GB2014562A - Cephalosporin analogues and processes for their preparation thereof - Google Patents

Cephalosporin analogues and processes for their preparation thereof

Info

Publication number
GB2014562A
GB2014562A GB7849670A GB7849670A GB2014562A GB 2014562 A GB2014562 A GB 2014562A GB 7849670 A GB7849670 A GB 7849670A GB 7849670 A GB7849670 A GB 7849670A GB 2014562 A GB2014562 A GB 2014562A
Authority
GB
United Kingdom
Prior art keywords
alkylene
suitable substituent
alkanoyl
alkoxyimino
processes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
GB7849670A
Other versions
GB2014562B (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujisawa Pharmaceutical Co Ltd
Original Assignee
Fujisawa Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujisawa Pharmaceutical Co Ltd filed Critical Fujisawa Pharmaceutical Co Ltd
Publication of GB2014562A publication Critical patent/GB2014562A/en
Application granted granted Critical
Publication of GB2014562B publication Critical patent/GB2014562B/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D505/00—Heterocyclic compounds containing 5-oxa-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

The invention provides pharmaceutically active compounds and processes for their preparation of the formula: <IMAGE> wherein R<1a> is acyl selected from ar(lower)alkanoyl which may have a sulfo group, aryloxy (lower) alkanoyl which may have suitable substituent(s), lower alkanoyl substituted with an unsaturated 3 to 8-membered heteromono-cyclic group containing 1 to 4 nitrogen atom(s) which may have suitable substituent(s), lower alkanoyl substituted with an unsaturated 3 to 8-membered heteromonocyclic group containing 1 to 2 sulfur atom(s) and 1 to 3 nitrogen atom(s) which may have suitable substituent(s), and a group of the formula: R<3>-A-CO- in which R<3> is aryl or a heterocyclic group which may have suitable substituent(s) and A is carbonyl, hydroxyimino (lower) - alkylene, lower alkoxyimino (lower) - alkylene, lower alkenyloxyimino - (lower) alkylene, lower alkynyloxyimino (lower) alkylene, cyclo (lower) - alkoxyimino (lower) alkylene or ar (lower) alkoxyimino (lower) - alkylene; R<2> is carboxy or a protected carboxy; and Y is hydrogen or lower alkoxy, and pharmaceutically acceptable salts thereof. Certain related azetidinones (used as starting materials) are also prepared.
GB7849670A 1977-12-23 1978-12-21 Cephalosporing analogues and processes for the preparation thereof Expired GB2014562B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB5373577 1977-12-23

Publications (2)

Publication Number Publication Date
GB2014562A true GB2014562A (en) 1979-08-30
GB2014562B GB2014562B (en) 1982-12-08

Family

ID=10468808

Family Applications (2)

Application Number Title Priority Date Filing Date
GB7849670A Expired GB2014562B (en) 1977-12-23 1978-12-21 Cephalosporing analogues and processes for the preparation thereof
GB8124258A Expired GB2089787B (en) 1977-12-23 1978-12-21 N-substituted azetidinones

Family Applications After (1)

Application Number Title Priority Date Filing Date
GB8124258A Expired GB2089787B (en) 1977-12-23 1978-12-21 N-substituted azetidinones

Country Status (3)

Country Link
BE (1) BE872889A (en)
FR (1) FR2438047A1 (en)
GB (2) GB2014562B (en)

Also Published As

Publication number Publication date
GB2014562B (en) 1982-12-08
GB2089787B (en) 1983-02-16
GB2089787A (en) 1982-06-30
BE872889A (en) 1979-06-20
FR2438047B1 (en) 1982-11-26
FR2438047A1 (en) 1980-04-30

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee