DE2527291C2 - - Google Patents

Info

Publication number
DE2527291C2
DE2527291C2 DE2527291A DE2527291A DE2527291C2 DE 2527291 C2 DE2527291 C2 DE 2527291C2 DE 2527291 A DE2527291 A DE 2527291A DE 2527291 A DE2527291 A DE 2527291A DE 2527291 C2 DE2527291 C2 DE 2527291C2
Authority
DE
Germany
Prior art keywords
compound
methyl
salts
dioxo
cephem
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE2527291A
Other languages
German (de)
English (en)
Other versions
DE2527291A1 (de
Inventor
Marc Dr. Montavon
Roland Dr. Basel Ch Reiner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F HOFFMANN-LA ROCHE and Co AG BASEL CH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F HOFFMANN-LA ROCHE and Co AG BASEL CH filed Critical F HOFFMANN-LA ROCHE and Co AG BASEL CH
Publication of DE2527291A1 publication Critical patent/DE2527291A1/de
Application granted granted Critical
Publication of DE2527291C2 publication Critical patent/DE2527291C2/de
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/553—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms with halogen atoms or nitro radicals directly attached to ring carbon atoms, e.g. fluorouracil
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/56—One oxygen atom and one sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/06—1,2,4-Triazines
    • C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
    • C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D253/075—Two hetero atoms, in positions 3 and 5
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/36—Methylene radicals, substituted by sulfur atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE19752527291 1974-06-21 1975-06-19 Acylderivate Granted DE2527291A1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH853774A CH609989A5 (en) 1974-06-21 1974-06-21 Process for the preparation of acyl derivatives

Publications (2)

Publication Number Publication Date
DE2527291A1 DE2527291A1 (de) 1976-01-08
DE2527291C2 true DE2527291C2 (hu) 1988-01-14

Family

ID=4341690

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19752527291 Granted DE2527291A1 (de) 1974-06-21 1975-06-19 Acylderivate

Country Status (25)

Country Link
JP (1) JPS625917B2 (hu)
AT (1) AT337897B (hu)
AU (1) AU498387B2 (hu)
BE (1) BE830455A (hu)
BR (1) BR7503782A (hu)
CA (1) CA1111021A (hu)
CH (1) CH609989A5 (hu)
CU (1) CU34293A (hu)
DD (1) DD121113A5 (hu)
DE (1) DE2527291A1 (hu)
DK (2) DK153155C (hu)
FI (1) FI751815A (hu)
FR (1) FR2275215A1 (hu)
GB (1) GB1471804A (hu)
HU (1) HU170576B (hu)
IE (1) IE41888B1 (hu)
IL (1) IL47299A (hu)
LU (1) LU72771A1 (hu)
NL (1) NL180665C (hu)
NO (1) NO752202L (hu)
NZ (1) NZ177508A (hu)
PH (1) PH13030A (hu)
SE (1) SE431755B (hu)
SU (2) SU635873A3 (hu)
ZA (1) ZA753086B (hu)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7805715A (nl) * 1977-06-03 1978-12-05 Hoffmann La Roche Werkwijze voor het bereiden van acylderivaten.
JPS5419990A (en) * 1977-07-14 1979-02-15 Shionogi & Co Ltd Dihydrotriazinylthioxacephalosporin
MC1259A1 (fr) * 1978-05-30 1980-01-14 Hoffmann La Roche Derives acyles
FR2474030A1 (fr) * 1980-01-17 1981-07-24 Rhone Poulenc Ind Nouvelles dioxotriazines et leur preparation
FR2494278A1 (fr) * 1980-11-20 1982-05-21 Rhone Poulenc Ind Nouveaux derives de la cephalosporine, leurs preparations et les medicaments qui les contiennent
JP2004538265A (ja) * 2001-04-19 2004-12-24 ビオフェルマ ムルシア，エス．アー． α−ケト酸誘導体を使用して３−セファロスポラン酸誘導体を製造する方法
EP2250156B1 (en) 2008-03-05 2015-05-06 Merck Patent GmbH Pyrazinone derivatives as insulin secretion stimulators, methods for obtaining them and use thereof for the treatment of diabetes

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3868369A (en) * 1972-11-14 1975-02-25 Smithkline Corp 3-heterocyclicthiomethylcephalosporins

Also Published As

Publication number Publication date
SE431755B (sv) 1984-02-27
PH13030A (en) 1979-11-15
SE7506908L (sv) 1975-12-22
DK153155B (da) 1988-06-20
ZA753086B (en) 1976-04-28
AU8191275A (en) 1976-12-09
JPS5113793A (hu) 1976-02-03
IL47299A (en) 1979-01-31
JPS625917B2 (hu) 1987-02-07
LU72771A1 (hu) 1977-03-04
NL180665B (nl) 1986-11-03
NZ177508A (en) 1978-04-03
DK155329C (da) 1989-08-07
DK155329B (da) 1989-03-28
IE41888L (en) 1975-12-21
IL47299A0 (en) 1976-10-31
CA1111021A (en) 1981-10-20
FR2275215B1 (hu) 1980-05-16
GB1471804A (en) 1977-04-27
AU498387B2 (en) 1979-03-08
FR2275215A1 (fr) 1976-01-16
BR7503782A (pt) 1976-07-06
SU635873A3 (ru) 1978-11-30
CU34293A (es) 1979-01-16
NL180665C (nl) 1987-04-01
DK453687A (da) 1987-08-28
NO752202L (hu) 1975-12-23
NL7507390A (nl) 1975-12-23
FI751815A (hu) 1975-12-22
SU589921A3 (ru) 1978-01-25
ATA476975A (de) 1976-11-15
AT337897B (de) 1977-07-25
IE41888B1 (en) 1980-04-23
CH609989A5 (en) 1979-03-30
DE2527291A1 (de) 1976-01-08
DK453687D0 (da) 1987-08-28
DD121113A5 (hu) 1976-07-12
DK271975A (da) 1975-12-22
DK153155C (da) 1988-10-31
HU170576B (hu) 1977-07-28
BE830455A (fr) 1975-12-22

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Legal Events

Date Code Title Description
8110 Request for examination paragraph 44
Q176 The application caused the suspense of an application

Ref document number: 2534071

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D2 Grant after examination
8364 No opposition during term of opposition
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Owner name: F. HOFFMANN-LA ROCHE AG, BASEL, CH

8328 Change in the person/name/address of the agent

Free format text: LEDERER, F., DIPL.-CHEM. DR., 8000 MUENCHEN RIEDERER FRHR. VON PAAR ZU SCHOENAU, A., DIPL.-ING., PAT.-ANWAELTE, 8300 LANDSHUT