DE2433440A1 - Eine einheit mit zwei abteilungen fuer nacheinander injizierbare, fluessige vitaminpraeparationen - Google Patents
Eine einheit mit zwei abteilungen fuer nacheinander injizierbare, fluessige vitaminpraeparationenInfo
- Publication number
- DE2433440A1 DE2433440A1 DE19742433440 DE2433440A DE2433440A1 DE 2433440 A1 DE2433440 A1 DE 2433440A1 DE 19742433440 DE19742433440 DE 19742433440 DE 2433440 A DE2433440 A DE 2433440A DE 2433440 A1 DE2433440 A1 DE 2433440A1
- Authority
- DE
- Germany
- Prior art keywords
- vitamin
- preparations
- syringe
- aqueous
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000002360 preparation method Methods 0.000 title claims description 47
- 229940088594 vitamin Drugs 0.000 title claims description 34
- 229930003231 vitamin Natural products 0.000 title claims description 34
- 235000013343 vitamin Nutrition 0.000 title claims description 34
- 239000011782 vitamin Substances 0.000 title claims description 34
- 150000003722 vitamin derivatives Chemical class 0.000 title claims description 26
- 239000007788 liquid Substances 0.000 title description 15
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 26
- 235000019155 vitamin A Nutrition 0.000 claims description 14
- 239000011719 vitamin A Substances 0.000 claims description 14
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 claims description 13
- 229960003966 nicotinamide Drugs 0.000 claims description 13
- 235000005152 nicotinamide Nutrition 0.000 claims description 13
- 239000011570 nicotinamide Substances 0.000 claims description 13
- RMRCNWBMXRMIRW-BYFNXCQMSA-M cyanocobalamin Chemical compound N#C[Co+]N([C@]1([H])[C@H](CC(N)=O)[C@]\2(CCC(=O)NC[C@H](C)OP(O)(=O)OC3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)C)C/2=C(C)\C([C@H](C/2(C)C)CCC(N)=O)=N\C\2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O RMRCNWBMXRMIRW-BYFNXCQMSA-M 0.000 claims description 12
- JZRWCGZRTZMZEH-UHFFFAOYSA-N thiamine Chemical compound CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N JZRWCGZRTZMZEH-UHFFFAOYSA-N 0.000 claims description 12
- 235000019154 vitamin C Nutrition 0.000 claims description 11
- 239000011718 vitamin C Substances 0.000 claims description 11
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 claims description 10
- 238000002347 injection Methods 0.000 claims description 10
- 239000007924 injection Substances 0.000 claims description 10
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims description 9
- 229930003268 Vitamin C Natural products 0.000 claims description 9
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 claims description 8
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 claims description 8
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 claims description 8
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 claims description 8
- 229940045997 vitamin a Drugs 0.000 claims description 8
- SNPLKNRPJHDVJA-ZETCQYMHSA-N D-panthenol Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCCO SNPLKNRPJHDVJA-ZETCQYMHSA-N 0.000 claims description 6
- 229960002104 cyanocobalamin Drugs 0.000 claims description 6
- 235000000639 cyanocobalamin Nutrition 0.000 claims description 6
- 239000011666 cyanocobalamin Substances 0.000 claims description 6
- 229960005055 sodium ascorbate Drugs 0.000 claims description 6
- 235000010378 sodium ascorbate Nutrition 0.000 claims description 6
- PPASLZSBLFJQEF-RKJRWTFHSA-M sodium ascorbate Substances [Na+].OC[C@@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RKJRWTFHSA-M 0.000 claims description 6
- PPASLZSBLFJQEF-RXSVEWSESA-M sodium-L-ascorbate Chemical compound [Na+].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RXSVEWSESA-M 0.000 claims description 6
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 claims description 5
- 229960000304 folic acid Drugs 0.000 claims description 5
