DE2941530A1 - N (pfeil abwaerts)b(pfeil hoch) -quartaere derivate von sandwicin und isosandwicin, verfahren und zwischenprodukte zur herstellung der derivate, die derivate enthaltende arzneimittel und die verwendung der derivate - Google Patents

N (pfeil abwaerts)b(pfeil hoch) -quartaere derivate von sandwicin und isosandwicin, verfahren und zwischenprodukte zur herstellung der derivate, die derivate enthaltende arzneimittel und die verwendung der derivate

Info

Publication number
DE2941530A1
DE2941530A1 DE19792941530 DE2941530A DE2941530A1 DE 2941530 A1 DE2941530 A1 DE 2941530A1 DE 19792941530 DE19792941530 DE 19792941530 DE 2941530 A DE2941530 A DE 2941530A DE 2941530 A1 DE2941530 A1 DE 2941530A1
Authority
DE
Germany
Prior art keywords
derivatives
radical
ethyl
quaternary
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE19792941530
Other languages
German (de)
English (en)
Inventor
Dr.med.vet. Renke Budden
Dr.med.vet. Gerd 3000 Hannover Buschmann
Dipl.-Chem. Dr.rer.nat. Wolfgang 3000 Hannover Kehrbach
Dr.med.vet. Ulrich Hannover Kühl
Dipl.-Chem. Dr.rer.nat. Joachim 3201 Algermissen Wegener
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AbbVie Pharmaceuticals GmbH
Original Assignee
Kali Chemie Pharma GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kali Chemie Pharma GmbH filed Critical Kali Chemie Pharma GmbH
Priority to DE19792941530 priority Critical patent/DE2941530A1/de
Priority to FI803087A priority patent/FI68625C/fi
Priority to SU802988600A priority patent/SU1012796A3/ru
Priority to ES495652A priority patent/ES8106525A1/es
Priority to ZA00806168A priority patent/ZA806168B/xx
Priority to IE2063/80A priority patent/IE50251B1/en
Priority to PT71895A priority patent/PT71895B/pt
Priority to DD80224436A priority patent/DD154699A5/de
Priority to HU802472A priority patent/HU184331B/hu
Priority to PH24701A priority patent/PH19151A/en
Priority to CA000362116A priority patent/CA1147330A/en
Priority to AT80106151T priority patent/ATE9228T1/de
Priority to NZ195217A priority patent/NZ195217A/xx
Priority to DK430680A priority patent/DK430680A/da
Priority to EP80106151A priority patent/EP0029116B1/de
Priority to NO803042A priority patent/NO154496C/no
Priority to DE8080106151T priority patent/DE3069106D1/de
Priority to GR63125A priority patent/GR70382B/el
Priority to JP14215580A priority patent/JPS5681583A/ja
Priority to AU63206/80A priority patent/AU538797B2/en
Priority to IL61265A priority patent/IL61265A/xx
Publication of DE2941530A1 publication Critical patent/DE2941530A1/de
Priority to SU813315696A priority patent/SU1074876A1/ru
Priority to US06/615,756 priority patent/US4552877A/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE19792941530 1979-10-13 1979-10-13 N (pfeil abwaerts)b(pfeil hoch) -quartaere derivate von sandwicin und isosandwicin, verfahren und zwischenprodukte zur herstellung der derivate, die derivate enthaltende arzneimittel und die verwendung der derivate Withdrawn DE2941530A1 (de)

Priority Applications (23)

