KR890008101A - β-아드레날린성 애고니스트 - Google Patents
β-아드레날린성 애고니스트 Download PDFInfo
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- KR890008101A KR890008101A KR1019880015592A KR880015592A KR890008101A KR 890008101 A KR890008101 A KR 890008101A KR 1019880015592 A KR1019880015592 A KR 1019880015592A KR 880015592 A KR880015592 A KR 880015592A KR 890008101 A KR890008101 A KR 890008101A
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/73—Unsubstituted amino or imino radicals
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/116—Heterocyclic compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Polymers & Plastics (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Obesity (AREA)
- Pharmacology & Pharmacy (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Husbandry (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Food Science & Technology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Fodder In General (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (22)
- 하기 일반식(I)의 화합물 및 이의 약제학적으로 허용되는 산부가염상기식에서, R₁,R₂ 및 R₃는 수소이거나, 또는 하이드록시 또는 저급 알콕시에 의해 임의로 치환될 수 있는 저급 알킬, 저급 알케닐 및 저급 알키닐중에서 독립적으로 선택되거나, 또는 R₁ 및 R₂는 결합되어 저급 알킬에 의해 추가로 치환될 수 있는 3 내지 6원의 사이클릭환을 형성할 수 있고 : Het는 하기 일반식(a) 내지(f)의 그룹중에서 선택된다[여기서, R₄ 및 R5는 독립적으로 수소, 저급 알킬, 페닐, 치환된 페닐, 페닐저급알킬 또는 치환된 페닐저급알킬(여기에서, 치환체는 저급알킬, 저급알콕시 또는 할로이다)이다]
- 제 2 항에 있어서, R₁,R₂ 및 R₃가 수소, 저급 알킬, 저급 알케닐 및 저급 알키닐중에서 독립적으로 선택되거나, 또는 R₁ 및 R₂는 결합되어 3내지 6원의 사이클릭 환을 형성할 수 있고 : Het가 일반식(a),(b),(c),(d) 및 (e)의 그룹중에서 선택되며 : R÷가 수소 또는 저급 알킬이고 : R5가 탄소수 1내지 3의 저급 알킬인 화합물
- 제 2 항에 있어서, R₁,R₂ 및 R₃가 저급 알킬중에서 독립적으로 선택되거나, R₃가 수소 또는 저급 알킬이며 R₁ 및 R₂는 결합되어 3내지 4원의 사이클릭 환을 형성할 수 있고 : Het가 일반식(a),(b) 및 (c),(d) 및 (e)의 그룹중에서 선택되고 : R÷가 수소 또는 탄소수 1내지 3의 저급 알킬인 화합물
- 제 3 항에 있어서, R₁,R₂ 및 R₃가 탄소수 1내지 3의 저급 알킬중에서 독립적으로 선택되며 : Het가 3위치에서 에틴올아민 부위에 결합된 일반식(a)의 그룹이고 : R₄가 수소인 화합물
- 제 1 항에 있어서, 이의 염산 또는 말레인산 염인 화합물
- 제 1 항에 있어서, (R)-6-아미노-a-[[(1,1-디메틸에틸)아미노]메틸]-3-피리딘메탄올인 화합물
- 제 1 항에 있어서, (R)-6-아미노-a-[[(1-메틸에틸)아미노]메틸]-3-피리딘메탄올인 화합물
- 제 1 항에 있어서, (R)-6-아미노-a-[[(1,1-디메틸프로필)아미노]메틸]-3-피리딘메탄올인 화합물
- 제 1 항에 있어서, (R)-6-아미노-a-[[(사이클로부틸)아미노]메틸]-3-피리딘메탄올인 화합물
- 제 1 항에 있어서, (R)-6-아미노-a-[[(1,1-메틸에틸)아미노]메틸]-3-피리딘메탄올인 화합물
- 제 1 항에 있어서, (R)-6-아미노-a-[[(1,1-사이클로부틸)아미노]메틸]-3-피리딘메탄올인 화합물
- 제 1 항에 있어서, (R)-6-아미노-a-[[(1,1-메틸사이클로부틸)아미노]메틸]-3-피리딘메탄올인 화합물
- 제 1 항에 있어서, (R)-6-아미노-a-[[(1,1-디메틸에틸)아미노]메틸]-3-피리딘메탄올인 화합물
- 제 1 항에 있어서, (R)-6-아미노-a-[[(1,1-디메틸에틸)아미노]메틸]-5-피리딘메탄올인 화합물
- 하기 일반식(4)의 화합물을 염화주석(II)과 방응시킨을 특징으로하여, 제 1 항에서 정의한 하기 일반식(6)의 화합물을 제조하는 방법상기식에서 R₁, R₂ 및 R₃는 제 1 항에서 정의한 바와 같다
- 적절하게 보호된 하기 일반식(6)의 화합물을 온화한 산화제로 처리함을 특징으로하여, 제 1 항에서 정의한 하기 일반식(7)의 화합물을 제조하는 방법상기식에서, R₁, R₂ 및 R₃는 제 1 항에서 정의한 바와 같다
- 하기 일반식(3)의 화합물을 과량의 아민 H₂NCR₁R₂R₃으로 처리한후, 중간체인 아민화된 케톤을 환원기키거나, 또는 하기 일반식(5)의 에폭사이드 화합물을 과량의 아민 H₂NCR₁R₂R₃으로 처리함을 특징으로 하여, 제 1 항에서 정의한 하기 일반식(4)의 화합물을 제조하는 방법상기식에서, R₁, R₂ 및 R₃는 제 1 항에서 정의한 바와 같다
- 제17항에 있어서, 에폭사이드 화합물이 R-이성체인 방법
- 하기 일반식(14)의 화합물을 과량의 아민H₂NCR₁R₂R₃으로 처리한후, 중간체인 아민화된 케톤을 환원시키거나, 또는 하기 일반식(13)의 화합물을 과량의 아민 H₂NCR₁R₂R₃으로 처리함을 특징으로 하여, 제 1 항에서 정의한 하기 일반식(4)의 화합물을 제조하는 방법상기식에서, R₁, R₂ R₃R₄ 및 R5는 제 1 항에서 정의한 바와 같고, A는 탄소 또는 질소 환원자이다
- 하기 일반식(15)의 화합물을 산 또는 염기 촉매하에서 가수분해시킴을 특징로하여, 제 1 항에서 정의한 하기 일반식(16)의 화합물을 제조하는 방법상기식에서, R₁, R₂ R₃R5및 R5는 제 1 항에서 정의한 바와 같고, A는 탄소 또는 질소 원자이다
