DE2941529A1 - N(pfeil abwaerts)b(pfeil abwaerts) -quartaere derivate von ajmalin und isoajmalin, verfahren und zwischenprodukte zur herstellung der derivate, die derivate enthaltende arzneimittel und die verwendung der derivate - Google Patents

N(pfeil abwaerts)b(pfeil abwaerts) -quartaere derivate von ajmalin und isoajmalin, verfahren und zwischenprodukte zur herstellung der derivate, die derivate enthaltende arzneimittel und die verwendung der derivate

Info

Publication number
DE2941529A1
DE2941529A1 DE19792941529 DE2941529A DE2941529A1 DE 2941529 A1 DE2941529 A1 DE 2941529A1 DE 19792941529 DE19792941529 DE 19792941529 DE 2941529 A DE2941529 A DE 2941529A DE 2941529 A1 DE2941529 A1 DE 2941529A1
Authority
DE
Germany
Prior art keywords
derivatives
ethyl
radical
formula
bromo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE19792941529
Other languages
German (de)
English (en)
Inventor
Dr.med.vet. Renke Budden
Dr.med.vet. Gerd 3000 Hannover Buschmann
Dipl.-Chem. Dr.rer.nat. Wolfgang 3000 Hannover Kehrbach
Dr.med.vet. Ulrich Kühl
Dipl.-Chem. Dr.rer.nat. Joachim 3201 Algermissen Wegener
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AbbVie Pharmaceuticals GmbH
Original Assignee
Kali Chemie Pharma GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kali Chemie Pharma GmbH filed Critical Kali Chemie Pharma GmbH
Priority to DE19792941529 priority Critical patent/DE2941529A1/de
Priority to FI803086A priority patent/FI68624C/fi
Priority to SU802983702A priority patent/SU963470A3/ru
Priority to ZA00806167A priority patent/ZA806167B/xx
Priority to ES495650A priority patent/ES495650A0/es
Priority to IE2077/80A priority patent/IE50203B1/en
Priority to PT71894A priority patent/PT71894B/pt
Priority to DD80224435A priority patent/DD153552A5/de
Priority to CA000362115A priority patent/CA1147329A/en
Priority to NZ195220A priority patent/NZ195220A/xx
Priority to EP80106150A priority patent/EP0029115B1/de
Priority to AT80106150T priority patent/ATE9349T1/de
Priority to DE8080106150T priority patent/DE3069166D1/de
Priority to HU802471A priority patent/HU184840B/hu
Priority to IL61253A priority patent/IL61253A/xx
Priority to DK430580A priority patent/DK430580A/da
Priority to NO803041A priority patent/NO156325C/no
Priority to GR63126A priority patent/GR70710B/el
Priority to PH24716A priority patent/PH15938A/en
Priority to AU63205/80A priority patent/AU538949B2/en
Priority to JP14215780A priority patent/JPS5681585A/ja
Publication of DE2941529A1 publication Critical patent/DE2941529A1/de
Priority to US06/615,757 priority patent/US4554274A/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
  • Saccharide Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
DE19792941529 1979-10-13 1979-10-13 N(pfeil abwaerts)b(pfeil abwaerts) -quartaere derivate von ajmalin und isoajmalin, verfahren und zwischenprodukte zur herstellung der derivate, die derivate enthaltende arzneimittel und die verwendung der derivate Withdrawn DE2941529A1 (de)

Priority Applications (22)

