DE2617592C3 - 2- [4-(3-Oxo- oder Hydroxy-alkyD-phenyl] -alkansäuren und deren nicht toxische Salze, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Zusammensetzungen - Google Patents

2- [4-(3-Oxo- oder Hydroxy-alkyD-phenyl] -alkansäuren und deren nicht toxische Salze, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Zusammensetzungen

Info

Publication number
DE2617592C3
DE2617592C3 DE2617592A DE2617592A DE2617592C3 DE 2617592 C3 DE2617592 C3 DE 2617592C3 DE 2617592 A DE2617592 A DE 2617592A DE 2617592 A DE2617592 A DE 2617592A DE 2617592 C3 DE2617592 C3 DE 2617592C3
Authority
DE
Germany
Prior art keywords
phenyl
methyl
oxo
ethyl
toxic salts
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE2617592A
Other languages
German (de)
English (en)
Other versions
DE2617592A1 (de
DE2617592B2 (de
Inventor
Yukitaka Hamatani
Kyoko Hongo
Masashi Imamura
Takuya Uozu Kodama
Koji Kanazawa Ishikawa Miura
Yasuyuki Suzuki
Noboru Takagawa
Kenjun Nyuzen Takeshima
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Toyama Chemical Co Ltd
Original Assignee
Toyama Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toyama Chemical Co Ltd filed Critical Toyama Chemical Co Ltd
Publication of DE2617592A1 publication Critical patent/DE2617592A1/de
Publication of DE2617592B2 publication Critical patent/DE2617592B2/de
Application granted granted Critical
Publication of DE2617592C3 publication Critical patent/DE2617592C3/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/56—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds
    • C07C45/57—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom
    • C07C45/58—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom in three-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/46—Friedel-Crafts reactions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/56—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds
    • C07C45/57—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom
    • C07C45/59—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom in five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/16—Preparation of carboxylic acids or their salts, halides or anhydrides by oxidation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
    • C07C59/48—Unsaturated compounds containing hydroxy or O-metal groups containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/76—Unsaturated compounds containing keto groups
    • C07C59/84—Unsaturated compounds containing keto groups containing six membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/48—Compounds containing oxirane rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE2617592A 1975-04-23 1976-04-22 2- [4-(3-Oxo- oder Hydroxy-alkyD-phenyl] -alkansäuren und deren nicht toxische Salze, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Zusammensetzungen Expired DE2617592C3 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP50048593A JPS51127041A (en) 1975-04-23 1975-04-23 A process for preparing novel 2-( substituted phenyl) alkane acids and their salts.

Publications (3)

Publication Number Publication Date
DE2617592A1 DE2617592A1 (de) 1976-11-11
DE2617592B2 DE2617592B2 (de) 1977-12-01
DE2617592C3 true DE2617592C3 (de) 1978-07-20

Family

ID=12807693

Family Applications (1)

Application Number Title Priority Date Filing Date
DE2617592A Expired DE2617592C3 (de) 1975-04-23 1976-04-22 2- [4-(3-Oxo- oder Hydroxy-alkyD-phenyl] -alkansäuren und deren nicht toxische Salze, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Zusammensetzungen

Country Status (5)

Country Link
US (1) US4092350A (enExample)
JP (1) JPS51127041A (enExample)
DE (1) DE2617592C3 (enExample)
FR (1) FR2308358A1 (enExample)
GB (1) GB1510042A (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH669523A5 (enExample) * 1986-06-25 1989-03-31 Mepha Ag
US5179124A (en) * 1988-01-25 1993-01-12 University Of Iowa Research Foundation Anti-inflammatory for use in external and internal eye inflammations
JP5770621B2 (ja) * 2011-12-27 2015-08-26 株式会社Ｌｔｔバイオファーマ ２−フルオロフェニルプロピオン酸誘導体

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3054779A (en) * 1959-03-24 1962-09-18 Dow Chemical Co Para hydroxy alkyl aromatic carboxylic acids and polymers thereof
US3452079A (en) * 1964-06-15 1969-06-24 Merck & Co Inc Acetic acid type compounds
US3457300A (en) * 1965-06-11 1969-07-22 Merck & Co Inc Acetic acid type compounds
US3880916A (en) * 1969-09-17 1975-04-29 Ciba Geigy Corp Cycloaliphatic acids
JPS5037183B2 (enExample) * 1973-01-29 1975-12-01
US3888920A (en) * 1973-08-06 1975-06-10 Sandoz Ag Aryl substituted-4-alkenoic acids

Also Published As

Publication number Publication date
GB1510042A (en) 1978-05-10
DE2617592A1 (de) 1976-11-11
FR2308358A1 (fr) 1976-11-19
JPS5642575B2 (enExample) 1981-10-06
US4092350A (en) 1978-05-30
JPS51127041A (en) 1976-11-05
FR2308358B1 (enExample) 1979-06-29
DE2617592B2 (de) 1977-12-01

Similar Documents

Publication Publication Date Title
DE2414680C2 (de) Substituierte 2-Furancarbonsäuren und 2-Furancarbonsäureester, Verfahren zu ihrer Herstellung und Arzneimittel, die diese Verbindungen enthalten
DE2244324C2 (de) 3-Benzoylpropionsäuren mit dreifach substituiertem Benzylrest, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
DE2549783C3 (de) Triglyceride mit entzündungshemmender Wirkung
EP0010156B1 (de) 6-Arylpyridazin-3-one, diese enthaltende pharmazeutische Zubereitungen und Verfahren zu ihrer Herstellung
EP0029247A1 (de) Alkenyl-thienyl-alkancarbonsäuren und ihre Derivate, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel
DE2714129A1 (de) Prostaglandinderivate, verfahren zu deren herstellung und deren verwendung
DE2617592C3 (de) 2- [4-(3-Oxo- oder Hydroxy-alkyD-phenyl] -alkansäuren und deren nicht toxische Salze, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Zusammensetzungen
DE3021169C2 (de) Pivaloyloxymethyl-2-propylpentanoat, Verfahren zu seiner Herstellung und diese Verbindung enthaltende Arzneimittel
DE2723051A1 (de) N-(acyl)-p-amino-n'-(monosubstit.)- benzamide sowie diese enthaltende arzneimittel
DE3880561T2 (de) Actinoninderivate mit physiologischen Aktivitäten.
DE2434929C2 (de) p-Acetylaminophenolester von Phenylsalicylsäuren, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
DD154816B3 (de) Verfahren zur herstellung neuer pyridine
DE2818351A1 (de) Benzoesaeurederivate, verfahren zu ihrer herstellung und ihre therapeutische verwendung
EP0313935B1 (de) Enolether von 6-Chlor-4-hydroxy-2-methyl-N-(2-pyridyl)-2H-thieno(2,3-e)-1,2-thiazin-3-carbonsäureamid-1,1-dioxid, ein Verfahren zu ihrer Herstellung sowie ihre Verwendung
DE2500808B2 (de) 4-cyclopropylmethylenoxy-3-chlorphenylessigsaeure und ihre salze, verfahren zu deren herstellung sowie diese enthaltende arzneimittel
DE2431561A1 (de) Cycloalkylphenoxycarbonsaeuren, verfahren zu ihrer herstellung und arzneimittel
DE3239189A1 (de) Zur verwendung als arzneimittel bestimmte derivate der 4-phenyl-4-oxo-2-butensaeure und diese enthaltende zusammensetzungen
DE2237832A1 (de) Verfahren zur herstellung von 4hydroxymethyl-1-keto-1,2-dihydrophthalazin
DE2727629C2 (de) 1-p-Chlorbenzoyl-5-methoxy-2-methyl- 3-indolyl-essigsäure-2'-phenyl-2'-carbonsäureäthylester, Verfahren zu seiner Herstellung und pharmazeutische Mittel
DE2428200A1 (de) Essigsaeurederivate, verfahren zu deren herstellung und diese derivate enthaltende arzneimittel
DE2526089B2 (de) Sauerstoff-heterocyclische Essigsäuren, Verfahren zur Herstellung derselben und diese Verbindungen enthaltende Arzneimittel
DE2412388A1 (de) Dibenzothiophenderivate, verfahren zu deren herstellung und sie enthaltende arzneimittel
DE3028776A1 (de) Neue 1,3-diphenoxypropan-2-on-derivate sowie verfahren zu ihrer herstellung und diese enthaltende arzneimittel
DE1941933C3 (de) Basisch substituierte 10,11- Dihydro-5,10-endoxa-SH-dibenzo- [a,d] -cycloheptene und deren pharmakologisch verträgliche Säureadditionssalze, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
DE3043712C2 (de) Arylalkansäure-phthalidylester, Verfahren zu ihrer Herstellung und solche Ester enthaltende Arzneimittel

Legal Events

Date Code Title Description
C3 Grant after two publication steps (3rd publication)
8339 Ceased/non-payment of the annual fee