DE2701408A1 - Pentolderivate, verfahren zu ihrer herstellung und arzneipraeparate - Google Patents

Pentolderivate, verfahren zu ihrer herstellung und arzneipraeparate

Info

Publication number
DE2701408A1
DE2701408A1 DE19772701408 DE2701408A DE2701408A1 DE 2701408 A1 DE2701408 A1 DE 2701408A1 DE 19772701408 DE19772701408 DE 19772701408 DE 2701408 A DE2701408 A DE 2701408A DE 2701408 A1 DE2701408 A1 DE 2701408A1
Authority
DE
Germany
Prior art keywords
general formula
alkyl
radicals
compound
trans
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
DE19772701408
Other languages
German (de)
English (en)
Inventor
Frederic P Hauck
Joyce A Reid
Joseph E Sundeen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ER Squibb and Sons LLC
Original Assignee
ER Squibb and Sons LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ER Squibb and Sons LLC filed Critical ER Squibb and Sons LLC
Publication of DE2701408A1 publication Critical patent/DE2701408A1/de
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
    • C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
    • C07D295/03—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to acyclic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00—Preparation of halogenated hydrocarbons
    • C07C17/26—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton
    • C07C17/32—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton by introduction of halogenated alkyl groups into ring compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C31/00—Saturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C31/13—Monohydroxylic alcohols containing saturated rings
    • C07C31/137—Monohydroxylic alcohols containing saturated rings polycyclic with condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/42—Oxygen atoms attached in position 3 or 5
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/06—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
    • C07D213/16—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom containing only one pyridine ring
    • C07D213/20—Quaternary compounds thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyridine Compounds (AREA)
DE19772701408 1976-01-14 1977-01-14 Pentolderivate, verfahren zu ihrer herstellung und arzneipraeparate Pending DE2701408A1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/649,116 US4053596A (en) 1976-01-14 1976-01-14 Indanpentol derivatives

Publications (1)

Publication Number Publication Date
DE2701408A1 true DE2701408A1 (de) 1977-07-21

Family

ID=24603529

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19772701408 Pending DE2701408A1 (de) 1976-01-14 1977-01-14 Pentolderivate, verfahren zu ihrer herstellung und arzneipraeparate

Country Status (6)

Country Link
US (2) US4053596A (enExample)
JP (1) JPS5287153A (enExample)
CA (1) CA1095037A (enExample)
DE (1) DE2701408A1 (enExample)
FR (1) FR2338261A1 (enExample)
GB (1) GB1568407A (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2399406A1 (fr) * 1977-08-04 1979-03-02 Squibb & Sons Inc Derives de perhydronaphtalenepentol et leur utilisation therapeutique
WO1997042164A1 (en) * 1996-05-03 1997-11-13 Dsm N.V. Indene substituted with a group comprising a hetero atom

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4172945A (en) * 1976-01-14 1979-10-30 E. R. Squibb & Sons, Inc. Precursors of indanpentol derivatives
US4053596A (en) * 1976-01-14 1977-10-11 E. R. Squibb & Sons, Inc. Indanpentol derivatives
US4173640A (en) * 1977-08-04 1979-11-06 E. R. Squibb & Sons, Inc. Hypotensive perhydro naphthalene pentol derivatives
US4127717A (en) * 1978-03-20 1978-11-28 E. R. Squibb & Sons, Inc. Benzo-cyclitolamines
JPS56123975A (en) * 1980-03-06 1981-09-29 Hokuriku Seiyaku Co Ltd Novel indanmethanamine derivative
JPS5795975A (en) * 1980-12-08 1982-06-15 Hokuriku Seiyaku Co Ltd Novel indanmethanamine derivative
FR2709126B1 (fr) * 1993-08-18 1995-09-29 Adir Nouveaux dérivés de naphtalène, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3894031A (en) * 1970-09-10 1975-07-08 Squibb & Sons Inc Indantetrol derivatives
US3751420A (en) * 1971-04-01 1973-08-07 Squibb & Sons Inc Monoolmonoene amines
US3984419A (en) 1972-06-21 1976-10-05 E. R. Squibb & Sons, Inc. Perhydrofluorenetetrol and perhydro-phenanthrenetetrol derivatives
US3984407A (en) * 1973-06-21 1976-10-05 E. R. Squibb & Sons, Inc. Diene intermediates for indantetrol derivatives
US3936465A (en) * 1973-07-30 1976-02-03 E. R. Squibb & Sons, Inc. Cyclohexane tetrols and derivatives thereof
US4033971A (en) * 1973-07-30 1977-07-05 E. R. Squibb & Sons, Inc. Cyclohexane tetrols and derivatives thereof
US4022788A (en) * 1974-05-06 1977-05-10 E. R. Squibb & Sons, Inc. Indane tetrol amines
US4053596A (en) * 1976-01-14 1977-10-11 E. R. Squibb & Sons, Inc. Indanpentol derivatives