Application Number Priority Date Filing Date Title
DE19792941529 DE2941529A1 (de) 1979-10-13 1979-10-13 N(pfeil abwaerts)b(pfeil abwaerts) -quartaere derivate von ajmalin und isoajmalin, verfahren und zwischenprodukte zur herstellung der derivate, die derivate enthaltende arzneimittel und die verwendung der derivate
FI803086A FI68624C (fi) 1979-10-13 1980-09-30 Foerfarande foer framstaellning av nb-kvaternaera derivat av 10-brom-ajmalin och 10-brom-isoajmalin
SU802983702A SU963470A3 (ru) 1979-10-13 1980-10-02 Способ получени N @ -четвертичных производных 10-бромаймалина и 10-бромизоаймалина
ZA00806167A ZA806167B (en) 1979-10-13 1980-10-06 Nb-quaternary derivatives of ajmalin and isoajmalin, process and intermediate products for the manufacture of the derivatives, the pharmaceuticals containing the derivatives,and the use of the derivatives
ES495650A ES495650A0 (es) 1979-10-13 1980-10-06 Procedimiento para la preparacion de derivados de 10-bro- moajmalina y 10-bromoisoajmalina nb-cuaternarios
IE2077/80A IE50203B1 (en) 1979-10-13 1980-10-07 Nb-quaternary derivatives of 10-bromoajmaline and 10-bromoisoajmaline,processes and intermediate products for the preparation of the derivatives,medicaments containing the derivatives and the use of the derivatives
PT71894A PT71894B (en) 1979-10-13 1980-10-09 Process for the preparation of nb-quaternary 10-bromoajmaline and 10-bromoisoajmaline derivatives
DD80224435A DD153552A5 (de) 1979-10-13 1980-10-09 Verfahren zur herstellung von n tief b-quartaeren derivaten von ajmalin und isoajmalin
AT80106150T ATE9349T1 (de) 1979-10-13 1980-10-10 N(b)-quartaere derivate von 10-bromajmalin und 10- bromisoajmalin, verfahren und zwischenprodukte zur herstellung der derivate und die derivate enthaltende arzneimittel.
DK430580A DK430580A (da) 1979-10-13 1980-10-10 Nb-kvarernaere derivater af 10-bromajmalin og 10-bromisoajmalin sakt fremgangsmaade og mellemprodukter til fremstilling af disse derivater
EP80106150A EP0029115B1 (de) 1979-10-13 1980-10-10 N(b)-quartäre Derivate von 10-Bromajmalin und 10-Bromisoajmalin, Verfahren und Zwischenprodukte zur Herstellung der Derivate und die Derivate enthaltende Arzneimittel
CA000362115A CA1147329A (en) 1979-10-13 1980-10-10 N.sub.b-quaternary derivatives of ajmaline and isoajmaline, methods and intermediate products in the manufacture of their derivatives and method of using same and pharmaceutical compositions thereof
DE8080106150T DE3069166D1 (en) 1979-10-13 1980-10-10 N(b)-quaternary 10-bromo-ajmaline and 10-bromo-isoajmaline derivatives, process and intermediates for preparing the derivatives and medicaments containing the derivatives
HU802471A HU184840B (en) 1979-10-13 1980-10-10 Process for preparing n down b-quaternary-10-bromo-ajmaline and n down b-quaternary-10-bromo-iso-ajmaline derivatives
IL61253A IL61253A (en) 1979-10-13 1980-10-10 Nb-quaternary derivatives of 10-bromoajmaline and 10-bromoisoajmaline,their preparation and pharmaceutical compositions containing them
NZ195220A NZ195220A (en) 1979-10-13 1980-10-10 Nb-quaternary derivatives of 10-bromoajmaline or 10-bromoisoajmaline
NO803041A NO156325C (no) 1979-10-13 1980-10-10 AnalogifremgangsmŸte ved fremstilling av terapeutisk aktive nb-kvartŸre derivater av ajmalin og isoajmalin.
GR63126A GR70710B (cg-RX-API-DMAC10.html) 1979-10-13 1980-10-11
PH24716A PH15938A (en) 1979-10-13 1980-10-13 Nb-quaternary derivatives of ajmaline and isoajmaline,process for their preparation and composition containing them
AU63205/80A AU538949B2 (en) 1979-10-13 1980-10-13 Derivatives of ajmaline and isoajmaline
JP14215780A JPS5681585A (en) 1979-10-13 1980-10-13 Nbbquaternary 100bromajmalinee and 100bromisoajmaline derivative* their manufacture* ringgopen aldehyde base and hearttbeat periodic trouble remedy
US06/615,757 US4554274A (en) 1979-10-13 1984-05-31 Nb Quaternary derivatives of ajmaline and isoajmaline, methods and intermediate products in the manufacture of their derivatives and method of using same and pharmaceutical compositions thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19792941529 DE2941529A1 (de) 1979-10-13 1979-10-13 N(pfeil abwaerts)b(pfeil abwaerts) -quartaere derivate von ajmalin und isoajmalin, verfahren und zwischenprodukte zur herstellung der derivate, die derivate enthaltende arzneimittel und die verwendung der derivate

Publications (1)

Publication Number Publication Date
DE2941529A1 true DE2941529A1 (de) 1981-04-23

Family

ID=6083411

Family Applications (2)

Application Number Title Priority Date Filing Date
DE19792941529 Withdrawn DE2941529A1 (de) 1979-10-13 1979-10-13 N(pfeil abwaerts)b(pfeil abwaerts) -quartaere derivate von ajmalin und isoajmalin, verfahren und zwischenprodukte zur herstellung der derivate, die derivate enthaltende arzneimittel und die verwendung der derivate
DE8080106150T Expired DE3069166D1 (en) 1979-10-13 1980-10-10 N(b)-quaternary 10-bromo-ajmaline and 10-bromo-isoajmaline derivatives, process and intermediates for preparing the derivatives and medicaments containing the derivatives

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE8080106150T Expired DE3069166D1 (en) 1979-10-13 1980-10-10 N(b)-quaternary 10-bromo-ajmaline and 10-bromo-isoajmaline derivatives, process and intermediates for preparing the derivatives and medicaments containing the derivatives

