DE3172516D1 - Penetrating topical pharmaceutical compositions - Google Patents

Penetrating topical pharmaceutical compositions

Info

Publication number
DE3172516D1
DE3172516D1 DE8181303128T DE3172516T DE3172516D1 DE 3172516 D1 DE3172516 D1 DE 3172516D1 DE 8181303128 T DE8181303128 T DE 8181303128T DE 3172516 T DE3172516 T DE 3172516T DE 3172516 D1 DE3172516 D1 DE 3172516D1
Authority
DE
Germany
Prior art keywords
pharmaceutical compositions
topical pharmaceutical
penetrating topical
penetrating
compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8181303128T
Other languages
English (en)
Inventor
Richard Randall Wickett
Eugene Rex Cooper
Maurice Edward Loomans
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Procter and Gamble Co
Original Assignee
Procter and Gamble Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procter and Gamble Co filed Critical Procter and Gamble Co
Application granted granted Critical
Publication of DE3172516D1 publication Critical patent/DE3172516D1/de
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Dermatology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
DE8181303128T 1980-07-09 1981-07-09 Penetrating topical pharmaceutical compositions Expired DE3172516D1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US16716780A 1980-07-09 1980-07-09

Publications (1)

Publication Number Publication Date
DE3172516D1 true DE3172516D1 (en) 1985-11-07

Family

ID=22606219

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8181303128T Expired DE3172516D1 (en) 1980-07-09 1981-07-09 Penetrating topical pharmaceutical compositions

Country Status (8)

Country Link
EP (1) EP0043738B1 (de)
JP (1) JPS5781408A (de)
AU (1) AU544969B2 (de)
CA (1) CA1165240A (de)
DE (1) DE3172516D1 (de)
IE (1) IE51377B1 (de)
NZ (1) NZ197668A (de)
ZA (1) ZA814650B (de)

