DK453687D0 - Cephalosporinderivater til anvendelse som mellemprodukter ved fremstilling af antibakterielt virksomme 3-cephem-4-carboxylsyrederivater - Google Patents

Cephalosporinderivater til anvendelse som mellemprodukter ved fremstilling af antibakterielt virksomme 3-cephem-4-carboxylsyrederivater

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Publication number
DK453687D0
DK453687D0 DK453687A DK453687A DK453687D0 DK 453687 D0 DK453687 D0 DK 453687D0 DK 453687 A DK453687 A DK 453687A DK 453687 A DK453687 A DK 453687A DK 453687 D0 DK453687 D0 DK 453687D0
Authority
DK
Denmark
Prior art keywords
antibacteryly
cephem
intermediates
preparation
effective
Prior art date
Application number
DK453687A
Other languages
English (en)
Other versions
DK453687A (da
DK155329C (da
DK155329B (da
Inventor
Marc Montavon
Roland Reiner
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of DK453687D0 publication Critical patent/DK453687D0/da
Publication of DK453687A publication Critical patent/DK453687A/da
Publication of DK155329B publication Critical patent/DK155329B/da
Application granted granted Critical
Publication of DK155329C publication Critical patent/DK155329C/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/553—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms with halogen atoms or nitro radicals directly attached to ring carbon atoms, e.g. fluorouracil
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/56—One oxygen atom and one sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/06—1,2,4-Triazines
    • C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
    • C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D253/075—Two hetero atoms, in positions 3 and 5
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/36—Methylene radicals, substituted by sulfur atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK453687A 1974-06-21 1987-08-28 7-aminocephalosporiner til anvendelse som mellemprodukter ved fremstilling af terapeutisk virksomme 7-acylamino-cephalosporiner DK155329C (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH853774A CH609989A5 (en) 1974-06-21 1974-06-21 Process for the preparation of acyl derivatives
CH853774 1974-06-21

Publications (4)

Publication Number Publication Date
DK453687D0 true DK453687D0 (da) 1987-08-28
DK453687A DK453687A (da) 1987-08-28
DK155329B DK155329B (da) 1989-03-28
DK155329C DK155329C (da) 1989-08-07

Family

ID=4341690

Family Applications (2)

Application Number Title Priority Date Filing Date
DK271975A DK153155C (da) 1974-06-21 1975-06-17 Analogifremgangsmaade til fremstilling af cephalosporiner
DK453687A DK155329C (da) 1974-06-21 1987-08-28 7-aminocephalosporiner til anvendelse som mellemprodukter ved fremstilling af terapeutisk virksomme 7-acylamino-cephalosporiner

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK271975A DK153155C (da) 1974-06-21 1975-06-17 Analogifremgangsmaade til fremstilling af cephalosporiner

Country Status (25)

Country Link
JP (1) JPS625917B2 (da)
AT (1) AT337897B (da)
AU (1) AU498387B2 (da)
BE (1) BE830455A (da)
BR (1) BR7503782A (da)
CA (1) CA1111021A (da)
CH (1) CH609989A5 (da)
CU (1) CU34293A (da)
DD (1) DD121113A5 (da)
DE (1) DE2527291A1 (da)
DK (2) DK153155C (da)
FI (1) FI751815A (da)
FR (1) FR2275215A1 (da)
GB (1) GB1471804A (da)
HU (1) HU170576B (da)
IE (1) IE41888B1 (da)
IL (1) IL47299A (da)
LU (1) LU72771A1 (da)
NL (1) NL180665C (da)
NO (1) NO752202L (da)
NZ (1) NZ177508A (da)
PH (1) PH13030A (da)
SE (1) SE431755B (da)
SU (2) SU635873A3 (da)
ZA (1) ZA753086B (da)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7805715A (nl) * 1977-06-03 1978-12-05 Hoffmann La Roche Werkwijze voor het bereiden van acylderivaten.
JPS5419990A (en) * 1977-07-14 1979-02-15 Shionogi & Co Ltd Dihydrotriazinylthioxacephalosporin
MC1259A1 (fr) * 1978-05-30 1980-01-14 Hoffmann La Roche Derives acyles
FR2474030A1 (fr) * 1980-01-17 1981-07-24 Rhone Poulenc Ind Nouvelles dioxotriazines et leur preparation
FR2494278A1 (fr) * 1980-11-20 1982-05-21 Rhone Poulenc Ind Nouveaux derives de la cephalosporine, leurs preparations et les medicaments qui les contiennent
CN1531539A (zh) * 2001-04-19 2004-09-22 ��ŷ�����¶����ǹɷ����޹�˾ 用α-酮酸衍生物制备头孢烷酸衍生物的酶促方法
KR101637381B1 (ko) 2008-03-05 2016-07-07 메르크 파텐트 게엠베하 인슐린 분비 자극제들로서의 피라지논 유도체들, 이들을 얻기 위한 방법들 및 당뇨병 치료를 위한 이들의 용도

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3868369A (en) * 1972-11-14 1975-02-25 Smithkline Corp 3-heterocyclicthiomethylcephalosporins

Also Published As

Publication number Publication date
DK153155C (da) 1988-10-31
DD121113A5 (da) 1976-07-12
ZA753086B (en) 1976-04-28
ATA476975A (de) 1976-11-15
SE431755B (sv) 1984-02-27
IE41888L (en) 1975-12-21
BR7503782A (pt) 1976-07-06
HU170576B (da) 1977-07-28
JPS5113793A (da) 1976-02-03
JPS625917B2 (da) 1987-02-07
GB1471804A (en) 1977-04-27
IL47299A0 (en) 1976-10-31
CA1111021A (en) 1981-10-20
IL47299A (en) 1979-01-31
AU8191275A (en) 1976-12-09
DK153155B (da) 1988-06-20
NL180665C (nl) 1987-04-01
FR2275215A1 (fr) 1976-01-16
LU72771A1 (da) 1977-03-04
SU635873A3 (ru) 1978-11-30
NO752202L (da) 1975-12-23
IE41888B1 (en) 1980-04-23
CH609989A5 (en) 1979-03-30
SU589921A3 (ru) 1978-01-25
DK271975A (da) 1975-12-22
AT337897B (de) 1977-07-25
DK453687A (da) 1987-08-28
CU34293A (es) 1979-01-16
NL180665B (nl) 1986-11-03
DE2527291C2 (da) 1988-01-14
NL7507390A (nl) 1975-12-23
NZ177508A (en) 1978-04-03
SE7506908L (sv) 1975-12-22
BE830455A (fr) 1975-12-22
DK155329C (da) 1989-08-07
DK155329B (da) 1989-03-28
DE2527291A1 (de) 1976-01-08
PH13030A (en) 1979-11-15
FI751815A (da) 1975-12-22
FR2275215B1 (da) 1980-05-16
AU498387B2 (en) 1979-03-08

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PUP Patent expired