DE3022681C2 - - Google Patents
Info
- Publication number
- DE3022681C2 DE3022681C2 DE3022681A DE3022681A DE3022681C2 DE 3022681 C2 DE3022681 C2 DE 3022681C2 DE 3022681 A DE3022681 A DE 3022681A DE 3022681 A DE3022681 A DE 3022681A DE 3022681 C2 DE3022681 C2 DE 3022681C2
- Authority
- DE
- Germany
- Prior art keywords
- serum
- agglutination
- prp
- buffer system
- test
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 210000002966 serum Anatomy 0.000 claims description 59
- 230000004520 agglutination Effects 0.000 claims description 51
- 239000002245 particle Substances 0.000 claims description 39
- 238000012360 testing method Methods 0.000 claims description 30
- 239000000427 antigen Substances 0.000 claims description 26
- 102000036639 antigens Human genes 0.000 claims description 26
- 108091007433 antigens Proteins 0.000 claims description 26
- DGVVWUTYPXICAM-UHFFFAOYSA-N β‐Mercaptoethanol Chemical compound OCCS DGVVWUTYPXICAM-UHFFFAOYSA-N 0.000 claims description 25
- 238000000034 method Methods 0.000 claims description 20
- 210000001124 body fluid Anatomy 0.000 claims description 19
- 239000010839 body fluid Substances 0.000 claims description 19
- 239000003153 chemical reaction reagent Substances 0.000 claims description 14
- 239000003638 chemical reducing agent Substances 0.000 claims description 14
- 239000000203 mixture Substances 0.000 claims description 13
- 238000001514 detection method Methods 0.000 claims description 10
- 241001465754 Metazoa Species 0.000 claims description 9
- 229920000447 polyanionic polymer Polymers 0.000 claims description 9
- 239000007853 buffer solution Substances 0.000 claims description 8
- 238000006243 chemical reaction Methods 0.000 claims description 8
- 230000000694 effects Effects 0.000 claims description 6
- 239000007788 liquid Substances 0.000 claims description 6
- VHJLVAABSRFDPM-QWWZWVQMSA-N dithiothreitol Chemical compound SC[C@@H](O)[C@H](O)CS VHJLVAABSRFDPM-QWWZWVQMSA-N 0.000 claims description 5
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 claims description 4
- 239000007900 aqueous suspension Substances 0.000 claims description 3
- 239000000470 constituent Substances 0.000 claims description 3
- 239000011541 reaction mixture Substances 0.000 claims description 3
- 108010024636 Glutathione Proteins 0.000 claims description 2
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 2
- 108060003951 Immunoglobulin Proteins 0.000 claims description 2
- 235000010418 carrageenan Nutrition 0.000 claims description 2
- 229920001525 carrageenan Polymers 0.000 claims description 2
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims description 2
- 235000018417 cysteine Nutrition 0.000 claims description 2
- 229960000633 dextran sulfate Drugs 0.000 claims description 2
- 229960003180 glutathione Drugs 0.000 claims description 2
- 229920000669 heparin Polymers 0.000 claims description 2
- 229960002897 heparin Drugs 0.000 claims description 2
- 102000018358 immunoglobulin Human genes 0.000 claims description 2
- 229910052708 sodium Inorganic materials 0.000 claims description 2
- 239000011734 sodium Substances 0.000 claims description 2
- 241000894007 species Species 0.000 claims description 2
- JXLHNMVSKXFWAO-UHFFFAOYSA-N azane;7-fluoro-2,1,3-benzoxadiazole-4-sulfonic acid Chemical compound N.OS(=O)(=O)C1=CC=C(F)C2=NON=C12 JXLHNMVSKXFWAO-UHFFFAOYSA-N 0.000 claims 1
- 239000004816 latex Substances 0.000 description 23
- 229920000126 latex Polymers 0.000 description 23
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 16
- 239000000872 buffer Substances 0.000 description 12
- 230000035945 sensitivity Effects 0.000 description 12
- 238000011534 incubation Methods 0.000 description 11
- 239000004471 Glycine Substances 0.000 description 8
- 239000000725 suspension Substances 0.000 description 8
- 239000007975 buffered saline Substances 0.000 description 6
- 238000002474 experimental method Methods 0.000 description 5
- 238000010438 heat treatment Methods 0.000 description 5
- 230000002779 inactivation Effects 0.000 description 5
- 238000003127 radioimmunoassay Methods 0.000 description 5
- 210000002700 urine Anatomy 0.000 description 5
