DE2655009A1 - Isoxazolderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende mittel - Google Patents

Isoxazolderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende mittel

Info

Publication number
DE2655009A1
DE2655009A1 DE19762655009 DE2655009A DE2655009A1 DE 2655009 A1 DE2655009 A1 DE 2655009A1 DE 19762655009 DE19762655009 DE 19762655009 DE 2655009 A DE2655009 A DE 2655009A DE 2655009 A1 DE2655009 A1 DE 2655009A1
Authority
DE
Germany
Prior art keywords
formula
methylisoxazole
compounds
bromine
chlorine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
DE19762655009
Other languages
German (de)
English (en)
Other versions
DE2655009C2 (xx
Inventor
Guenther Dr Heubach
Friedrich-Johannes D Kaemmerer
Rudolf Dr Schleyerbach
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Priority to DE19762655009 priority Critical patent/DE2655009A1/de
Priority to CH1393477A priority patent/CH608498A5/xx
Priority to NL7713151A priority patent/NL7713151A/xx
Priority to GB5034777A priority patent/GB1596383A/en
Priority to DK538677A priority patent/DK538677A/da
Priority to CA292,302A priority patent/CA1102341A/en
Priority to LU78628A priority patent/LU78628A1/xx
Priority to IT3035277A priority patent/IT1126219B/it
Priority to IE245277A priority patent/IE46269B1/en
Priority to AT866377A priority patent/AT362366B/de
Priority to JP14562277A priority patent/JPS5371070A/ja
Priority to FR7736547A priority patent/FR2372830A2/fr
Priority to BE183170A priority patent/BE861503R/xx
Publication of DE2655009A1 publication Critical patent/DE2655009A1/de
Application granted granted Critical
Publication of DE2655009C2 publication Critical patent/DE2655009C2/de
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE19762655009 1976-12-04 1976-12-04 Isoxazolderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende mittel Granted DE2655009A1 (de)

Priority Applications (13)

Application Number Priority Date Filing Date Title
DE19762655009 DE2655009A1 (de) 1976-12-04 1976-12-04 Isoxazolderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende mittel
CH1393477A CH608498A5 (en) 1976-12-04 1977-11-15 Process for the preparation of novel 5-methylisoxazole- 4-carboxamides
NL7713151A NL7713151A (nl) 1976-12-04 1977-11-29 Isoxazoolderivaten, hun bereiding en geneesmid- delen met deze stoffen.
LU78628A LU78628A1 (xx) 1976-12-04 1977-12-02
DK538677A DK538677A (da) 1976-12-04 1977-12-02 Isoxazolderivater fremgangsmaade til deres fremstilling og midler indeholdende disse forbindelser
CA292,302A CA1102341A (en) 1976-12-04 1977-12-02 Isoxazole derivatives, process for their manufacture and agents containing these compounds
GB5034777A GB1596383A (en) 1976-12-04 1977-12-02 Isoxazole derivatives process for their manufacture and preparations containing these compounds
IT3035277A IT1126219B (it) 1976-12-04 1977-12-02 Derivati isossazolici,processo per la loro preparazione e mezzi contenenti tali composti
IE245277A IE46269B1 (en) 1976-12-04 1977-12-02 Isoxazole derivatives,process for their manufacture and preparations containing these compounds
AT866377A AT362366B (de) 1976-12-04 1977-12-02 Verfahren zur herstellung von neuen 5-methyl- -isoxazol-4-carbonsaeureamiden sowie deren salzen
JP14562277A JPS5371070A (en) 1976-12-04 1977-12-03 Isooxazole derivative and process for preparing same
BE183170A BE861503R (fr) 1976-12-04 1977-12-05 Nouveaux derives d'isoxazoles, leur procede de preparation et leurs applications
FR7736547A FR2372830A2 (fr) 1976-12-04 1977-12-05 Derives d'isoxazole, leur procede de preparation et leur application en therapeutique

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19762655009 DE2655009A1 (de) 1976-12-04 1976-12-04 Isoxazolderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende mittel

Publications (2)

Publication Number Publication Date
DE2655009A1 true DE2655009A1 (de) 1978-06-15
DE2655009C2 DE2655009C2 (xx) 1990-03-29

Family

ID=5994666

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19762655009 Granted DE2655009A1 (de) 1976-12-04 1976-12-04 Isoxazolderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende mittel

Country Status (13)

Country Link
JP (1) JPS5371070A (xx)
AT (1) AT362366B (xx)
BE (1) BE861503R (xx)
CA (1) CA1102341A (xx)
CH (1) CH608498A5 (xx)
DE (1) DE2655009A1 (xx)
DK (1) DK538677A (xx)
FR (1) FR2372830A2 (xx)
GB (1) GB1596383A (xx)
IE (1) IE46269B1 (xx)
IT (1) IT1126219B (xx)
LU (1) LU78628A1 (xx)
NL (1) NL7713151A (xx)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0012435A2 (de) * 1978-12-16 1980-06-25 Hoechst Aktiengesellschaft Isoxazolderivate, Verfahren zu ihrer Herstellung, diese Verbindungen enthaltende Arzneimittel und bei dem Verfahren benötigte Zwischenprodukte
EP0016277A1 (en) * 1978-11-03 1980-10-01 American Cyanamid Company 2-Carbonyl-3-hydroxy-alkenonitriles, their use as anti-arthritic agents and processes for their preparation
EP0035285A2 (en) * 1979-08-17 1981-09-09 American Cyanamid Company Novel isoxazole carboxylic acid phenyl esters, pharmaceutical compositions containing certain of said esters, and process for preparing said esters
DE3247454A1 (de) * 1982-12-22 1984-06-28 Laboratorios Bago S.A., Buenos Aires Substituierte 3-phenyl-5-methyl-isoxazol-4-carboxy-anilide, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
EP0378111A1 (en) * 1989-01-09 1990-07-18 ZAMBON GROUP S.p.A. Isoxazole derivatives having anti-serotonin activity, their preparation process and compositions containing them
US4983619A (en) * 1986-08-08 1991-01-08 Lilly Industries Limited Pharmaceutical compounds
EP0440503A1 (en) * 1990-02-02 1991-08-07 Syntex (U.S.A.) Inc. 4-Isoxazolecarboxamide derivatives
LT3416B (en) 1990-05-18 1995-09-25 Hoechst Ag Isoxazole-4-carboxamides, hydroxyalkylidene-cyanoacetamides, drugs containing these compounds and method for the preparation of such drugs

