DE2726754A1 - Substituierte (3-niedrigalkylamino- 2-acyl-0-propoxy)-pyridine, verfahren zu ihrer herstellung und ihre verwendung - Google Patents

Substituierte (3-niedrigalkylamino- 2-acyl-0-propoxy)-pyridine, verfahren zu ihrer herstellung und ihre verwendung

Info

Publication number
DE2726754A1
DE2726754A1 DE19772726754 DE2726754A DE2726754A1 DE 2726754 A1 DE2726754 A1 DE 2726754A1 DE 19772726754 DE19772726754 DE 19772726754 DE 2726754 A DE2726754 A DE 2726754A DE 2726754 A1 DE2726754 A1 DE 2726754A1
Authority
DE
Germany
Prior art keywords
formula
compound
alkyl
compounds
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE19772726754
Other languages
German (de)
English (en)
Inventor
John James Baldwin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of DE2726754A1 publication Critical patent/DE2726754A1/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/84—Nitriles
    • C07D213/85—Nitriles in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
DE19772726754 1976-06-15 1977-06-14 Substituierte (3-niedrigalkylamino- 2-acyl-0-propoxy)-pyridine, verfahren zu ihrer herstellung und ihre verwendung Withdrawn DE2726754A1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/696,236 US4053605A (en) 1976-06-15 1976-06-15 Esterified-2(3-lower-alkyl-amino-propoxy)-3-cyano-pyridines and derivatives

Publications (1)

Publication Number Publication Date
DE2726754A1 true DE2726754A1 (de) 1977-12-29

Family

ID=24796248

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19772726754 Withdrawn DE2726754A1 (de) 1976-06-15 1977-06-14 Substituierte (3-niedrigalkylamino- 2-acyl-0-propoxy)-pyridine, verfahren zu ihrer herstellung und ihre verwendung

Country Status (9)

Country Link
US (3) US4053605A (enExample)
JP (1) JPS52153972A (enExample)
CH (1) CH632499A5 (enExample)
DE (1) DE2726754A1 (enExample)
DK (1) DK236477A (enExample)
FR (1) FR2355007A1 (enExample)
GB (1) GB1545708A (enExample)
NL (1) NL7705883A (enExample)
SE (1) SE428685B (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4000282A (en) * 1974-12-16 1976-12-28 Merck & Co., Inc. 2-(3-tert. butyl or isopropylamino-2-hydroxypropoxy)-3-cyanopyridines
JPS54106476A (en) * 1978-01-04 1979-08-21 Merck & Co Inc Multiisubstituted 22*33lower alkylaminoo22 r100propoxy*pyridine
US4279913A (en) * 1978-01-04 1981-07-21 Merck & Co., Inc. Polysubstituted-2-(3-loweralkylamino-2-R1 O-propoxy)pyridines
DK267779A (da) * 1978-06-27 1979-12-28 Merck & Co Inc Fr&mgangsmaade til fremstilling af n-aralkylamino-propoxycyanopyridiner
US4208416A (en) * 1978-06-27 1980-06-17 Merck & Co., Inc. N-Aralkyl containing cyanopyridines
US4175128A (en) * 1979-01-03 1979-11-20 Pfizer Inc. Method for treating congestive heart failure
US4294969A (en) * 1979-01-29 1981-10-13 Merck & Co., Inc. Process for producing 2-bromo-3,5-disubstituted pyridines
US4393212A (en) * 1979-01-29 1983-07-12 Merck & Co., Inc. Certain nicotinic acid esters and corresponding nicotinonitriles
DE2943774A1 (de) * 1979-10-26 1981-05-14 1000 Berlin Schering Ag Berlin Und Bergkamen Substituierte pyridine, verfahren zu ihrer herstellung und ihre verwendung
US4550117A (en) * 1982-07-26 1985-10-29 Merck & Co., Inc. 3-Cycloalkylamino-2-OR-propoxycyanopyridines, derivatives thereof, having anti-hypertensive activity
US4436740A (en) 1982-07-26 1984-03-13 Merck & Co., Inc. 3-Cycloalkylamino-2-OR-propoxycyanopyridines
AU2014360673A1 (en) 2013-12-02 2016-07-14 The University Of Queensland Separator

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3946009A (en) * 1972-05-05 1976-03-23 Merck Sharp & Dohme (I.A.) Corporation 2-(3-Substituted amino-2-hydroxypropoxy)-3-substituted pyrazines
US4001327A (en) * 1972-07-05 1977-01-04 The Regents Of The University Of Michigan Novel quaternary salts and method
JPS5641637B2 (enExample) * 1973-11-26 1981-09-29
GB1449420A (en) * 1973-11-26 1976-09-15 Sankyo Co 7alpha-methoxycephalosporing derivatives
US4000282A (en) * 1974-12-16 1976-12-28 Merck & Co., Inc. 2-(3-tert. butyl or isopropylamino-2-hydroxypropoxy)-3-cyanopyridines
US4060601A (en) * 1976-06-15 1977-11-29 Merck & Co., Inc. Certain lower-alkyl amino-2'-hydroxy-propoxy pyridines

Also Published As

Publication number Publication date
US4053605A (en) 1977-10-11
CH632499A5 (de) 1982-10-15
US4119630A (en) 1978-10-10
DK236477A (da) 1977-12-16
JPS52153972A (en) 1977-12-21
US4119721A (en) 1978-10-10
SE428685B (sv) 1983-07-18
FR2355007A1 (fr) 1978-01-13
FR2355007B1 (enExample) 1980-04-18
NL7705883A (nl) 1977-12-19
GB1545708A (en) 1979-05-10
SE7706182L (sv) 1977-12-16

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Legal Events

Date Code Title Description
8110 Request for examination paragraph 44
8139 Disposal/non-payment of the annual fee