DE3152175T1 - Platinum(ii)complexes and antineoplastic agents containing same as effective ingredients - Google Patents
Platinum(ii)complexes and antineoplastic agents containing same as effective ingredientsInfo
- Publication number
- DE3152175T1 DE3152175T1 DE813152175T DE3152175T DE3152175T1 DE 3152175 T1 DE3152175 T1 DE 3152175T1 DE 813152175 T DE813152175 T DE 813152175T DE 3152175 T DE3152175 T DE 3152175T DE 3152175 T1 DE3152175 T1 DE 3152175T1
- Authority
- DE
- Germany
- Prior art keywords
- hcoh
- platinum
- coo
- meaning
- complex according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- HRGDZIGMBDGFTC-UHFFFAOYSA-N platinum(2+) Chemical class [Pt+2] HRGDZIGMBDGFTC-UHFFFAOYSA-N 0.000 title claims 9
- 229940034982 antineoplastic agent Drugs 0.000 title 1
- 239000002246 antineoplastic agent Substances 0.000 title 1
- 239000004615 ingredient Substances 0.000 title 1
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 claims 19
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Substances [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims 9
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- 125000005843 halogen group Chemical group 0.000 claims 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 2
- 239000001257 hydrogen Substances 0.000 claims 2
- ZUYYQGFCSKJGDO-UHFFFAOYSA-N 2-(aminomethyl)cyclohexan-1-amine Chemical compound NCC1CCCCC1N ZUYYQGFCSKJGDO-UHFFFAOYSA-N 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- SSJXIUAHEKJCMH-UHFFFAOYSA-N cyclohexane-1,2-diamine Chemical compound NC1CCCCC1N SSJXIUAHEKJCMH-UHFFFAOYSA-N 0.000 claims 1
- AVKNGPAMCBSNSO-UHFFFAOYSA-N cyclohexylmethanamine Chemical compound NCC1CCCCC1 AVKNGPAMCBSNSO-UHFFFAOYSA-N 0.000 claims 1
- PONXTPCRRASWKW-KBPBESRZSA-N diphenylethylenediamine Chemical compound C1([C@H](N)[C@@H](N)C=2C=CC=CC=2)=CC=CC=C1 PONXTPCRRASWKW-KBPBESRZSA-N 0.000 claims 1
- OCIDXARMXNJACB-UHFFFAOYSA-N n'-phenylethane-1,2-diamine Chemical compound NCCNC1=CC=CC=C1 OCIDXARMXNJACB-UHFFFAOYSA-N 0.000 claims 1
- 229910052697 platinum Inorganic materials 0.000 claims 1
- XOJVVFBFDXDTEG-UHFFFAOYSA-N pristane Chemical compound CC(C)CCCC(C)CCCC(C)CCCC(C)C XOJVVFBFDXDTEG-UHFFFAOYSA-N 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/01—Saturated compounds having only one carboxyl group and containing hydroxy or O-metal groups
- C07C59/10—Polyhydroxy carboxylic acids
- C07C59/105—Polyhydroxy carboxylic acids having five or more carbon atoms, e.g. aldonic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
- C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
- C07F15/0086—Platinum compounds
- C07F15/0093—Platinum compounds without a metal-carbon linkage
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Description
Leerseite
Claims (1)
- 52 110 ' Pat ent ansprüche.Ά. Platin(II)-komplex, dargestellt durch die allgemeine Formel ' ·J>Pt(II)'20 worin -B-B- die Bedeutung hat vonR1C o) -NH9 1 IR1-CH-NH,-NH «Ι« i {?2^ \ 2 m λ \ R1-CH-NH225 . " Ζ" ' ' ■• ' (worin R^ und· Ro gleich oder verschieden sind und jedes Wasserstoff eine Alkylgruppe oder eine Arylgruppe ist, und n, m und X O sind oder eine ganze Zahl von Λ bis' 3), mindestens eines von A. und Ap30 die Bedeutung hat vonCOO' HCOHHOCH35 HCOHHCOH 1 CHλίund das andere die Bedeutung hat vonr- COO"*IHCOHHOCH HCOH HCOH CH2OHCl",.Bt",. I", P", XCH2COO" (worin X ein Halogenatom ist), NO-,", SO/"", HpPO/~ oder HpO, oder zusammengenommen, A. und Ap einen Ring zusammen mit Pt(II) bilden können, wobei im letzteren Falle -A^-Ap- die Bedeutung hat voncoo-HCOHHOCH IHCOHHCOH I
CH2OH2. Platin(II)-komplex nach Anspruch Λ , worin mindestens-eines von Ax, und Ap in der allgemeinen Formel die t Bedeutung hat vonCOO"HC(HCOHI HOCHHCOHHCOH ICH2OH\.:Ό* Ü\.": ■" r*/-'.::3i'5215. Platin(II)-komplex nach Anspruch 1 oder 2, worin -B-B- 1^-Diaminocyclohexan ist.4-, Piatin(II)-komplex nach Anspruch 3, worin das 1,2-Diaminocyclohexan in der cis-Form, trans-d-Form oder trans-X-Fornr ist.!0 5· Platin(II)-komplex nach Anspruch 1 oder 2, worin ■ -B-B- in der allgemeinen Formel 1-Amino~2-aminomethylcyclohexan ist.6. Platin(II)-komplex nach Anspruch 5, worin das 1-■ Amino-2-aminomethylcyclohexan die cis-d-Porm, cis-£- Form, trans-d-Porm oder trans-ü-Form ist.. ?. Platin(II)-komplex nach Anspruch 1 oder 2, worin -B-B- in der allgemeinen Formel Λ,2-Diphenyläthylendiamin ist.8. Platin(II)-komplex nach Anspruch 7i worin das 1,2- : Diphenylathylendiamin die meso-Porm, trans-d-Porm oder trans-j£-Form ist.
