DE2810261A1 - Thiopropanoylaminocarbonsaeure-verbindungen - Google Patents

Thiopropanoylaminocarbonsaeure-verbindungen

Info

Publication number
DE2810261A1
DE2810261A1 DE19782810261 DE2810261A DE2810261A1 DE 2810261 A1 DE2810261 A1 DE 2810261A1 DE 19782810261 DE19782810261 DE 19782810261 DE 2810261 A DE2810261 A DE 2810261A DE 2810261 A1 DE2810261 A1 DE 2810261A1
Authority
DE
Germany
Prior art keywords
general formula
compounds according
hydrogen atoms
compounds
atom
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
DE19782810261
Other languages
German (de)
English (en)
Other versions
DE2810261C2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html
Inventor
Miguel Angel Ondetti
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ER Squibb and Sons LLC
Original Assignee
ER Squibb and Sons LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ER Squibb and Sons LLC filed Critical ER Squibb and Sons LLC
Publication of DE2810261A1 publication Critical patent/DE2810261A1/de
Application granted granted Critical
Publication of DE2810261C2 publication Critical patent/DE2810261C2/de
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
DE19782810261 1977-03-11 1978-03-09 Thiopropanoylaminocarbonsaeure-verbindungen Granted DE2810261A1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/776,792 US4108886A (en) 1977-03-11 1977-03-11 Thiopropanoylamino acid derivatives

Publications (2)

Publication Number Publication Date
DE2810261A1 true DE2810261A1 (de) 1978-09-14
DE2810261C2 DE2810261C2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1988-04-28

Family

ID=25108379

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19782810261 Granted DE2810261A1 (de) 1977-03-11 1978-03-09 Thiopropanoylaminocarbonsaeure-verbindungen

Country Status (7)

Country Link
US (1) US4108886A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (1) JPS53112810A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
BE (1) BE867269A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CA (1) CA1090355A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (1) DE2810261A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
FR (1) FR2383171A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
GB (1) GB1593712A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0015544A3 (en) * 1979-03-06 1981-01-07 Zambon S.P.A. Derivatives of the mercaptopropionamido-acetic acid, process for the preparation thereof and compositions
US4512979A (en) * 1981-03-23 1985-04-23 Merck & Co., Inc. Dipeptides containing thialysine and related amino acids as antihypertensives
US4634716A (en) * 1982-09-30 1987-01-06 Merck & Co., Inc. Substituted N-carboxymethyl-aminoacylaminoalkanoic acids useful as antihypertensive agents

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT7851510A0 (it) * 1977-10-28 1978-10-16 Sandoz Ag Ammidi di amminoacidi ciclici loro preparazione e loro applicazione quali medicamenti
US4241076A (en) * 1978-02-21 1980-12-23 E. R. Squibb & Sons, Inc. Halogenated substituted mercaptoacylamino acids
IT1098328B (it) * 1978-06-16 1985-09-07 Gargani Pietro Sale sodico della mercapropropionilglicina,processo per la sua preparazione e suoi impieghi terapeutici
CA1144930A (en) * 1978-08-11 1983-04-19 Miguel A. Ondetti Mercaptoacyl derivatives of substituted prolines
JPS5531022A (en) * 1978-08-24 1980-03-05 Yoshitomi Pharmaceut Ind Ltd Hydroxamic acid derivative and its preparation
GR73585B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * 1978-09-11 1984-03-26 Univ Miami
ZA794723B (en) * 1978-09-11 1980-08-27 Univ Miami Anti-hypertensive agents
US4698356A (en) * 1979-08-14 1987-10-06 University Of Miami Anti-hypertensive agents
US4690937A (en) * 1979-08-14 1987-09-01 University Of Miami Anti-hypertensive agents
US4695577A (en) * 1979-08-14 1987-09-22 University Of Miami Anti-hypertensive agents
US4690939A (en) * 1979-08-14 1987-09-01 University Of Miami Anti-hypertensive agents
US4690940A (en) * 1979-08-14 1987-09-01 University Of Miami Anti-hypertensive agents
US4698355A (en) * 1979-08-14 1987-10-06 University Of Miami Anti-hypertensive agents
US4690938A (en) * 1979-08-14 1987-09-01 University Of Miami Anti-hypertensive agents
JPS5829950B2 (ja) * 1978-10-05 1983-06-25 ウェルファイド株式会社 環状イミノカルボン酸誘導体およびその塩類
US4198515A (en) * 1978-12-08 1980-04-15 E. R. Squibb & Sons, Inc. Mercaptoacyl derivatives of 4,5-dihydro-1H-pyrrole-2-carboxylic acids and 1,4,5,6-tetrahydropyridine-2-carboxylic acids
IT1111384B (it) * 1978-12-21 1986-01-13 Sigma Tau Ind Farmaceuti Guaiacil esteri di derivati dello acido mercaptopropionico procedimento per la loro preparazione e loro uso terapeutico
JPS55164673A (en) * 1979-06-08 1980-12-22 Yoshitomi Pharmaceut Ind Ltd Zinc compound and its preparation
US4256761A (en) * 1979-07-13 1981-03-17 Usv Pharmaceutical Corporation Antihypertensive amides
US4291040A (en) * 1979-10-22 1981-09-22 E. R. Squibb & Sons, Inc. Mercaptoacyl derivatives of 4-disubstituted prolines and 4-substituted dehydroprolines
GB2065643B (en) * 1979-12-13 1983-08-24 Kanegafuchi Chemical Ind Optically active n-mercaptoalkanoylamino acids
US4734420A (en) * 1980-03-05 1988-03-29 University Of Miami Anti-hypertensive agents
US4690936A (en) * 1980-03-05 1987-09-01 University Of Miami Anti-hypertensive agents
AU542211B2 (en) * 1980-03-07 1985-02-14 Gruppo Lepetit S.P.A. Mercaptocycloalkyl carbonyl prolines
FR2480747A1 (fr) * 1980-04-17 1981-10-23 Roques Bernard Derives d'acides amines et leur application therapeutique
ZA811340B (en) * 1980-06-09 1982-03-31 Morton Norwich Products Inc N-(cycloalkyl)amino acid compounds
US4316905A (en) * 1980-07-01 1982-02-23 E. R. Squibb & Sons, Inc. Mercaptoacyl derivatives of various 4-substituted prolines
IE52884B1 (en) * 1981-05-11 1988-03-30 Sigma Tau Ind Farmaceuti 2-methoxyphenyl esters of n-substituted amino acids, their preparation and pharmaceutical use
IT1140394B (it) * 1981-12-23 1986-09-24 Maggioni Farma Dipeptidi contenenti un residuo di metionina ad attivita' epatoprotettrice
US5760241A (en) * 1995-12-28 1998-06-02 Zambon Group S.P.A. Thiol derivatives with metallopeptidase inhibitory activity
JP4525885B2 (ja) * 2001-01-12 2010-08-18 三菱瓦斯化学株式会社 フォトレジスト用現像液及びフォトレジストの現像方法
CN103130692B (zh) * 2011-12-02 2016-09-14 天津市国际生物医药联合研究院 3-巯基丙酰胺类化合物在抑制ndm-1活性中的应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2124451A1 (de) * 1970-07-28 1972-02-24 E.R. Squibb & Sons Inc., New York, N.Y. (V.St.A.) Peptide und Arzneipräparate

