CH609989A5 - Process for the preparation of acyl derivatives - Google Patents

Process for the preparation of acyl derivatives

Info

Publication number
CH609989A5
CH609989A5 CH853774A CH853774A CH609989A5 CH 609989 A5 CH609989 A5 CH 609989A5 CH 853774 A CH853774 A CH 853774A CH 853774 A CH853774 A CH 853774A CH 609989 A5 CH609989 A5 CH 609989A5
Authority
CH
Switzerland
Prior art keywords
preparation
acyl derivatives
acyl
derivatives
Prior art date
Application number
CH853774A
Other languages
English (en)
Inventor
Marc Dr Montavon
Roland Dr Reiner
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Priority to CH853774A priority Critical patent/CH609989A5/xx
Priority to ZA00753086A priority patent/ZA753086B/xx
Priority to NZ177508A priority patent/NZ177508A/xx
Priority to IL47299A priority patent/IL47299A/xx
Priority to AU81912/75A priority patent/AU498387B2/en
Priority to US05/586,677 priority patent/US4091211A/en
Priority to SE7506908A priority patent/SE431755B/xx
Priority to BR4864/75D priority patent/BR7503782A/pt
Priority to DK271975A priority patent/DK153155C/da
Priority to PH17273A priority patent/PH13030A/en
Priority to FI751815A priority patent/FI751815A/fi
Priority to SU752145554A priority patent/SU635873A3/ru
Priority to IE1366/75A priority patent/IE41888B1/en
Priority to JP50074251A priority patent/JPS625917B2/ja
Priority to DE19752527291 priority patent/DE2527291A1/de
Priority to FR7519213A priority patent/FR2275215A1/fr
Priority to LU72771A priority patent/LU72771A1/xx
Priority to CA229,803A priority patent/CA1111021A/en
Priority to CU7534293A priority patent/CU34293A/es
Priority to AT476975A priority patent/AT337897B/de
Priority to HUHO1808A priority patent/HU170576B/hu
Priority to DD186797A priority patent/DD121113A5/xx
Priority to BE157517A priority patent/BE830455A/xx
Priority to NO752202A priority patent/NO752202L/no
Priority to ES75438748A priority patent/ES438748A1/es
Priority to NLAANVRAGE7507390,A priority patent/NL180665C/xx
Priority to GB2634175A priority patent/GB1471804A/en
Priority to ES75443791A priority patent/ES443791A1/es
Priority to SU762309104A priority patent/SU589921A3/ru
Priority to AT976776A priority patent/AT347585B/de
Priority to US05/873,446 priority patent/US4348518A/en
Publication of CH609989A5 publication Critical patent/CH609989A5/xx
Priority to NL8103936A priority patent/NL8103936A/nl
Priority to CA000387618A priority patent/CA1240314A/en
Priority to DK453687A priority patent/DK155329C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/553—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms with halogen atoms or nitro radicals directly attached to ring carbon atoms, e.g. fluorouracil
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/56—One oxygen atom and one sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/06—1,2,4-Triazines
    • C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
    • C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D253/075—Two hetero atoms, in positions 3 and 5
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/36—Methylene radicals, substituted by sulfur atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CH853774A 1974-05-05 1974-06-21 Process for the preparation of acyl derivatives CH609989A5 (en)

Priority Applications (34)

Application Number Priority Date Filing Date Title
CH853774A CH609989A5 (en) 1974-06-21 1974-06-21 Process for the preparation of acyl derivatives
ZA00753086A ZA753086B (en) 1974-06-21 1975-05-13 Acyl derivatives
NZ177508A NZ177508A (en) 1974-06-21 1975-05-13 Cephalosporin derivatives and antibiotic compositions
IL47299A IL47299A (en) 1974-06-21 1975-05-14 3-thiomethyl-3-cephem-4-carboxylic acid derivatives,their preparation and pharmaceutical compositions containing them
AU81912/75A AU498387B2 (en) 1974-06-21 1975-06-06 Cephem derivatives
US05/586,677 US4091211A (en) 1974-05-05 1975-06-13 Cephalosporins
SE7506908A SE431755B (sv) 1974-06-21 1975-06-16 Forfarande for framstellning av nya acylderivat av cefalosporiner
BR4864/75D BR7503782A (pt) 1974-06-21 1975-06-17 Processo para a preparacao de derivados de acila de formula geral x-s-y;derivados de acila de formula geral x-s-y;e seus compostos
DK271975A DK153155C (da) 1974-06-21 1975-06-17 Analogifremgangsmaade til fremstilling af cephalosporiner
PH17273A PH13030A (en) 1974-06-21 1975-06-17 Cephalosporin derivative and pharmaceutical preparation thereof
FI751815A FI751815A (xx) 1974-06-21 1975-06-18
SU752145554A SU635873A3 (ru) 1974-06-21 1975-06-18 Способ получени ациловых производных или их щелочно-металлических солей или гидратов этих солей
IE1366/75A IE41888B1 (en) 1974-06-21 1975-06-18 Substituted desacetoxy-7-acylamino-cephalosporanic acids
JP50074251A JPS625917B2 (xx) 1974-06-21 1975-06-18
DE19752527291 DE2527291A1 (de) 1974-06-21 1975-06-19 Acylderivate
FR7519213A FR2275215A1 (fr) 1974-06-21 1975-06-19 Nouveaux derives heterocycliques de desacetoxycephalosporine, procede pour leur preparation et application en tant que medicament
LU72771A LU72771A1 (xx) 1974-06-21 1975-06-19
CA229,803A CA1111021A (en) 1974-06-21 1975-06-20 Acyl derivatives
GB2634175A GB1471804A (en) 1974-06-21 1975-06-20 Substituted desacetoxy-7-acylaminocephalosporanic acids
AT476975A AT337897B (de) 1974-06-21 1975-06-20 Verfahren zur herstellung von neuen acylderivaten
HUHO1808A HU170576B (xx) 1974-06-21 1975-06-20
DD186797A DD121113A5 (xx) 1974-06-21 1975-06-20
BE157517A BE830455A (fr) 1974-06-21 1975-06-20 Derives acyles
NO752202A NO752202L (xx) 1974-06-21 1975-06-20
ES75438748A ES438748A1 (es) 1974-05-05 1975-06-20 Procedimiento para la preparacion de derivados del acido 3- cefem-4-carboxilico.
NLAANVRAGE7507390,A NL180665C (nl) 1974-06-21 1975-06-20 Werkwijze voor de bereiding of vervaardiging van een farmaceutisch preparaat met antibacteriele werking, alsmede werkwijze voor het bereiden van een 7-acylamino-3-heterocyclylthiomethyl-3-cefem-4-carbonzuur derivaat.
CU7534293A CU34293A (es) 1974-06-21 1975-06-20 Derivados acilicos
ES75443791A ES443791A1 (es) 1974-05-05 1975-12-23 Procedimiento para la preparacion de derivados del acido 3- cefem-4-carboxilico.
SU762309104A SU589921A3 (ru) 1974-06-21 1976-01-07 Способ получени производных 3-цефем4-карбоновой кислоты или их солей
AT976776A AT347585B (de) 1974-06-21 1976-12-29 Verfahren zur herstellung von neuen 3-cephem-4- carbonsaeure-derivaten
US05/873,446 US4348518A (en) 1974-05-05 1978-01-30 Cephalosporins
NL8103936A NL8103936A (nl) 1974-06-21 1981-08-24 Cefalosporinederivaten.
CA000387618A CA1240314A (en) 1974-06-21 1981-10-08 Acyl derivatives
DK453687A DK155329C (da) 1974-06-21 1987-08-28 7-aminocephalosporiner til anvendelse som mellemprodukter ved fremstilling af terapeutisk virksomme 7-acylamino-cephalosporiner

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH853774A CH609989A5 (en) 1974-06-21 1974-06-21 Process for the preparation of acyl derivatives

Publications (1)

Publication Number Publication Date
CH609989A5 true CH609989A5 (en) 1979-03-30

Family

ID=4341690

Family Applications (1)

Application Number Title Priority Date Filing Date
CH853774A CH609989A5 (en) 1974-05-05 1974-06-21 Process for the preparation of acyl derivatives

Country Status (25)

