FR2275215A1 - NEW HETEROCYCLICAL DERIVATIVES OF DESACETOXYCEPHALOSPORIN, PROCESS FOR THEIR PREPARATION AND APPLICATION AS A MEDICINAL PRODUCT - Google Patents

NEW HETEROCYCLICAL DERIVATIVES OF DESACETOXYCEPHALOSPORIN, PROCESS FOR THEIR PREPARATION AND APPLICATION AS A MEDICINAL PRODUCT

Info

Publication number
FR2275215A1
FR2275215A1 FR7519213A FR7519213A FR2275215A1 FR 2275215 A1 FR2275215 A1 FR 2275215A1 FR 7519213 A FR7519213 A FR 7519213A FR 7519213 A FR7519213 A FR 7519213A FR 2275215 A1 FR2275215 A1 FR 2275215A1
Authority
FR
France
Prior art keywords
desacetoxycephalosporin
heterocyclical
derivatives
preparation
new
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7519213A
Other languages
French (fr)
Other versions
FR2275215B1 (en
Inventor
Marc Montavon
Roland Reiner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of FR2275215A1 publication Critical patent/FR2275215A1/en
Application granted granted Critical
Publication of FR2275215B1 publication Critical patent/FR2275215B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/553—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms with halogen atoms or nitro radicals directly attached to ring carbon atoms, e.g. fluorouracil
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/56—One oxygen atom and one sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/06—1,2,4-Triazines
    • C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
    • C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D253/075—Two hetero atoms, in positions 3 and 5
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/36—Methylene radicals, substituted by sulfur atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FR7519213A 1974-06-21 1975-06-19 NEW HETEROCYCLICAL DERIVATIVES OF DESACETOXYCEPHALOSPORIN, PROCESS FOR THEIR PREPARATION AND APPLICATION AS A MEDICINAL PRODUCT Granted FR2275215A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH853774A CH609989A5 (en) 1974-06-21 1974-06-21 Process for the preparation of acyl derivatives

Publications (2)

Publication Number Publication Date
FR2275215A1 true FR2275215A1 (en) 1976-01-16
FR2275215B1 FR2275215B1 (en) 1980-05-16

Family

ID=4341690

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7519213A Granted FR2275215A1 (en) 1974-06-21 1975-06-19 NEW HETEROCYCLICAL DERIVATIVES OF DESACETOXYCEPHALOSPORIN, PROCESS FOR THEIR PREPARATION AND APPLICATION AS A MEDICINAL PRODUCT

Country Status (25)

Country Link
JP (1) JPS625917B2 (en)
AT (1) AT337897B (en)
AU (1) AU498387B2 (en)
BE (1) BE830455A (en)
BR (1) BR7503782A (en)
CA (1) CA1111021A (en)
CH (1) CH609989A5 (en)
CU (1) CU34293A (en)
DD (1) DD121113A5 (en)
DE (1) DE2527291A1 (en)
DK (2) DK153155C (en)
FI (1) FI751815A (en)
FR (1) FR2275215A1 (en)
GB (1) GB1471804A (en)
HU (1) HU170576B (en)
IE (1) IE41888B1 (en)
IL (1) IL47299A (en)
LU (1) LU72771A1 (en)
NL (1) NL180665C (en)
NO (1) NO752202L (en)
NZ (1) NZ177508A (en)
PH (1) PH13030A (en)
SE (1) SE431755B (en)
SU (2) SU635873A3 (en)
ZA (1) ZA753086B (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0000005A1 (en) * 1977-06-03 1978-12-20 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft New cephalosporin derivatives, their preparations and their pharmaceutical compositions
FR2474030A1 (en) * 1980-01-17 1981-07-24 Rhone Poulenc Ind 2-Mercapto-1,2,4-triazine, 1,3,4-triazole or tetrazole derivs. - useful as intermediates for antibacterial cephalosporin(s)
EP0045525A2 (en) * 1978-05-30 1982-02-10 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Cephalosporin derivatives and process for their preparation
FR2494278A1 (en) * 1980-11-20 1982-05-21 Rhone Poulenc Ind NEW DERIVATIVES OF CEPHALOSPORIN, THEIR PREPARATIONS AND THE MEDICINAL PRODUCTS CONTAINING THEM