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2399406A1 (fr) * 1977-08-04 1979-03-02 Squibb & Sons Inc Derives de perhydronaphtalenepentol et leur utilisation therapeutique
WO1997042164A1 (en) * 1996-05-03 1997-11-13 Dsm N.V. Indene substituted with a group comprising a hetero atom

Also Published As

Publication number Publication date
US4138497A (en) 1979-02-06
CA1095037A (en) 1981-02-03
FR2338261B1 (enExample) 1978-11-03
FR2338261A1 (fr) 1977-08-12
GB1568407A (en) 1980-05-29
JPS5287153A (en) 1977-07-20
US4053596A (en) 1977-10-11

Similar Documents

Publication Publication Date Title
EP0006524A1 (de) Neue Tetrahydropyridin- und Piperidinderivate und deren Säureadditionssalze, Verfahren zu deren Herstellung und solche enthaltende pharmazeutische Zusammensetzungen
EP0241003A2 (de) 4H-1-Benzopyran-4-on-Derivate, ein Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
DE3852107T2 (de) Bestimmte 3-substituierte 2-alkyl-benzofuran-derivate.
DE2701408A1 (de) Pentolderivate, verfahren zu ihrer herstellung und arzneipraeparate
CH631164A5 (de) Verfahren zur herstellung von neuem 1-cyclopropylmethyl-4-(3-jod-5h-dibenzo(a,d)cyclohepten-5-yliden)piperidin.
EP0019172A1 (de) 6-Substituierte 11-Alkylen-morphantridine, Verfahren zu ihrer Herstellung und diese enthaltende therapeutische Mittel
DE68902946T2 (de) Heteroarotinoid-derivate, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammenstellungen.
DE3209304A1 (de) Basische derivate von tricyclischen verbindungen, verfahren zu ihrer herstellung und pharmazeutische mittel
EP0233483A2 (de) Pyrrolo[1,2-a][4,1]benzoxazepine, Verfahren zur ihrer Herstellung, pharmazeutische Präparate enthaltend diese Verbindungen, sowie therapeutische Verwendung
DE2834372A1 (de) Perhydronaphthalinpentolderivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
DD239403A5 (de) Verfahren zur herstellung neuer 3-phenyl-2-propenamin-derivate
EP0271099A2 (de) Substituierte Aminopropionsäureamide, Verfahren zu ihrer Herstellung, diese enthaltende Mittel und ihre Verwendung sowie die bei der Herstellung anfallenden neuen Zwischenprodukte
US4092318A (en) Indantetrol derivatives
DE1695962A1 (de) (2-Aminocycloalkyl)hydrochinone und Derivate derselben sowie Verfahren zu ihrer Herstellung
DE2747987C2 (enExample)
DE3520104A1 (de) Naphthoxazine, ihre herstellung und verwendung
US4044040A (en) 4,7-Dihydroindanyl alkanols, analogues thereof and their corresponding tosylates
US3984407A (en) Diene intermediates for indantetrol derivatives
DE2331549A1 (de) Perhydrofluoren- und -phenanthrenderivate, verfahren zu deren herstellung und diese verbindungen enthaltende aqzneipraeparate
DE3003323A1 (de) 4-amino-2-piperidinochinazolin-derivate, verfahren zu ihrer herstellung und solche derivate enthaltende arzneimittel
US4127578A (en) Diene intermediates for indantetrols
CH663615A5 (de) Azabicyclische verbindungen, verfahren zu ihrer herstellung sowie diese enthaltendes pharmazeutisches praeparat.
DE1695944A1 (de) Verfahren zur Herstellung neuer 1,3-Aminoalkohole
DE2264663C3 (de) Ungesättigte Sulfoxyde und Verfahren zu ihrer Herstellung
DE2139016A1 (de) Neue organische Verbindungen und Verfahren zu deren Herstellung

Legal Events

Date Code Title Description
OHJ Non-payment of the annual fee