JPS5583754A - Imidazolidine derivative - Google Patents

Imidazolidine derivative

Info

Publication number
JPS5583754A
JPS5583754A JP16289679A JP16289679A JPS5583754A JP S5583754 A JPS5583754 A JP S5583754A JP 16289679 A JP16289679 A JP 16289679A JP 16289679 A JP16289679 A JP 16289679A JP S5583754 A JPS5583754 A JP S5583754A
Authority
JP
Japan
Prior art keywords
fluoro
group
methylphenyl
see diagramm
general formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP16289679A
Other languages
Japanese (ja)
Other versions
JPH0118071B2 (en
Inventor
Sutaare Herumutsuto
Kotsupe Heruberuto
Kumaa Berunaa
Barando Arekusandaa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CH Boehringer Sohn AG and Co KG
Original Assignee
CH Boehringer Sohn AG and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CH Boehringer Sohn AG and Co KG filed Critical CH Boehringer Sohn AG and Co KG
Publication of JPS5583754A publication Critical patent/JPS5583754A/en
Publication of JPH0118071B2 publication Critical patent/JPH0118071B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/44—Nitrogen atoms not forming part of a nitro radical
    • C07D233/50—Nitrogen atoms not forming part of a nitro radical with carbocyclic radicals directly attached to said nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Luminescent Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Photoreceptors In Electrophotography (AREA)

Abstract

1. Claims for the contracting states : BE, CH, DE, FR, GB, IT, LU, NL, SE 3,4-Disubstituted 2-phenylimino-imidazolidines of general formula (I) see diagramm : EP0012822,P5,F1 wherein Z represents a radical selected from the group comprising 3-fluoro-4-methylphenyl, 4-fluoro-3-methylphenyl, 4-fluoro-3-nitrophenyl, 4-fluoro-3-chlorophenyl and 4-fluoro-3-aminophenyl, and the acid addition salts thereof. 1. Claims for the contracting state : AT Process for the preparation of 3,4-disubstituted 2-phenylimino-imidazolidines of general formula (I) see diagramm : EP0012822,P6,F1 wherein Z represents a radical selected from the group comprising 3-fluoro-4-methylphenyl, 4-fluoro-3-methylphenyl, 4-fluoro-3-nitrophenyl, 4-fluoro-3-chlorophenyl and 4-fluoro-3-aminophenyl, and the acid additions salts thereof, characterised in that a) a compound of the formula (II) see diagramm : EP0012822,P6,F3 wherein Z is as hereinbefore defined and X and Y, which may be the same or different, represent a chlorine atom, an alkylthio group with 1 to 4 carbon atoms or an amino or ammonium group, is reacted with ethylenediamine or an acid addition salt thereof ; or b) the aliphatic acyl group is hydrolytically split off from a 1-acyl-2-phenylamino-imidazoline of general formula (III) see diagramm : EP0012822,P6,F5 wherein Z is as hereinbefore defined and R represents an aliphatic acyl group ; or c) in order to prepare 2-(4-fluoro-3-aminophenylimino)-imidazolidine, 2-(4-fluoro-3-nitrophenylimino)-imidazoline is hydrogenated and, if desired, the compound thus obtained is converted into a physiologically acceptable acid addition salt.
JP16289679A 1978-12-18 1979-12-17 Imidazolidine derivative Granted JPS5583754A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19782854659 DE2854659A1 (en) 1978-12-18 1978-12-18 NEW 3,4-DISUBSTITUTED 2-PHENYLIMINO IMIDAZOLIDINES, THEIR ACID ADDITION SALTS, THE MEDICINAL PRODUCTS CONTAINING THEM AND METHOD FOR THE PRODUCTION THEREOF

Publications (2)

Publication Number Publication Date
JPS5583754A true JPS5583754A (en) 1980-06-24
JPH0118071B2 JPH0118071B2 (en) 1989-04-03

Family

ID=6057553

Family Applications (1)

Application Number Title Priority Date Filing Date
JP16289679A Granted JPS5583754A (en) 1978-12-18 1979-12-17 Imidazolidine derivative

Country Status (18)

Country Link
EP (1) EP0012822B1 (en)
JP (1) JPS5583754A (en)
AT (1) ATE1903T1 (en)
AU (1) AU526539B2 (en)
CA (1) CA1112648A (en)
DE (2) DE2854659A1 (en)
DK (1) DK146821C (en)
ES (3) ES486970A0 (en)
FI (1) FI68814C (en)
GR (1) GR73913B (en)
IE (1) IE49239B1 (en)
IL (1) IL58971A (en)
NO (1) NO148555C (en)
NZ (1) NZ192426A (en)
PH (1) PH22130A (en)
PT (1) PT70592A (en)
YU (1) YU41901B (en)
ZA (1) ZA796832B (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60255773A (en) * 1984-05-23 1985-12-17 エジス　ジヨジセルジヤール Preparation of imidazolidine derivative
CN111303038A (en) * 2020-03-18 2020-06-19 滨州德润化工有限责任公司 Preparation process of amphoteric imidazoline corrosion inhibitor for oil field water treatment