- 241000606768 Haemophilus influenzae Species 0.000 description 4
- 241000282414 Homo sapiens Species 0.000 description 4
- 239000004793 Polystyrene Substances 0.000 description 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
- 210000001175 cerebrospinal fluid Anatomy 0.000 description 4
- 238000003745 diagnosis Methods 0.000 description 4
- 150000004676 glycans Chemical class 0.000 description 4
- 229920001282 polysaccharide Polymers 0.000 description 4
- 239000005017 polysaccharide Substances 0.000 description 4
- 238000000760 immunoelectrophoresis Methods 0.000 description 3
- 239000013642 negative control Substances 0.000 description 3
- 229920002223 polystyrene Polymers 0.000 description 3
- 239000013641 positive control Substances 0.000 description 3
- 235000018102 proteins Nutrition 0.000 description 3
- 102000004169 proteins and genes Human genes 0.000 description 3
- 108090000623 proteins and genes Proteins 0.000 description 3
- 239000011780 sodium chloride Substances 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- 241000283074 Equus asinus Species 0.000 description 2
- 201000009906 Meningitis Diseases 0.000 description 2
- 206010035664 Pneumonia Diseases 0.000 description 2
- 241000589884 Treponema pallidum Species 0.000 description 2
- 239000000910 agglutinin Substances 0.000 description 2
- 230000001580 bacterial effect Effects 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 238000010790 dilution Methods 0.000 description 2
- 239000012895 dilution Substances 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 239000012153 distilled water Substances 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 238000013100 final test Methods 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 230000000813 microbial effect Effects 0.000 description 2
- 244000005700 microbiome Species 0.000 description 2
- 230000001717 pathogenic effect Effects 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 230000000405 serological effect Effects 0.000 description 2
- 244000171897 Acacia nilotica subsp nilotica Species 0.000 description 1
- 101710186708 Agglutinin Proteins 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 208000035143 Bacterial infection Diseases 0.000 description 1
- 241000370738 Chlorion Species 0.000 description 1
- 208000035473 Communicable disease Diseases 0.000 description 1
- 238000002965 ELISA Methods 0.000 description 1
- 241000283086 Equidae Species 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 108010044091 Globulins Proteins 0.000 description 1
- 102000006395 Globulins Human genes 0.000 description 1
- 229920000084 Gum arabic Polymers 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 101710146024 Horcolin Proteins 0.000 description 1
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 description 1
- 101710189395 Lectin Proteins 0.000 description 1
- 101710179758 Mannose-specific lectin Proteins 0.000 description 1
- 101710150763 Mannose-specific lectin 1 Proteins 0.000 description 1
- 101710150745 Mannose-specific lectin 2 Proteins 0.000 description 1
- 206010029719 Nonspecific reaction Diseases 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 239000005062 Polybutadiene Substances 0.000 description 1
- 239000012506 Sephacryl® Substances 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 235000010489 acacia gum Nutrition 0.000 description 1
- 239000000205 acacia gum Substances 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000003712 anti-aging effect Effects 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 208000022362 bacterial infectious disease Diseases 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- 239000011324 bead Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 210000001136 chorion Anatomy 0.000 description 1
- 208000037976 chronic inflammation Diseases 0.000 description 1
- 208000037893 chronic inflammatory disorder Diseases 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000009833 condensation Methods 0.000 description 1
- 230000005494 condensation Effects 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- -1 dextran sulfate Polymers 0.000 description 1
