GB1299136A - Improvements in or relating to prostaglandins and the preparation thereof - Google Patents
Improvements in or relating to prostaglandins and the preparation thereofInfo
- Publication number
- GB1299136A GB1299136A GB26409/71A GB2640971A GB1299136A GB 1299136 A GB1299136 A GB 1299136A GB 26409/71 A GB26409/71 A GB 26409/71A GB 2640971 A GB2640971 A GB 2640971A GB 1299136 A GB1299136 A GB 1299136A
- Authority
- GB
- United Kingdom
- Prior art keywords
- alkyl
- substituted
- atoms
- phenyl
- chlorine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000003180 prostaglandins Chemical class 0.000 title abstract 3
- 229940094443 oxytocics prostaglandins Drugs 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 4
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 2
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 2
- 125000001153 fluoro group Chemical group F* 0.000 abstract 2
- 125000006376 (C3-C10) cycloalkyl group Chemical group 0.000 abstract 1
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical group [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 abstract 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 125000005677 ethinylene group Chemical group [*:2]C#C[*:1] 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 239000011737 fluorine Substances 0.000 abstract 1
- 125000001181 organosilyl group Chemical group [SiH3]* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/18—Carboxylic ester hydrolases (3.1.1)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C35/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring
- C07C35/22—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system
- C07C35/23—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system with hydroxy on a condensed ring system having two rings
- C07C35/27—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system with hydroxy on a condensed ring system having two rings the condensed ring system containing six carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/10—Oxygen atoms
- C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/54—Quaternary phosphonium compounds
- C07F9/5428—Acyclic unsaturated phosphonium compounds
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P31/00—Preparation of compounds containing a five-membered ring having two side-chains in ortho position to each other, and having at least one oxygen atom directly bound to the ring in ortho position to one of the side-chains, one side-chain containing, not directly bound to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having at least one oxygen atom bound in gamma-position to the ring, e.g. prostaglandins
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
1299136 Silyl derivatives of prostaglandin UPJOHN CO 19 April 1971 [20 April 1970 2 Feb 1971] 26409/71 Heading C3S [Also in Division C2] Novel prostaglandin derivatives of the formula wherein G is C 1-4 alkyl, C 7-12 aralkyl, phenyl or phenyl substituted by 1 or 2 fluorine or chlorine atoms, or C 1-4 alkyl groups, Q is cis-vinylene or ethynylene, R 2 is C 1-4 alkyl substituted with 0 to 3 fluorine atoms, R 4 is H or C 1-4 alkyl, R 1a is -Si(G) 3 , C 1-8 alkyl, C 3-10 cycloalkyl, C 7-12 aralkyl, phenyl, phenyl substituted by 1 to 3 chlorine atoms or C 1-4 alkyl groups, or ethyl substituted in the #-position with 3-chlorine, 2 or 3 bromine or 1, 2 or 3 iodine atoms, n is 1 to 4 and A is C 1-10 alkylene, substituted with 0 to 2 fluorine atoms, and with 1 to 5 carbon atoms between COOR 1a and Q are prepared by silylating the corresponding dihydroxy acids or esters thereof.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3031270A | 1970-04-20 | 1970-04-20 | |
| US11203271A | 1971-02-02 | 1971-02-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1299136A true GB1299136A (en) | 1972-12-06 |
Family
ID=26705894
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB26409/71A Expired GB1299136A (en) | 1970-04-20 | 1971-04-19 | Improvements in or relating to prostaglandins and the preparation thereof |
Country Status (4)
| Country | Link |
|---|---|
| BE (1) | BE766009A (en) |
| DE (1) | DE2118686A1 (en) |
| GB (1) | GB1299136A (en) |
| NL (1) | NL7105210A (en) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3954851A (en) * | 1970-04-20 | 1976-05-04 | The Upjohn Company | PGB3 analogs |
| US3883576A (en) * | 1971-02-02 | 1975-05-13 | Upjohn Co | Prostaglandin E{HD 3 {B analogs |
| US3883575A (en) * | 1971-02-02 | 1975-05-13 | Upjohn Co | Prostaglandin B{HD 3 {B analogs |
| US3883574A (en) * | 1971-02-02 | 1975-05-13 | Upjohn Co | Prostaglandin A{HD 3 {B analogs |
| US3879437A (en) * | 1971-02-02 | 1975-04-22 | Upjohn Co | Prostaglandin F{HD 3{B {331 {0 analogs |
| US3879439A (en) * | 1971-02-02 | 1975-04-22 | Upjohn Co | Prostaglandin F{HD 3{301 {0 {B analogs |
| US4032560A (en) * | 1975-08-13 | 1977-06-28 | The Upjohn Company | Oxa phenylene prostaglandin analogs |
| DE2907118A1 (en) * | 1979-02-20 | 1980-09-04 | Schering Ag | NEW PROSTACYCLINE DERIVATIVES AND METHOD FOR THE PRODUCTION THEREOF |
| US4472428A (en) * | 1980-12-09 | 1984-09-18 | Teijin Limited | Halogenated prostacyclins pharmaceutical use thereof and hydroxy intermediates therefore |
| ATE164763T1 (en) * | 1990-12-10 | 1998-04-15 | Allergan Inc | OCCULAR HYPOTENSIVE HOMO-PROSTAGLAND INDERIVATIVES |
| US5262437A (en) * | 1990-12-10 | 1993-11-16 | Allergan, Inc. | Homo-prostaglandin derivatives as ocular hypotensives |
-
1971
- 1971-04-17 DE DE19712118686 patent/DE2118686A1/en active Pending
- 1971-04-19 NL NL7105210A patent/NL7105210A/xx unknown
- 1971-04-19 GB GB26409/71A patent/GB1299136A/en not_active Expired
- 1971-04-20 BE BE766009A patent/BE766009A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| BE766009A (en) | 1971-10-20 |
| DE2118686A1 (en) | 1971-11-11 |
| NL7105210A (en) | 1971-10-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PCNP | Patent ceased through non-payment of renewal fee |