IE46269L - Isoxazole derivatives, process for their manufacture and¹preparations containing these compounds - Google Patents
Isoxazole derivatives, process for their manufacture and¹preparations containing these compoundsInfo
- Publication number
- IE46269L IE46269L IE245277A IE245277A IE46269L IE 46269 L IE46269 L IE 46269L IE 245277 A IE245277 A IE 245277A IE 245277 A IE245277 A IE 245277A IE 46269 L IE46269 L IE 46269L
- Authority
- IE
- Ireland
- Prior art keywords
- formula
- compounds
- nitrogen
- hetero atoms
- manufacture
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Novel 5-methylisoxazole-4-carboxamides of the formula I <IMAGE> are prepared in which R denotes a mono-, di- or trinuclear, unsaturated heterocyclic radical having 3 to 13 carbon atoms and one, two, three or four hetero atoms from the group comprising oxygen, sulphur and nitrogen, where at most one of the hetero atoms is other than nitrogen, in the ring system, which radical is unsubstituted or ring-substituted one, two or three times by C1-C3-alkyl, C1-C3-alkoxy, halogen, nitro, hydroxyl, carboxyl, carbamoyl or oxo, and their physiologically tolerable acid addition salts, by reaction of corresponding carboxylic acid derivatives, namely the corresponding acid halides, esters or anhydrides, with amines of the formula H2N-R. The compounds of the formula I are distinguished in particular by anti-inflammatory, antipyretic and analgesic properties combined with low toxicity and good gastric tolerability.
[GB1596383A]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19762655009 DE2655009A1 (en) | 1976-12-04 | 1976-12-04 | ISOXAZOLE DERIVATIVES, THE PROCESS FOR THEIR MANUFACTURING AND MEANS CONTAINING THESE COMPOUNDS |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE46269L true IE46269L (en) | 1978-06-04 |
| IE46269B1 IE46269B1 (en) | 1983-04-20 |
Family
ID=5994666
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE245277A IE46269B1 (en) | 1976-12-04 | 1977-12-02 | Isoxazole derivatives,process for their manufacture and preparations containing these compounds |
Country Status (13)
| Country | Link |
|---|---|
| JP (1) | JPS5371070A (en) |
| AT (1) | AT362366B (en) |
| BE (1) | BE861503R (en) |
| CA (1) | CA1102341A (en) |
| CH (1) | CH608498A5 (en) |
| DE (1) | DE2655009A1 (en) |
| DK (1) | DK538677A (en) |
| FR (1) | FR2372830A2 (en) |
| GB (1) | GB1596383A (en) |
| IE (1) | IE46269B1 (en) |
| IT (1) | IT1126219B (en) |
| LU (1) | LU78628A1 (en) |
| NL (1) | NL7713151A (en) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1980000964A1 (en) * | 1978-11-03 | 1980-05-15 | American Cyanamid Co | Anti-inflammatory agents including 2-carbonyl-3-hydroxy-2-alkenonitriles |
| EP0035285A3 (en) * | 1979-08-17 | 1981-10-14 | American Cyanamid Company | Novel isoxazole carboxylic acid phenyl esters, pharmaceutical compositions containing certain of said esters, and process for preparing said esters |
| DE2854438A1 (en) * | 1978-12-16 | 1980-07-03 | Hoechst Ag | ISOXAZOLE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, MEANS CONTAINING THESE COMPOUNDS AND THEIR USE |
| DE3247454A1 (en) * | 1982-12-22 | 1984-06-28 | Laboratorios Bago S.A., Buenos Aires | Substituted 3-phenyl-5-methylisoxazole-4-carboxanilides, process for their preparation and pharmaceutical compositions containing these compounds |
| GB8619432D0 (en) * | 1986-08-08 | 1986-09-17 | Lilly Industries Ltd | Pharmaceutical compounds |
| GB8619433D0 (en) * | 1986-08-08 | 1986-09-17 | Lilly Industries Ltd | Pharmaceutical compounds |
| US4935434A (en) * | 1988-01-26 | 1990-06-19 | Bristol-Myers Company | Antiarthritic isoxazole-4-carboxamides |
| IT1228288B (en) * | 1989-01-09 | 1991-06-07 | Zambon Spa | COMPOUNDS WITH ANTI-SEROTONIN ACTIVITY |
| US5001124A (en) * | 1990-02-02 | 1991-03-19 | Syntex (U.S.A.) Inc. | 4-isoxazolecarboxamide derivatives |
| ZA913762B (en) | 1990-05-18 | 1992-01-29 | Hoechst Ag | Isoxazole-4-carboxamides and hydroxyalkylidenecyanoacetamides,pharmaceuticals containing these compounds and their use |
| DK0527736T3 (en) * | 1990-05-18 | 1997-10-20 | Hoechst Ag | Isoxazole-4-carboxylic acid amides and hydroxyalkylidene-cyanoacetamides, drugs containing these compounds and the use of these drugs. |
| US7338956B2 (en) * | 2002-08-07 | 2008-03-04 | Sanofi-Aventis Deutschland Gmbh | Acylamino-substituted heteroaromatic compounds and their use as pharmaceuticals |
| CN103772376B (en) * | 2012-10-24 | 2017-01-11 | 中国医学科学院医药生物技术研究所 | Substituted benzo-1,3-miscellaneous azole compound and preparation method and application thereof |
| WO2015173656A1 (en) * | 2014-05-14 | 2015-11-19 | Novartis Ag | Carboxamide derivatives |
| US9403810B2 (en) * | 2014-05-14 | 2016-08-02 | Novartis Ag | Carboxamide derivatives |
-
1976
- 1976-12-04 DE DE19762655009 patent/DE2655009A1/en active Granted
-
1977
- 1977-11-15 CH CH1393477A patent/CH608498A5/en not_active IP Right Cessation
- 1977-11-29 NL NL7713151A patent/NL7713151A/en not_active Application Discontinuation
- 1977-12-02 IE IE245277A patent/IE46269B1/en unknown
- 1977-12-02 GB GB5034777A patent/GB1596383A/en not_active Expired
- 1977-12-02 IT IT3035277A patent/IT1126219B/en active
- 1977-12-02 LU LU78628A patent/LU78628A1/xx unknown
- 1977-12-02 AT AT866377A patent/AT362366B/en not_active IP Right Cessation
- 1977-12-02 CA CA292,302A patent/CA1102341A/en not_active Expired
- 1977-12-02 DK DK538677A patent/DK538677A/en unknown
- 1977-12-03 JP JP14562277A patent/JPS5371070A/en active Pending
- 1977-12-05 BE BE183170A patent/BE861503R/en not_active IP Right Cessation
- 1977-12-05 FR FR7736547A patent/FR2372830A2/en active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| LU78628A1 (en) | 1978-07-11 |
| IE46269B1 (en) | 1983-04-20 |
| DE2655009C2 (en) | 1990-03-29 |
| FR2372830A2 (en) | 1978-06-30 |
| CA1102341A (en) | 1981-06-02 |
| JPS5371070A (en) | 1978-06-24 |
| ATA866377A (en) | 1980-10-15 |
| DK538677A (en) | 1978-06-05 |
| FR2372830B2 (en) | 1980-06-20 |
| IT1126219B (en) | 1986-05-14 |
| NL7713151A (en) | 1978-06-06 |
| BE861503R (en) | 1978-06-05 |
| GB1596383A (en) | 1981-08-26 |
| AT362366B (en) | 1981-05-11 |
| DE2655009A1 (en) | 1978-06-15 |
| CH608498A5 (en) | 1979-01-15 |
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