9· Platin(II)-komplex nach Anspruch 1 oder 2, worin -B-B- in der allgemeinen Formel 1~Phenyläthylendiamin ist.10. Antineoplastisch.es Mittel, enthaltend einen Platin-. (Il)-komplex, dargestellt durch die allgemeine Formel :B
35vr Igworin -B-B- die Bedeutung hat vonH |(CH2}n-NH2oderR,r-CH-NHO )R1-CH-NH2101520253035(worin R. und R2 gleich oder verschieden sind und ■ jedes Wasserstoff eine Alkylgruppe oder eine Arylgruppe ist, und n, m und Jl 0 oder eine ganze Zahl von 1 "bis 3 sind), mindestens eines von A^ und A2 die Bedeutung hat vonCOO" HCOHHOCH . I HCOHHCOH Iund das andere die Bedeutung hat vonCOO" HCOH HOCH HCOH HCOHCH2OHCr", Br"XCH2COO(worin X ein Halogenatom ist), NO,"", SO^ , H2PO^" oder H2O, oder zusammengenommen A. und A2 einen Ring zusammen mit Pt(II) bilden können, wobei im letzteren Falle -A^-A2- dieBedeutung hat voncoo-HCOHHOCHHCOHI HCOHCH2OH
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP9206680A JPS5716895A (en) | 1980-07-05 | 1980-07-05 | Platinum 2 complex and antitumor agent containing the same as active principle |
PCT/JP1981/000154 WO1982000145A1 (en) | 1980-07-05 | 1981-07-04 | Platinum(ii)complexes and antineoplastic agents containing same as effective ingredients |
Publications (2)
Publication Number | Publication Date |
---|---|
DE3152175T1 true DE3152175T1 (de) | 1982-11-18 |
DE3152175C2 DE3152175C2 (de) | 1989-11-30 |
Family
ID=14044093
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE813152175T Granted DE3152175T1 (de) | 1980-07-05 | 1981-07-04 | Platinum(ii)complexes and antineoplastic agents containing same as effective ingredients |
Country Status (5)
Country | Link |
---|---|
US (1) | US4477387A (de) |
EP (1) | EP0055300A4 (de) |
JP (1) | JPS5716895A (de) |
DE (1) | DE3152175T1 (de) |
WO (1) | WO1982000145A1 (de) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5921697A (ja) * | 1982-06-24 | 1984-02-03 | Yoshinori Kitani | 新規な白金錯体 |
JPS59112995A (ja) * | 1982-12-21 | 1984-06-29 | Shionogi & Co Ltd | 新規グリコ−ル酸白金錯体 |
US4598091A (en) * | 1983-02-18 | 1986-07-01 | Degussa Aktiengesellschaft | (1,2-diphenyl)-ethylenediamine)-platinum (II) complex compounds |
DE3405611A1 (de) * | 1983-02-18 | 1984-08-23 | Degussa Ag, 6000 Frankfurt | (1,2-diphenyl-ethylendiamin)-platin(ii)-komplexverbindungen |
EP0130482B1 (de) * | 1983-06-20 | 1988-12-28 | Research Corporation | Diaminocyclohexan-Platin-Komplexe, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Zusammensetzungen |
US4661516A (en) * | 1983-06-20 | 1987-04-28 | Research Corporation | Diaminocyclohexane platinum complexes |
US4758588A (en) * | 1983-06-20 | 1988-07-19 | Research Corporation Technologies | Diaminocyclohexane platinum complexes |
DE3477788D1 (en) * | 1983-08-05 | 1989-05-24 | Yoshinori Kidani | Cytostatic platinum complexes |
JPS6087295A (ja) * | 1983-10-19 | 1985-05-16 | Nippon Kayaku Co Ltd | 新規白金錯体 |
US4562275A (en) * | 1984-03-23 | 1985-12-31 | Bristol-Myers Co. | Antitumor platinum complexes |
US4665210A (en) * | 1984-12-17 | 1987-05-12 | American Cyanamid Company | Platinum complexes of aliphatic tricarboxylic acids |
ZA86704B (en) * | 1985-02-23 | 1986-10-29 | Asta Werke Ag Chem Fab | Tumor retarding(1-benzyl-ethylenediamine9-platin(ii)-complexes |
JPS6296A (ja) * | 1985-03-06 | 1987-01-06 | Sumitomo Pharmaceut Co Ltd | 脂溶性白金(2)錯体 |