Families Citing this family (106)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3348500C2 (de) * 1982-05-28 1998-10-22 Eisai Co Ltd beta,gamma-Dihydropolyprenylalkoholderivat
EP0095813A3 (de) * 1982-06-01 1985-05-08 THE PROCTER & GAMBLE COMPANY Durchdringende topische pharmazeutische Präparate, die 9-(2-Hydroxyäthoxymethyl)-guanin enthalten
CH655656B (de) * 1982-10-07 1986-05-15
GB8302683D0 (en) * 1983-02-01 1983-03-02 Unilever Plc Skin treatment composition
CA1225594A (en) * 1983-05-20 1987-08-18 Jourge Heller Method for percutaneously administering physiologically active agents
JPS59216825A (ja) * 1983-05-23 1984-12-06 Takeda Chem Ind Ltd 経皮吸収外用製剤
JPS60199822A (ja) * 1984-03-23 1985-10-09 Takeda Chem Ind Ltd 経皮吸収外用製剤
US4552872A (en) * 1983-06-21 1985-11-12 The Procter & Gamble Company Penetrating topical pharmaceutical compositions containing corticosteroids
US4537776A (en) * 1983-06-21 1985-08-27 The Procter & Gamble Company Penetrating topical pharmaceutical compositions containing N-(2-hydroxyethyl) pyrrolidone
US4731384A (en) * 1983-07-01 1988-03-15 Troponwerke Gmbh & Co, Kg Etofenamate formulation
DE3323833A1 (de) * 1983-07-01 1985-01-03 Troponwerke Gmbh & Co Kg Etofenamat-zubereitung
JPS6013720A (ja) * 1983-07-01 1985-01-24 Nitto Electric Ind Co Ltd 生理的活性剤の吸収促進剤
US5128376A (en) * 1983-07-01 1992-07-07 Nitto Denko Corporation Method for percutaneously administering physiologically active agents using an adjuvant a solvent and a diol moderator
DE3323832A1 (de) * 1983-07-01 1985-01-03 Troponwerke Gmbh & Co Kg Etofenamat-zubereitung
US4590190A (en) * 1983-07-01 1986-05-20 Nitto Electric Industrial Co., Ltd. Method for percutaneously administering physiologically active agents using an alcohol adjuvant and a solvent
US4605670A (en) * 1984-02-01 1986-08-12 Nitto Electric Industrial Co., Ltd. Method for percutaneously administering metoclopramide
CA1249968A (en) * 1984-04-05 1989-02-14 Kazuo Kigasawa Ointment base
US4764381A (en) * 1985-12-06 1988-08-16 Key Pharmaceuticals, Inc. Percutaneous penetration enhancer of oleic acid and 2-ethyl-1, 3-hexanediol
LU86393A1 (fr) * 1986-04-16 1987-12-07 Oreal Composition anti-acneique stable a base d'erythromycine
DE3781034T2 (de) * 1986-06-13 1993-02-18 Procter & Gamble Topische pharmazeutische zubereitung mit besserer durchdringungsfaehigkeit.
LU86548A1 (fr) * 1986-08-07 1988-03-02 Oreal Composition sous forme de gel pour induire et stimuler la croissance des cheveux et diminuer leur chute a base de derives de piperidino-pyrimidine
US4908389A (en) * 1986-08-27 1990-03-13 Warner-Lambert Company Penetration enhancement system
US5196410A (en) * 1986-10-31 1993-03-23 Pfizer Inc. Transdermal flux enhancing compositions
US4959365A (en) * 1986-10-31 1990-09-25 Pfizer Inc. Topical compositions of lipophilic pharmaceuticals agents
US4863970A (en) * 1986-11-14 1989-09-05 Theratech, Inc. Penetration enhancement with binary system of oleic acid, oleins, and oleyl alcohol with lower alcohols
AU601528B2 (en) † 1986-12-22 1990-09-13 Ortho-Mcneil Pharmaceutical, Inc. Resilient transdermal drug-delivery device and compositions and devices employing fatty acid esters/ethers of alkanediols and percutaneous absorption enhancers
EP0302147A1 (de) * 1987-08-03 1989-02-08 The Procter & Gamble Company Topische Bräunungsmittel
JP2537062B2 (ja) * 1987-10-02 1996-09-25 株式会社資生堂 薬剤組成物
ATE176396T1 (de) 1987-10-22 1999-02-15 Procter & Gamble Chelatbildner enthaltende lichtschutzmittel
US5057497A (en) * 1987-11-10 1991-10-15 Calam & Associates, Inc. Oral method for the maintenance of healthy gingival tissues using TRF
US5064654A (en) * 1989-01-11 1991-11-12 Ciba-Geigy Corporation Mixed solvent mutually enhanced transdermal therapeutic system
US5925372A (en) * 1987-12-16 1999-07-20 Novartis Corporation Mixed solvent mutually enhanced transdermal therapeutic system
US4888354A (en) * 1987-12-21 1989-12-19 Theratech, Inc. Skin penetration enhancement using free base and acid addition salt combinations of active agents
CA1331137C (en) * 1988-02-29 1994-08-02 Pfizer, Inc. Transdermal flux enhancing compositions
CH679119A5 (de) * 1988-05-13 1991-12-31 Sandoz Ag
EP0351897A3 (de) * 1988-06-17 1990-03-21 The Procter & Gamble Company Hautpenetrierendes System für aminfunktionelle Anrzneistoffsalze
US4855294A (en) * 1988-09-06 1989-08-08 Theratech, Inc. Method for reducing skin irritation associated with drug/penetration enhancer compositions
