and production method therefor
MX2023006262A (es) 2020-11-27 2023-06-12 Jfe Steel Corp Lamina de acero electrico de grano orientado y metodo de produccion de la misma.
CN115724824B (zh) * 2021-09-01 2024-03-15 四川大学 3-(酰胺烷硫基)苯酞类化合物、其制备方法和用途

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2852506A (en) * 1955-10-31 1958-09-16 American Cyanamid Co Method of preparing aminodeoxyglycosidopurines
US2844576A (en) * 1955-11-22 1958-07-22 American Cyanamid Co Preparation of purines
BE733669A (da) * 1968-06-04 1969-11-27
US3915958A (en) * 1972-05-22 1975-10-28 Icn Pharmaceuticals 6-Substituted purine nucleotides
JPS49117479A (da) * 1973-05-30 1974-11-09
US3957803A (en) * 1975-01-06 1976-05-18 Interx Research Corporation Certain transient pro-drug forms of phenylbutazone
US4275064A (en) * 1976-02-06 1981-06-23 Interx Research Corporation Transient pro-drug forms of xanthine derivatives and their use as topical anti-inflammatory agents
US4061753A (en) * 1976-02-06 1977-12-06 Interx Research Corporation Treating psoriasis with transient pro-drug forms of xanthine derivatives
US4235887A (en) * 1977-04-13 1980-11-25 The Upjohn Company Process for therapeutic treatment
JPS5589257A (en) * 1978-12-22 1980-07-05 Kanebo Ltd New easily-absorbable sulfur-containing prodrug of non- steroidal antiphlogistic, and their drug compositions
NZ196349A (en) * 1980-03-07 1984-08-24 Interx Research Corp Enhancement of absorption rate of orally administered polar bioactive agents
GR75219B (da) * 1980-04-21 1984-07-13 Merck & Co Inc

Also Published As

Publication number Publication date
PT72877B (en) 1983-03-29
GR75219B (da) 1984-07-13
PT72877A (en) 1981-05-01
JPH0226630B2 (da) 1990-06-12
JPS572252A (en) 1982-01-07
DE3175100D1 (en) 1986-09-18
IE810869L (en) 1982-10-21
EP0038541A1 (en) 1981-10-28
IE52017B1 (en) 1987-05-27
ES501496A0 (es) 1982-12-01
EP0038541B1 (en) 1986-08-13
ATE21388T1 (de) 1986-08-15
ES8301197A1 (es) 1982-12-01
US4443435A (en) 1984-04-17

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Legal Events

Date Code Title Description
AHS Application shelved for other reasons than non-payment
B1 Patent granted (law 1993)
PBP Patent lapsed