DE2801123C2 - Verfahren zur Herstellung eines intravenös applizierbaren Serumeiweiß-Präparates - Google Patents
Verfahren zur Herstellung eines intravenös applizierbaren Serumeiweiß-PräparatesInfo
- Publication number
- DE2801123C2 DE2801123C2 DE2801123A DE2801123A DE2801123C2 DE 2801123 C2 DE2801123 C2 DE 2801123C2 DE 2801123 A DE2801123 A DE 2801123A DE 2801123 A DE2801123 A DE 2801123A DE 2801123 C2 DE2801123 C2 DE 2801123C2
- Authority
- DE
- Germany
- Prior art keywords
- fraction
- serum
- protein
- preparation
- weight
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title claims description 28
- 238000002360 preparation method Methods 0.000 title claims description 21
- 238000004519 manufacturing process Methods 0.000 title claims description 9
- 102000004506 Blood Proteins Human genes 0.000 title description 14
- 108010017384 Blood Proteins Proteins 0.000 title description 14
- 210000002381 plasma Anatomy 0.000 claims description 14
- 239000002244 precipitate Substances 0.000 claims description 13
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 10
- 239000000203 mixture Substances 0.000 claims description 10
- 239000012141 concentrate Substances 0.000 claims description 7
- 239000003463 adsorbent Substances 0.000 claims description 5
- 239000011780 sodium chloride Substances 0.000 claims description 5
- 239000007853 buffer solution Substances 0.000 claims description 4
- 239000013049 sediment Substances 0.000 claims description 4
- 108010039209 Blood Coagulation Factors Proteins 0.000 claims description 3
- 102000015081 Blood Coagulation Factors Human genes 0.000 claims description 3
- 108090001030 Lipoproteins Proteins 0.000 claims description 3
- 102000004895 Lipoproteins Human genes 0.000 claims description 3
- 239000003114 blood coagulation factor Substances 0.000 claims description 3
- 239000002699 waste material Substances 0.000 claims description 2
- 235000018102 proteins Nutrition 0.000 description 20
- 102000004169 proteins and genes Human genes 0.000 description 20
- 108090000623 proteins and genes Proteins 0.000 description 20
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 16
- 239000006228 supernatant Substances 0.000 description 14
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 13
- 210000002966 serum Anatomy 0.000 description 13
- 239000000243 solution Substances 0.000 description 13
- 210000004369 blood Anatomy 0.000 description 9
- 239000008280 blood Substances 0.000 description 9
- 239000007788 liquid Substances 0.000 description 9
- 239000000126 substance Substances 0.000 description 9
- 108010088751 Albumins Proteins 0.000 description 8
- 102000009027 Albumins Human genes 0.000 description 8
- 102000006395 Globulins Human genes 0.000 description 7
- 108010044091 Globulins Proteins 0.000 description 7
- 239000007787 solid Substances 0.000 description 6
- 108060003951 Immunoglobulin Proteins 0.000 description 5
- 239000008119 colloidal silica Substances 0.000 description 5
- 239000000306 component Substances 0.000 description 5
- 102000018358 immunoglobulin Human genes 0.000 description 5
- 239000002904 solvent Substances 0.000 description 5
- 239000007858 starting material Substances 0.000 description 5
- 241001233037 catfish Species 0.000 description 4
- 238000005119 centrifugation Methods 0.000 description 4
- 229920001223 polyethylene glycol Polymers 0.000 description 4
- 238000001179 sorption measurement Methods 0.000 description 4
- 241000894006 Bacteria Species 0.000 description 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 3
- 108010075016 Ceruloplasmin Proteins 0.000 description 3
- 102100023321 Ceruloplasmin Human genes 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 241000700605 Viruses Species 0.000 description 3