US5008110A (en) * 1988-11-10 1991-04-16 The Procter & Gamble Company Storage-stable transdermal patch
US5026556A (en) * 1988-11-10 1991-06-25 Norwich Eaton Pharmaceuticals, Inc. Compositions for the transdermal delivery of pharmaceutical actives
GR1001303B (el) * 1989-01-23 1993-07-30 Wolff Chem Pharm Gmbh Μεθοδος παρασκευης μεσου που περιεχει σαλικυλικο οξυ εναντιον απολεπιστικων νοσων της επιδερμιδας.
EP0455631B1 (de) * 1989-01-25 1993-06-30 DR. AUGUST WOLFF CHEMISCH-PHARMAZEUTISCHE FABRIK GMBH & CO. KG Salicylsäurehaltiges mittel gegen schuppende hauterkrankungen
EP0399432B1 (de) * 1989-05-25 1994-06-22 Takeda Chemical Industries, Ltd. Transdermales therapeutisches Mittel
US5262165A (en) * 1992-02-04 1993-11-16 Schering Corporation Transdermal nitroglycerin patch with penetration enhancers
CA2067820A1 (en) * 1989-10-23 1991-04-24 Srinivasan Venkateshwaran Iontophoresis device and method using a rate-controlling membrane
US5149719A (en) * 1990-04-27 1992-09-22 Minnesota Mining And Manufacturing Company Composition for transdermal penetration of medicaments
TW222591B (de) 1991-08-30 1994-04-21 Procter & Gamble
US5229130A (en) * 1991-12-20 1993-07-20 Cygnus Therapeutics Systems Vegetable oil-based skin permeation enhancer compositions, and associated methods and systems
DE4234225A1 (de) * 1992-10-10 1994-04-14 Roehm Pharma Gmbh Stabile topische Formulierungen mit gutem Wirkstoff-Freisetzungsvermögen enthaltend mindestens ein lipophilisiertes Makrolidantibiotikum
US5814599A (en) * 1995-08-04 1998-09-29 Massachusetts Insitiute Of Technology Transdermal delivery of encapsulated drugs
US5861439A (en) * 1994-11-14 1999-01-19 Alza Corporation Method for enhanced electrotransport agent delivery
AU5578096A (en) * 1995-04-28 1996-11-18 Pharmetrix, Inc. Compositions and methods for inducing dermal analgesia
US5785991A (en) * 1995-06-07 1998-07-28 Alza Corporation Skin permeation enhancer compositions comprising glycerol monolaurate and lauryl acetate
US5780050A (en) 1995-07-20 1998-07-14 Theratech, Inc. Drug delivery compositions for improved stability of steroids
US6002961A (en) * 1995-07-25 1999-12-14 Massachusetts Institute Of Technology Transdermal protein delivery using low-frequency sonophoresis
US6041253A (en) * 1995-12-18 2000-03-21 Massachusetts Institute Of Technology Effect of electric field and ultrasound for transdermal drug delivery
US5947921A (en) * 1995-12-18 1999-09-07 Massachusetts Institute Of Technology Chemical and physical enhancers and ultrasound for transdermal drug delivery
DK1563788T3 (da) 1995-08-29 2015-05-11 Nitto Denko Corp Mikroperforering af human hud til stofindgift og overvågningsformål
JP2002515786A (ja) 1996-06-28 2002-05-28 ソントラ メディカル，エル．ピー． 経皮輸送の超音波増強
DE19641259A1 (de) * 1996-10-07 1998-04-16 Kade Pharma Fab Gmbh Arzneimittel auf Basis von Diclofenac
PL332724A1 (en) 1996-10-14 1999-10-11 Kowa Co Local anaesthetic for extracorporeal use
US20020006913A1 (en) 1997-11-04 2002-01-17 Von Borstel Reid W. Antimutagenic compositions for treatment and prevention of photodamage to skin
GB9723669D0 (en) * 1997-11-07 1998-01-07 Univ Aberdeen Skin penetration enhancing components
IL136042A (en) 1997-11-10 2005-12-18 Cellegy Pharma Inc Alcohol-containing composition for topical application
US8287483B2 (en) 1998-01-08 2012-10-16 Echo Therapeutics, Inc. Method and apparatus for enhancement of transdermal transport
US20040171980A1 (en) 1998-12-18 2004-09-02 Sontra Medical, Inc. Method and apparatus for enhancement of transdermal transport
WO2000072883A2 (en) * 1999-06-02 2000-12-07 Aviana Biopharm Pharmaceutical transdermal compositions
US6242491B1 (en) 1999-06-25 2001-06-05 Rima Kaddurah-Daouk Use of creatine or creatine compounds for skin preservation
KR100452972B1 (ko) 2000-05-16 2004-10-14 주식회사 삼양사 경피투여용 하이드로젤 조성물
US6503894B1 (en) 2000-08-30 2003-01-07 Unimed Pharmaceuticals, Inc. Pharmaceutical composition and method for treating hypogonadism
CZ20031761A3 (cs) * 2000-12-22 2004-01-14 Dr. August Wolff Gmbh & Co. Gelová kompozice s obsahem steroidu pro ošetřování hypogonadismu
WO2002098396A1 (fr) * 2001-05-31 2002-12-12 Hisamitsu Pharmaceutical Co., Inc. Timbres a absorption par voie percutanee
US20030060422A1 (en) 2001-08-31 2003-03-27 Balaji Venkataraman Tannate compositions and methods of treatment
US6509492B1 (en) 2001-08-31 2003-01-21 First Horizon Pharmaceutical Corporation Tannate compositions and methods of treatment