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8619432D0 (en) * 1986-08-08 1986-09-17 Lilly Industries Ltd Pharmaceutical compounds
US4935434A (en) * 1988-01-26 1990-06-19 Bristol-Myers Company Antiarthritic isoxazole-4-carboxamides
AU649421B2 (en) * 1990-05-18 1994-05-26 Sanofi-Aventis Deutschland Gmbh Isoxazole-4-carboxamides and hydroxyalkylidene-cyanoacetamides, drugs containing these compounds and use of such drugs
US7338956B2 (en) * 2002-08-07 2008-03-04 Sanofi-Aventis Deutschland Gmbh Acylamino-substituted heteroaromatic compounds and their use as pharmaceuticals
CN103772376B (zh) * 2012-10-24 2017-01-11 中国医学科学院医药生物技术研究所 取代的苯并-1,3-杂唑类化合物、其制备方法及用途
US20170088545A1 (en) * 2014-05-14 2017-03-30 Novartis Ag Carboxamide inhibitors
TW201946921A (zh) * 2014-05-14 2019-12-16 瑞士商諾華公司 甲醯胺衍生物

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2208351B2 (de) * 1971-03-01 1976-09-16 Warner-Lambert Co., Morris Plains, N.J. (V.StA.) 4-hydroxy-3-(3-isoxazolocarbamoyl)-2h-1,2-benzothiazin-1,1-dioxide und verfahren zu ihrer herstellung

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2208351B2 (de) * 1971-03-01 1976-09-16 Warner-Lambert Co., Morris Plains, N.J. (V.StA.) 4-hydroxy-3-(3-isoxazolocarbamoyl)-2h-1,2-benzothiazin-1,1-dioxide und verfahren zu ihrer herstellung

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Arzneimittelforsch. 30, 1980, S. 1314-1325, 33, 1983, S. 1555-1569, 23, 1973, S. 1690-1695 *
Drugs of the Future, Vol. III, Nr. 8, 1978, S. 615-617 *
Med. Klinik, 77, 1982, 14, 15 *

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0016277A1 (en) * 1978-11-03 1980-10-01 American Cyanamid Company 2-Carbonyl-3-hydroxy-alkenonitriles, their use as anti-arthritic agents and processes for their preparation
EP0012435A2 (de) * 1978-12-16 1980-06-25 Hoechst Aktiengesellschaft Isoxazolderivate, Verfahren zu ihrer Herstellung, diese Verbindungen enthaltende Arzneimittel und bei dem Verfahren benötigte Zwischenprodukte
EP0012435A3 (de) * 1978-12-16 1980-10-01 Hoechst Aktiengesellschaft Isoxazolderivate, Verfahren zu ihrer Herstellung, diese Verbindungen enthaltende Arzneimittel und bei dem Verfahren benötigte Zwischenprodukte
EP0035285A2 (en) * 1979-08-17 1981-09-09 American Cyanamid Company Novel isoxazole carboxylic acid phenyl esters, pharmaceutical compositions containing certain of said esters, and process for preparing said esters
EP0035285A3 (en) * 1979-08-17 1981-10-14 American Cyanamid Company Novel isoxazole carboxylic acid phenyl esters, pharmaceutical compositions containing certain of said esters, and process for preparing said esters
DE3247454A1 (de) * 1982-12-22 1984-06-28 Laboratorios Bago S.A., Buenos Aires Substituierte 3-phenyl-5-methyl-isoxazol-4-carboxy-anilide, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
US4983619A (en) * 1986-08-08 1991-01-08 Lilly Industries Limited Pharmaceutical compounds
EP0378111A1 (en) * 1989-01-09 1990-07-18 ZAMBON GROUP S.p.A. Isoxazole derivatives having anti-serotonin activity, their preparation process and compositions containing them
EP0440503A1 (en) * 1990-02-02 1991-08-07 Syntex (U.S.A.) Inc. 4-Isoxazolecarboxamide derivatives
LT3416B (en) 1990-05-18 1995-09-25 Hoechst Ag Isoxazole-4-carboxamides, hydroxyalkylidene-cyanoacetamides, drugs containing these compounds and method for the preparation of such drugs

Also Published As

Publication number Publication date
BE861503R (fr) 1978-06-05
DE2655009C2 (xx) 1990-03-29
LU78628A1 (xx) 1978-07-11
CA1102341A (en) 1981-06-02
IE46269L (en) 1978-06-04
GB1596383A (en) 1981-08-26
ATA866377A (de) 1980-10-15
IE46269B1 (en) 1983-04-20
JPS5371070A (en) 1978-06-24
AT362366B (de) 1981-05-11
FR2372830B2 (xx) 1980-06-20
FR2372830A2 (fr) 1978-06-30
DK538677A (da) 1978-06-05
IT1126219B (it) 1986-05-14
NL7713151A (nl) 1978-06-06
CH608498A5 (en) 1979-01-15

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