GB1471804A - Substituted desacetoxy-7-acylaminocephalosporanic acids - Google Patents
Substituted desacetoxy-7-acylaminocephalosporanic acidsInfo
- Publication number
- GB1471804A GB1471804A GB2634175A GB2634175A GB1471804A GB 1471804 A GB1471804 A GB 1471804A GB 2634175 A GB2634175 A GB 2634175A GB 2634175 A GB2634175 A GB 2634175A GB 1471804 A GB1471804 A GB 1471804A
- Authority
- GB
- United Kingdom
- Prior art keywords
- group
- nitrogen atoms
- acetoxy
- substituted
- radical
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
- C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/553—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms with halogen atoms or nitro radicals directly attached to ring carbon atoms, e.g. fluorouracil
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/56—One oxygen atom and one sulfur atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
- C07D253/06—1,2,4-Triazines
- C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
- C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D253/075—Two hetero atoms, in positions 3 and 5
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/36—Methylene radicals, substituted by sulfur atoms
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Acyl derivatives of the general formula X-S-Y in which X denotes a 3-acetoxymethylcephalosporinyl radical decreased by the acetoxy group and -S-Y denotes the thio group standing instead of the acetoxy group, in which Y represents a 6-membered, optionally substituted, heterocyclic radical having 1 to 3 nitrogen atoms, which is not heteroaromatic and cannot be enolised to give a heteroaromatic radical, where at least one of these nitrogen atoms is substituted and at least one of these nitrogen atoms forms an amide group with an adjacent carbonyl group, or salts of these compounds or hydrates of these salts are antibiotically active products. These products can be prepared by reacting a cephalosporin derivative which carries an easily removable group on the 3-methyl group instead of the acetoxy substituent and whose carboxyl group in position 4 is present in protected form, with a mercapto compound Y-SH and removing the protective group.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH853774A CH609989A5 (en) | 1974-06-21 | 1974-06-21 | Process for the preparation of acyl derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1471804A true GB1471804A (en) | 1977-04-27 |
Family
ID=4341690
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB2634175A Expired GB1471804A (en) | 1974-06-21 | 1975-06-20 | Substituted desacetoxy-7-acylaminocephalosporanic acids |
Country Status (25)
| Country | Link |
|---|---|
| JP (1) | JPS625917B2 (en) |
| AT (1) | AT337897B (en) |
| AU (1) | AU498387B2 (en) |
| BE (1) | BE830455A (en) |
| BR (1) | BR7503782A (en) |
| CA (1) | CA1111021A (en) |
| CH (1) | CH609989A5 (en) |
| CU (1) | CU34293A (en) |
| DD (1) | DD121113A5 (en) |
| DE (1) | DE2527291A1 (en) |
| DK (2) | DK153155C (en) |
| FI (1) | FI751815A (en) |
| FR (1) | FR2275215A1 (en) |
| GB (1) | GB1471804A (en) |
| HU (1) | HU170576B (en) |
| IE (1) | IE41888B1 (en) |
| IL (1) | IL47299A (en) |
| LU (1) | LU72771A1 (en) |
| NL (1) | NL180665C (en) |
| NO (1) | NO752202L (en) |
| NZ (1) | NZ177508A (en) |
| PH (1) | PH13030A (en) |
| SE (1) | SE431755B (en) |
| SU (2) | SU635873A3 (en) |
| ZA (1) | ZA753086B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009109259A1 (en) | 2008-03-05 | 2009-09-11 | Merck Patent Gmbh | Pyrazinone derivatives as insulin secretion stimulators, methods for obtaining them and use thereof for the treatment of diabetes |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL7805715A (en) * | 1977-06-03 | 1978-12-05 | Hoffmann La Roche | METHOD FOR PREPARING ACYL DERIVATIVES. |
| JPS5419990A (en) * | 1977-07-14 | 1979-02-15 | Shionogi & Co Ltd | Dihydrotriazinylthioxacephalosporin |
| MC1259A1 (en) * | 1978-05-30 | 1980-01-14 | Hoffmann La Roche | ACYL DERIVATIVES |
| FR2474030A1 (en) * | 1980-01-17 | 1981-07-24 | Rhone Poulenc Ind | 2-Mercapto-1,2,4-triazine, 1,3,4-triazole or tetrazole derivs. - useful as intermediates for antibacterial cephalosporin(s) |
| FR2494278A1 (en) * | 1980-11-20 | 1982-05-21 | Rhone Poulenc Ind | NEW DERIVATIVES OF CEPHALOSPORIN, THEIR PREPARATIONS AND THE MEDICINAL PRODUCTS CONTAINING THEM |
| CN1531539A (en) * | 2001-04-19 | 2004-09-22 | ��ŷ�����¶����ǹɷ�����˾ | Enzymatic process for preparing cephalosporanic acid derivatives using 2-ketoacid derivatives |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3868369A (en) * | 1972-11-14 | 1975-02-25 | Smithkline Corp | 3-heterocyclicthiomethylcephalosporins |
-
1974
- 1974-06-21 CH CH853774A patent/CH609989A5/en not_active IP Right Cessation
-
1975
- 1975-05-13 ZA ZA00753086A patent/ZA753086B/en unknown
- 1975-05-13 NZ NZ177508A patent/NZ177508A/en unknown
- 1975-05-14 IL IL47299A patent/IL47299A/en unknown
- 1975-06-06 AU AU81912/75A patent/AU498387B2/en not_active Expired
- 1975-06-16 SE SE7506908A patent/SE431755B/en not_active IP Right Cessation
- 1975-06-17 PH PH17273A patent/PH13030A/en unknown
- 1975-06-17 DK DK271975A patent/DK153155C/en not_active IP Right Cessation
- 1975-06-17 BR BR4864/75D patent/BR7503782A/en unknown
- 1975-06-18 IE IE1366/75A patent/IE41888B1/en unknown
- 1975-06-18 SU SU752145554A patent/SU635873A3/en active
- 1975-06-18 JP JP50074251A patent/JPS625917B2/ja not_active Expired
- 1975-06-18 FI FI751815A patent/FI751815A/fi not_active Application Discontinuation
- 1975-06-19 FR FR7519213A patent/FR2275215A1/en active Granted
- 1975-06-19 LU LU72771A patent/LU72771A1/xx unknown
- 1975-06-19 DE DE19752527291 patent/DE2527291A1/en active Granted
- 1975-06-20 AT AT476975A patent/AT337897B/en not_active IP Right Cessation
- 1975-06-20 NO NO752202A patent/NO752202L/no unknown
- 1975-06-20 CU CU7534293A patent/CU34293A/en unknown
- 1975-06-20 BE BE157517A patent/BE830455A/en not_active IP Right Cessation
- 1975-06-20 HU HUHO1808A patent/HU170576B/hu unknown
- 1975-06-20 GB GB2634175A patent/GB1471804A/en not_active Expired
- 1975-06-20 DD DD186797A patent/DD121113A5/xx unknown
- 1975-06-20 CA CA229,803A patent/CA1111021A/en not_active Expired
- 1975-06-20 NL NLAANVRAGE7507390,A patent/NL180665C/en not_active IP Right Cessation
-
1976
- 1976-01-07 SU SU762309104A patent/SU589921A3/en active
-
1987
- 1987-08-28 DK DK453687A patent/DK155329C/en not_active IP Right Cessation
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009109259A1 (en) | 2008-03-05 | 2009-09-11 | Merck Patent Gmbh | Pyrazinone derivatives as insulin secretion stimulators, methods for obtaining them and use thereof for the treatment of diabetes |
| US8637522B2 (en) | 2008-03-05 | 2014-01-28 | Merck Patent Gmbh | Pyrazinone derivatives as insulin secretion stimulators, methods for obtaining them and use thereof for the treatment of diabetes |
| EA021325B1 (en) * | 2008-03-05 | 2015-05-29 | Мерк Патент Гмбх | Pyrazinone derivatives as insulin secretion stimulators, methods for obtaining them and use thereof for the treatment of diabetes |
| US9102632B2 (en) | 2008-03-05 | 2015-08-11 | Merck Patent Gmbh | Pyrazinone derivatives as insulin secretion stimulators, methods for obtaining them and use thereof for the treatment of diabetes |
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| 429A | Application made for amendment of specification (sect. 29/1949) | ||
| 429H | Application (made) for amendment of specification now open to opposition (sect. 29/1949) | ||
| 429D | Case decided by the comptroller ** specification amended (sect. 29/1949) | ||
| SP | Amendment (slips) printed | ||
| 704A | Declaration that licence is not available as of right for an excepted use (par. 4a/1977) | ||
| 732 | Registration of transactions, instruments or events in the register (sect. 32/1977) | ||
| PCNP | Patent ceased through non-payment of renewal fee |
Effective date: 19930620 |