DE2854659A1 - Neue 3,4-disubstituierte 2-phenylimino-imidazolidine, deren saeureadditionssalze, diese enthaltende arzneimittel und verfahren zu deren herstellung - Google Patents

Neue 3,4-disubstituierte 2-phenylimino-imidazolidine, deren saeureadditionssalze, diese enthaltende arzneimittel und verfahren zu deren herstellung

Info

Publication number
DE2854659A1
DE2854659A1 DE19782854659 DE2854659A DE2854659A1 DE 2854659 A1 DE2854659 A1 DE 2854659A1 DE 19782854659 DE19782854659 DE 19782854659 DE 2854659 A DE2854659 A DE 2854659A DE 2854659 A1 DE2854659 A1 DE 2854659A1
Authority
DE
Germany
Prior art keywords
fluoro
acid addition
addition salts
general formula
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE19782854659
Other languages
German (de)
English (en)
Inventor
Werner Dr Kimmer
Herbert Dr Koeppe
Helmut Dr Staehle
Alexander Dr Walland
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CH Boehringer Sohn AG and Co KG
Original Assignee
CH Boehringer Sohn AG and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CH Boehringer Sohn AG and Co KG filed Critical CH Boehringer Sohn AG and Co KG
Priority to DE19782854659 priority Critical patent/DE2854659A1/de
Priority to DE7979104381T priority patent/DE2964166D1/de
Priority to EP79104381A priority patent/EP0012822B1/de
Priority to AT79104381T priority patent/ATE1903T1/de
Priority to GR60628A priority patent/GR73913B/el
Priority to PT70592A priority patent/PT70592A/pt
Priority to ES486967A priority patent/ES486967A0/es
Priority to IL58971A priority patent/IL58971A/xx
Priority to NO794114A priority patent/NO148555C/no
Priority to NZ192426A priority patent/NZ192426A/en
Priority to CA342,041A priority patent/CA1112648A/en
Priority to JP16289679A priority patent/JPS5583754A/ja
Priority to IE2447/79A priority patent/IE49239B1/en
Priority to YU3089/79A priority patent/YU41901B/xx
Priority to FI793948A priority patent/FI68814C/fi
Priority to ES486971A priority patent/ES8100272A1/es
Priority to ES486970A priority patent/ES486970A0/es
Priority to AU53893/79A priority patent/AU526539B2/en
Priority to DK537179A priority patent/DK146821C/da
Priority to ZA00796832A priority patent/ZA796832B/xx
Publication of DE2854659A1 publication Critical patent/DE2854659A1/de
Priority to PH28680A priority patent/PH22130A/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/44—Nitrogen atoms not forming part of a nitro radical
    • C07D233/50—Nitrogen atoms not forming part of a nitro radical with carbocyclic radicals directly attached to said nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Photoreceptors In Electrophotography (AREA)
  • Luminescent Compositions (AREA)
DE19782854659 1978-12-18 1978-12-18 Neue 3,4-disubstituierte 2-phenylimino-imidazolidine, deren saeureadditionssalze, diese enthaltende arzneimittel und verfahren zu deren herstellung Withdrawn DE2854659A1 (de)

Priority Applications (21)