- 239000012530 fluid Substances 0.000 description 3
- 229940072221 immunoglobulins Drugs 0.000 description 3
- 239000012528 membrane Substances 0.000 description 3
- 229910002012 Aerosil® Inorganic materials 0.000 description 2
- 108010054218 Factor VIII Proteins 0.000 description 2
- 102000001690 Factor VIII Human genes 0.000 description 2
- 108010049003 Fibrinogen Proteins 0.000 description 2
- 102000008946 Fibrinogen Human genes 0.000 description 2
- 102000035195 Peptidases Human genes 0.000 description 2
- 108091005804 Peptidases Proteins 0.000 description 2
- 229920001030 Polyethylene Glycol 4000 Polymers 0.000 description 2
- 102000004338 Transferrin Human genes 0.000 description 2
- 108090000901 Transferrin Proteins 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- 238000000502 dialysis Methods 0.000 description 2
- 239000003792 electrolyte Substances 0.000 description 2
- 229960000301 factor viii Drugs 0.000 description 2
- 229940012952 fibrinogen Drugs 0.000 description 2
- 239000000706 filtrate Substances 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 238000005194 fractionation Methods 0.000 description 2
- 239000003112 inhibitor Substances 0.000 description 2
- 150000002632 lipids Chemical class 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 229940024999 proteolytic enzymes for treatment of wounds and ulcers Drugs 0.000 description 2
- 239000000377 silicon dioxide Substances 0.000 description 2
- 230000001954 sterilising effect Effects 0.000 description 2
- 238000004659 sterilization and disinfection Methods 0.000 description 2
- 239000012581 transferrin Substances 0.000 description 2
- 101710150350 Albumin-2 Proteins 0.000 description 1
- 101710081722 Antitrypsin Proteins 0.000 description 1
- 102000014914 Carrier Proteins Human genes 0.000 description 1
- 108010078791 Carrier Proteins Proteins 0.000 description 1
- 102000003914 Cholinesterases Human genes 0.000 description 1
- 108090000322 Cholinesterases Proteins 0.000 description 1
- 108010032608 Cohn fraction IV Proteins 0.000 description 1
- 238000000665 Cohn process Methods 0.000 description 1
- 102000014702 Haptoglobin Human genes 0.000 description 1
- 108050005077 Haptoglobin Proteins 0.000 description 1
- 108010054147 Hemoglobins Proteins 0.000 description 1
- 102000001554 Hemoglobins Human genes 0.000 description 1
- 102000013271 Hemopexin Human genes 0.000 description 1
- 108010026027 Hemopexin Proteins 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 239000005909 Kieselgur Substances 0.000 description 1
- 102000007584 Prealbumin Human genes 0.000 description 1
- 108010071690 Prealbumin Proteins 0.000 description 1
- 108010094028 Prothrombin Proteins 0.000 description 1
- 102100027378 Prothrombin Human genes 0.000 description 1
- 241001080024 Telles Species 0.000 description 1
- 208000036141 Viral hepatitis carrier Diseases 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- 230000001475 anti-trypsic effect Effects 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 210000000601 blood cell Anatomy 0.000 description 1
- 239000012503 blood component Substances 0.000 description 1
- 239000003914 blood derivative Substances 0.000 description 1
- 238000010261 blood fractionation Methods 0.000 description 1
- 239000001506 calcium phosphate Substances 0.000 description 1
- 229910000389 calcium phosphate Inorganic materials 0.000 description 1
- 235000011010 calcium phosphates Nutrition 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 229940048961 cholinesterase Drugs 0.000 description 1