US6894078B2 (en) * 2001-09-17 2005-05-17 James G. Castillo Alcohol based topical anesthetic formulation and method
US6795727B2 (en) 2001-10-17 2004-09-21 Pedro Giammarusti Devices and methods for promoting transcutaneous movement of substances
DE10341179A1 (de) † 2003-09-06 2005-03-31 Beiersdorf Ag Wirkstoffkombination gegen Akne
US20060094944A1 (en) 2004-10-28 2006-05-04 Sontra Medical Corporation System and method for analyte sampling and analysis with error correction
WO2006089082A2 (en) 2005-02-17 2006-08-24 Velcera Pharmaceuticals Transmucosal administration of drug compositions for treating and preventing disorders in animals
US10137135B2 (en) * 2005-08-15 2018-11-27 Allergan Sales, Llc Formulations and methods for providing progestin-only contraception while minimizing adverse side effects associated therewith
DK1937276T3 (da) 2005-10-12 2013-02-11 Besins Healthcare Luxembourg Forbedret testosterongel og fremgangsmåde til anvendelse deraf
EP2124723A1 (de) 2007-03-07 2009-12-02 Echo Therapeutics, Inc. Überwachungssystem für transdermale marker und verfahren für den nachweis von markern
SI2152358T1 (sl) 2007-04-27 2011-08-31 Echo Therapeutics Inc Naprava za prodiranje skozi koĺ˝o za analizno merjenje ali za transdermalni prenos zdravil
ES2349906T3 (es) * 2007-07-25 2011-01-12 Ixodes Gmbh Composición antibiótica tópica para prevenir la enfermedad de lyme.
JP5358574B2 (ja) * 2007-08-17 2013-12-04 アルション セラピューティクス， インコーポレイテッド 高濃度の局所麻酔薬調合物
US8658699B2 (en) 2008-05-19 2014-02-25 Massachusetts Institute Of Technology Chemical permeation enhancers enhance nerve blockade by toxins
WO2009143175A2 (en) 2008-05-19 2009-11-26 Children's Medical Center Corporation Sensory-specific local anesthesia and prolonged duration local anesthesia
WO2010019953A1 (en) 2008-08-15 2010-02-18 Arcion Therapeutics, Inc. High concentration local anesthetic formulations for treating non-neuropathic pain
WO2010101625A2 (en) 2009-03-02 2010-09-10 Seventh Sense Biosystems, Inc. Oxygen sensor
US9033898B2 (en) 2010-06-23 2015-05-19 Seventh Sense Biosystems, Inc. Sampling devices and methods involving relatively little pain
WO2010101620A2 (en) 2009-03-02 2010-09-10 Seventh Sense Biosystems, Inc. Systems and methods for creating and using suction blisters or other pooled regions of fluid within the skin
US9041541B2 (en) 2010-01-28 2015-05-26 Seventh Sense Biosystems, Inc. Monitoring or feedback systems and methods
US9295417B2 (en) 2011-04-29 2016-03-29 Seventh Sense Biosystems, Inc. Systems and methods for collecting fluid from a subject
US8952152B2 (en) 2009-03-24 2015-02-10 Proteus S.A. Methods for purifying phycotoxins, pharmaceutical compositions containing purified phycotoxins, and methods of use thereof
AU2010279384A1 (en) 2009-08-05 2012-03-01 Wake Forest University Compositions and methods for inducing apoptosis in prostate cancer cells
EP2593014B1 (de) 2010-07-16 2015-11-04 Seventh Sense Biosystems, Inc. Niederdruckumgebung für flüssigkeitstransfervorrichtungen
US20120039809A1 (en) 2010-08-13 2012-02-16 Seventh Sense Biosystems, Inc. Systems and techniques for monitoring subjects
WO2012064802A1 (en) 2010-11-09 2012-05-18 Seventh Sense Biosystems, Inc. Systems and interfaces for blood sampling
EP3236259A1 (de) 2011-04-29 2017-10-25 Seventh Sense Biosystems, Inc. Plasma- oder serumherstellung und entfernung von flüssigkeiten bei reduziertem druck
US20130158468A1 (en) 2011-12-19 2013-06-20 Seventh Sense Biosystems, Inc. Delivering and/or receiving material with respect to a subject surface
WO2012149143A1 (en) 2011-04-29 2012-11-01 Seventh Sense Biosystems, Inc. Delivering and/or receiving fluids
US8853189B2 (en) 2012-05-31 2014-10-07 Prima Innovations, Llc Antispasmodic 1,2-Diols and 1,2,3-triols
AU2014232881B2 (en) 2013-03-15 2017-04-27 The Children's Medical Center Corporation Neosaxitoxin combination formulations for prolonged local anesthesia
US20170186270A1 (en) 2013-08-06 2017-06-29 Patent Investment & Licensing Company Method and system for dispatching casino personnel and tracking interactions with players
PT3124016T (pt) 2015-07-31 2019-12-13 Univ Warszawski Medyczny Composição de emulsão antipsoriática que compreende cefazolina
KR102073726B1 (ko) * 2016-12-29 2020-02-05 주식회사 모다이노칩 복합 소자 및 이를 구비하는 전자기기
KR102053356B1 (ko) * 2018-06-08 2019-12-06 주식회사 모다이노칩 복합 소자의 제조 방법, 이에 의해 제조된 복합 소자 및 이를 구비하는 전자기기

