FR2308358A1 - Nouvel acide ((oxo- ou hydroxy-3-alcoyl)-4-phenyl)-2-alcanoique et sel non toxique de celui-ci, procede de production de cet acide, composition pharmaceutique contenant un tel compose et methode pour traiter les symptomes d'inflammation et douleur - Google Patents

Nouvel acide ((oxo- ou hydroxy-3-alcoyl)-4-phenyl)-2-alcanoique et sel non toxique de celui-ci, procede de production de cet acide, composition pharmaceutique contenant un tel compose et methode pour traiter les symptomes d'inflammation et douleur

Info

Publication number
FR2308358A1
FR2308358A1 FR7611706A FR7611706A FR2308358A1 FR 2308358 A1 FR2308358 A1 FR 2308358A1 FR 7611706 A FR7611706 A FR 7611706A FR 7611706 A FR7611706 A FR 7611706A FR 2308358 A1 FR2308358 A1 FR 2308358A1
Authority
FR
France
Prior art keywords
acid
alcoyl
oxo
inflammation
pain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7611706A
Other languages
English (en)
French (fr)
Other versions
FR2308358B1 (enExample
Inventor
Koji Miura
Kenjun Takeshima
Takuya Kodama
Masashi Imamura
Kyoko Hongo
Noboru Takagawa
Yukitaka Hamatani
Yasuyuki Suzuki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Toyama Chemical Co Ltd
Original Assignee
Toyama Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toyama Chemical Co Ltd filed Critical Toyama Chemical Co Ltd
Publication of FR2308358A1 publication Critical patent/FR2308358A1/fr
Application granted granted Critical
Publication of FR2308358B1 publication Critical patent/FR2308358B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/56—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds
    • C07C45/57—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom
    • C07C45/58—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom in three-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/46—Friedel-Crafts reactions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/56—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds
    • C07C45/57—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom
    • C07C45/59—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom in five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/16—Preparation of carboxylic acids or their salts, halides or anhydrides by oxidation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
    • C07C59/48—Unsaturated compounds containing hydroxy or O-metal groups containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/76—Unsaturated compounds containing keto groups
    • C07C59/84—Unsaturated compounds containing keto groups containing six membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/48—Compounds containing oxirane rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FR7611706A 1975-04-23 1976-04-21 Nouvel acide ((oxo- ou hydroxy-3-alcoyl)-4-phenyl)-2-alcanoique et sel non toxique de celui-ci, procede de production de cet acide, composition pharmaceutique contenant un tel compose et methode pour traiter les symptomes d'inflammation et douleur Granted FR2308358A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP50048593A JPS51127041A (en) 1975-04-23 1975-04-23 A process for preparing novel 2-( substituted phenyl) alkane acids and their salts.

Publications (2)

Publication Number Publication Date
FR2308358A1 true FR2308358A1 (fr) 1976-11-19
FR2308358B1 FR2308358B1 (enExample) 1979-06-29

Family

ID=12807693

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7611706A Granted FR2308358A1 (fr) 1975-04-23 1976-04-21 Nouvel acide ((oxo- ou hydroxy-3-alcoyl)-4-phenyl)-2-alcanoique et sel non toxique de celui-ci, procede de production de cet acide, composition pharmaceutique contenant un tel compose et methode pour traiter les symptomes d'inflammation et douleur

Country Status (5)

Country Link
US (1) US4092350A (enExample)
JP (1) JPS51127041A (enExample)
DE (1) DE2617592C3 (enExample)
FR (1) FR2308358A1 (enExample)
GB (1) GB1510042A (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH669523A5 (enExample) * 1986-06-25 1989-03-31 Mepha Ag
US5179124A (en) * 1988-01-25 1993-01-12 University Of Iowa Research Foundation Anti-inflammatory for use in external and internal eye inflammations
JP5770621B2 (ja) * 2011-12-27 2015-08-26 株式会社Ｌｔｔバイオファーマ ２−フルオロフェニルプロピオン酸誘導体

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3054779A (en) * 1959-03-24 1962-09-18 Dow Chemical Co Para hydroxy alkyl aromatic carboxylic acids and polymers thereof
US3452079A (en) * 1964-06-15 1969-06-24 Merck & Co Inc Acetic acid type compounds
US3457300A (en) * 1965-06-11 1969-07-22 Merck & Co Inc Acetic acid type compounds
US3880916A (en) * 1969-09-17 1975-04-29 Ciba Geigy Corp Cycloaliphatic acids
JPS5037183B2 (enExample) * 1973-01-29 1975-12-01
US3888920A (en) * 1973-08-06 1975-06-10 Sandoz Ag Aryl substituted-4-alkenoic acids

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
NEANT *

Also Published As

Publication number Publication date
US4092350A (en) 1978-05-30
DE2617592C3 (de) 1978-07-20
DE2617592B2 (de) 1977-12-01
JPS51127041A (en) 1976-11-05
JPS5642575B2 (enExample) 1981-10-06
GB1510042A (en) 1978-05-10
FR2308358B1 (enExample) 1979-06-29
DE2617592A1 (de) 1976-11-11

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Legal Events

Date Code Title Description
ST Notification of lapse