DE2905674A1 - Steroidverbindungen und verfahren zu ihrer herstellung - Google Patents

Steroidverbindungen und verfahren zu ihrer herstellung

Info

Publication number
DE2905674A1
DE2905674A1 DE19792905674 DE2905674A DE2905674A1 DE 2905674 A1 DE2905674 A1 DE 2905674A1 DE 19792905674 DE19792905674 DE 19792905674 DE 2905674 A DE2905674 A DE 2905674A DE 2905674 A1 DE2905674 A1 DE 2905674A1
Authority
DE
Germany
Prior art keywords
compound
formula
group
hydrolyzed
trimethylsiloxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
DE19792905674
Other languages
German (de)
English (en)
Inventor
Peter Lindsay Macdonald
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
PATPHARMA ETS
Original Assignee
PATPHARMA ETS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by PATPHARMA ETS filed Critical PATPHARMA ETS
Publication of DE2905674A1 publication Critical patent/DE2905674A1/de
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0061—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16
    • C07J5/0069—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group
    • C07J5/0076—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group by an alkyl group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/008—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21
    • C07J7/0085—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21 by an halogen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE19792905674 1978-02-16 1979-02-14 Steroidverbindungen und verfahren zu ihrer herstellung Ceased DE2905674A1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP1589478A JPS54109958A (en) 1978-02-16 1978-02-16 Steroid compound and its manufacture

Publications (1)

Publication Number Publication Date
DE2905674A1 true DE2905674A1 (de) 1979-08-30

Family

ID=11901485

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19792905674 Ceased DE2905674A1 (de) 1978-02-16 1979-02-14 Steroidverbindungen und verfahren zu ihrer herstellung

Country Status (6)

Country Link
JP (1) JPS54109958A (ja)
AT (1) AT369020B (ja)
DE (1) DE2905674A1 (ja)
GB (2) GB2018257B (ja)
NL (1) NL7901259A (ja)
PH (1) PH14881A (ja)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ225100A (en) * 1987-06-29 1991-09-25 Merck & Co Inc Reaction of steroids (including 4-azasteroids) with a silylating agent in the presence of a quinone to introduce a delta' double bond and silylated intermediates
US5084574A (en) * 1988-04-18 1992-01-28 Merck & Co., Inc. Dehydrogenation process
US5120847A (en) * 1990-08-27 1992-06-09 Merck & Co., Inc. Process for iodinating or brominating the α-methylenic carbon of a secondary amide
US5091534A (en) * 1990-08-27 1992-02-25 Merck & Co., Inc. Trialkylsilyl trifluoromethanesulfonate mediated α-methylenic carbon functionalization of 4-AZA-5α-androstan-3-one steroids

Also Published As

Publication number Publication date
PH14881A (en) 1982-01-08
GB2096614B (en) 1983-02-16
JPS54109958A (en) 1979-08-29
AT369020B (de) 1982-11-25
NL7901259A (nl) 1979-08-20
JPS569520B2 (ja) 1981-03-02
GB2018257A (en) 1979-10-17
GB2096614A (en) 1982-10-20
ATA123679A (de) 1982-04-15
GB2018257B (en) 1982-12-08

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Legal Events

Date Code Title Description
8110 Request for examination paragraph 44
8131 Rejection