DE2644820A1 - Cancerostatisch und immunstimulierend wirkende 1-(n-acyl-carbamoyl)-2-cyanaziridine sowie verfahren zur herstellung derselben - Google Patents

Cancerostatisch und immunstimulierend wirkende 1-(n-acyl-carbamoyl)-2-cyanaziridine sowie verfahren zur herstellung derselben

Info

Publication number
DE2644820A1
DE2644820A1 DE19762644820 DE2644820A DE2644820A1 DE 2644820 A1 DE2644820 A1 DE 2644820A1 DE 19762644820 DE19762644820 DE 19762644820 DE 2644820 A DE2644820 A DE 2644820A DE 2644820 A1 DE2644820 A1 DE 2644820A1
Authority
DE
Germany
Prior art keywords
group
carbamoyl
formula
halogen
alkoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE19762644820
Other languages
German (de)
English (en)
Inventor
Herbert Dr Phil Berger
Uwe Dr Rer Nat Bicker
Rudi Dr Phil Gall
Gottfried Dr Med Hebold
Wolfgang Dr Rer Nat Kampe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics GmbH
Original Assignee
Boehringer Mannheim GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim GmbH filed Critical Boehringer Mannheim GmbH
Priority to DE19762644820 priority Critical patent/DE2644820A1/de
Priority to CA287,572A priority patent/CA1092606A/fr
Priority to CS776290A priority patent/CS199711B2/cs
Priority to US05/838,426 priority patent/US4282212A/en
Priority to PT67108A priority patent/PT67108B/pt
Priority to GB40926/77A priority patent/GB1547513A/en
Priority to LU7778237A priority patent/LU78237A1/xx
Priority to NL7710790A priority patent/NL7710790A/xx
Priority to NZ185319A priority patent/NZ185319A/xx
Priority to DD7700201316A priority patent/DD131927A5/xx
Priority to IT28225/77A priority patent/IT1087759B/it
Priority to ES462890A priority patent/ES462890A1/es
Priority to AT706577A priority patent/AT356129B/de
Priority to NO773377A priority patent/NO773377L/no
Priority to DK438177A priority patent/DK438177A/da
Priority to BE181441A priority patent/BE859355A/fr
Priority to FI772924A priority patent/FI772924A/fi
Priority to IE2023/77A priority patent/IE45782B1/en
Priority to PL1977201285A priority patent/PL110162B1/pl
Priority to AU29314/77A priority patent/AU2931477A/en
Priority to SE7711093A priority patent/SE7711093L/xx
Priority to ZA00775904A priority patent/ZA775904B/xx
Priority to FR7729924A priority patent/FR2367062A1/fr
Priority to AR269465A priority patent/AR217085A1/es
Priority to JP11989577A priority patent/JPS5350153A/ja
Priority to OA56292A priority patent/OA05778A/fr
Publication of DE2644820A1 publication Critical patent/DE2644820A1/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D203/00—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D203/04—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D203/06—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D203/16—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with acylated ring nitrogen atoms
    • C07D203/20—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with acylated ring nitrogen atoms by carbonic acid, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D203/00—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D203/04—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D203/06—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D203/00—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D203/04—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D203/06—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D203/22—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
    • C07D203/24—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/564—Three-membered rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE19762644820 1976-10-05 1976-10-05 Cancerostatisch und immunstimulierend wirkende 1-(n-acyl-carbamoyl)-2-cyanaziridine sowie verfahren zur herstellung derselben Withdrawn DE2644820A1 (de)

Priority Applications (26)