- 238000003776 cleavage reaction Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 108010074605 gamma-Globulins Proteins 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- BTIJJDXEELBZFS-QDUVMHSLSA-K hemin Chemical compound CC1=C(CCC(O)=O)C(C=C2C(CCC(O)=O)=C(C)\C(N2[Fe](Cl)N23)=C\4)=N\C1=C/C2=C(C)C(C=C)=C3\C=C/1C(C)=C(C=C)C/4=N\1 BTIJJDXEELBZFS-QDUVMHSLSA-K 0.000 description 1
- 229940025294 hemin Drugs 0.000 description 1
- 208000006454 hepatitis Diseases 0.000 description 1
- 231100000283 hepatitis Toxicity 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 238000002649 immunization Methods 0.000 description 1
- 230000003053 immunization Effects 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 238000002642 intravenous therapy Methods 0.000 description 1
- 238000005342 ion exchange Methods 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 102000013415 peroxidase activity proteins Human genes 0.000 description 1
- 108040007629 peroxidase activity proteins Proteins 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 230000004962 physiological condition Effects 0.000 description 1
- 229940057838 polyethylene glycol 4000 Drugs 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 235000004252 protein component Nutrition 0.000 description 1
- 239000012460 protein solution Substances 0.000 description 1
- 229940039716 prothrombin Drugs 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- 239000012266 salt solution Substances 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 230000007017 scission Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 description 1
- 235000012239 silicon dioxide Nutrition 0.000 description 1
- 238000011146 sterile filtration Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- AXOIZCJOOAYSMI-UHFFFAOYSA-N succinylcholine Chemical compound C[N+](C)(C)CCOC(=O)CCC(=O)OCC[N+](C)(C)C AXOIZCJOOAYSMI-UHFFFAOYSA-N 0.000 description 1
- 229940032712 succinylcholine Drugs 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 108700012359 toxins Proteins 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 239000002753 trypsin inhibitor Substances 0.000 description 1
- 238000009281 ultraviolet germicidal irradiation Methods 0.000 description 1
- 230000002227 vasoactive effect Effects 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/76—Albumins
- C07K14/765—Serum albumin, e.g. HSA
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
- C07K16/065—Purification, fragmentation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/827—Proteins from mammals or birds
- Y10S530/829—Blood
- Y10S530/83—Plasma; serum
- Y10S530/831—Cohn fractions
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Pharmacology & Pharmacy (AREA)
- Gastroenterology & Hepatology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Zoology (AREA)
- Dermatology (AREA)
- Immunology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH93477 | 1977-01-26 | ||
| AT0185977A AT367297B (de) | 1977-03-17 | 1977-03-17 | Verfahren zur herstellung eines serumeiweiss-pr[parates |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE2801123A1 DE2801123A1 (de) | 1978-07-27 |
| DE2801123C2 true DE2801123C2 (de) | 1986-01-02 |
Family
ID=25597003
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE2801123A Expired DE2801123C2 (de) | 1977-01-26 | 1978-01-12 | Verfahren zur Herstellung eines intravenös applizierbaren Serumeiweiß-Präparates |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US4216205A (en:Method) |
| JP (1) | JPS5396315A (en:Method) |
| AR (1) | AR220328A1 (en:Method) |
| AU (1) | AU522413B2 (en:Method) |
| BE (1) | BE863278A (en:Method) |
| DD (1) | DD133632A5 (en:Method) |
| DE (1) | DE2801123C2 (en:Method) |
| DK (1) | DK152334C (en:Method) |
| EG (1) | EG13119A (en:Method) |
| ES (1) | ES466385A1 (en:Method) |
| FI (1) | FI63673C (en:Method) |
| FR (1) | FR2378524A1 (en:Method) |
| GB (1) | GB1597204A (en:Method) |
| HU (1) | HU182554B (en:Method) |
| IE (1) | IE46304B1 (en:Method) |
| IL (1) | IL53856A (en:Method) |
| IN (1) | IN147713B (en:Method) |
| NL (1) | NL7800606A (en:Method) |
| PL (1) | PL124730B1 (en:Method) |
| SE (1) | SE447204B (en:Method) |
| SU (1) | SU786854A3 (en:Method) |
| YU (1) | YU16578A (en:Method) |
| ZA (1) | ZA78295B (en:Method) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4321192A (en) * | 1980-01-10 | 1982-03-23 | Ionics Incorporated | Fractionation of protein mixtures by salt addition followed by dialysis treatment |
| US4322275A (en) * | 1980-01-10 | 1982-03-30 | Ionics Incorporated | Fractionation of protein mixtures |
| US4351710A (en) * | 1980-01-10 | 1982-09-28 | Ionics, Incorporated | Fractionation of protein mixtures |
| FR2492269A2 (fr) * | 1980-01-10 | 1982-04-23 | Ionics | Appareil d'electrodialyse et procede de fractionnement de melanges de proteines |
| WO1982002841A1 (en) * | 1981-02-18 | 1982-09-02 | University Patents Inc | Precipitation of proteins |
| US4452893A (en) * | 1981-08-03 | 1984-06-05 | Cutter Laboratories, Inc. | Cell growth medium supplement |
| US4391801A (en) * | 1981-10-29 | 1983-07-05 | Cutter Laboratories, Inc. | Plasma protein fraction substantially free of acetate ions |
| US4439421A (en) * | 1982-08-30 | 1984-03-27 | Baxter Travenol Laboratories, Inc. | Stabilized gamma globulin concentrate |
| DE3245591C2 (de) * | 1982-12-09 | 1986-11-06 | Schott Glaswerke, 6500 Mainz | Verfahren zur fraktionierten Auftrennung von Stoffgemischen mit Membranen |
| US4486282A (en) * | 1983-02-22 | 1984-12-04 | University Patents, Inc. | Precipitation of proteins from salt-containing proteinaceous fluids employing a desalting treatment, and use thereof in selective plasmapheresis |
| DE3344656A1 (de) * | 1983-12-09 | 1985-06-13 | Lentia GmbH Chem. u. pharm. Erzeugnisse - Industriebedarf, 8000 München | Verfahren zur herstellung einer serumproteinloesung |
| US5420250A (en) * | 1990-08-06 | 1995-05-30 | Fibrin Corporation | Phase transfer process for producing native plasma protein concentrates |
| CA2066374C (en) * | 1991-04-19 | 2002-01-29 | Paul E. Segall | Solution for perfusing primates |
| CN1055095C (zh) * | 1992-12-11 | 2000-08-02 | 上海莱士血制品有限公司 | 白蛋白的纯化方法 |
| US5945272A (en) * | 1993-06-04 | 1999-08-31 | Biotime, Incorporated | Plasma expanders and blood substitutes |
| WO1994028950A1 (en) * | 1993-06-04 | 1994-12-22 | Biotime, Inc. | Plasma-like solution |
| US6680305B1 (en) * | 1993-06-04 | 2004-01-20 | Biotime, Inc. | Physiologically acceptable aqueous solutions and methods for their use |
| US6300322B1 (en) | 1993-06-04 | 2001-10-09 | Biotime, Inc. | Plasma-like solution |
| US6627393B2 (en) * | 1993-06-04 | 2003-09-30 | Biotime, Inc. | Solutions for use as plasma expanders and substitutes |
| US6218099B1 (en) | 1994-06-03 | 2001-04-17 | Biotime, Inc. | Methods and compositions for use in perfusion applications |
| US6589223B1 (en) | 1999-02-03 | 2003-07-08 | Biotime, Inc. | Method and compositions for use in perfusion applications |
| US6441144B1 (en) | 1999-05-20 | 2002-08-27 | Alpha Therapeutic Corporation | Method for repairing dual virally inactivated immune globulin for intravenous administration |
| US6596262B2 (en) * | 2001-02-15 | 2003-07-22 | Aeropharm Technology Incorporated | Modulated release particles for aerosol delivery |
| US6806355B2 (en) * | 2001-08-14 | 2004-10-19 | Statens Serum Institut | Purification process for large scale production of Gc-globulin, the Gc-globulin produced hereby, a use of Gc.globulin and a Gc-globulin medicinal product |
| AU2009314011A1 (en) * | 2008-11-12 | 2011-06-30 | Baxalta GmbH | Purification of butyrylcholinesterase using membrane adsorption |
