DE3069433D1 - Method for producing pertussis toxoid - Google Patents

Method for producing pertussis toxoid

Info

Publication number
DE3069433D1
DE3069433D1 DE8080108246T DE3069433T DE3069433D1 DE 3069433 D1 DE3069433 D1 DE 3069433D1 DE 8080108246 T DE8080108246 T DE 8080108246T DE 3069433 T DE3069433 T DE 3069433T DE 3069433 D1 DE3069433 D1 DE 3069433D1
Authority
DE
Germany
Prior art keywords
pertussis toxoid
producing
producing pertussis
toxoid
pertussis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8080108246T
Other languages
German (de)
English (en)
Inventor
Yukio Syukuda
Hideo Watanabe
Shigeo Matsuyama
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Application granted granted Critical
Publication of DE3069433D1 publication Critical patent/DE3069433D1/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
    • C12P1/04—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes by using bacteria
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K2039/10—Brucella; Bordetella, e.g. Bordetella pertussis; Not used, see subgroups
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/82—Proteins from microorganisms
    • Y10S530/825—Bacteria

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mycology (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
DE8080108246T 1980-09-12 1980-12-30 Method for producing pertussis toxoid Expired DE3069433D1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP55127825A JPS5750925A (en) 1980-09-12 1980-09-12 Preparation of pertussis toxoid

Publications (1)

Publication Number Publication Date
DE3069433D1 true DE3069433D1 (en) 1984-11-15

Family

ID=14969595

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8080108246T Expired DE3069433D1 (en) 1980-09-12 1980-12-30 Method for producing pertussis toxoid

Country Status (12)

Country Link
US (1) US4455297A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
EP (1) EP0047802B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (1) JPS5750925A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
KR (1) KR840001512B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CA (1) CA1152001A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (1) DE3069433D1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DK (1) DK155915C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ES (1) ES8202058A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
GB (1) GB2083358A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
HU (1) HU185404B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NO (1) NO159667C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
SU (1) SU1297712A3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59206316A (ja) * 1983-05-11 1984-11-22 Kaken Pharmaceut Co Ltd インシユリン分泌増強活性物質誘導体およびその製法
US4551429A (en) * 1983-09-15 1985-11-05 American Home Products Corporation Stimulation of antigen production by Bordetella pertussis
CA1237998A (en) * 1984-04-14 1988-06-14 Akihiro Ginnaga Method for purification of filamentous hemagglutinin
GB8412207D0 (en) * 1984-05-12 1984-06-20 Wellcome Found Antigenic preparations
JPS60155127A (ja) * 1984-12-10 1985-08-15 Teijin Ltd 生物学的活性物質の製法
GB8512972D0 (en) * 1985-05-22 1985-06-26 Univ Glasgow Vaccine production
GB8601279D0 (en) * 1986-01-20 1986-02-26 Public Health Lab Service Purification of pertussis antigens
FR2597344B1 (fr) * 1986-04-16 1989-06-23 Merieux Inst Perfectionnement au procede de purification d'antigenes proteiques de bacteries appartenant au genre bordetella, en vue de l'obtention d'un vaccin acellulaire.
US4705686A (en) * 1986-05-09 1987-11-10 American Cyanamid Process for the preparation of acellular Bordetalla pertussis vaccine
US5165927A (en) * 1986-08-01 1992-11-24 University Of Southern California Composition with modified pertussis toxin
US5032398A (en) * 1986-08-01 1991-07-16 Kaslow Harvey R Selective modification of the catalytic subunit of pertussis toxin
CA1337859C (en) * 1987-04-24 1996-01-02 Masashi Chazono Method for culturing bordetella pertussis, a pertussis toxoid and a pertussis vaccine
US5139776A (en) * 1987-04-24 1992-08-18 The Research Foundation For Microbial Diseases Of Osaka University Method for culturing Bordetella pertussis, a pertussis toxoid and a pertussis vaccine
US5101019A (en) * 1987-05-22 1992-03-31 Takeda Chemical Industries, Ltd. Method for removing pertussis endotoxin, a pertussis toxoid and its production
JPS6485926A (en) * 1987-06-24 1989-03-30 Teijin Ltd Mutant of bordetella pertussis
GB8807860D0 (en) * 1988-04-05 1988-05-05 Connaught Lab Pertussis vaccine
JP2706792B2 (ja) * 1988-11-29 1998-01-28 財団法人化学及血清療法研究所 百日咳毒素のトキソイド化法
DK0396964T3 (da) * 1989-04-28 1995-10-30 Sclavo Spa Pertussistoxin-mutanter, Bordetella-stammer, der er i stand til at producere sådanne mutanter, samt deres anvendelse til udvikling af antipertussis-vacciner
GB8910570D0 (en) 1989-05-08 1989-06-21 Wellcome Found Acellular vaccine
US5578308A (en) * 1990-02-12 1996-11-26 Capiau; Carine Glutaraldehyde and formalin detoxified bordetella toxin vaccine
EP0515415B1 (en) * 1990-02-12 1995-10-18 SMITHKLINE BEECHAM BIOLOGICALS s.a. Novel vaccine and method therefor
JPH0432188U (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * 1990-07-10 1992-03-16
EP0669971B1 (en) * 1991-11-15 2003-03-19 Pfizer Inc. Method of producing gram-negative bacterial vaccines
JP2634545B2 (ja) * 1992-10-27 1997-07-30 日本全薬工業株式会社 Ｒｔｘトキシンファミリーに属する細菌毒素ワクチンの製造法
WO1995029934A1 (en) * 1994-04-28 1995-11-09 Takeda Chemical Industries, Ltd. Method of separating protective components of bordetella pertussis
RU2227746C1 (ru) * 2003-02-13 2004-04-27 Научно-исследовательский институт вакцин и сывороток им. И.И. Мечникова РАМН Способ получения анатоксина bordetella pertussis
BRPI0402630B8 (pt) * 2004-07-05 2021-05-25 Fund Butantan processo de obtenção de vacina pertussis celular menos reatogênica
RU2285540C2 (ru) * 2005-01-20 2006-10-20 Научно-исследовательский институт вакцин и сывороток им. И.И. Мечникова СПОСОБ ПОЛУЧЕНИЯ АНАТОКСИНА Bordetella pertussis
RU2332231C2 (ru) * 2006-07-31 2008-08-27 Федеральное государственное унитарное предприятие "Научно-производственное объединение по медицинским иммунобиологическим препаратам "Микроген" Министерства здравоохранения Российской Федерации Способ получения бесклеточной вакцины для иммунопрофилактики коклюша
RU2504399C1 (ru) * 2012-12-06 2014-01-20 Федеральное государственное унитарное предприятие "Научно-производственное объединение по медицинским и иммунопрофилактическим препаратам "Микроген" Министерства здравоохранения Российской Федерации (ФГУП "НПО "Микроген" Минздрава России) Способ получения бесклеточной вакцины для иммунопрофилактики коклюша