Application Number Priority Date Filing Date Title
DE19762644820 DE2644820A1 (de) 1976-10-05 1976-10-05 Cancerostatisch und immunstimulierend wirkende 1-(n-acyl-carbamoyl)-2-cyanaziridine sowie verfahren zur herstellung derselben
CA287,572A CA1092606A (fr) 1976-10-05 1977-09-27 1-(n-acylcarbamoyl)-2-cyano-aziridines et procede de preparation
CS776290A CS199711B2 (en) 1976-10-05 1977-09-28 Method of producing 1-/n-acylcarbamoyl/-2-cyanaziridines
US05/838,426 US4282212A (en) 1976-10-05 1977-09-30 Immune-stimulating 1-(N-acylcarbamoyl)-2-cyanoaziridines
PT67108A PT67108B (de) 1976-10-05 1977-10-03 Cancerostatisch und immunstimulierend wirkende 1-(n-acyl-carbamoil)-2-cyanaziridine sowie verfahren zur herstellung derselben
GB40926/77A GB1547513A (en) 1976-10-05 1977-10-03 1-(n-acylcarbamoyl)-2-cyanoaziridines
LU7778237A LU78237A1 (fr) 1976-10-05 1977-10-03
NL7710790A NL7710790A (nl) 1976-10-05 1977-10-03 Werkwijze ter bereiding van cancerostatisch en immunostimulerend werkende 1-(n-acylcarbamoyl)- -2-cyanaziridinen.
NZ185319A NZ185319A (en) 1976-10-05 1977-10-03 1-(n-acylcarbamoyl)-2-cyanoaziridines and pharmaceutical compositions
DD7700201316A DD131927A5 (de) 1976-10-05 1977-10-03 Verfahren zur herstellung cancerostatisch und immunstimulierend wirkender 1-(n-acyl-carbamoyl)-2-cyanaziridine
IT28225/77A IT1087759B (it) 1976-10-05 1977-10-03 1-(n-acil-carbamoil)-2-cianaziridin e con attivita' cancerostatica e immunostimolante e processi per la loro preparazione
ES462890A ES462890A1 (es) 1976-10-05 1977-10-04 Procedimiento para la preparacion de 1-(n-acil-carbamoil)-2-cianazi-ridinas con efecto cancerostatico y estimulador de inmunidad.
AT706577A AT356129B (de) 1976-10-05 1977-10-04 Verfahren zur herstellung von substituierten 1-carbamoyl-2-cyanaziridinen
NO773377A NO773377L (no) 1976-10-05 1977-10-04 Fremgangsmaate ved fremstilling av 1-(n-acyl-carbamoyl)-2-cyanaziridiner
DK438177A DK438177A (da) 1976-10-05 1977-10-04 Cancerostatisk og immunstimulerende 1-(n-acylcarbamoyl)-2-cyanaziridiner samt fremgangsmaade til deres fremstilling
BE181441A BE859355A (fr) 1976-10-05 1977-10-04 1-(n-acyl-carbamoyl)-2-cyanaziridines a action oncostatique et immuno-stimulatrice et procedes pour leur preparation
FI772924A FI772924A (fi) 1976-10-05 1977-10-04 Foerfarande foer framstaellning av 1-(n-acylkarbomoyl)-2-cyanaziridiner med cancerostatisk och immunstimulerande verkan
IE2023/77A IE45782B1 (en) 1976-10-05 1977-10-04 1-(n-acylcarbamoyl)-2-cyanoziridines
PL1977201285A PL110162B1 (en) 1976-10-05 1977-10-04 Method of producing new 1-/n-acylocarbamylo/-2-cyanoazyridins
AU29314/77A AU2931477A (en) 1976-10-05 1977-10-04 1(n-acylcarbamoyl)-2-cyanoaziridines
SE7711093A SE7711093L (sv) 1976-10-05 1977-10-04 1-(n-acyl-karbamoyl)-2-cyanaziridiner
ZA00775904A ZA775904B (en) 1976-10-05 1977-10-04 New 1-(n-acylcarbamoyl)-2-cyanoaziridines and the preparation thereof
FR7729924A FR2367062A1 (fr) 1976-10-05 1977-10-05 Derives 1-(n-acylcarbamoyl) 2-cyano-aziridines ayant une action cancerostatique et immunostimulatrice et procede pour leur preparation
AR269465A AR217085A1 (es) 1976-10-05 1977-10-05 Procedimiento para preparar 1-(n-acil-carbamoil)-2-cianaziridinas
JP11989577A JPS5350153A (en) 1976-10-05 1977-10-05 Production of 11*nnacyll carbamoyl**22cyanaziridine and pharmaceutical agent containing same with antii cancer and immune stimulating action
OA56292A OA05778A (fr) 1976-10-05 1977-10-05 Procédé de préparation de dérivés l-(N-acylcarbamoyl) 2-cyano-aziridines.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19762644820 DE2644820A1 (de) 1976-10-05 1976-10-05 Cancerostatisch und immunstimulierend wirkende 1-(n-acyl-carbamoyl)-2-cyanaziridine sowie verfahren zur herstellung derselben

Publications (1)

Publication Number Publication Date
DE2644820A1 true DE2644820A1 (de) 1978-04-06

Family

ID=5989674

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19762644820 Withdrawn DE2644820A1 (de) 1976-10-05 1976-10-05 Cancerostatisch und immunstimulierend wirkende 1-(n-acyl-carbamoyl)-2-cyanaziridine sowie verfahren zur herstellung derselben

Country Status (4)

Country Link
BE (1) BE859355A (fr)
DE (1) DE2644820A1 (fr)
LU (1) LU78237A1 (fr)
ZA (1) ZA775904B (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2399840A1 (fr) * 1977-08-12 1979-03-09 Boehringer Mannheim Gmbh Application de la 2-cyano-aziridine et de ses derives a l'immunostimulation
EP0014976A1 (fr) * 1979-02-21 1980-09-03 Roche Diagnostics GmbH 2-Cyanaziridines N-substituées, procédés pour leur préparation et médicaments les contenant ainsi que les aziridines-2-carbonamides substituées correspondantes et leur préparation
US4376731A (en) * 1978-01-31 1983-03-15 Boehringer Mannheim Gmbh 1-Aziridine carboxylic acid derivatives with immunostimulant activity
US4935413A (en) * 1984-07-03 1990-06-19 Nippon Paint Co., Ltd. Carbamate physical property-improving reagent