- 235000019152 folic acid Nutrition 0.000 claims description 5
- 239000011724 folic acid Substances 0.000 claims description 5
- AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 claims description 4
- 235000010323 ascorbic acid Nutrition 0.000 claims description 4
- 239000011668 ascorbic acid Substances 0.000 claims description 4
- 229960005070 ascorbic acid Drugs 0.000 claims description 4
- 235000019171 pyridoxine hydrochloride Nutrition 0.000 claims description 4
- 239000011764 pyridoxine hydrochloride Substances 0.000 claims description 4
- VYGQUTWHTHXGQB-FFHKNEKCSA-N retinyl palmitate group Chemical group C(CCCCCCCCCCCCCCC)(=O)OC\C=C(\C=C\C=C(\C=C\C1=C(CCCC1(C)C)C)/C)/C VYGQUTWHTHXGQB-FFHKNEKCSA-N 0.000 claims description 4
- 229960002477 riboflavin Drugs 0.000 claims description 4
- 235000019192 riboflavin Nutrition 0.000 claims description 4
- 239000002151 riboflavin Substances 0.000 claims description 4
- 229930003270 Vitamin B Natural products 0.000 claims description 3
- 235000019156 vitamin B Nutrition 0.000 claims description 3
- 239000011720 vitamin B Substances 0.000 claims description 3
- VYGQUTWHTHXGQB-UHFFFAOYSA-N Retinol hexadecanoate Natural products CCCCCCCCCCCCCCCC(=O)OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C VYGQUTWHTHXGQB-UHFFFAOYSA-N 0.000 claims description 2
- 229940108325 retinyl palmitate Drugs 0.000 claims description 2
- 235000019172 retinyl palmitate Nutrition 0.000 claims description 2
- 239000011769 retinyl palmitate Substances 0.000 claims description 2
- MECHNRXZTMCUDQ-RKHKHRCZSA-N vitamin D2 Chemical group C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)/C=C/[C@H](C)C(C)C)=C\C=C1\C[C@@H](O)CCC1=C MECHNRXZTMCUDQ-RKHKHRCZSA-N 0.000 claims description 2
- AEDORKVKMIVLBW-BLDDREHASA-N 3-oxo-3-[[(2r,3s,4s,5r,6r)-3,4,5-trihydroxy-6-[[5-hydroxy-4-(hydroxymethyl)-6-methylpyridin-3-yl]methoxy]oxan-2-yl]methoxy]propanoic acid Chemical compound OCC1=C(O)C(C)=NC=C1CO[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](COC(=O)CC(O)=O)O1 AEDORKVKMIVLBW-BLDDREHASA-N 0.000 claims 2
- OHSHFZJLPYLRIP-BMZHGHOISA-M Riboflavin sodium phosphate Chemical compound [Na+].OP(=O)([O-])OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O OHSHFZJLPYLRIP-BMZHGHOISA-M 0.000 claims 2
- 229960004172 pyridoxine hydrochloride Drugs 0.000 claims 2
- 229960000344 thiamine hydrochloride Drugs 0.000 claims 2
- 235000019190 thiamine hydrochloride Nutrition 0.000 claims 2
- 239000011747 thiamine hydrochloride Substances 0.000 claims 2
- DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 claims 2
- WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 description 18
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 14
- 239000000203 mixture Substances 0.000 description 12
- 239000000243 solution Substances 0.000 description 9
- 239000008215 water for injection Substances 0.000 description 7
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 6
- 235000019445 benzyl alcohol Nutrition 0.000 description 6
- 239000012299 nitrogen atmosphere Substances 0.000 description 6
- LXNHXLLTXMVWPM-UHFFFAOYSA-N pyridoxine Chemical compound CC1=NC=C(CO)C(CO)=C1O LXNHXLLTXMVWPM-UHFFFAOYSA-N 0.000 description 6
- 238000000034 method Methods 0.000 description 5
- 238000011049 filling Methods 0.000 description 4
- 238000009472 formulation Methods 0.000 description 4
- 229960003495 thiamine Drugs 0.000 description 4
- 229940011671 vitamin b6 Drugs 0.000 description 4
- PFKAKHILNWLJRT-UHFFFAOYSA-H 2-hydroxypropane-1,2,3-tricarboxylate;iron(2+) Chemical compound [Fe+2].[Fe+2].[Fe+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O PFKAKHILNWLJRT-UHFFFAOYSA-H 0.000 description 3
- 235000004866 D-panthenol Nutrition 0.000 description 3
- 239000011703 D-panthenol Substances 0.000 description 3
- 239000000654 additive Substances 0.000 description 3