Country Link
JP (1) JPS625917B2 (xx)
AT (1) AT337897B (xx)
AU (1) AU498387B2 (xx)
BE (1) BE830455A (xx)
BR (1) BR7503782A (xx)
CA (1) CA1111021A (xx)
CH (1) CH609989A5 (xx)
CU (1) CU34293A (xx)
DD (1) DD121113A5 (xx)
DE (1) DE2527291A1 (xx)
DK (2) DK153155C (xx)
FI (1) FI751815A (xx)
FR (1) FR2275215A1 (xx)
GB (1) GB1471804A (xx)
HU (1) HU170576B (xx)
IE (1) IE41888B1 (xx)
IL (1) IL47299A (xx)
LU (1) LU72771A1 (xx)
NL (1) NL180665C (xx)
NO (1) NO752202L (xx)
NZ (1) NZ177508A (xx)
PH (1) PH13030A (xx)
SE (1) SE431755B (xx)
SU (2) SU635873A3 (xx)
ZA (1) ZA753086B (xx)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7805715A (nl) * 1977-06-03 1978-12-05 Hoffmann La Roche Werkwijze voor het bereiden van acylderivaten.
JPS5419990A (en) * 1977-07-14 1979-02-15 Shionogi & Co Ltd Dihydrotriazinylthioxacephalosporin
MC1259A1 (fr) * 1978-05-30 1980-01-14 Hoffmann La Roche Derives acyles
FR2474030A1 (fr) * 1980-01-17 1981-07-24 Rhone Poulenc Ind Nouvelles dioxotriazines et leur preparation
FR2494278A1 (fr) * 1980-11-20 1982-05-21 Rhone Poulenc Ind Nouveaux derives de la cephalosporine, leurs preparations et les medicaments qui les contiennent
CN1531539A (zh) * 2001-04-19 2004-09-22 ��ŷ�����¶����ǹɷ����޹�˾ 用α-酮酸衍生物制备头孢烷酸衍生物的酶促方法
KR101637381B1 (ko) 2008-03-05 2016-07-07 메르크 파텐트 게엠베하 인슐린 분비 자극제들로서의 피라지논 유도체들, 이들을 얻기 위한 방법들 및 당뇨병 치료를 위한 이들의 용도

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3868369A (en) * 1972-11-14 1975-02-25 Smithkline Corp 3-heterocyclicthiomethylcephalosporins

Also Published As

Publication number Publication date
DK153155C (da) 1988-10-31
DD121113A5 (xx) 1976-07-12
ZA753086B (en) 1976-04-28
ATA476975A (de) 1976-11-15
SE431755B (sv) 1984-02-27
IE41888L (en) 1975-12-21
BR7503782A (pt) 1976-07-06
HU170576B (xx) 1977-07-28
JPS5113793A (xx) 1976-02-03
JPS625917B2 (xx) 1987-02-07
GB1471804A (en) 1977-04-27
IL47299A0 (en) 1976-10-31
CA1111021A (en) 1981-10-20
IL47299A (en) 1979-01-31
AU8191275A (en) 1976-12-09
DK153155B (da) 1988-06-20
NL180665C (nl) 1987-04-01
DK453687D0 (da) 1987-08-28
FR2275215A1 (fr) 1976-01-16
LU72771A1 (xx) 1977-03-04
SU635873A3 (ru) 1978-11-30
NO752202L (xx) 1975-12-23
IE41888B1 (en) 1980-04-23
SU589921A3 (ru) 1978-01-25
DK271975A (da) 1975-12-22
AT337897B (de) 1977-07-25
DK453687A (da) 1987-08-28
CU34293A (es) 1979-01-16
NL180665B (nl) 1986-11-03
DE2527291C2 (xx) 1988-01-14
NL7507390A (nl) 1975-12-23
NZ177508A (en) 1978-04-03
SE7506908L (sv) 1975-12-22
BE830455A (fr) 1975-12-22
DK155329C (da) 1989-08-07
DK155329B (da) 1989-03-28
DE2527291A1 (de) 1976-01-08
PH13030A (en) 1979-11-15
FI751815A (xx) 1975-12-22
FR2275215B1 (xx) 1980-05-16
AU498387B2 (en) 1979-03-08

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Legal Events

Date Code Title Description
AEN Modification of the scope of the patent

Free format text: TEILWEISER VERZICHT,VEROEFF. 13.11.81

PUE Assignment

Owner name: F. HOFFMANN-LA ROCHE AG

PL Patent ceased