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2399840A1 (fr) * 1977-08-12 1979-03-09 Boehringer Mannheim Gmbh Application de la 2-cyano-aziridine et de ses derives a l'immunostimulation
US4376731A (en) * 1978-01-31 1983-03-15 Boehringer Mannheim Gmbh 1-Aziridine carboxylic acid derivatives with immunostimulant activity
EP0014976A1 (fr) * 1979-02-21 1980-09-03 Roche Diagnostics GmbH 2-Cyanaziridines N-substituées, procédés pour leur préparation et médicaments les contenant ainsi que les aziridines-2-carbonamides substituées correspondantes et leur préparation
US4935413A (en) * 1984-07-03 1990-06-19 Nippon Paint Co., Ltd. Carbamate physical property-improving reagent
US5354495A (en) * 1984-07-03 1994-10-11 Nippon Paint Co., Ltd. Alkenoylcarbamate compounds as elasticity, adhesion, and dispersibility enhancer

Also Published As

Publication number Publication date
ZA775904B (en) 1978-06-28
BE859355A (fr) 1978-04-04
LU78237A1 (fr) 1979-02-02

Similar Documents

Publication Publication Date Title
DE1595915C3 (de) Pyrrolidinderivate
DE1185180B (de) Verfahren zur Herstellung von Benzolsulfonylharnstoffen
DE2634288B2 (fr)
EP0003056B1 (fr) Acides oméga-aminoalcanoyl-oméga-aminoalcanecarboxyliques N-substitués, leur utilisation et procédé pour leur préparation ainsi que médicaments contenant ces composés
DE2731264A1 (de) Neue 1-acyl-2-cyanaziridine, verfahren zu deren herstellung und diese verbindungen enthaltende pharmazeutische zubereitungen
EP0028765A1 (fr) Dérivés de l'alkylurée pour le traitement des maladies du métabolisme des graisses; procédé pour leur préparation, leur application dans des médicaments pour le traitement des altérations du métabolisme des graisses, médicaments les contenant, procédé pour leur préparation, ainsi que quelques dérivés de l'alkylurée
DE1518874C3 (de) Benzolsulfonylharnstoffe und Verfahren zu ihrer Herstellung
DE1493672C3 (de) Verfahren zur Herstellung von Benzolsulfonylharnstoffen
DE2362754A1 (de) Cyclopropylmethylamine, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
DE2644820A1 (de) Cancerostatisch und immunstimulierend wirkende 1-(n-acyl-carbamoyl)-2-cyanaziridine sowie verfahren zur herstellung derselben
DE2515146A1 (de) Carbonsaeureamide, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
DE10224892A1 (de) Substituierte Thiophene, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE1181208B (de) Verfahren zur Herstellung von N-Benzolsulfonyl-N'-cyclohexyl-harnstoffen
EP0211157A1 (fr) Derivés d'isoxazole, procédé de préparation et préparations pharmaceutiques les contenant
DE2157607C3 (de) Sulfonylharnstoffe, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Präparate
DE2727550A1 (de) Cancerostatisch und immunstimulierend wirkende 1-(n-acyl-carbamoyl)- 2-cyanaziridine sowie verfahren zur herstellung derselben
DE2022694B2 (de) alpha-(3,4-Dihydro-4-oxo-1 H-2,3benzothiazin-S-dioxyd-3-yl)-N,N-dimethylacetamid und Verfahren zur Herstellung desselben
DE2745280A1 (de) Tricyclische verbindungen
AT238215B (de) Verfahren zur Herstellung von neuen Benzolsulfonylharnstoffen
EP0007643A1 (fr) Dérivés de l'oxadiazolotriazine
CH374984A (de) Verfahren zur Herstellung von Benzolsulfonylharnstoffen
AT330745B (de) Verfahren zur herstellung von neuen 4- aminophenoxy- oder 4- aminophenylthio- 3-amino-5-sulfamoyl-benzoesauren sowie deren niederalkylestern und salzen
AT332881B (de) Verfahren zur herstellung des neuen n-(4-(beta- (2-methoxy-5-chlor-benzamido) -athyl)-benzolsulfonyl) -n'-cyclopentylharnstoffs und seiner salze
DE844897C (de) Verfahren zur Herstellung von Diamidinderivaten
AT345274B (de) Verfahren zur herstellung von neuen aromatischen dicarbonsaeureimiden und ihren salzen

Legal Events

Date Code Title Description
8139 Disposal/non-payment of the annual fee