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB512196A (en) * 1937-08-19 1939-08-30 Lederle Lab Inc Method of preparing pertussis toxin and toxoid
US2359388A (en) * 1941-02-13 1944-10-03 Lederle Lab Inc Method of preparing pertussis toxin and toxoid
US3135662A (en) * 1961-01-05 1964-06-02 Burroughs Wellcome Co Diphtheria toxoid preparation and its production
NL6600706A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * 1965-02-05 1966-08-08
US4075321A (en) * 1973-05-04 1978-02-21 Agence Nationale De Valorisation De La Recherche (Anvar) Vaccines, the process for preparing the same and the applications thereof
DE2448530C3 (de) * 1974-10-11 1980-03-27 Behringwerke Ag, 3550 Marburg Verfahren zum Herstellen von Derivaten des Diphtherietoxins und diese enthaltende Mittel
DE2457047C3 (de) * 1974-12-03 1979-10-31 Behringwerke Ag, 3550 Marburg Verfahren zur Herstellung eines Derivates der leichten Kette des Tetanustoxins, dessen Verwendung zur Tetanusprophylaxe
FR2393065A1 (fr) * 1977-05-31 1978-12-29 Merieux Inst Procede de separation de lipides d'endotoxines bacteriennes et notamment d'endotoxine de bordetella pertussis

Also Published As

Publication number Publication date
HU185404B (en) 1985-02-28
SU1297712A3 (ru) 1987-03-15
JPS5750925A (en) 1982-03-25
ES499112A0 (es) 1982-02-01
KR830004851A (ko) 1983-07-20
ES8202058A1 (es) 1982-02-01
DK155915B (da) 1989-06-05
JPS64928B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1989-01-10
US4455297A (en) 1984-06-19
KR840001512B1 (ko) 1984-09-29
EP0047802B1 (en) 1984-10-10
EP0047802A2 (en) 1982-03-24
NO159667B (no) 1988-10-17
NO810014L (no) 1982-03-15
DK9281A (da) 1982-03-13
NO159667C (no) 1989-02-01
DK155915C (da) 1989-10-23
GB2083358A (en) 1982-03-24
EP0047802A3 (en) 1982-12-29
CA1152001A (en) 1983-08-16

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Legal Events

Date Code Title Description
V448 Application of spc

Free format text: PRODUCT NAME: AZELLULAERER-PERTUSSIS-ADSORBAT-IMPFSTOFF; REGISTRATION NO/DATE: 284A/93, 19940117

Spc suppl protection certif: 194 75 012

Filing date: 19940706

V457 Spc granted

Free format text: PRODUCT NAME: AZELLULAERER-PERTUSSIS-ADSORBAT-IMPFSTOFF; REGISTRATION NO/DATE: 284A/93, 19940117

Spc suppl protection certif: 194 75 012

Filing date: 19940706

V465 Spc lapsed due to nonpayment of the annual fee

Free format text: PRODUCT NAME: AZELLULAERER-PERTUSSIS-ADSORBAT-IMPFSTOFF; REGISTRATION NO/DATE: 284A/93, 19940117

Spc suppl protection certif: 194 75 012

Filing date: 19940706