| US8796430B2 (en) | 2010-05-26 | 2014-08-05 | Baxter International Inc. | Method to produce an immunoglobulin preparation with improved yield |
| WO2011150284A2 (en) | 2010-05-26 | 2011-12-01 | Baxter International Inc. | Removal of serine proteases by treatment with finely divided silicon dioxide |
| AU2010202125B1 (en) * | 2010-05-26 | 2010-09-02 | Takeda Pharmaceutical Company Limited | A method to produce an immunoglobulin preparation with improved yield |
| CN110054685A (zh) * | 2019-04-26 | 2019-07-26 | 兰州兰生血液制品有限公司 | 一种静注人免疫球蛋白（pH4）低温乙醇组分Ⅲ的生产方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1207477A (en) * | 1969-04-29 | 1970-10-07 | Ts I Gematologii I Perelivania | Plasma proteins solution |
| US3770631A (en) * | 1971-06-29 | 1973-11-06 | Baxter Laboratories Inc | Clarification of blood serum and plasma |
| JPS5620287B2 (en:Method) * | 1972-06-19 | 1981-05-13 | ||
| US4073886A (en) * | 1973-01-30 | 1978-02-14 | Baxter Travenol Laboratories, Inc. | Blood fractionation process using block copolymers of ethylene oxide and polyoxypropylene |
| US3850903A (en) * | 1973-06-21 | 1974-11-26 | S Mankarious | Plasma volume expander prepared from cohn iv precipitate using block copolymers of ethylene oxide and polyoxypropylene |
| DE2459291C3 (de) * | 1974-12-14 | 1981-06-04 | Biotest-Serum-Institut Gmbh, 6000 Frankfurt | Verfahren zur Herstellung eines antihämophiles Globulin A enthaltenden Konzentrats neben einem Prothrombin- Komplex und einer Lösung von lagerstabilen Serumproteinen |
-
1978
- 1978-01-12 DE DE2801123A patent/DE2801123C2/de not_active Expired
- 1978-01-16 SE SE7800443A patent/SE447204B/sv not_active IP Right Cessation
- 1978-01-16 IE IE88/78A patent/IE46304B1/en unknown
- 1978-01-17 ZA ZA00780295A patent/ZA78295B/xx unknown
- 1978-01-18 NL NL7800606A patent/NL7800606A/xx not_active Application Discontinuation
- 1978-01-19 GB GB2285/78A patent/GB1597204A/en not_active Expired
- 1978-01-20 AU AU32600/78A patent/AU522413B2/en not_active Expired
- 1978-01-20 IL IL53856A patent/IL53856A/xx unknown
- 1978-01-23 US US05/871,620 patent/US4216205A/en not_active Expired - Lifetime
- 1978-01-24 DD DD7800203381A patent/DD133632A5/xx unknown
- 1978-01-24 FI FI780212A patent/FI63673C/fi not_active IP Right Cessation
- 1978-01-24 EG EG41/78A patent/EG13119A/xx active
- 1978-01-24 YU YU00165/78A patent/YU16578A/xx unknown
- 1978-01-25 HU HU78PA303A patent/HU182554B/hu unknown
- 1978-01-25 DK DK035478A patent/DK152334C/da not_active IP Right Cessation
- 1978-01-25 IN IN98/CAL/78A patent/IN147713B/en unknown
- 1978-01-25 PL PL1978204214A patent/PL124730B1/pl unknown
- 1978-01-25 FR FR7802028A patent/FR2378524A1/fr active Granted
- 1978-01-25 BE BE2056636A patent/BE863278A/xx not_active IP Right Cessation
- 1978-01-25 AR AR270851A patent/AR220328A1/es active
- 1978-01-26 SU SU782572351A patent/SU786854A3/ru active
- 1978-01-26 ES ES466385A patent/ES466385A1/es not_active Expired
- 1978-01-26 JP JP778978A patent/JPS5396315A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| DK35478A (da) | 1978-07-27 |
| DK152334C (da) | 1988-07-25 |
| IN147713B (en:Method) | 1980-06-07 |
| PL124730B1 (en) | 1983-02-28 |
| YU16578A (en) | 1983-10-31 |
| PL204214A1 (pl) | 1978-09-25 |
| HU182554B (en) | 1984-02-28 |
| DK152334B (da) | 1988-02-22 |
| AU3260078A (en) | 1979-07-26 |
| SU786854A3 (ru) | 1980-12-07 |
| FI780212A7 (fi) | 1978-07-27 |
| BE863278A (nl) | 1978-05-16 |
| SE7800443L (sv) | 1978-07-27 |
| FI63673B (fi) | 1983-04-29 |
| US4216205A (en) | 1980-08-05 |
| DD133632A5 (de) | 1979-01-17 |
| EG13119A (en) | 1981-03-31 |
| FR2378524A1 (fr) | 1978-08-25 |
| FR2378524B1 (en:Method) | 1983-02-04 |
| JPS5396315A (en) | 1978-08-23 |
| AR220328A1 (es) | 1980-10-31 |