Country Status (21)

Country Link
US (1) US4554274A (cg-RX-API-DMAC10.html)
EP (1) EP0029115B1 (cg-RX-API-DMAC10.html)
JP (1) JPS5681585A (cg-RX-API-DMAC10.html)
AT (1) ATE9349T1 (cg-RX-API-DMAC10.html)
AU (1) AU538949B2 (cg-RX-API-DMAC10.html)
CA (1) CA1147329A (cg-RX-API-DMAC10.html)
DD (1) DD153552A5 (cg-RX-API-DMAC10.html)
DE (2) DE2941529A1 (cg-RX-API-DMAC10.html)
DK (1) DK430580A (cg-RX-API-DMAC10.html)
ES (1) ES495650A0 (cg-RX-API-DMAC10.html)
FI (1) FI68624C (cg-RX-API-DMAC10.html)
GR (1) GR70710B (cg-RX-API-DMAC10.html)
HU (1) HU184840B (cg-RX-API-DMAC10.html)
IE (1) IE50203B1 (cg-RX-API-DMAC10.html)
IL (1) IL61253A (cg-RX-API-DMAC10.html)
NO (1) NO156325C (cg-RX-API-DMAC10.html)
NZ (1) NZ195220A (cg-RX-API-DMAC10.html)
PH (1) PH15938A (cg-RX-API-DMAC10.html)
PT (1) PT71894B (cg-RX-API-DMAC10.html)
SU (1) SU963470A3 (cg-RX-API-DMAC10.html)
ZA (1) ZA806167B (cg-RX-API-DMAC10.html)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4558052A (en) * 1979-10-13 1985-12-10 Kali-Chemie Pharma Gmbh 10-Bromosandwicine, 10-bromoisosandwicine, pharmaceutical compositions thereof, and methods of treating heart rhythm disorders with them

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3442452A1 (de) * 1984-11-22 1986-05-22 Kali-Chemie Pharma Gmbh, 3000 Hannover Neue n(pfeil abwaerts)b(pfeil abwaerts)-quartaere dibromderivate von ajmalin, isoajmalin, sandwicin und isosandwicin sowie diese derivate enthaltende pharmazeutische zubereitungen und zwischenprodukte und verfahren zu ihrer herstellung
RU2296765C1 (ru) * 2005-10-13 2007-04-10 Государственное образовательное учреждение высшего профессионального образования САНКТ-ПЕТЕРБУРГСКАЯ ГОСУДАРСТВЕННАЯ ХИМИКО-ФАРМАЦЕВТИЧЕСКАЯ АКАДЕМИЯ (ГОУ ВПО СПХФА Росздрава) Способ получения солей n4-пропилаймалиния с карбоновыми кислотами, стабильный раствор n4-пропилаймалиния гидромалоната и способ его получения

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1196207B (de) * 1962-12-17 1965-07-08 Thomae Gmbh Dr K Verfahren zur Herstellung von neuen quartaeren Ajmaliniumsalzen

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4558052A (en) * 1979-10-13 1985-12-10 Kali-Chemie Pharma Gmbh 10-Bromosandwicine, 10-bromoisosandwicine, pharmaceutical compositions thereof, and methods of treating heart rhythm disorders with them

Also Published As

Publication number Publication date
NO803041L (no) 1981-04-14
PT71894A (en) 1980-11-01
JPS6241598B2 (cg-RX-API-DMAC10.html) 1987-09-03
AU6320580A (en) 1981-04-16
NO156325C (no) 1987-09-02
DE3069166D1 (en) 1984-10-18
FI803086A7 (fi) 1981-04-14
EP0029115A1 (de) 1981-05-27
ES8106523A1 (es) 1981-07-01
SU963470A3 (ru) 1982-09-30
US4554274A (en) 1985-11-19
DD153552A5 (de) 1982-01-13
IL61253A0 (en) 1980-12-31
EP0029115B1 (de) 1984-09-12
NZ195220A (en) 1983-12-16
IL61253A (en) 1983-10-31
ZA806167B (en) 1981-09-30
PH15938A (en) 1983-04-29
IE50203B1 (en) 1986-03-05
DK430580A (da) 1981-04-14
ATE9349T1 (de) 1984-09-15
ES495650A0 (es) 1981-07-01
HU184840B (en) 1984-10-29
CA1147329A (en) 1983-05-31
IE802077L (en) 1980-04-13
AU538949B2 (en) 1984-09-06
FI68624B (fi) 1985-06-28
JPS5681585A (en) 1981-07-03
FI68624C (fi) 1985-10-10
PT71894B (en) 1981-08-31
GR70710B (cg-RX-API-DMAC10.html) 1983-01-07
NO156325B (no) 1987-05-25

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