IE43583L - 11-oxodibenzoxepinealkanoic acids and esters. - Google Patents
11-oxodibenzoxepinealkanoic acids and esters.Info
- Publication number
- IE43583L IE43583L IE761682A IE168276A IE43583L IE 43583 L IE43583 L IE 43583L IE 761682 A IE761682 A IE 761682A IE 168276 A IE168276 A IE 168276A IE 43583 L IE43583 L IE 43583L
- Authority
- IE
- Ireland
- Prior art keywords
- acids
- alkyl
- esters
- ester
- oxodibenzoxepinealkanoic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
- C07D313/02—Seven-membered rings
- C07D313/06—Seven-membered rings condensed with carbocyclic rings or ring systems
- C07D313/10—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with two six-membered rings
- C07D313/12—[b,e]-condensed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pain & Pain Management (AREA)
- Public Health (AREA)
- Rheumatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyrane Compounds (AREA)
Abstract
6,11-Dihydro-11-oxodibenz[b,e]oxepinealkanoic acids of the formula I, their C1- to C4-alkyl esters and the pharmacologically compatible salts are prepared. An alpha -bromo-2-toluylic ester which is optionally substituted by halogen, C1- to C4-alkoxy, C1- to C4-alkyl or trifluoromethyl is reacted with an alkyl ester of a hydroxyphenylacetic acid. The resulting diester is hydrolysed, cyclised and, where appropriate, converted into the corresponding alkyl ester. The resulting compounds can be used as anti-inflammatory and analgesic agents. <IMAGE>
[GB1560629A]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US60021075A | 1975-07-30 | 1975-07-30 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE43583L true IE43583L (en) | 1977-01-30 |
| IE43583B1 IE43583B1 (en) | 1981-04-08 |
Family
ID=24402733
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE1682/76A IE43583B1 (en) | 1975-07-30 | 1976-07-29 | 6,11-dihydro-11-oxodibenz/b,e/oxepinealkanoic acids and esters |
Country Status (23)
| Country | Link |
|---|---|
| JP (1) | JPS5217487A (en) |
| AT (1) | AT359066B (en) |
| AU (1) | AU512130B2 (en) |
| BE (1) | BE844728A (en) |
| CA (1) | CA1088078A (en) |
| CH (1) | CH627752A5 (en) |
| DE (1) | DE2629569A1 (en) |
| DK (1) | DK342476A (en) |
| ES (1) | ES450125A1 (en) |
| FI (1) | FI63569C (en) |
| FR (1) | FR2319339A1 (en) |
| GB (1) | GB1560629A (en) |
| GR (1) | GR70328B (en) |
| HU (1) | HU178243B (en) |
| IE (1) | IE43583B1 (en) |
| IL (1) | IL50155A (en) |
| LU (1) | LU75491A1 (en) |
| MX (1) | MX3366E (en) |
| NL (1) | NL7608203A (en) |
| NO (1) | NO147561C (en) |
| PT (1) | PT65421B (en) |
| SE (1) | SE426320B (en) |
| ZA (1) | ZA764557B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0159684B1 (en) * | 1984-04-27 | 1989-09-27 | Hoechst-Roussel Pharmaceuticals Incorporated | (6,11-dihydro-11-oxodibenz(b,e)oxepinyl)pentanoic acids and derivatives, a process and intermediates for their preparation and their use as medicaments |
| US5008285A (en) * | 1984-04-27 | 1991-04-16 | Hoechst-Roussel Pharmaceuticals, Inc. | (6,11-dihydro-11-oxodibenz[b,e]oxepin-yl)pentanoic acids and derivatives thereof |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2138257B1 (en) * | 1971-05-21 | 1974-08-23 | Roussel Uclaf | |
| YU204274A (en) * | 1973-07-24 | 1982-06-30 | Hoechst Ag | Process for preparing new dibenzoxepin derivatives |
-
1976
- 1976-07-01 DE DE19762629569 patent/DE2629569A1/en not_active Withdrawn
- 1976-07-21 FR FR7622242A patent/FR2319339A1/en active Granted
- 1976-07-23 NL NL7608203A patent/NL7608203A/en not_active Application Discontinuation
- 1976-07-24 ES ES450125A patent/ES450125A1/en not_active Expired
- 1976-07-27 CH CH961676A patent/CH627752A5/en not_active IP Right Cessation
- 1976-07-28 IL IL50155A patent/IL50155A/en unknown
- 1976-07-28 GR GR51369A patent/GR70328B/el unknown
- 1976-07-28 GB GB31436/76A patent/GB1560629A/en not_active Expired
- 1976-07-28 HU HU76HO1918A patent/HU178243B/en unknown
- 1976-07-28 FI FI762154A patent/FI63569C/en not_active IP Right Cessation
- 1976-07-29 PT PT65421A patent/PT65421B/en unknown
- 1976-07-29 AU AU16363/76A patent/AU512130B2/en not_active Expired
- 1976-07-29 CA CA258,122A patent/CA1088078A/en not_active Expired
- 1976-07-29 MX MX002107U patent/MX3366E/en unknown
- 1976-07-29 ZA ZA764557A patent/ZA764557B/en unknown
- 1976-07-29 SE SE7608546A patent/SE426320B/en unknown
- 1976-07-29 LU LU75491A patent/LU75491A1/xx unknown
- 1976-07-29 NO NO762647A patent/NO147561C/en unknown
- 1976-07-29 AT AT559976A patent/AT359066B/en not_active IP Right Cessation
- 1976-07-29 IE IE1682/76A patent/IE43583B1/en unknown
- 1976-07-29 DK DK342476A patent/DK342476A/en not_active Application Discontinuation
- 1976-07-30 JP JP51090428A patent/JPS5217487A/en active Pending
- 1976-07-30 BE BE169420A patent/BE844728A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IE43583B1 (en) | 1981-04-08 |
| PT65421B (en) | 1978-04-05 |
| SE426320B (en) | 1982-12-27 |
| IL50155A (en) | 1979-12-30 |
| LU75491A1 (en) | 1977-04-15 |
| JPS5217487A (en) | 1977-02-09 |
| MX3366E (en) | 1980-10-15 |
| FR2319339B1 (en) | 1978-11-17 |
| FR2319339A1 (en) | 1977-02-25 |
| DE2629569A1 (en) | 1977-03-31 |
| FI63569B (en) | 1983-03-31 |
| SE7608546L (en) | 1977-01-31 |
| AT359066B (en) | 1980-10-27 |
| CA1088078A (en) | 1980-10-21 |
| HU178243B (en) | 1982-04-28 |
| FI762154A (en) | 1977-01-31 |
| NO147561C (en) | 1983-05-04 |
| CH627752A5 (en) | 1982-01-29 |
| GB1560629A (en) | 1980-02-06 |
| PT65421A (en) | 1976-08-01 |
| NO147561B (en) | 1983-01-24 |
| ES450125A1 (en) | 1977-09-16 |
| IL50155A0 (en) | 1976-09-30 |
| GR70328B (en) | 1982-09-15 |
| FI63569C (en) | 1983-07-11 |
| NL7608203A (en) | 1977-02-01 |
| BE844728A (en) | 1977-01-31 |
| DK342476A (en) | 1977-01-31 |
| ZA764557B (en) | 1977-07-27 |
| NO762647L (en) | 1977-02-01 |
| AU512130B2 (en) | 1980-09-25 |
| AU1636376A (en) | 1978-02-02 |
| ATA559976A (en) | 1980-03-15 |
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