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3098078A (en) * 1958-02-19 1963-07-16 Ciba Geigy Corp Thio alkane carboxylic acids and functional derivatives thereof
FR1491204A (fr) * 1962-08-10 1967-08-11 Santen Pharmaceutical Co Ltd Procédés pour la préparation des alpha-et beta mercaptopropionylglycocolle et de leurs dérivés
CA1009252A (en) * 1972-10-03 1977-04-26 Santen Pharmaceutical Co. N-(mercaptoacyl) aminoacids
JPS6058230A (ja) * 1983-09-09 1985-04-04 Babcock Hitachi Kk 排煙脱硫方法および装置

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2124451A1 (de) * 1970-07-28 1972-02-24 E.R. Squibb & Sons Inc., New York, N.Y. (V.St.A.) Peptide und Arzneipräparate

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0015544A3 (en) * 1979-03-06 1981-01-07 Zambon S.P.A. Derivatives of the mercaptopropionamido-acetic acid, process for the preparation thereof and compositions
US4512979A (en) * 1981-03-23 1985-04-23 Merck & Co., Inc. Dipeptides containing thialysine and related amino acids as antihypertensives
US4634716A (en) * 1982-09-30 1987-01-06 Merck & Co., Inc. Substituted N-carboxymethyl-aminoacylaminoalkanoic acids useful as antihypertensive agents

Also Published As

Publication number Publication date
US4108886A (en) 1978-08-22
JPS53112810A (en) 1978-10-02
GB1593712A (en) 1981-07-22
FR2383171A1 (fr) 1978-10-06
JPS6216944B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1987-04-15
CA1090355A (en) 1980-11-25
DE2810261C2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1988-04-28
FR2383171B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1980-04-11
BE867269A (fr) 1978-11-20

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Legal Events

Date Code Title Description
8110 Request for examination paragraph 44
D2 Grant after examination
8364 No opposition during term of opposition
8328 Change in the person/name/address of the agent

Free format text: VOSSIUS, V., DIPL.-CHEM. DR.RER.NAT. TAUCHNER, P., DIPL.-CHEM. DR.RER.NAT. HEUNEMANN, D., DIPL.-PHYS. DR.RER.NAT., PAT.-ANWAELTE, 8000 MUENCHEN

8328 Change in the person/name/address of the agent

Free format text: TAUCHNER, P., DIPL.-CHEM. DR.RER.NAT. HEUNEMANN, D., DIPL.-PHYS. DR.RER.NAT., PAT.-ANWAELTE, 8000 MUENCHEN

8339 Ceased/non-payment of the annual fee