Application Number Priority Date Filing Date Title
DE19792941530 DE2941530A1 (de) 1979-10-13 1979-10-13 N (pfeil abwaerts)b(pfeil hoch) -quartaere derivate von sandwicin und isosandwicin, verfahren und zwischenprodukte zur herstellung der derivate, die derivate enthaltende arzneimittel und die verwendung der derivate
FI803087A FI68625C (fi) 1979-10-13 1980-09-30 Foerfarande foer framstaellning av nb-kvaternaera derivat av 10-brom-sandvicin och 10-brom-isosandvicin
SU802988600A SU1012796A3 (ru) 1979-10-13 1980-10-02 Способ получени @ -четвертичных производных 10-бромсандвицина и 10-бромизосандвицина
ES495652A ES8106525A1 (es) 1979-10-13 1980-10-06 Procedimiento para la preparacion de derivados de 10-bromo- sandwicina y 10-bromoisosandwicina nb-cuaternarios
ZA00806168A ZA806168B (en) 1979-10-13 1980-10-06 N -quaternary derivatives of sandwicin and isosandwicin,process and intermediate products for the manufacture of the derivatives,the pharmaceuticals containing the derivatives and the use of the derivatives
IE2063/80A IE50251B1 (en) 1979-10-13 1980-10-07 Nb-quaternary derivatives of 10-bromosandwicine and 10-bromo-isosandwicine,process and intermediate products for the preparation of the derivatives,medicaments containing the derivatives and the use of the derivatives
PT71895A PT71895B (en) 1979-10-13 1980-10-09 Process for the preparation of nb-quaternary 10-bromosanduicine and 10-bromoisanduicine derivatives
DD80224436A DD154699A5 (de) 1979-10-13 1980-10-09 Verfahren zur herstellung von n-quartaeren derivaten von sandwicin und isosandwicin
AT80106151T ATE9228T1 (de) 1979-10-13 1980-10-10 N(b)-quartaere derivate von 10-bromsandwicin und 10-bromisosandwicin, verfahren und zwischenprodukte zur herstellung der derivate und diese derivate enthaltende arzneimittel.
PH24701A PH19151A (en) 1979-10-13 1980-10-10 Nb-quaternary derivative of sandwicine
CA000362116A CA1147330A (en) 1979-10-13 1980-10-10 N.sub.b-quaternary derivatives of sandwicine and isosandwicine methods and intermediate products in the manufacture of their derivatives and methods of using same and pharmaceutical compositions thereof
HU802472A HU184331B (en) 1979-10-13 1980-10-10 Process for preparing n down b-quaternary derivatives of 10-br omo-sandwicine and 10-bromo-isosandwicine
NZ195217A NZ195217A (en) 1979-10-13 1980-10-10 Nb-quaternary derivatives of 10-bromosandwicine or 10-bromoisosandwicine
DK430680A DK430680A (da) 1979-10-13 1980-10-10 Nb-kvarternaere derivater af sandwicin og isosandwicin samt fremgangsmaade og mellemprodukter til fremstilling af disse derivater
EP80106151A EP0029116B1 (de) 1979-10-13 1980-10-10 N(b)-quartäre Derivate von 10-Bromsandwicin und 10-Bromisosandwicin, Verfahren und Zwischenprodukte zur Herstellung der Derivate und diese Derivate enthaltende Arzneimittel
NO803042A NO154496C (no) 1979-10-13 1980-10-10 Analogifremgangsmaate ved fremstilling av terapeutisk virksomme nb-kvartaere derivater av sandwicin og isosandwicin.
DE8080106151T DE3069106D1 (en) 1979-10-13 1980-10-10 N(b)-quaternary 10-bromo-sandwicine and 10-bromo-isosandwicine derivatives, process and intermediates for preparing the derivatives and medicaments containing these derivatives
GR63125A GR70382B (cg-RX-API-DMAC10.html) 1979-10-13 1980-10-11
JP14215580A JPS5681583A (en) 1979-10-13 1980-10-13 Nbbquaternary 100bromsandwicinn and 100bromisosandwicin derivative* their manufacture* ringgopen aldehyde base and hearttbeat periodic trouble remedy
AU63206/80A AU538797B2 (en) 1979-10-13 1980-10-13 Derivatives of sandwicine and isosandwicine
IL61265A IL61265A (en) 1979-10-13 1980-10-13 Nb-quaternary derivatives of 10-bromosandwicine and 10-bromoisosandwicine,their preparation and pharmaceutical compositions containing them
SU813315696A SU1074876A1 (ru) 1979-10-13 1981-08-06 @ -Четвертичные производные 10-бромсандвицина или 10-бромизосандвицина,обладающие антиаритмическими свойствами
US06/615,756 US4552877A (en) 1979-10-13 1984-05-31 Nb -Quaternary derivatives of sandwicine and isosandwicine methods and intermediate products in the manufacture of their derivatives and methods of using same and pharmaceutical compositions thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19792941530 DE2941530A1 (de) 1979-10-13 1979-10-13 N (pfeil abwaerts)b(pfeil hoch) -quartaere derivate von sandwicin und isosandwicin, verfahren und zwischenprodukte zur herstellung der derivate, die derivate enthaltende arzneimittel und die verwendung der derivate

Publications (1)

Publication Number Publication Date
DE2941530A1 true DE2941530A1 (de) 1981-04-23

Family

ID=6083413

Family Applications (2)

Application Number Title Priority Date Filing Date
DE19792941530 Withdrawn DE2941530A1 (de) 1979-10-13 1979-10-13 N (pfeil abwaerts)b(pfeil hoch) -quartaere derivate von sandwicin und isosandwicin, verfahren und zwischenprodukte zur herstellung der derivate, die derivate enthaltende arzneimittel und die verwendung der derivate
DE8080106151T Expired DE3069106D1 (en) 1979-10-13 1980-10-10 N(b)-quaternary 10-bromo-sandwicine and 10-bromo-isosandwicine derivatives, process and intermediates for preparing the derivatives and medicaments containing these derivatives