- 239000003708 ampul Substances 0.000 description 3
- 239000007864 aqueous solution Substances 0.000 description 3
- 229960003949 dexpanthenol Drugs 0.000 description 3
- 239000011640 ferrous citrate Substances 0.000 description 3
- 235000019850 ferrous citrate Nutrition 0.000 description 3
- 238000001802 infusion Methods 0.000 description 3
- 238000003780 insertion Methods 0.000 description 3
- 230000037431 insertion Effects 0.000 description 3
- 238000001990 intravenous administration Methods 0.000 description 3
- 238000002955 isolation Methods 0.000 description 3
- 239000012528 membrane Substances 0.000 description 3
- 238000004806 packaging method and process Methods 0.000 description 3
- 230000000717 retained effect Effects 0.000 description 3
- VVIAGPKUTFNRDU-UHFFFAOYSA-N 6S-folinic acid Natural products C1NC=2NC(N)=NC(=O)C=2N(C=O)C1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 VVIAGPKUTFNRDU-UHFFFAOYSA-N 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- MPJKWIXIYCLVCU-UHFFFAOYSA-N Folinic acid Natural products NC1=NC2=C(N(C=O)C(CNc3ccc(cc3)C(=O)NC(CCC(=O)O)CC(=O)O)CN2)C(=O)N1 MPJKWIXIYCLVCU-UHFFFAOYSA-N 0.000 description 2
- 235000008191 folinic acid Nutrition 0.000 description 2
- 239000011672 folinic acid Substances 0.000 description 2
- VVIAGPKUTFNRDU-ABLWVSNPSA-N folinic acid Chemical compound C1NC=2NC(N)=NC(=O)C=2N(C=O)C1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 VVIAGPKUTFNRDU-ABLWVSNPSA-N 0.000 description 2
- 239000013505 freshwater Substances 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 229910052500 inorganic mineral Inorganic materials 0.000 description 2
- 229960001691 leucovorin Drugs 0.000 description 2
- 239000011707 mineral Substances 0.000 description 2
- 235000010755 mineral Nutrition 0.000 description 2
- 230000035515 penetration Effects 0.000 description 2
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 2
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 2
- 229920000053 polysorbate 80 Polymers 0.000 description 2
- 229940068968 polysorbate 80 Drugs 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 235000008160 pyridoxine Nutrition 0.000 description 2
- 239000011677 pyridoxine Substances 0.000 description 2
- 239000002002 slurry Substances 0.000 description 2
- OHSHFZJLPYLRIP-LQDWTQKMSA-M sodium;[(2s,3r,4r)-5-(7,8-dimethyl-2,4-dioxobenzo[g]pteridin-10-yl)-2,3,4-trihydroxypentyl] hydrogen phosphate Chemical compound [Na+].OP(=O)([O-])OC[C@H](O)[C@H](O)[C@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O OHSHFZJLPYLRIP-LQDWTQKMSA-M 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 239000011721 thiamine Substances 0.000 description 2
- 235000019157 thiamine Nutrition 0.000 description 2
- XZMCDFZZKTWFGF-UHFFFAOYSA-N Cyanamide Chemical compound NC#N XZMCDFZZKTWFGF-UHFFFAOYSA-N 0.000 description 1
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 description 1
- 235000002414 D-alpha-tocopherylacetate Nutrition 0.000 description 1
- 239000011740 D-alpha-tocopherylacetate Substances 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 235000001014 amino acid Nutrition 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- ZAKOWWREFLAJOT-UHFFFAOYSA-N d-alpha-Tocopheryl acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-UHFFFAOYSA-N 0.000 description 1
- 229940039770 d-alpha-tocopheryl acetate Drugs 0.000 description 1
- 238000005429 filling process Methods 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 238000007918 intramuscular administration Methods 0.000 description 1
- 238000010255 intramuscular injection Methods 0.000 description 1
- 239000007927 intramuscular injection Substances 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 230000003387 muscular Effects 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 231100000344 non-irritating Toxicity 0.000 description 1