EP0207202A1 (de) * | 1985-07-04 | 1987-01-07 | Yoshinori Kidani | Antitumor Platinkomplexe |
US4567285A (en) * | 1985-07-10 | 1986-01-28 | Yoshinori Kidani | Complex compounds of platinum |
JPS6345290A (ja) * | 1985-08-27 | 1988-02-26 | Nippon Kayaku Co Ltd | 新規白金錯体 |
US4737589A (en) * | 1985-08-27 | 1988-04-12 | Nippon Kayaku Kabushiki Kaisha | Platinum Complexes |
JPS63203692A (ja) * | 1987-02-19 | 1988-08-23 | Nippon Kayaku Co Ltd | 新規白金錯体 |
US4904809A (en) * | 1987-09-25 | 1990-02-27 | Ss Pharmaceutical Co., Ltd. | Platinum complex |
DE3843571A1 (de) * | 1988-01-09 | 1989-07-20 | Asta Pharma Ag | 1,2-bis(aminomethyl)cyclobutan-platin-komplexe |
US5049686A (en) * | 1989-09-13 | 1991-09-17 | Warner-Lambert Company | Novel large-ring diamine platinum(II) and platinum(IV) chelates |
CZ300665B6 (cs) * | 2007-01-22 | 2009-07-15 | Pliva-Lachema A. S. | Sterilní kapalná farmaceutická kompozice a zpusob její výroby |
CZ300664B6 (cs) * | 2007-01-22 | 2009-07-15 | Pliva-Lachema A. S. | Sterilní kapalná farmaceutická kompozice a zpusob její výroby |
WO2015070177A2 (en) * | 2013-11-11 | 2015-05-14 | Collaborative Medicinal Development, Llc | Metal complexes and methods of treatment |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH588505A5 (de) * | 1972-06-08 | 1977-06-15 | Research Corp | |
US4115418A (en) * | 1976-09-02 | 1978-09-19 | Government Of The United States Of America | 1,2-diaminocyclohexane platinum (ii) complexes having antineoplastic activity |
JPS6041077B2 (ja) * | 1976-09-06 | 1985-09-13 | 喜徳 喜谷 | 1,2‐ジアミノシクロヘキサン異性体のシス白金(2)錯体 |
JPS5829957B2 (ja) * | 1977-09-12 | 1983-06-25 | 喜徳 喜谷 | 新規な白金錯体 |
US4203912A (en) * | 1977-10-19 | 1980-05-20 | Johnson, Matthey & Co., Limited | Compositions containing platinum |
SE7903361L (sv) * | 1978-04-20 | 1979-10-21 | Johnson Matthey Co Ltd | Kompositioner innehallande platina |
NL7807334A (nl) * | 1978-07-06 | 1980-01-08 | Tno | Platina-diaminecomplexen, werkwijze voor het bereiden daarvan, werkwijze voor het bereiden van een genees- middel met toepassing van een dergelijk platina-dia- minecomplex voor de behandeling van kanker, alsmede al- dus verkregen gevormd geneesmiddel. |
JPS6034958B2 (ja) * | 1978-09-02 | 1985-08-12 | 喜徳 喜谷 | 新規白金錯体 |
US4271085A (en) * | 1979-06-20 | 1981-06-02 | Engelhard Minerals & Chemicals Corporation | Cis-platinum (II) amine lactate complexes |
JPS56154493A (en) * | 1980-04-30 | 1981-11-30 | Shionogi & Co Ltd | Novel platinum complex |
-
1980
- 1980-07-05 JP JP9206680A patent/JPS5716895A/ja active Pending
-
1981
- 1981-03-04 US US06/355,742 patent/US4477387A/en not_active Expired - Fee Related
- 1981-07-04 EP EP19810901897 patent/EP0055300A4/de not_active Withdrawn
- 1981-07-04 DE DE813152175T patent/DE3152175T1/de active Granted
- 1981-07-04 WO PCT/JP1981/000154 patent/WO1982000145A1/ja not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
WO1982000145A1 (en) | 1982-01-21 |
JPS5716895A (en) | 1982-01-28 |
DE3152175C2 (de) | 1989-11-30 |
EP0055300A4 (de) | 1982-10-14 |
US4477387A (en) | 1984-10-16 |
EP0055300A1 (de) | 1982-07-07 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8110 | Request for examination paragraph 44 | ||
8125 | Change of the main classification |
Ipc: C07C 87/00 |
|
D2 | Grant after examination | ||
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |