DE3003147A1 - Suppositorium mit einem gehalt an sulfamethoxazol und trimethoprim - Google Patents
Suppositorium mit einem gehalt an sulfamethoxazol und trimethoprimInfo
- Publication number
- DE3003147A1 DE3003147A1 DE19803003147 DE3003147A DE3003147A1 DE 3003147 A1 DE3003147 A1 DE 3003147A1 DE 19803003147 DE19803003147 DE 19803003147 DE 3003147 A DE3003147 A DE 3003147A DE 3003147 A1 DE3003147 A1 DE 3003147A1
- Authority
- DE
- Germany
- Prior art keywords
- sulfamethoxazole
- complex
- amount
- suppository
- trimethoprim
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- WZRJTRPJURQBRM-UHFFFAOYSA-N 4-amino-n-(5-methyl-1,2-oxazol-3-yl)benzenesulfonamide;5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-diamine Chemical compound O1C(C)=CC(NS(=O)(=O)C=2C=CC(N)=CC=2)=N1.COC1=C(OC)C(OC)=CC(CC=2C(=NC(N)=NC=2)N)=C1 WZRJTRPJURQBRM-UHFFFAOYSA-N 0.000 title claims description 15
- 229940006995 sulfamethoxazole and trimethoprim Drugs 0.000 title claims description 14
- 239000000829 suppository Substances 0.000 claims description 35
- JLKIGFTWXXRPMT-UHFFFAOYSA-N sulphamethoxazole Chemical compound O1C(C)=CC(NS(=O)(=O)C=2C=CC(N)=CC=2)=N1 JLKIGFTWXXRPMT-UHFFFAOYSA-N 0.000 claims description 22
- 239000004480 active ingredient Substances 0.000 claims description 19
- 238000004519 manufacturing process Methods 0.000 claims description 15
- 229960005404 sulfamethoxazole Drugs 0.000 claims description 14
- 238000000034 method Methods 0.000 claims description 12
- 238000002360 preparation method Methods 0.000 claims description 7
- 230000000144 pharmacologic effect Effects 0.000 claims description 5
- 239000007901 soft capsule Substances 0.000 claims description 5
- 230000036760 body temperature Effects 0.000 claims description 4
- 239000002904 solvent Substances 0.000 claims description 4
- 239000011159 matrix material Substances 0.000 claims description 3
- 239000007787 solid Substances 0.000 claims description 3
- 239000000155 melt Substances 0.000 claims description 2
- 239000000203 mixture Substances 0.000 description 34
- 238000009472 formulation Methods 0.000 description 25
- 239000000047 product Substances 0.000 description 15
- -1 glycerogelatin Polymers 0.000 description 12
- 230000008018 melting Effects 0.000 description 9
- 238000002844 melting Methods 0.000 description 9
- IEDVJHCEMCRBQM-UHFFFAOYSA-N trimethoprim Chemical compound COC1=C(OC)C(OC)=CC(CC=2C(=NC(N)=NC=2)N)=C1 IEDVJHCEMCRBQM-UHFFFAOYSA-N 0.000 description 9
- 229960001082 trimethoprim Drugs 0.000 description 9
- 238000004090 dissolution Methods 0.000 description 8
- 238000010521 absorption reaction Methods 0.000 description 7
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 6
- 238000002156 mixing Methods 0.000 description 6
- 239000006185 dispersion Substances 0.000 description 5
- 239000000463 material Substances 0.000 description 5
- 210000000664 rectum Anatomy 0.000 description 5
- 239000002775 capsule Substances 0.000 description 4
- 235000014113 dietary fatty acids Nutrition 0.000 description 4
- 239000000194 fatty acid Substances 0.000 description 4
- 229930195729 fatty acid Natural products 0.000 description 4
- 210000002784 stomach Anatomy 0.000 description 4
- 239000000080 wetting agent Substances 0.000 description 4
- 230000036765 blood level Effects 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 239000002552 dosage form Substances 0.000 description 3
- 150000002148 esters Chemical class 0.000 description 3
- 210000000936 intestine Anatomy 0.000 description 3
- 238000004898 kneading Methods 0.000 description 3
- 235000011803 sesame oil Nutrition 0.000 description 3
- 239000008159 sesame oil Substances 0.000 description 3
- 238000007711 solidification Methods 0.000 description 3
- 230000008023 solidification Effects 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 241000282472 Canis lupus familiaris Species 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerol Natural products OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- 239000000969 carrier Substances 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 239000010685 fatty oil Substances 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 230000036470 plasma concentration Effects 0.000 description 2
- 150000004671 saturated fatty acids Chemical class 0.000 description 2
- 235000003441 saturated fatty acids Nutrition 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- MJYQFWSXKFLTAY-OVEQLNGDSA-N (2r,3r)-2,3-bis[(4-hydroxy-3-methoxyphenyl)methyl]butane-1,4-diol;(2r,3r,4s,5s,6r)-6-(hydroxymethyl)oxane-2,3,4,5-tetrol Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O.C1=C(O)C(OC)=CC(C[C@@H](CO)[C@H](CO)CC=2C=C(OC)C(O)=CC=2)=C1 MJYQFWSXKFLTAY-OVEQLNGDSA-N 0.000 description 1
- 241001133760 Acoelorraphe Species 0.000 description 1
- 235000017060 Arachis glabrata Nutrition 0.000 description 1
- 244000105624 Arachis hypogaea Species 0.000 description 1
- 235000010777 Arachis hypogaea Nutrition 0.000 description 1
- 235000018262 Arachis monticola Nutrition 0.000 description 1
- 240000002791 Brassica napus Species 0.000 description 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
- 208000035473 Communicable disease Diseases 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- 244000068988 Glycine max Species 0.000 description 1
- 235000010469 Glycine max Nutrition 0.000 description 1
- 240000007817 Olea europaea Species 0.000 description 1
- 240000007594 Oryza sativa Species 0.000 description 1
- 235000007164 Oryza sativa Nutrition 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 229920001214 Polysorbate 60 Polymers 0.000 description 1
- 235000019484 Rapeseed oil Nutrition 0.000 description 1
- 244000000231 Sesamum indicum Species 0.000 description 1
- 235000003434 Sesamum indicum Nutrition 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 230000010933 acylation Effects 0.000 description 1
- 238000005917 acylation reaction Methods 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 150000003973 alkyl amines Chemical class 0.000 description 1
- 229940045714 alkyl sulfonate alkylating agent Drugs 0.000 description 1
- 150000008052 alkyl sulfonates Chemical class 0.000 description 1
- 150000001408 amides Chemical class 0.000 description 1
- 125000000129 anionic group Chemical group 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 239000004599 antimicrobial Substances 0.000 description 1
- 210000000436 anus Anatomy 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- 239000003899 bactericide agent Substances 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
- 125000002091 cationic group Chemical group 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 238000002512 chemotherapy Methods 0.000 description 1
- 229940110456 cocoa butter Drugs 0.000 description 1
- 235000019868 cocoa butter Nutrition 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 238000012790 confirmation Methods 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 235000005687 corn oil Nutrition 0.000 description 1
- 239000002285 corn oil Substances 0.000 description 1
- 235000012343 cottonseed oil Nutrition 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 239000002270 dispersing agent Substances 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 210000001198 duodenum Anatomy 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 238000005538 encapsulation Methods 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 125000005313 fatty acid group Chemical group 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 235000004426 flaxseed Nutrition 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 238000004817 gas chromatography Methods 0.000 description 1
- 210000004051 gastric juice Anatomy 0.000 description 1
- 239000007903 gelatin capsule Substances 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 238000005984 hydrogenation reaction Methods 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- FJQXCDYVZAHXNS-UHFFFAOYSA-N methadone hydrochloride Chemical compound Cl.C=1C=CC=CC=1C(CC(C)N(C)C)(C(=O)CC)C1=CC=CC=C1 FJQXCDYVZAHXNS-UHFFFAOYSA-N 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 235000010981 methylcellulose Nutrition 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 235000020232 peanut Nutrition 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920001451 polypropylene glycol Polymers 0.000 description 1
- 230000002028 premature Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 239000008279 sol Substances 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 150000005846 sugar alcohols Polymers 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 230000009974 thixotropic effect Effects 0.000 description 1
- 150000003626 triacylglycerols Chemical class 0.000 description 1
- 210000001215 vagina Anatomy 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/02—Suppositories; Bougies; Bases therefor; Ovules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
- A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S424/00—Drug, bio-affecting and body treating compositions
- Y10S424/15—Suppositories
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP999279A JPS55102517A (en) | 1979-01-30 | 1979-01-30 | Preparation of sulfamethoxazole-trimethoprim complex for administration via body cavity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE3003147A1 true DE3003147A1 (de) | 1980-08-07 |
Family
ID=11735349
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19803003147 Withdrawn DE3003147A1 (de) | 1979-01-30 | 1980-01-29 | Suppositorium mit einem gehalt an sulfamethoxazol und trimethoprim |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US4461765A (en, 2012) |
| JP (1) | JPS55102517A (en, 2012) |
| AR (1) | AR221525A1 (en, 2012) |
| CA (1) | CA1136986A (en, 2012) |
| CH (1) | CH641958A5 (en, 2012) |
| DE (1) | DE3003147A1 (en, 2012) |
| ES (1) | ES488367A0 (en, 2012) |
| FR (1) | FR2447719A1 (en, 2012) |
| GB (1) | GB2041749B (en, 2012) |
| IT (1) | IT1133051B (en, 2012) |
| MX (1) | MX5865E (en, 2012) |
| NL (1) | NL8000515A (en, 2012) |
| SE (1) | SE8000286L (en, 2012) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS57109713A (en) * | 1980-12-26 | 1982-07-08 | Shionogi & Co Ltd | Pharmaceutical preparation of combined agent of sulfamethoxazole and trimethoprim for medication through celom |
| HU197670B (en) * | 1986-02-28 | 1989-05-29 | Egyt Gyogyszervegyeszeti Gyar | Process for producing composition comprising 2,4-diamino-5-(3,4-dimethoxybenzyl)-pyrimidine or pharmaceutically suitable acid addition salt thereof as active ingredient |
| HU199683B (en) * | 1987-07-22 | 1990-03-28 | Egyt Gyogyszervegyeszeti Gyar | Process for producing pharmaceutical compositions analgesic, antiphlogistic, antipyretic, antianginic and/or antioxidative activity |
| RU2139707C1 (ru) * | 1996-12-24 | 1999-10-20 | ОАО Нижегородский химико-фармацевтический завод | Суппозитории, обладающие противогрибковым действием (варианты) |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3197369A (en) * | 1962-02-15 | 1965-07-27 | Scherer Gmbh R P | Coated gelatin capsules |
| BE633957A (en, 2012) * | 1962-06-22 | |||
| US3485840A (en) * | 1964-11-12 | 1969-12-23 | Hoffmann La Roche | 2,4-diamino - 5 - (2',4',5'-substituted benzyl) pyrimidines,intermediates and processes |
| IT1043853B (it) * | 1973-04-19 | 1980-02-29 | Chiesi P | Supposte contenenti l associazione trimetoprim sulfametossazolo e metodo per ottenerle |
| DE2631780C3 (de) * | 1976-07-15 | 1981-11-19 | Basf Ag, 6700 Ludwigshafen | Sulfonamid-Trimethoprim-Lösungen |
| JPS54101415A (en) * | 1978-01-27 | 1979-08-10 | Gea As | Stable suspension containing sulfamethoxal and trimetoprim and production thereof |
| JPS555379A (en) * | 1978-03-27 | 1980-01-16 | Muscarella James Allen | Capturing apparatus |
-
1979
- 1979-01-30 JP JP999279A patent/JPS55102517A/ja active Pending
-
1980
- 1980-01-04 CA CA000343059A patent/CA1136986A/en not_active Expired
- 1980-01-14 SE SE8000286A patent/SE8000286L/xx not_active Application Discontinuation
- 1980-01-28 MX MX808609U patent/MX5865E/es unknown
- 1980-01-28 NL NL8000515A patent/NL8000515A/nl not_active Application Discontinuation
- 1980-01-29 ES ES488367A patent/ES488367A0/es active Granted
- 1980-01-29 CH CH70580A patent/CH641958A5/de not_active IP Right Cessation
- 1980-01-29 FR FR8001854A patent/FR2447719A1/fr active Granted
- 1980-01-29 DE DE19803003147 patent/DE3003147A1/de not_active Withdrawn
- 1980-01-29 IT IT67127/80A patent/IT1133051B/it active
- 1980-01-30 GB GB8003152A patent/GB2041749B/en not_active Expired
- 1980-01-30 AR AR279801A patent/AR221525A1/es active
-
1981
- 1981-07-31 US US06/288,795 patent/US4461765A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| US4461765A (en) | 1984-07-24 |
| GB2041749A (en) | 1980-09-17 |
| IT1133051B (it) | 1986-07-09 |
| GB2041749B (en) | 1983-05-05 |
| NL8000515A (nl) | 1980-08-01 |
| CH641958A5 (de) | 1984-03-30 |
| FR2447719A1 (fr) | 1980-08-29 |
| JPS55102517A (en) | 1980-08-05 |
| MX5865E (es) | 1984-08-13 |
| FR2447719B1 (en, 2012) | 1984-02-24 |
| SE8000286L (sv) | 1980-07-31 |
| IT8067127A0 (it) | 1980-01-29 |
| ES8100076A1 (es) | 1980-11-01 |
| AR221525A1 (es) | 1981-02-13 |
| CA1136986A (en) | 1982-12-07 |
| ES488367A0 (es) | 1980-11-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8139 | Disposal/non-payment of the annual fee |