- -1 pH regulators Substances 0.000 description 1
- 229940101267 panthenol Drugs 0.000 description 1
- 235000020957 pantothenol Nutrition 0.000 description 1
- 239000011619 pantothenol Substances 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 229940046008 vitamin d Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/28—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
- A61M5/284—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle comprising means for injection of two or more media, e.g. by mixing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31596—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms comprising means for injection of two or more media, e.g. by mixing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M2005/1787—Syringes for sequential delivery of fluids, e.g. first medicament and then flushing liquid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/3129—Syringe barrels
- A61M2005/3132—Syringe barrels having flow passages for injection agents at the distal end of the barrel to bypass a sealing stopper after its displacement to this end due to internal pressure increase
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Anesthesiology (AREA)
- Engineering & Computer Science (AREA)
- Vascular Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38499573A | 1973-08-02 | 1973-08-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE2433440A1 true DE2433440A1 (de) | 1975-02-13 |
Family
ID=23519605
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19742433440 Pending DE2433440A1 (de) | 1973-08-02 | 1974-07-11 | Eine einheit mit zwei abteilungen fuer nacheinander injizierbare, fluessige vitaminpraeparationen |
Country Status (8)
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102004051245A1 (de) * | 2004-10-20 | 2006-04-27 | Aquanova German Solubilisate Technologies (Agt) Gmbh | Vitamin C-Solubilisat |
| DE102017208255A1 (de) * | 2017-05-16 | 2018-11-22 | Vetter Pharma-Fertigung GmbH & Co. KG | Medikamentenbehälter mit einem Endstopfen, Verwendung eines Stopfensicherungsteils zum Sichern eines Endstopfens in einem Medikamentenbehälter und Stopfensicherungsteil |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0071288B1 (en) * | 1981-07-29 | 1985-10-02 | Duphar International Research B.V | Hypodermic syringe |
| EP0072058A1 (en) * | 1981-08-10 | 1983-02-16 | Duphar International Research B.V | Multiple-compartment syringe |
| EP0295337B1 (en) * | 1987-06-16 | 1991-12-04 | Akzo Nobel N.V. | Two compartment syringe and method of manufacturing |
| JPH0620219B2 (ja) * | 1989-04-11 | 1994-03-16 | 松下電送株式会社 | 原稿走行部解除装置 |
| JPH0715552Y2 (ja) * | 1989-08-01 | 1995-04-12 | 武田薬品工業株式会社 | 注射器型２成分分封容器 |
| JP2942962B2 (ja) * | 1990-03-30 | 1999-08-30 | 株式会社バルダン | 長尺布切断装置 |
| FR2672868B1 (fr) * | 1991-02-15 | 1993-06-04 | Pasteur Merieux Serums Vacc | Procede de conditionnement de vaccins lyophilises en seringue et bouchon pour sa mise en óoeuvre. |
| JP3199475B2 (ja) | 1992-07-21 | 2001-08-20 | ライオン株式会社 | ビタミンａ類可溶化水溶液の安定化法 |
| EP0704199B1 (en) * | 1994-04-20 | 2003-03-19 | Mitsubishi Pharma Corporation | Transfusion container, transfusion preparation, and comprehensive vitamin-containing high-calorie transfusion preparation |
| AU725161B2 (en) * | 1995-08-09 | 2000-10-05 | Tetsuro Higashikawa | Syringe, its sealing structure and sealing method and sliding valve for syringe |
| FR2881052B1 (fr) * | 2005-01-26 | 2016-07-29 | Becton Dickinson France | Dispositif de stockage et de melange de deux substances, procede de fabrication et applications |
| JP2018531065A (ja) * | 2015-10-02 | 2018-10-25 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | 多チャンバシリンジユニットおよび多チャンバシリンジを作製する方法 |
| CN106039480A (zh) * | 2016-08-04 | 2016-10-26 | 山东威高集团医用高分子制品股份有限公司 | 连续治疗的预填充注射器 |
-
1974
- 1974-07-04 GB GB2978674A patent/GB1464797A/en not_active Expired
