DE2542415A1 - Hoch 82 sr- hoch 82 rb-radioisotop- generator - Google Patents
Hoch 82 sr- hoch 82 rb-radioisotop- generatorInfo
- Publication number
- DE2542415A1 DE2542415A1 DE19752542415 DE2542415A DE2542415A1 DE 2542415 A1 DE2542415 A1 DE 2542415A1 DE 19752542415 DE19752542415 DE 19752542415 DE 2542415 A DE2542415 A DE 2542415A DE 2542415 A1 DE2542415 A1 DE 2542415A1
- Authority
- DE
- Germany
- Prior art keywords
- generator
- column
- radio
- elution
- strontium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000926 separation method Methods 0.000 claims description 10
- 239000000126 substance Substances 0.000 claims description 7
- NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 claims description 4
- 239000003456 ion exchange resin Substances 0.000 claims description 3
- 229920003303 ion-exchange polymer Polymers 0.000 claims description 3
- 229920001577 copolymer Polymers 0.000 claims description 2
- NBZBKCUXIYYUSX-UHFFFAOYSA-N iminodiacetic acid Chemical group OC(=O)CNCC(O)=O NBZBKCUXIYYUSX-UHFFFAOYSA-N 0.000 claims description 2
- 239000011159 matrix material Substances 0.000 claims 1
- 238000010828 elution Methods 0.000 description 14
- 229910052712 strontium Inorganic materials 0.000 description 12
- CIOAGBVUUVVLOB-UHFFFAOYSA-N strontium atom Chemical compound [Sr] CIOAGBVUUVVLOB-UHFFFAOYSA-N 0.000 description 12
- 239000011347 resin Substances 0.000 description 9
- 229920005989 resin Polymers 0.000 description 9
- 239000000243 solution Substances 0.000 description 8
- 239000003480 eluent Substances 0.000 description 5
- 230000000694 effects Effects 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 229910052701 rubidium Inorganic materials 0.000 description 4
- 238000002474 experimental method Methods 0.000 description 3
- IGLNJRXAVVLDKE-UHFFFAOYSA-N rubidium atom Chemical compound [Rb] IGLNJRXAVVLDKE-UHFFFAOYSA-N 0.000 description 3
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 230000002378 acidificating effect Effects 0.000 description 2
- 229910052791 calcium Inorganic materials 0.000 description 2
- 239000011575 calcium Substances 0.000 description 2
- 238000000354 decomposition reaction Methods 0.000 description 2
- 230000014759 maintenance of location Effects 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 238000009206 nuclear medicine Methods 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- USFZMSVCRYTOJT-UHFFFAOYSA-N Ammonium acetate Chemical compound N.CC(O)=O USFZMSVCRYTOJT-UHFFFAOYSA-N 0.000 description 1
- 239000005695 Ammonium acetate Substances 0.000 description 1
- ZOKXTWBITQBERF-UHFFFAOYSA-N Molybdenum Chemical compound [Mo] ZOKXTWBITQBERF-UHFFFAOYSA-N 0.000 description 1
- JBLPUHBAIJVVMG-UHFFFAOYSA-N [Rb].[Sr] Chemical compound [Rb].[Sr] JBLPUHBAIJVVMG-UHFFFAOYSA-N 0.000 description 1
- -1 acetate compound Chemical class 0.000 description 1
- 229910052783 alkali metal Inorganic materials 0.000 description 1
- 229940043376 ammonium acetate Drugs 0.000 description 1
- 235000019257 ammonium acetate Nutrition 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- 239000003729 cation exchange resin Substances 0.000 description 1
- 239000013522 chelant Substances 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000012149 elution buffer Substances 0.000 description 1
- IDGUHHHQCWSQLU-UHFFFAOYSA-N ethanol;hydrate Chemical compound O.CCO IDGUHHHQCWSQLU-UHFFFAOYSA-N 0.000 description 1
- 230000004992 fission Effects 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 229910052750 molybdenum Inorganic materials 0.000 description 1
- 239000011733 molybdenum Substances 0.000 description 1
- 230000002107 myocardial effect Effects 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- 238000010979 pH adjustment Methods 0.000 description 1
- 238000005192 partition Methods 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 230000002285 radioactive effect Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000003252 repetitive effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- G—PHYSICS
- G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
- G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
- G21G1/00—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes
Landscapes
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Engineering & Computer Science (AREA)
- General Engineering & Computer Science (AREA)
- High Energy & Nuclear Physics (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Manufacture And Refinement Of Metals (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US05/509,991 US3953567A (en) | 1974-09-27 | 1974-09-27 | 82 Sr-82 Rb Radioisotope generator |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE2542415A1 true DE2542415A1 (de) | 1976-04-15 |
Family
ID=24028906
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19752542415 Pending DE2542415A1 (de) | 1974-09-27 | 1975-09-23 | Hoch 82 sr- hoch 82 rb-radioisotop- generator |
Country Status (6)
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4276267A (en) * | 1979-10-17 | 1981-06-30 | The United States Of America As Represented By The United States Department Of Energy | Hot cell purification of strontium-82, 85 and other isotopes from proton irradiated molybdenum |
| US4406877A (en) * | 1980-06-04 | 1983-09-27 | E. R. Squibb & Sons, Inc. | 82 Rb Generating method and eluent |
| US4400358A (en) * | 1980-06-25 | 1983-08-23 | E. R. Squibb & Sons, Inc. | Method and adsorbant composition for 82 Rb generation |
| US4597951A (en) | 1984-08-16 | 1986-07-01 | E. R. Squibb & Sons, Inc. | Strontium-82/rubidium-82 generator |
| US5167938A (en) * | 1991-08-14 | 1992-12-01 | United States Department Of Energy | Process for strontium-82 separation |
| US5966583A (en) * | 1998-05-12 | 1999-10-12 | The Regents Of The University Of California | Recovery of strontium activity from a strontium-82/rubidium-82 generator |
| US6908598B2 (en) * | 2001-08-02 | 2005-06-21 | Lynntech, Inc. | Rubidlum-82 generator based on sodium nonatitanate support, and improved separation methods for the recovery of strontium-82 from irradiated targets |
| US7476377B2 (en) * | 2001-08-02 | 2009-01-13 | Lynntech, Inc. | Rubidium-82 generator based on sodium nonatitanate support, and improved separation methods for the recovery of strontium-82 from irradiated targets |
| US6974563B2 (en) * | 2002-06-18 | 2005-12-13 | Lynntech, Inc. | Ion exchange materials for the separation of 90Y from 90SR |
| AU2002368529A1 (en) * | 2002-12-30 | 2004-07-22 | Lynntech, Inc. | Rubidium-82 generator based on sodium nonatitanate support, and separation methods for the recovery of the recovery of strontium-82 from irradiated targets |
| JP4907535B2 (ja) | 2004-08-30 | 2012-03-28 | ブラッコ・ダイアグノスティクス・インコーポレーテッド | 医薬品用、特に放射線同位体生成装置で使用するための容器 |
| EP2328633B1 (en) | 2008-06-11 | 2019-09-18 | Bracco Diagnostics Inc. | Infusion system configurations |
| US8317674B2 (en) | 2008-06-11 | 2012-11-27 | Bracco Diagnostics Inc. | Shielding assemblies for infusion systems |
| ES2883188T3 (es) | 2016-09-20 | 2021-12-07 | Bracco Diagnostics Inc | Conjunto de blindaje para un sistema de administración de radioisótopos que tiene múltiples detectores de radiación |
| EP3776598B1 (en) | 2018-03-28 | 2022-05-04 | Bracco Diagnostics Inc. | Systems and techniques for calibrating radioisotope delivery systems with a gamma detector |
| US11810685B2 (en) | 2018-03-28 | 2023-11-07 | Bracco Diagnostics Inc. | Early detection of radioisotope generator end life |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3554709A (en) * | 1968-06-17 | 1971-01-12 | Atomic Energy Commission | Selective ion-exchange separation of alkali metals |
-
1974
- 1974-09-27 US US05/509,991 patent/US3953567A/en not_active Expired - Lifetime
-
1975
- 1975-09-05 CA CA234,826A patent/CA1057946A/en not_active Expired
- 1975-09-23 DE DE19752542415 patent/DE2542415A1/de active Pending
- 1975-09-25 CH CH1248775A patent/CH591750A5/xx not_active IP Right Cessation
- 1975-09-26 FR FR7529657A patent/FR2286480A1/fr active Granted
- 1975-09-27 JP JP50115992A patent/JPS5160900A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| FR2286480A1 (fr) | 1976-04-23 |
| FR2286480B3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1978-05-12 |
| JPS5160900A (en) | 1976-05-27 |
| US3953567A (en) | 1976-04-27 |
| CH591750A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1977-09-30 |
| CA1057946A (en) | 1979-07-10 |
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