- 238000002405 diagnostic procedure Methods 0.000 description 1
- 230000003292 diminished effect Effects 0.000 description 1
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 1
- 231100000676 disease causative agent Toxicity 0.000 description 1
- 208000001606 epiglottitis Diseases 0.000 description 1
- DNJIEGIFACGWOD-UHFFFAOYSA-N ethyl mercaptane Natural products CCS DNJIEGIFACGWOD-UHFFFAOYSA-N 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 238000005187 foaming Methods 0.000 description 1
- 108010074605 gamma-Globulins Proteins 0.000 description 1
- 238000002523 gelfiltration Methods 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 229940045808 haemophilus influenzae type b Drugs 0.000 description 1
- 230000003053 immunization Effects 0.000 description 1
- 238000002649 immunization Methods 0.000 description 1
- 230000000951 immunodiffusion Effects 0.000 description 1
- 239000012678 infectious agent Substances 0.000 description 1
- 230000002427 irreversible effect Effects 0.000 description 1
- 238000011068 loading method Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 239000002953 phosphate buffered saline Substances 0.000 description 1
- 229920002857 polybutadiene Polymers 0.000 description 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 1
- 229920000053 polysorbate 80 Polymers 0.000 description 1
- 229940068968 polysorbate 80 Drugs 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 238000009589 serological test Methods 0.000 description 1
- 239000012086 standard solution Substances 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 208000006379 syphilis Diseases 0.000 description 1
- 210000001550 testis Anatomy 0.000 description 1
- 239000011800 void material Substances 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56983—Viruses
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54393—Improving reaction conditions or stability, e.g. by coating or irradiation of surface, by reduction of non-specific binding, by promotion of specific binding
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/811—Test for named disease, body condition or organ function
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Physics & Mathematics (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Tropical Medicine & Parasitology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/050,269 US4310508A (en) | 1979-06-19 | 1979-06-19 | Diagnostic test and reagent therefor |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE3022681A1 DE3022681A1 (de) | 1981-01-22 |
| DE3022681C2 true DE3022681C2 (en, 2012) | 1992-07-30 |
Family
ID=21964303
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19803022681 Granted DE3022681A1 (de) | 1979-06-19 | 1980-06-18 | Verfahren zur herstellung eines reagens, das agglutination bewirkt und direkter agglutinationstest fuer koerperfluessigkeiten |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US4310508A (en, 2012) |
| JP (1) | JPS5631648A (en, 2012) |
| AU (1) | AU538062B2 (en, 2012) |
| BE (1) | BE883905A (en, 2012) |
| CA (1) | CA1138331A (en, 2012) |
| CH (1) | CH646524A5 (en, 2012) |
| DE (1) | DE3022681A1 (en, 2012) |
| DK (1) | DK166234C (en, 2012) |
| FI (1) | FI68468C (en, 2012) |
| FR (1) | FR2459480B1 (en, 2012) |
| GB (1) | GB2052059B (en, 2012) |
| IT (1) | IT1129088B (en, 2012) |
| NL (1) | NL191323C (en, 2012) |
| NO (1) | NO153910C (en, 2012) |
| SE (1) | SE448577B (en, 2012) |
| ZA (1) | ZA803473B (en, 2012) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3206729A1 (de) * | 1982-02-25 | 1983-09-01 | Behringwerke Ag, 3550 Marburg | Immunologisches agglutinationsverfahren |
| US4403042A (en) * | 1982-08-19 | 1983-09-06 | Miles Laboratories, Inc. | Detection of cell membrane antigens and corresponding antibodies |
| JPS5992353A (ja) * | 1982-11-19 | 1984-05-28 | Shinotesuto Kenkyusho:Kk | 不溶性担体粒子を用いる凝集反応測定方法 |
| JPS60256057A (ja) * | 1984-06-01 | 1985-12-17 | Dai Ichi Pure Chem Co Ltd | 免疫学的測定法 |
| JPS63106561A (ja) * | 1986-05-31 | 1988-05-11 | Toshiba Corp | 免疫分析試薬 |
| DE3715333A1 (de) * | 1987-05-08 | 1988-11-24 | Behringwerke Ag | Verfahren zur quantitativen bestimmung von serumproteinen in koerperfluessigkeiten und mittel zur durchfuehrung des verfahrens |
| US4921809A (en) * | 1987-09-29 | 1990-05-01 | Findley Adhesives, Inc. | Polymer coated solid matrices and use in immunoassays |
| EP0341439B1 (en) * | 1988-05-11 | 1993-08-04 | Abbott Laboratories | Method for increasing specificity in competitive immunoassays |
| JPH0354465A (ja) * | 1989-07-21 | 1991-03-08 | Sekisui Chem Co Ltd | 免疫学的測定用希釈液 |
| JPH0354466A (ja) * | 1989-07-21 | 1991-03-08 | Sekisui Chem Co Ltd | 免疫学的測定試薬及び測定方法 |
| US5817525A (en) * | 1995-05-19 | 1998-10-06 | Chiron Diagnostics Corporation | Stable protein solutions for diagnostics and method of making and using the same |
| US6927071B2 (en) * | 2001-12-07 | 2005-08-09 | Beckman Coulter, Inc. | Method for reducing non-specific aggregation of latex microparticles in the presence of serum or plasma |
| US20060190188A1 (en) * | 2005-01-25 | 2006-08-24 | Nauta Jozef J | Methods and systems for determining lot consistency |
| CA2552596A1 (en) * | 2005-08-09 | 2007-02-09 | Solvay Pharmaceuticals B.V. | Methods and systems for determining mid-value titers |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1078939A (en) * | 1964-08-12 | 1967-08-09 | Pfizer & Co C | Diagnostic reagent |
| US3600494A (en) * | 1967-11-06 | 1971-08-17 | Fujizokiseiyaku Kk | Serological test for syphilis |
| US3873683A (en) * | 1968-12-10 | 1975-03-25 | Princeton Lab Inc | Pregnancy test composition and method |
| GB1340180A (en) * | 1969-12-18 | 1973-12-12 | Kowa Co | Process for the preparation of diagnostic agents for primary hepatoma |
| GB1362776A (en) * | 1970-07-17 | 1974-08-07 | Wellcome Found | Immunological reagent |
| US3992517A (en) * | 1975-02-19 | 1976-11-16 | Pfizer Inc. | Detection of hepatitis B surface antigen by latex agglutination |
| DE2546166A1 (de) * | 1975-10-15 | 1977-04-28 | Behringwerke Ag | Gegerbte thrombozyten |
| GB2005275B (en) * | 1977-09-19 | 1982-03-10 | Hoffmann La Roche | Immunological reagent |
| JPS5552945U (en, 2012) * | 1978-10-05 | 1980-04-09 |
-
1979
- 1979-06-19 US US06/050,269 patent/US4310508A/en not_active Expired - Lifetime
-
1980
- 1980-06-11 FI FI801870A patent/FI68468C/fi not_active IP Right Cessation
- 1980-06-11 IT IT67909/80A patent/IT1129088B/it active
- 1980-06-11 ZA ZA00803473A patent/ZA803473B/xx unknown
- 1980-06-16 JP JP8030880A patent/JPS5631648A/ja active Granted
- 1980-06-17 DK DK258080A patent/DK166234C/da not_active IP Right Cessation
- 1980-06-18 CH CH467880A patent/CH646524A5/fr not_active IP Right Cessation
- 1980-06-18 GB GB8019881A patent/GB2052059B/en not_active Expired
- 1980-06-18 SE SE8004542A patent/SE448577B/sv unknown
- 1980-06-18 DE DE19803022681 patent/DE3022681A1/de active Granted
- 1980-06-18 AU AU59402/80A patent/AU538062B2/en not_active Ceased
- 1980-06-18 NL NL8003542A patent/NL191323C/xx not_active IP Right Cessation
- 1980-06-18 NO NO801830A patent/NO153910C/no unknown
- 1980-06-19 FR FR8013626A patent/FR2459480B1/fr not_active Expired
- 1980-06-19 CA CA000354397A patent/CA1138331A/en not_active Expired
- 1980-06-19 BE BE0/201096A patent/BE883905A/fr not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DK166234C (da) | 1993-08-16 |
| NO153910C (no) | 1986-06-11 |
| NO801830L (no) | 1980-12-22 |
| JPS5631648A (en) | 1981-03-31 |
| BE883905A (fr) | 1980-12-19 |
| DK258080A (da) | 1980-12-20 |
| FR2459480A1 (fr) | 1981-01-09 |
| NO153910B (no) | 1986-03-03 |
| FI801870A7 (fi) | 1980-12-20 |
| CH646524A5 (fr) | 1984-11-30 |
| NL191323B (nl) | 1994-12-16 |
| NL191323C (nl) | 1995-05-16 |
| IT8067909A0 (it) | 1980-06-11 |
| FI68468C (fi) | 1985-09-10 |
| GB2052059B (en) | 1983-11-30 |
| DK166234B (da) | 1993-03-22 |
| DE3022681A1 (de) | 1981-01-22 |
| SE448577B (sv) | 1987-03-02 |
| IT1129088B (it) | 1986-06-04 |
| GB2052059A (en) | 1981-01-21 |
| AU538062B2 (en) | 1984-07-26 |
| ZA803473B (en) | 1981-09-30 |
| FI68468B (fi) | 1985-05-31 |
| CA1138331A (en) | 1982-12-28 |
| US4310508A (en) | 1982-01-12 |
| JPH0256633B2 (en, 2012) | 1990-11-30 |
| FR2459480B1 (fr) | 1985-01-11 |
| NL8003542A (nl) | 1980-12-23 |
| AU5940280A (en) | 1981-01-08 |
| SE8004542L (sv) | 1980-12-20 |
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