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1133800A (en) * 1966-11-10 1968-11-20 Ici Ltd Pharmaceutical compositions
US4006218A (en) * 1974-07-08 1977-02-01 Johnson & Johnson Potentiated medicaments
DE2514873C2 (de) * 1975-04-05 1983-12-29 Merck Patent Gmbh, 6100 Darmstadt Salbengrundlage
US4126681A (en) * 1975-12-08 1978-11-21 The Procter & Gamble Company Topical composition containing acetyl salicylic acid
US4075353A (en) * 1976-06-09 1978-02-21 Dermatologics For Veterinary Medicine, Inc. Process for the treatment of acarid skin infections in animals

Also Published As

Publication number Publication date
JPH0420886B2 (de) 1992-04-07
ZA814650B (en) 1982-07-28
CA1165240A (en) 1984-04-10
NZ197668A (en) 1984-03-16
AU7272081A (en) 1982-01-14
IE51377B1 (en) 1986-12-10
EP0043738B1 (de) 1985-10-02
JPS5781408A (en) 1982-05-21
EP0043738A3 (en) 1982-09-22
EP0043738A2 (de) 1982-01-13
AU544969B2 (en) 1985-06-27
IE811543L (en) 1982-01-09

Similar Documents

Publication Publication Date Title
DE3172516D1 (en) Penetrating topical pharmaceutical compositions
GB2148711B (en) Topical pharmaceutical compositions
ZA813465B (en) Pharmaceutical composition
DE3172028D1 (en) Pharmaceutical formulation
ZA81136B (en) Pharmaceutical compositions
GB2072504B (en) Pharmaceutical compositions
ZA815700B (en) Pharmaceutical compositions
GB2076285B (en) Dermatological compositions
AU558670B2 (en) Pharmaceutical compositions
IL62432A0 (en) Pharmaceutical compositions based on sulphonamide-potentiator combinations
DE3176849D1 (en) Pharmaceutical composition comprising 4-carbamoyl-imidazolium-5-olate
PT73952A (en) Pharmaceutical compositions
GB2124485B (en) Penetrating topical medicament
ZA814056B (en) Pharmaceutical bicyclo-octatriene compounds and compositions
SG62587G (en) Pharmaceutical formulation
ZA822357B (en) Topical pharmaceutical compositions
ZA815175B (en) Pharmaceutical composition
PH20383A (en) Penetrating topical pharmaceutical composition
IL81538A0 (en) Topical pharmaceutical compositions
MY8600640A (en) Topical pharmaceutical compositions
IL64208A0 (en) Topical pharmaceutical composition
ZA816940B (en) Pharmaceutical compositions
PT73810A (en) Pharmaceutical compositions
ZA812902B (en) Pharmaceutical compositions
ZA817456B (en) Pharmaceutical bismuth compositions

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee