DE2627190A1 - Neue fuenfring-verbindungen, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzungen - Google Patents
Neue fuenfring-verbindungen, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzungenInfo
- Publication number
- DE2627190A1 DE2627190A1 DE19762627190 DE2627190A DE2627190A1 DE 2627190 A1 DE2627190 A1 DE 2627190A1 DE 19762627190 DE19762627190 DE 19762627190 DE 2627190 A DE2627190 A DE 2627190A DE 2627190 A1 DE2627190 A1 DE 2627190A1
- Authority
- DE
- Germany
- Prior art keywords
- added
- solution
- mixture
- indolo
- quinolizine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
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- 150000003839 salts Chemical class 0.000 claims description 30
- 239000002253 acid Substances 0.000 claims description 9
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 9
- 239000004480 active ingredient Substances 0.000 claims description 6
- -1 halogen radical Chemical class 0.000 claims description 6
- 238000006243 chemical reaction Methods 0.000 claims description 5
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- CBOIHMRHGLHBPB-UHFFFAOYSA-N hydroxymethyl Chemical compound O[CH2] CBOIHMRHGLHBPB-UHFFFAOYSA-N 0.000 claims description 3
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- BAZAXWOYCMUHIX-UHFFFAOYSA-M sodium perchlorate Chemical compound [Na+].[O-]Cl(=O)(=O)=O BAZAXWOYCMUHIX-UHFFFAOYSA-M 0.000 description 9
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- JIAARYAFYJHUJI-UHFFFAOYSA-L zinc dichloride Chemical compound [Cl-].[Cl-].[Zn+2] JIAARYAFYJHUJI-UHFFFAOYSA-L 0.000 description 6
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- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 3
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- 150000002895 organic esters Chemical class 0.000 description 1
- MUMZUERVLWJKNR-UHFFFAOYSA-N oxoplatinum Chemical compound [Pt]=O MUMZUERVLWJKNR-UHFFFAOYSA-N 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052763 palladium Inorganic materials 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
- 230000010412 perfusion Effects 0.000 description 1
- 239000008177 pharmaceutical agent Substances 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 229940067157 phenylhydrazine Drugs 0.000 description 1
- 238000000053 physical method Methods 0.000 description 1
- 238000011197 physicochemical method Methods 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 229910003446 platinum oxide Inorganic materials 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- OVARTBFNCCXQKS-UHFFFAOYSA-N propan-2-one;hydrate Chemical compound O.CC(C)=O OVARTBFNCCXQKS-UHFFFAOYSA-N 0.000 description 1
- 150000003856 quaternary ammonium compounds Chemical class 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- 238000007363 ring formation reaction Methods 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- 235000012239 silicon dioxide Nutrition 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 239000008247 solid mixture Substances 0.000 description 1
- 239000012265 solid product Substances 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 238000003892 spreading Methods 0.000 description 1
- 230000007480 spreading Effects 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008223 sterile water Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 229940095064 tartrate Drugs 0.000 description 1
- 238000004809 thin layer chromatography Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 229940005605 valeric acid Drugs 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 229960002726 vincamine Drugs 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D211/74—Oxygen atoms
- C07D211/76—Oxygen atoms attached in position 2 or 6
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7519960A FR2315277A1 (fr) | 1975-06-25 | 1975-06-25 | Nouveaux derives pentacycliques, leur preparation et les compositions qui les contiennent |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE2627190A1 true DE2627190A1 (de) | 1977-01-20 |
Family
ID=9157046
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19762627190 Ceased DE2627190A1 (de) | 1975-06-25 | 1976-06-16 | Neue fuenfring-verbindungen, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzungen |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US4138489A (cg-RX-API-DMAC7.html) |
| JP (1) | JPS6039679B2 (cg-RX-API-DMAC7.html) |
| AU (1) | AU496905B2 (cg-RX-API-DMAC7.html) |
| BE (1) | BE843215A (cg-RX-API-DMAC7.html) |
| CH (1) | CH616425A5 (cg-RX-API-DMAC7.html) |
| DE (1) | DE2627190A1 (cg-RX-API-DMAC7.html) |
| DK (1) | DK285576A (cg-RX-API-DMAC7.html) |
| ES (1) | ES449209A1 (cg-RX-API-DMAC7.html) |
| FR (1) | FR2315277A1 (cg-RX-API-DMAC7.html) |
| GB (1) | GB1543807A (cg-RX-API-DMAC7.html) |
| HU (1) | HU174882B (cg-RX-API-DMAC7.html) |
| IE (1) | IE43138B1 (cg-RX-API-DMAC7.html) |
| IL (1) | IL49864A0 (cg-RX-API-DMAC7.html) |
| LU (1) | LU75242A1 (cg-RX-API-DMAC7.html) |
| NL (1) | NL7606884A (cg-RX-API-DMAC7.html) |
| SE (1) | SE420730B (cg-RX-API-DMAC7.html) |
| ZA (1) | ZA763779B (cg-RX-API-DMAC7.html) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA786426B (en) * | 1977-11-25 | 1979-10-31 | Scras | New indulo(2,3-a)quinolizidines,preparation and therapeutic use |
| US4428877A (en) | 1978-07-12 | 1984-01-31 | Richter Gedeon Vegyeszeti Gyar Rt. | Cis-10-bromo-E-homoeburnanes |
| IT1248881B (it) * | 1989-06-21 | 1995-01-30 | Richter Gedeon Vegyeszet | Derivati diesteri di ottaidro-indolo/2,3-a/tetraidropiramil/2,3-c/ chinolizina racemici ed otticamente attivi e procedimento per la loro preparazione |
| ITRM20010356A1 (it) * | 2001-06-21 | 2002-12-23 | Sigma Tau Ind Farmaceuti | "5-alogeno derivati della triptamina utili come ligandi del recettore5-ht6 e/o 5-ht7 della serotonina. |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3536725A (en) * | 1967-11-22 | 1970-10-27 | Miles Lab | Cyanoethylated derivatives of 2,3,4,6,7,12-hexahydroindolo(2,3-alpha)-quinolizine |
| FR2168853B1 (cg-RX-API-DMAC7.html) * | 1972-01-24 | 1975-04-25 | Centre Etd Ind Pharma |
-
1975
- 1975-06-25 FR FR7519960A patent/FR2315277A1/fr active Granted
-
1976
- 1976-06-14 CH CH751576A patent/CH616425A5/fr not_active IP Right Cessation
- 1976-06-16 DE DE19762627190 patent/DE2627190A1/de not_active Ceased
- 1976-06-21 BE BE168153A patent/BE843215A/xx not_active IP Right Cessation
- 1976-06-21 IE IE1337/76A patent/IE43138B1/en unknown
- 1976-06-22 IL IL49864A patent/IL49864A0/xx unknown
- 1976-06-23 GB GB26130/76A patent/GB1543807A/en not_active Expired
- 1976-06-23 SE SE7607231A patent/SE420730B/xx unknown
- 1976-06-24 HU HU76AE468A patent/HU174882B/hu unknown
- 1976-06-24 ZA ZA763779A patent/ZA763779B/xx unknown
- 1976-06-24 AU AU15236/76A patent/AU496905B2/en not_active Expired
- 1976-06-24 DK DK285576A patent/DK285576A/da not_active Application Discontinuation
- 1976-06-24 NL NL7606884A patent/NL7606884A/xx not_active Application Discontinuation
- 1976-06-25 US US05/700,028 patent/US4138489A/en not_active Expired - Lifetime
- 1976-06-25 ES ES449209A patent/ES449209A1/es not_active Expired
- 1976-06-25 LU LU75242A patent/LU75242A1/xx unknown
- 1976-06-25 JP JP51074537A patent/JPS6039679B2/ja not_active Expired
Non-Patent Citations (5)
| Title |
|---|
| Bull.Soc.Chim. 7, 1973, S. 2705-2709 * |
| Forth, W. - Henschler, D. - Rummel, W.: Pharmakologie und Toxikologie, 4. Aufl., S. 259, 517 * |
| Fülgraff, G. - Palm, D.: Pharmakotherapie, 3. Aufl., 1979, S. 107-109 * |
| J.Chem.Soc. Perkin Trans, 72, S. 2776-2787 * |
| J.Chem.Soc., 1969, S. 799 * |
Also Published As
| Publication number | Publication date |
|---|---|
| LU75242A1 (cg-RX-API-DMAC7.html) | 1978-01-18 |
| GB1543807A (en) | 1979-04-04 |
| US4138489A (en) | 1979-02-06 |
| JPS6039679B2 (ja) | 1985-09-06 |
| NL7606884A (nl) | 1976-12-28 |
| FR2315277B1 (cg-RX-API-DMAC7.html) | 1979-08-10 |
| FR2315277A1 (fr) | 1977-01-21 |
| BE843215A (fr) | 1976-12-21 |
| AU1523676A (en) | 1978-01-05 |
| CH616425A5 (cg-RX-API-DMAC7.html) | 1980-03-31 |
| HU174882B (hu) | 1980-04-28 |
| DK285576A (da) | 1976-12-26 |
| IE43138B1 (en) | 1980-12-31 |
| SE7607231L (sv) | 1976-12-26 |
| ES449209A1 (es) | 1977-07-16 |
| AU496905B2 (en) | 1978-11-09 |
| SE420730B (sv) | 1981-10-26 |
| IL49864A0 (en) | 1976-08-31 |
| JPS5217488A (en) | 1977-02-09 |
| ZA763779B (en) | 1977-06-29 |
| IE43138L (en) | 1976-12-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8110 | Request for examination paragraph 44 | ||
| 8131 | Rejection |