| IL53856A (en) | 1981-03-31 |
| ES466385A1 (es) | 1978-10-01 |
| DE2801123A1 (de) | 1978-07-27 |
| SE447204B (sv) | 1986-11-03 |
| ZA78295B (en) | 1978-12-27 |
| IE46304B1 (en) | 1983-04-20 |
| FI63673C (fi) | 1983-08-10 |
| AU522413B2 (en) | 1982-06-03 |
| GB1597204A (en) | 1981-09-03 |
| IE780088L (en) | 1978-07-26 |
| JPS6241211B2 (en:Method) | 1987-09-02 |
| NL7800606A (nl) | 1978-07-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE2801123C2 (de) | Verfahren zur Herstellung eines intravenös applizierbaren Serumeiweiß-Präparates | |
| EP0329605B1 (de) | Verfahren zur Herstellung von Apolipoproteinen aus Blutplasma- oder Serumfraktionen | |
| DE69127384T2 (de) | Verfahren zur Reinigung von Immunserumglobulinen | |
| EP0447585B2 (de) | Verfahren zur Herstellung eines intravenös verträglichen Immunglobulin-G-Präparates | |
| DE69011136T2 (de) | Verfahren zur Herstellung einer Protein enthaltenden Zusammensetzung. | |
| DE3734923C1 (de) | Verfahren zur Herstellung einer sterilen Plasmaproteinloesung,die Fibrinogen und den Gerinnungsfaktor XIII enthaelt | |
| DE3825429C2 (de) | Verfahren zur Herstellung eines intravenös verabreichbaren polyklonalen Immunglobulin-Präparates mit hohem IgM-Gehalt | |
| DE69808012T3 (de) | Bei Raumtemperatur lagerfähiges Immunoglobolin-Präparat für intravenöse Injektion | |
| EP0013901B1 (de) | Verfahren zur Herstellung einer für die intravenöse Applikation geeigneten Immunglobulinlösung, die IgM in ankonzentrierter Form enthält | |
| EP0122909B1 (de) | Immunglobulin-G-hältige Fraktion | |
| DE69821741T2 (de) | Immunoglobulin enthaltende zusammensetzung | |
| DE2459291C3 (de) | Verfahren zur Herstellung eines antihämophiles Globulin A enthaltenden Konzentrats neben einem Prothrombin- Komplex und einer Lösung von lagerstabilen Serumproteinen | |
| DE3786832T2 (de) | Verfahren zur Herstellung von Immunoglobulinzubereitungen für intravenöse Injektion. | |
| DE2752694A1 (de) | Verfahren zur gewinnung von immunglobulin zur intravenoesen verabreichung | |
| DE3751576T2 (de) | Virale Inaktivierung und Reinigung von aktiven Proteinen. | |
| DE2640387C3 (de) | Gewebespezifisches Protein und Verfahren zu dessen Herstellung | |
| AT391808B (de) | Verfahren zur herstellung einer faktor viii (ahf)-haeltigen fraktion | |
| DE69631229T2 (de) | Herstellung von virusinaktivierten intravenös injektierbaren Globulin aus Immunserum | |
| DE69130736T2 (de) | Methode für die präparation von pyridoxyliertem hämoglobin | |
| DE3330770A1 (de) | Verfahren zur pasteurisierung von humanplasma | |
| EP0120835B1 (de) | Verfahren zur Inaktivierung von Unverträglichkeitsreaktionen verursachenden Substanzen | |
| DE3430320A1 (de) | Verfahren zur herstellung von immunglobulin-praeparaten mit verminderter komplementaktivitaet | |
| DE2658334C3 (de) | Verfahren zum Herstellen von Immunglobulinpräparationen mit verminderter Komplementaktivität und ein diese enthaltendes Arzneimittel | |
| EP0873362B1 (de) | VERFAHREN ZUR TRENNUNG VON IgG und IgA | |
| DE2014957C2 (de) | Verfahren zur Reinigung von Proteinen des Blutserums oder -plasmas |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| OD | Request for examination | ||
| OGA | New person/name/address of the applicant | ||
| 8127 | New person/name/address of the applicant |
Owner name: ARMOUR PHARMA GMBH & CO KG, 3440 ESCHWEGE, DE |
|
| D2 | Grant after examination | ||
| 8364 | No opposition during term of opposition | ||
| 8327 | Change in the person/name/address of the patent owner |
Owner name: ARMOUR PHARMA GMBH & CO. KG, 4800 BIELEFELD, DE |
|
| 8327 | Change in the person/name/address of the patent owner |
Owner name: ARMOUR PHARMA GMBH, 3440 ESCHWEGE, DE |
|
| 8339 | Ceased/non-payment of the annual fee |