- 동물에 유효량의 제 1 항에 화합물을 투여함을 특징으로하여 동물의성장을 촉진시키며 사료 효율을 증가시키는 방법
- 불활성 담체 및 제 1 항의 화합물을 함유함을 특징으로하는, 동물의 성장 촉진과 사료 효율을 증가 시키는데 유용한 조성물※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12698787A | 1987-11-27 | 1987-11-27 | |
US126,987 | 1987-11-27 | ||
US18563788A | 1988-04-25 | 1988-04-25 | |
US185.637 | 1988-04-25 |
Publications (1)
Publication Number | Publication Date |
---|---|
KR890008101A true KR890008101A (ko) | 1989-07-08 |
Family
ID=26825220
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019880015592A KR890008101A (ko) | 1987-11-27 | 1988-11-26 | β-아드레날린성 애고니스트 |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP0318092A3 (ko) |
JP (1) | JPH01186867A (ko) |
KR (1) | KR890008101A (ko) |
AU (1) | AU613681B2 (ko) |
DK (1) | DK659688A (ko) |
NZ (1) | NZ226991A (ko) |
PT (1) | PT89085B (ko) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3801521A1 (de) * | 1988-01-20 | 1989-07-27 | Bayer Ag | Pyrimidinderivate als leistungsfoerderer |
CA2220538A1 (en) * | 1995-05-10 | 1996-11-14 | Pfizer Inc. | .beta.-adrenergic agonists |
JPH11504649A (ja) * | 1995-05-10 | 1999-04-27 | ファイザー・インコーポレーテッド | β−アドレナリン作働性アゴニスト |
AUPP796798A0 (en) * | 1998-12-30 | 1999-01-28 | Fujisawa Pharmaceutical Co., Ltd. | New compound |
KR100408122B1 (ko) * | 2000-12-08 | 2003-12-01 | 한국디디에스제약 주식회사 | 광학 입체 이성질체의 성질을 갖는 베타 아드레날린 길항제의 제조 방법 |
GB201714745D0 (en) * | 2017-09-13 | 2017-10-25 | Atrogi Ab | New compounds and uses |
US11040944B2 (en) * | 2019-03-27 | 2021-06-22 | Curasen Therapeutics, Inc. | Beta adrenergic agonist and methods of using the same |
JP2022538907A (ja) * | 2019-07-01 | 2022-09-06 | キュラセン セラピューティクス インコーポレイテッド | βアドレナリンアゴニストおよびその使用方法 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0105053B1 (en) * | 1982-10-01 | 1988-01-20 | Merck & Co. Inc. | Aralkylaminoethanol heterocyclic compounds |
NZ212204A (en) * | 1984-06-04 | 1988-07-28 | Merck & Co Inc | Growth-promoting compositions containing hydroxylic compounds |
DE3615293A1 (de) * | 1986-05-06 | 1987-11-12 | Bayer Ag | Verwendung von heteroarylethylaminen zur leistungsfoerderung bei tieren, heteroarylethylamine und verfahren zu ihrer herstellung |
DE3813839A1 (de) * | 1988-04-23 | 1989-11-02 | Bayer Ag | 4-brom-6-chlor-5-amino-2-pyridil-ethanolamine verfahren zu ihrer herstellung u. ihre verwendung als leistungsfoerderer |
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1988
- 1988-11-17 NZ NZ226991A patent/NZ226991A/en unknown
- 1988-11-18 EP EP88202604A patent/EP0318092A3/en not_active Withdrawn
- 1988-11-25 PT PT89085A patent/PT89085B/pt not_active IP Right Cessation
- 1988-11-25 DK DK659688A patent/DK659688A/da not_active Application Discontinuation
- 1988-11-25 AU AU25929/88A patent/AU613681B2/en not_active Ceased
- 1988-11-26 KR KR1019880015592A patent/KR890008101A/ko not_active Application Discontinuation
- 1988-11-28 JP JP63298419A patent/JPH01186867A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
DK659688A (da) | 1989-07-31 |
NZ226991A (en) | 1992-03-26 |
EP0318092A3 (en) | 1989-11-23 |
EP0318092A2 (en) | 1989-05-31 |
PT89085A (pt) | 1988-12-01 |
AU2592988A (en) | 1989-06-01 |
PT89085B (pt) | 1993-03-31 |
DK659688D0 (da) | 1988-11-25 |
AU613681B2 (en) | 1991-08-08 |
JPH01186867A (ja) | 1989-07-26 |
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