Application Number Priority Date Filing Date Title
DE19782854659 DE2854659A1 (de) 1978-12-18 1978-12-18 Neue 3,4-disubstituierte 2-phenylimino-imidazolidine, deren saeureadditionssalze, diese enthaltende arzneimittel und verfahren zu deren herstellung
DE7979104381T DE2964166D1 (en) 1978-12-18 1979-11-08 3,4-disubstituted 2-phenylimino-imidazolidines, their acid addition salts, pharmaceutical preparations containing them and process for their production
EP79104381A EP0012822B1 (de) 1978-12-18 1979-11-08 Neue 3,4-disubstituierte 2-Phenylimino-imidazolidine, deren Säureadditionssalze, diese enthaltende Arzneimittel und Verfahren zu deren Herstellung
AT79104381T ATE1903T1 (de) 1978-12-18 1979-11-08 Neue 3,4-disubstituierte 2-phenyliminoimidazolidine, deren saeureadditionssalze, diese enthaltende arzneimittel und verfahren zu deren herstellung.
GR60628A GR73913B (OSRAM) 1978-12-18 1979-11-28
PT70592A PT70592A (de) 1978-12-18 1979-12-13 Neue 3,4-disubstituierte 2-phenylimino-imidazolidine derensaureadditionssalze diese enthaltende arzneimittel und verfahren zu deren herstellung
JP16289679A JPS5583754A (en) 1978-12-18 1979-12-17 Imidazolidine derivative
ES486971A ES8100272A1 (es) 1978-12-18 1979-12-17 Procedimiento para la preparacion de una nueva 2-(4-fluoro-3-amino fenilimino)-imidazolidina
NO794114A NO148555C (no) 1978-12-18 1979-12-17 Analogifremgangsmaate for fremstilling av farmakologisk aktive 2-fenylimino-imidazolidiner
NZ192426A NZ192426A (en) 1978-12-18 1979-12-17 2-(3,4-disubstituted-phenylimino)-imidazolidine compounds;pharmaceutical compositions
CA342,041A CA1112648A (en) 1978-12-18 1979-12-17 2-[3,4-disubstituted-phenylimino]-imidazolidines
ES486967A ES486967A0 (es) 1978-12-18 1979-12-17 Procedimiento para la preparacion de nuevas 2-fenilimino- imidazolidinas disustituidas en 3,4
IE2447/79A IE49239B1 (en) 1978-12-18 1979-12-17 Novel 2-(3,4-disubstituted-phenylimino)-imidazolidines
YU3089/79A YU41901B (en) 1978-12-18 1979-12-17 Process for preparing new 3,4-disubstituted-2-phenylimino-imidazolidines and acid addition salts thereof
FI793948A FI68814C (fi) 1978-12-18 1979-12-17 Foerfarande foer framstaellning av farmakologiskt vaerdefulla 3,4-disubstituerade 2-fenylimino-imidazolidiner
IL58971A IL58971A (en) 1978-12-18 1979-12-17 2-((3,4-disubstituted-phenyl)imino)-imidazolidine derivatives,their preparation and pharmaceutical compositions containing them
ES486970A ES486970A0 (es) 1978-12-18 1979-12-17 Procedimiento para la preparacion de nuevas 2-fenilimino-i- midazolidinas disustituidas en 3,4
AU53893/79A AU526539B2 (en) 1978-12-18 1979-12-17 2-(3,4-disubstituted-phenylimino)-imidazolidines
DK537179A DK146821C (da) 1978-12-18 1979-12-17 Analogifremgangsmaade til fremstilling af 3,4-disubstituerede 2-phenylimino-imidazolidiner eller syreadditionssalte deraf
ZA00796832A ZA796832B (en) 1978-12-18 1979-12-18 2-(3,4-disubstituted-phenylimino)-imidazolidines
PH28680A PH22130A (en) 1978-12-18 1983-03-22 2(3,4-disubstituted-phenylimino)-imidazolidines and salts thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19782854659 DE2854659A1 (de) 1978-12-18 1978-12-18 Neue 3,4-disubstituierte 2-phenylimino-imidazolidine, deren saeureadditionssalze, diese enthaltende arzneimittel und verfahren zu deren herstellung

Publications (1)

Publication Number Publication Date
DE2854659A1 true DE2854659A1 (de) 1980-07-10

Family

ID=6057553

Family Applications (2)

Application Number Title Priority Date Filing Date
DE19782854659 Withdrawn DE2854659A1 (de) 1978-12-18 1978-12-18 Neue 3,4-disubstituierte 2-phenylimino-imidazolidine, deren saeureadditionssalze, diese enthaltende arzneimittel und verfahren zu deren herstellung
DE7979104381T Expired DE2964166D1 (en) 1978-12-18 1979-11-08 3,4-disubstituted 2-phenylimino-imidazolidines, their acid addition salts, pharmaceutical preparations containing them and process for their production

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE7979104381T Expired DE2964166D1 (en) 1978-12-18 1979-11-08 3,4-disubstituted 2-phenylimino-imidazolidines, their acid addition salts, pharmaceutical preparations containing them and process for their production

Country Status (18)

Country Link
EP (1) EP0012822B1 (OSRAM)
JP (1) JPS5583754A (OSRAM)
AT (1) ATE1903T1 (OSRAM)
AU (1) AU526539B2 (OSRAM)
CA (1) CA1112648A (OSRAM)
DE (2) DE2854659A1 (OSRAM)
DK (1) DK146821C (OSRAM)
ES (3) ES486970A0 (OSRAM)
FI (1) FI68814C (OSRAM)
GR (1) GR73913B (OSRAM)
IE (1) IE49239B1 (OSRAM)
IL (1) IL58971A (OSRAM)
NO (1) NO148555C (OSRAM)
NZ (1) NZ192426A (OSRAM)
PH (1) PH22130A (OSRAM)
PT (1) PT70592A (OSRAM)
YU (1) YU41901B (OSRAM)
ZA (1) ZA796832B (OSRAM)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19514579A1 (de) * 1995-04-20 1996-10-24 Boehringer Ingelheim Kg Verwendung von alpha¶1¶¶L¶-Agonisten zur Behandlung der Harninkontinenz
EP0775134A4 (en) * 1994-08-04 1997-08-13 Synaptic Pharma Corp NEW BENZIMIDAZOLE DERIVATIVES

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2933930A1 (de) * 1979-08-22 1981-03-12 C.H. Boehringer Sohn, 6507 Ingelheim 2-(2-chlor-4-cyclopropyl-phenylimino)-imidazolidin, dessen saeureadditionssalze, diese enthaltende arzneimittel und verfahren zur herstellung derselben.
HU192986B (en) * 1984-05-23 1987-08-28 Egyt Gyogyszervegyeszeti Gyar Process for production of imidasodiline derivatives
AU732056B2 (en) * 1996-11-25 2001-04-12 Board Of Regents Of The University Of Nebraska, The Process for making 2-amino-2-imidazoline, guanidine, and 2-amino-3,4,5,6-tetrahydropyrimidine derivatives
US6495583B1 (en) 1997-03-25 2002-12-17 Synaptic Pharmaceutical Corporation Benzimidazole derivatives
US6066740A (en) * 1997-11-25 2000-05-23 The Procter & Gamble Company Process for making 2-amino-2-imidazoline, guanidine and 2-amino-3,4,5,6-tetrahydropyrimidine derivatives
CN111303038A (zh) * 2020-03-18 2020-06-19 滨州德润化工有限责任公司 一种油田水处理用缓蚀剂两性咪唑啉制作工艺

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL123037C (OSRAM) * 1963-10-04
DE1545628A1 (de) * 1965-10-01 1970-06-25 Boehringer Sohn Ingelheim Verfahren zur Herstellung von blutdrucksenkend und sedativ wirksamen Derivaten des 2-(2-Halogenanilino)-1,3-diazacyclopentens-(2)
BE687656A (OSRAM) * 1965-10-01 1967-03-30
AT278775B (de) * 1967-01-19 1970-02-10 Chinoin Gyogyszer Es Vegyeszet Verfahren zur Herstellung von Δ<2>-Imidazolinderivaten und ihren Salzen
AT330769B (de) * 1974-04-05 1976-07-26 Chemie Linz Ag Verfahren zur herstellung von 2-arylamino- 2-imidazolin-derivaten und ihren salzen
DE2806775A1 (de) * 1978-02-17 1979-08-30 Boehringer Sohn Ingelheim Neue substituierte 2-phenylimino- imidazolidine deren saeureadditionssalze, diese enthaltende arzneimittel und verfahren zur herstellung derselben

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0775134A4 (en) * 1994-08-04 1997-08-13 Synaptic Pharma Corp NEW BENZIMIDAZOLE DERIVATIVES
DE19514579A1 (de) * 1995-04-20 1996-10-24 Boehringer Ingelheim Kg Verwendung von alpha¶1¶¶L¶-Agonisten zur Behandlung der Harninkontinenz
WO1996032939A1 (de) * 1995-04-20 1996-10-24 Boehringer Ingelheim Kg VERWENDUNG VON α1L-AGONISTEN ZUR BEHANDLUNG DER HARNINKONTINENZ
US6268389B1 (en) 1995-04-20 2001-07-31 Boehringer Ingelheim Kg Treatment of urinary incontinence by administration of α1L-adrenoceptor agonists
EP1285653A1 (de) * 1995-04-20 2003-02-26 Boehringer Ingelheim Pharma KG Verwendung von alpha/1L-Agonisten zur Behandlung der Harninkontinenz
US7019021B2 (en) 1995-04-20 2006-03-28 Boehringer Ingelheim Pharma Gmbh & Co. Kg Compounds and methods for treating urinary incontinence

Also Published As

Publication number Publication date
ES8103054A1 (es) 1981-02-16
FI793948A7 (fi) 1980-06-19
AU526539B2 (en) 1983-01-20
NO794114L (no) 1980-06-19
DK146821B (da) 1984-01-16
YU41901B (en) 1988-02-29
ES486971A0 (es) 1980-11-01
ES8102100A1 (es) 1980-12-16
EP0012822B1 (de) 1982-12-01
JPH0118071B2 (OSRAM) 1989-04-03
NZ192426A (en) 1984-07-06
JPS5583754A (en) 1980-06-24
ATE1903T1 (de) 1982-12-15
IE49239B1 (en) 1985-09-04
DE2964166D1 (en) 1983-01-05
ZA796832B (en) 1981-08-26
ES486967A0 (es) 1981-02-16
EP0012822A1 (de) 1980-07-09
ES8100272A1 (es) 1980-11-01
DK146821C (da) 1984-06-25
CA1112648A (en) 1981-11-17
ES486970A0 (es) 1980-12-16
GR73913B (OSRAM) 1984-05-22
NO148555C (no) 1983-11-23
PT70592A (de) 1980-01-01
FI68814C (fi) 1985-11-11
IE792447L (en) 1980-06-18
AU5389379A (en) 1980-06-26
FI68814B (fi) 1985-07-31
NO148555B (no) 1983-07-25
PH22130A (en) 1988-06-01
YU308979A (en) 1983-04-30
IL58971A0 (en) 1980-03-31
IL58971A (en) 1984-03-30
DK537179A (da) 1980-06-19

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Legal Events

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8139 Disposal/non-payment of the annual fee