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2933930A1 (en) * 1979-08-22 1981-03-12 C.H. Boehringer Sohn, 6507 Ingelheim 2- (2-CHLORINE-4-CYCLOPROPYL-PHENYLIMINO) -IMIDAZOLIDINE, ITS ACID ADDITIONAL SALTS, THE MEDICINAL PRODUCTS CONTAINING IT AND METHOD FOR THE PRODUCTION THEREOF.
EP0775134A4 (en) 1994-08-04 1997-08-13 Synaptic Pharma Corp Novel benzimidazole derivatives
DE19514579A1 (en) 1995-04-20 1996-10-24 Boehringer Ingelheim Kg Use of alpha-1-olone agonists for the treatment of urinary incontinence
ZA9710581B (en) * 1996-11-25 1998-06-12 Procter & Gamble Process for making 2-amino-2-imidazoline, guanidine and 2-amino-3,4,5,6-tetrahydropyrimidine derivates.
US6495583B1 (en) 1997-03-25 2002-12-17 Synaptic Pharmaceutical Corporation Benzimidazole derivatives
US6066740A (en) * 1997-11-25 2000-05-23 The Procter & Gamble Company Process for making 2-amino-2-imidazoline, guanidine and 2-amino-3,4,5,6-tetrahydropyrimidine derivatives

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS50137978A (en) * 1974-04-05 1975-11-01

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL123037C (en) * 1963-10-04
SE331280B (en) * 1965-10-01 1970-12-21 Boehringer Sohn Ingelheim
DE1545628A1 (en) * 1965-10-01 1970-06-25 Boehringer Sohn Ingelheim Process for the preparation of antihypertensive and sedative derivatives of 2- (2-haloanilino) -1,3-diazacyclopentene- (2)
AT278775B (en) * 1967-01-19 1970-02-10 Chinoin Gyogyszer Es Vegyeszet Process for the preparation of Δ <2> -imidazoline derivatives and their salts
DE2806775A1 (en) * 1978-02-17 1979-08-30 Boehringer Sohn Ingelheim NEW SUBSTITUTED 2-PHENYLIMINO IMIDAZOLIDINE THEIR ACID ADDITION SALTS, MEDICINAL PRODUCTS CONTAINING THEM AND METHOD FOR THE PRODUCTION THEREOF

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS50137978A (en) * 1974-04-05 1975-11-01

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60255773A (en) * 1984-05-23 1985-12-17 エジス　ジヨジセルジヤール Preparation of imidazolidine derivative
CN111303038A (en) * 2020-03-18 2020-06-19 滨州德润化工有限责任公司 Preparation process of amphoteric imidazoline corrosion inhibitor for oil field water treatment

Also Published As

Publication number Publication date
ES486967A0 (en) 1981-02-16
NO148555C (en) 1983-11-23
IE792447L (en) 1980-06-18
YU308979A (en) 1983-04-30
IL58971A (en) 1984-03-30
FI68814C (en) 1985-11-11
PH22130A (en) 1988-06-01
AU526539B2 (en) 1983-01-20
YU41901B (en) 1988-02-29
FI793948A (en) 1980-06-19
ES8100272A1 (en) 1980-11-01
NZ192426A (en) 1984-07-06
EP0012822B1 (en) 1982-12-01
NO148555B (en) 1983-07-25
DK146821B (en) 1984-01-16
GR73913B (en) 1984-05-22
ATE1903T1 (en) 1982-12-15
ZA796832B (en) 1981-08-26
EP0012822A1 (en) 1980-07-09
AU5389379A (en) 1980-06-26
ES486971A0 (en) 1980-11-01
DK146821C (en) 1984-06-25
ES8102100A1 (en) 1980-12-16
DK537179A (en) 1980-06-19
CA1112648A (en) 1981-11-17
DE2964166D1 (en) 1983-01-05
NO794114L (en) 1980-06-19
IE49239B1 (en) 1985-09-04
DE2854659A1 (en) 1980-07-10
ES486970A0 (en) 1980-12-16
ES8103054A1 (en) 1981-02-16
JPH0118071B2 (en) 1989-04-03
IL58971A0 (en) 1980-03-31
FI68814B (en) 1985-07-31
PT70592A (en) 1980-01-01

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