DE2500451A1 - Prostaglandinanaloge, verfahren zu ihrer herstellung und diese enthaltende arzneimittel - Google Patents
Prostaglandinanaloge, verfahren zu ihrer herstellung und diese enthaltende arzneimittelInfo
- Publication number
- DE2500451A1 DE2500451A1 DE19752500451 DE2500451A DE2500451A1 DE 2500451 A1 DE2500451 A1 DE 2500451A1 DE 19752500451 DE19752500451 DE 19752500451 DE 2500451 A DE2500451 A DE 2500451A DE 2500451 A1 DE2500451 A1 DE 2500451A1
- Authority
- DE
- Germany
- Prior art keywords
- radical
- cis
- trans
- general formula
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 150000003180 prostaglandins Chemical class 0.000 title claims description 56
- 238000000034 method Methods 0.000 title claims description 39
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- 229940126601 medicinal product Drugs 0.000 title claims description 3
- 150000001875 compounds Chemical class 0.000 claims description 219
- -1 Alkyl radical Chemical class 0.000 claims description 203
- 150000003254 radicals Chemical group 0.000 claims description 83
- 238000006243 chemical reaction Methods 0.000 claims description 49
- 125000004432 carbon atom Chemical group C* 0.000 claims description 43
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- TUJKJAMUKRIRHC-UHFFFAOYSA-N hydroxyl Chemical compound [OH] TUJKJAMUKRIRHC-UHFFFAOYSA-N 0.000 claims description 28
- 239000003960 organic solvent Substances 0.000 claims description 25
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical group C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 claims description 17
- 238000002360 preparation method Methods 0.000 claims description 17
- 229910052717 sulfur Chemical group 0.000 claims description 15
- 125000004434 sulfur atom Chemical group 0.000 claims description 15
- 229920000858 Cyclodextrin Polymers 0.000 claims description 13
- DHKHKXVYLBGOIT-UHFFFAOYSA-N acetaldehyde Diethyl Acetal Chemical class CCOC(C)OCC DHKHKXVYLBGOIT-UHFFFAOYSA-N 0.000 claims description 13
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 claims description 13
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
- C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
- C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
- C07C405/0025—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing keto groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
- C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
- C07C405/0033—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing sulfur
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/10—Oxygen atoms
- C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB127874A GB1464471A (en) | 1974-01-10 | 1974-01-10 | Prostaglandin analogues |
| GB4377774 | 1974-10-09 | ||
| GB4568474 | 1974-10-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE2500451A1 true DE2500451A1 (de) | 1975-07-17 |
Family
ID=27253867
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19752500451 Withdrawn DE2500451A1 (de) | 1974-01-10 | 1975-01-08 | Prostaglandinanaloge, verfahren zu ihrer herstellung und diese enthaltende arzneimittel |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US3953435A (en:Method) |
| JP (1) | JPS50123642A (en:Method) |
| AU (1) | AU7719475A (en:Method) |
| BE (1) | BE824196A (en:Method) |
| DE (1) | DE2500451A1 (en:Method) |
| DK (1) | DK4075A (en:Method) |
| FI (1) | FI750039A7 (en:Method) |
| LU (1) | LU71603A1 (en:Method) |
| NL (1) | NL7500224A (en:Method) |
| SE (1) | SE7500173L (en:Method) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2840142A1 (de) * | 1977-09-23 | 1979-04-05 | Chinoin Gyogyszer Es Vegyeszet | Die mit cyclodextrin gebildeten einschlusskomplexe des prostacyclins und seiner derivate sowie verfahren zur herstellung dieser komplexe |
| EP0130142A1 (de) * | 1983-06-23 | 1985-01-02 | Schering Aktiengesellschaft | Neue Prostacyclinderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1482010A (en) * | 1974-10-28 | 1977-08-03 | Ono Pharmaceutical Co | Prostaglandin analogues |
| US4123463A (en) * | 1978-03-21 | 1978-10-31 | The Upjohn Company | 2-Decarboxy-2-alkylketone prostaglandins |
| US4176282A (en) * | 1978-03-21 | 1979-11-27 | The Upjohn Company | 2-Decarboxy-2-alkylcarbonyl-3,7-inter-m-phenylene-3-oxa-4,5,6-trinor-PGF1 compounds |
| DE2851051A1 (de) * | 1978-11-25 | 1980-06-04 | Basf Ag | Verfahren zur herstellung von polyenaldehyden |
| US4542155A (en) * | 1984-04-02 | 1985-09-17 | E. R. Squibb & Sons, Inc. | Tetrahydrofuranyl substituted prostaglandin analogs |
| CN101948484B (zh) * | 2010-09-19 | 2012-07-11 | 武汉武药科技有限公司 | 一种曲伏前列素中间体的制备方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3504020A (en) * | 1967-10-04 | 1970-03-31 | American Home Prod | Prostaglandin thiosemicarbazones,1-ester and 1-carbinol derivatives thereof |
| US3636120A (en) * | 1967-10-09 | 1972-01-18 | Upjohn Co | Prostaglandin e primary alcohols |
| US3749741A (en) * | 1968-02-01 | 1973-07-31 | American Home Prod | Tetrahydropyranyl-dihydro-pge1 |
| GB1334952A (en) * | 1971-01-06 | 1973-10-24 | Ici Ltd | Cyclopentane derivat-ves and a process for their manufacture |
| US3849474A (en) * | 1972-03-27 | 1974-11-19 | Ayerst Mckenna & Harrison | 11-deoxyprostaglandin derivatives and process therefor |
| JPS5432773B2 (en:Method) * | 1972-05-09 | 1979-10-16 |
-
1974
- 1974-12-30 US US05/537,522 patent/US3953435A/en not_active Expired - Lifetime
-
1975
- 1975-01-08 NL NL7500224A patent/NL7500224A/xx unknown
- 1975-01-08 AU AU77194/75A patent/AU7719475A/en not_active Expired
- 1975-01-08 BE BE152225A patent/BE824196A/xx unknown
- 1975-01-08 DE DE19752500451 patent/DE2500451A1/de not_active Withdrawn
- 1975-01-08 LU LU71603A patent/LU71603A1/xx unknown
- 1975-01-08 SE SE7500173A patent/SE7500173L/xx unknown
- 1975-01-08 FI FI750039A patent/FI750039A7/fi not_active Application Discontinuation
- 1975-01-09 DK DK4075*BA patent/DK4075A/da not_active Application Discontinuation
- 1975-01-10 JP JP50005012A patent/JPS50123642A/ja active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2840142A1 (de) * | 1977-09-23 | 1979-04-05 | Chinoin Gyogyszer Es Vegyeszet | Die mit cyclodextrin gebildeten einschlusskomplexe des prostacyclins und seiner derivate sowie verfahren zur herstellung dieser komplexe |
| EP0130142A1 (de) * | 1983-06-23 | 1985-01-02 | Schering Aktiengesellschaft | Neue Prostacyclinderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
Also Published As
| Publication number | Publication date |
|---|---|
| US3953435A (en) | 1976-04-27 |
| NL7500224A (nl) | 1975-07-14 |
| BE824196A (fr) | 1975-05-02 |
| DK4075A (en:Method) | 1975-08-25 |
| FI750039A7 (en:Method) | 1975-07-11 |
| JPS50123642A (en:Method) | 1975-09-29 |
| SE7500173L (en:Method) | 1975-07-11 |
| LU71603A1 (en:Method) | 1975-06-17 |
| AU7719475A (en) | 1976-07-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8141 | Disposal/no request for examination |