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE8080106151T Expired DE3069106D1 (en) 1979-10-13 1980-10-10 N(b)-quaternary 10-bromo-sandwicine and 10-bromo-isosandwicine derivatives, process and intermediates for preparing the derivatives and medicaments containing these derivatives

Country Status (21)

Country Link
US (1) US4552877A (cg-RX-API-DMAC10.html)
EP (1) EP0029116B1 (cg-RX-API-DMAC10.html)
JP (1) JPS5681583A (cg-RX-API-DMAC10.html)
AT (1) ATE9228T1 (cg-RX-API-DMAC10.html)
AU (1) AU538797B2 (cg-RX-API-DMAC10.html)
CA (1) CA1147330A (cg-RX-API-DMAC10.html)
DD (1) DD154699A5 (cg-RX-API-DMAC10.html)
DE (2) DE2941530A1 (cg-RX-API-DMAC10.html)
DK (1) DK430680A (cg-RX-API-DMAC10.html)
ES (1) ES8106525A1 (cg-RX-API-DMAC10.html)
FI (1) FI68625C (cg-RX-API-DMAC10.html)
GR (1) GR70382B (cg-RX-API-DMAC10.html)
HU (1) HU184331B (cg-RX-API-DMAC10.html)
IE (1) IE50251B1 (cg-RX-API-DMAC10.html)
IL (1) IL61265A (cg-RX-API-DMAC10.html)
NO (1) NO154496C (cg-RX-API-DMAC10.html)
NZ (1) NZ195217A (cg-RX-API-DMAC10.html)
PH (1) PH19151A (cg-RX-API-DMAC10.html)
PT (1) PT71895B (cg-RX-API-DMAC10.html)
SU (2) SU1012796A3 (cg-RX-API-DMAC10.html)
ZA (1) ZA806168B (cg-RX-API-DMAC10.html)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4558052A (en) * 1979-10-13 1985-12-10 Kali-Chemie Pharma Gmbh 10-Bromosandwicine, 10-bromoisosandwicine, pharmaceutical compositions thereof, and methods of treating heart rhythm disorders with them

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3442452A1 (de) * 1984-11-22 1986-05-22 Kali-Chemie Pharma Gmbh, 3000 Hannover Neue n(pfeil abwaerts)b(pfeil abwaerts)-quartaere dibromderivate von ajmalin, isoajmalin, sandwicin und isosandwicin sowie diese derivate enthaltende pharmazeutische zubereitungen und zwischenprodukte und verfahren zu ihrer herstellung

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1582627A (en) * 1976-01-16 1981-01-14 Inverni Della Beffa Spa Derivatives of sandwicine and isosandwicine and pharmaceutical compositions comprising sandwicine isosandwicine and derivatives thereof
DE2611162A1 (de) * 1976-03-17 1977-10-06 Kali Chemie Pharma Gmbh Neue quartaere derivate von sandwicin und verfahren zu ihrer herstellung

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4558052A (en) * 1979-10-13 1985-12-10 Kali-Chemie Pharma Gmbh 10-Bromosandwicine, 10-bromoisosandwicine, pharmaceutical compositions thereof, and methods of treating heart rhythm disorders with them

Also Published As

Publication number Publication date
PT71895A (en) 1980-11-01
ES495652A0 (es) 1981-07-01
NO154496C (no) 1986-10-01
JPS5681583A (en) 1981-07-03
EP0029116A1 (de) 1981-05-27
US4552877A (en) 1985-11-12
PT71895B (en) 1981-08-31
AU538797B2 (en) 1984-08-30
ES8106525A1 (es) 1981-07-01
NO154496B (no) 1986-06-23
JPS6241596B2 (cg-RX-API-DMAC10.html) 1987-09-03
DD154699A5 (de) 1982-04-14
CA1147330A (en) 1983-05-31
FI68625B (fi) 1985-06-28
GR70382B (cg-RX-API-DMAC10.html) 1982-10-05
NZ195217A (en) 1983-11-18
ZA806168B (en) 1981-10-28
SU1074876A1 (ru) 1984-02-23
SU1012796A3 (ru) 1983-04-15
IE50251B1 (en) 1986-03-05
ATE9228T1 (de) 1984-09-15
IL61265A0 (en) 1980-12-31
IL61265A (en) 1983-10-31
AU6320680A (en) 1981-04-16
FI803087A7 (fi) 1981-04-14
DK430680A (da) 1981-04-14
DE3069106D1 (en) 1984-10-11
FI68625C (fi) 1985-10-10
NO803042L (no) 1981-04-14
IE802063L (en) 1981-04-13
HU184331B (en) 1984-08-28
PH19151A (en) 1986-01-15
EP0029116B1 (de) 1984-09-05

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Legal Events

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8139 Disposal/non-payment of the annual fee