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5419990A (en) * 1977-07-14 1979-02-15 Shionogi & Co Ltd Dihydrotriazinylthioxacephalosporin
JP2004538265A (en) * 2001-04-19 2004-12-24 ビオフェルマ ムルシア，エス．アー． Method for producing 3-cephalosporanic acid derivative using α-keto acid derivative
CN101945858B (en) 2008-03-05 2014-05-21 默克专利有限公司 Pyrazinone derivatives as insulin secretion stimulators, methods for obtaining them and use thereof for the treatment of diabetes

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3868369A (en) * 1972-11-14 1975-02-25 Smithkline Corp 3-heterocyclicthiomethylcephalosporins

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0000005A1 (en) * 1977-06-03 1978-12-20 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft New cephalosporin derivatives, their preparations and their pharmaceutical compositions
EP0045525A2 (en) * 1978-05-30 1982-02-10 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Cephalosporin derivatives and process for their preparation
EP0045525A3 (en) * 1978-05-30 1982-02-17 F. Hoffmann-La Roche & Co. Aktiengesellschaft Cephalosporin derivatives and process for their preparation
FR2474030A1 (en) * 1980-01-17 1981-07-24 Rhone Poulenc Ind 2-Mercapto-1,2,4-triazine, 1,3,4-triazole or tetrazole derivs. - useful as intermediates for antibacterial cephalosporin(s)
FR2494278A1 (en) * 1980-11-20 1982-05-21 Rhone Poulenc Ind NEW DERIVATIVES OF CEPHALOSPORIN, THEIR PREPARATIONS AND THE MEDICINAL PRODUCTS CONTAINING THEM
EP0053539A1 (en) * 1980-11-20 1982-06-09 Rhone-Poulenc Sante Cephalosporin derivatives, process for their preparation and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
CU34293A (en) 1979-01-16
IE41888L (en) 1975-12-21
DK153155B (en) 1988-06-20
DK155329C (en) 1989-08-07
AT337897B (en) 1977-07-25
CA1111021A (en) 1981-10-20
CH609989A5 (en) 1979-03-30
DK453687A (en) 1987-08-28
NO752202L (en) 1975-12-23
NZ177508A (en) 1978-04-03
AU8191275A (en) 1976-12-09
ATA476975A (en) 1976-11-15
PH13030A (en) 1979-11-15
SU635873A3 (en) 1978-11-30
DE2527291C2 (en) 1988-01-14
DD121113A5 (en) 1976-07-12
IE41888B1 (en) 1980-04-23
FI751815A (en) 1975-12-22
DK453687D0 (en) 1987-08-28
LU72771A1 (en) 1977-03-04
NL180665B (en) 1986-11-03
BE830455A (en) 1975-12-22
JPS5113793A (en) 1976-02-03
ZA753086B (en) 1976-04-28
IL47299A (en) 1979-01-31
FR2275215B1 (en) 1980-05-16
BR7503782A (en) 1976-07-06
GB1471804A (en) 1977-04-27
IL47299A0 (en) 1976-10-31
DE2527291A1 (en) 1976-01-08
DK155329B (en) 1989-03-28
AU498387B2 (en) 1979-03-08
SU589921A3 (en) 1978-01-25
NL180665C (en) 1987-04-01
DK153155C (en) 1988-10-31
NL7507390A (en) 1975-12-23
DK271975A (en) 1975-12-22
HU170576B (en) 1977-07-28
SE431755B (en) 1984-02-27
SE7506908L (en) 1975-12-22
JPS625917B2 (en) 1987-02-07

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TP Transmission of property
ST Notification of lapse