- 1974-07-10 AU AU71054/74A patent/AU7105474A/en not_active Expired
- 1974-07-11 DE DE19742433440 patent/DE2433440A1/de active Pending
- 1974-07-19 NL NL7409809A patent/NL7409809A/xx unknown
- 1974-08-01 BE BE147185A patent/BE818372A/xx unknown
- 1974-08-02 JP JP49088182A patent/JPS5043789A/ja active Pending
- 1974-08-02 FR FR7426974A patent/FR2239990B1/fr not_active Expired
- 1974-08-02 ES ES428890A patent/ES428890A1/es not_active Expired
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102004051245A1 (de) * | 2004-10-20 | 2006-04-27 | Aquanova German Solubilisate Technologies (Agt) Gmbh | Vitamin C-Solubilisat |
| DE102017208255A1 (de) * | 2017-05-16 | 2018-11-22 | Vetter Pharma-Fertigung GmbH & Co. KG | Medikamentenbehälter mit einem Endstopfen, Verwendung eines Stopfensicherungsteils zum Sichern eines Endstopfens in einem Medikamentenbehälter und Stopfensicherungsteil |
Also Published As
| Publication number | Publication date |
|---|---|
| ES428890A1 (es) | 1977-04-01 |
| NL7409809A (nl) | 1975-02-04 |
| FR2239990A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1975-03-07 |
| GB1464797A (en) | 1977-02-16 |
| JPS5043789A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1975-04-19 |
| BE818372A (fr) | 1975-02-03 |
| AU7105474A (en) | 1976-01-15 |
| FR2239990B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1977-07-08 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE2433440A1 (de) | Eine einheit mit zwei abteilungen fuer nacheinander injizierbare, fluessige vitaminpraeparationen | |
| DE69224619T2 (de) | Arzneimittelausgabesystem | |
| DE60011589T2 (de) | Hochwirksame dihydroergotaminhaltige arzneizusammensetzungen | |
| DE602004012718T2 (de) | Formulierung für einen dosierinhalator unter verwendung von hydro-fluoro-alkanen als treibstoffe | |
| AT394947B (de) | Verfahren zur herstellung einer fluessigen nasal verabreichbaren calcitoninzusammensetzung | |
| DE68904922T2 (de) | Piroxicam in waessrigen loesungen enthaltende arzneizubereitungen und verfahren zu deren herstellung. | |
| DE1792410A1 (de) | Pharmakologische Komposition und Verfahren zu ihrer Herstellung | |
| DE2329704A1 (de) | Behaelter zur aufnahme mischbarer produkte, insbesondere fuer medizinische praeparate | |
| DE60005376T2 (de) | Oxaliplatinhaltige parenteral anzuwendende stabilisierte arzneizubereitung und verfahren zu deren herstellung | |
| DE2364414A1 (de) | Zusatzstoff und verfahren zum herstellen von infusionsloesungen | |
| DE69123847T2 (de) | Verfahren und vorrichtung zum dosieren eines flüssigen produkts | |
| DE19535571A1 (de) | Pharmazeutische Kombinationspräparate und deren Verwendung zur Behandlung von Hämodialysepatienten | |
| EP0254902B1 (de) | Lösungen von Oxazaphosphorinen mit verbesserter Stabilität und Verfahren zu deren Herstellung | |
| DE3536560A1 (de) | Augentropfen enthaltend bromokryptin | |
| EP0461505B1 (de) | Nitroglycerin-Spray | |
| DE60220766T2 (de) | Verwendung eines eine oxaliplatinlösung beinhaltenden fläschchens | |
| DE60101979T2 (de) | Lösung enthaltend N-[O-(p-pivaloyloxybenzenesulfonylamino)benzoyl]glyzin Mononatriumsalz Tetrahydrat und diese Lösung enthaltendes Arzneimittel | |
| DE3324964C2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | ||
| DE1053736B (de) | Verfahren zur Erhoehung der Loeslichkeit therapeutisch wirksamer Stoffe in Wasser | |
| EP0336000A1 (de) | Ambiphile Creme | |
| DE3208505C2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | ||
| DE69509508T2 (de) | Vorrichtung und verfahren zum aseptischen vermischen von flüssigkeiten | |
| DE2907452C2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | ||
| DE2117762A1 (de) | Behandlung von Alopecia und pharmazeutische Präparation für die Durchführung der Behandlung | |
| DE3044753C2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| OHJ | Non-payment of the annual fee |