GB1464471A - Prostaglandin analogues - Google Patents

Prostaglandin analogues

Info

Publication number
GB1464471A
GB1464471A GB127874A GB127874A GB1464471A GB 1464471 A GB1464471 A GB 1464471A GB 127874 A GB127874 A GB 127874A GB 127874 A GB127874 A GB 127874A GB 1464471 A GB1464471 A GB 1464471A
Authority
GB
United Kingdom
Prior art keywords
cis
alkyl
enoate
hept
cyclopentyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB127874A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ono Pharmaceutical Co Ltd
Original Assignee
Ono Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ono Pharmaceutical Co Ltd filed Critical Ono Pharmaceutical Co Ltd
Priority to GB127874A priority Critical patent/GB1464471A/en
Priority to US05/537,522 priority patent/US3953435A/en
Priority to NL7500224A priority patent/NL7500224A/en
Priority to FI750039A priority patent/FI750039A/fi
Priority to SE7500173A priority patent/SE7500173L/xx
Priority to ZA00750146A priority patent/ZA75146B/en
Priority to DE19752500451 priority patent/DE2500451A1/en
Priority to AU77194/75A priority patent/AU7719475A/en
Priority to BE152225A priority patent/BE824196A/en
Priority to LU71603A priority patent/LU71603A1/xx
Priority to DK4075*BA priority patent/DK4075A/da
Priority to JP50005012A priority patent/JPS50123642A/ja
Publication of GB1464471A publication Critical patent/GB1464471A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
    • C07C405/0025—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing keto groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
    • C07C405/0033—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing sulfur
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)

Abstract

1464471 Cyclodextrin complexes; silylated prostaglandin ONO PHARMACEUTICAL CO Ltd 9 Jan 1975 [10 Jan 1974 9 Oct 1974 22 Oct 1974] 01278/74 43777/74 and 45684/74 Headings C3U and C3S [Also in Division C2] Novel cyclodextrin clathrates of prostaglandins of the formula wherein X is ethylene or cis-vinylene; Y is ethylene or trans-vinylene; R<SP>1</SP> is H or C 1-4 alkyl; R<SP>2</SP> is C 1-10 alkyl; C 1-4 alkyl substituted by a phenyl or cycloalkyl radical, or R<SP>2</SP> is a grouping of the formula -B-Z-Ph, wherein B is C 1-4 alkylene, Z is O, S or SO, and the phenyl radical is optionally substituted once or twice by halogen atoms or trifluoromethyl or C 1-3 alkyl radicals; and A is a grouping of the formula are prepared by heating solutions containing the prostaglandins and the cyelodextrins Methyt 7 - [5α - acetoxy - 3α - (2 - tetrahydropyranyloxy) - 2# - trimethylsilyloxymethyl - 1α- cyclopentyl]hept - cis - 5 - enoate is prepared by acetylating methyl 7 - [5α - hydroxy - 3α - (2- tetrahydropyranyloxy)- 2# - trimethylsilyloxymethyl - 1α - cyclopentyl]hept - cis - 5 - enoate, obtained by reacting trimethylchlorosilane with methyl 7 - [5α - hydroxy - 2# - hydroxymethyl- 3α - (2 - tetrahydropyronyloxy) - 1α - cyclopentyl]hept - cis - 5 - enoate.
GB127874A 1974-01-10 1974-01-10 Prostaglandin analogues Expired GB1464471A (en)

Priority Applications (12)

Application Number Priority Date Filing Date Title
GB127874A GB1464471A (en) 1974-01-10 1974-01-10 Prostaglandin analogues
US05/537,522 US3953435A (en) 1974-01-10 1974-12-30 Aldehyde derivatives of prostaglandins
NL7500224A NL7500224A (en) 1974-01-10 1975-01-08 PROCESS FOR PREPARING PROSTAGLANDIN-OGA; PROCESS FOR THE PREPARATION OF PHARMACEUTICAL PREPARATIONS, AND THE ARTICLES MANUFACTURED BY USE.
FI750039A FI750039A (en) 1974-01-10 1975-01-08
SE7500173A SE7500173L (en) 1974-01-10 1975-01-08
ZA00750146A ZA75146B (en) 1974-01-10 1975-01-08 Prostanaldehydes
DE19752500451 DE2500451A1 (en) 1974-01-10 1975-01-08 PROSTAGLANDIN ANALOGS, THE PROCESS FOR THEIR MANUFACTURING AND MEDICINAL PRODUCTS CONTAINING THESE
AU77194/75A AU7719475A (en) 1974-01-10 1975-01-08 Prostaglandin analogues
BE152225A BE824196A (en) 1974-01-10 1975-01-08 PROSTAGLANDINS
LU71603A LU71603A1 (en) 1974-01-10 1975-01-08
DK4075*BA DK4075A (en) 1974-01-10 1975-01-09
JP50005012A JPS50123642A (en) 1974-01-10 1975-01-10

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB127874A GB1464471A (en) 1974-01-10 1974-01-10 Prostaglandin analogues

Publications (1)

Publication Number Publication Date
GB1464471A true GB1464471A (en) 1977-02-16

Family

ID=9719191

Family Applications (1)

Application Number Title Priority Date Filing Date
GB127874A Expired GB1464471A (en) 1974-01-10 1974-01-10 Prostaglandin analogues

Country Status (2)

Country Link
GB (1) GB1464471A (en)
ZA (1) ZA75146B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4008527A1 (en) 2020-12-07 2022-06-08 Herz Austria Gesellschaft m.b.H Welding device

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4008527A1 (en) 2020-12-07 2022-06-08 Herz Austria Gesellschaft m.b.H Welding device

Also Published As

Publication number Publication date
ZA75146B (en) 1976-01-28

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee