DE2357250A1 - 7 alpha-cyano-17-hydroxy-3-oxo-17 alpha-pregn-4-en-21-carbonsaeure-gamma lacton und verwandte verbindungen, verfahren zu deren herstellung und diese verbindungen enthaltende mittel - Google Patents
7 alpha-cyano-17-hydroxy-3-oxo-17 alpha-pregn-4-en-21-carbonsaeure-gamma lacton und verwandte verbindungen, verfahren zu deren herstellung und diese verbindungen enthaltende mittelInfo
- Publication number
- DE2357250A1 DE2357250A1 DE2357250A DE2357250A DE2357250A1 DE 2357250 A1 DE2357250 A1 DE 2357250A1 DE 2357250 A DE2357250 A DE 2357250A DE 2357250 A DE2357250 A DE 2357250A DE 2357250 A1 DE2357250 A1 DE 2357250A1
- Authority
- DE
- Germany
- Prior art keywords
- hydroxy
- oxo
- lactone
- cyano
- carboxylic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
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- 235000010355 mannitol Nutrition 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 235000010755 mineral Nutrition 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 150000004682 monohydrates Chemical class 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 239000004006 olive oil Substances 0.000 description 1
- 235000008390 olive oil Nutrition 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 239000000312 peanut oil Substances 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 235000021317 phosphate Nutrition 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 235000019422 polyvinyl alcohol Nutrition 0.000 description 1
- 229910000027 potassium carbonate Inorganic materials 0.000 description 1
- 235000011181 potassium carbonates Nutrition 0.000 description 1
- 229920001592 potato starch Polymers 0.000 description 1
- JWMFYGXQPXQEEM-WZBAXQLOSA-N pregnane Chemical compound C1CC2CCCC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](CC)[C@@]1(C)CC2 JWMFYGXQPXQEEM-WZBAXQLOSA-N 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 239000008159 sesame oil Substances 0.000 description 1
- 235000011803 sesame oil Nutrition 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- 235000010265 sodium sulphite Nutrition 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 235000010356 sorbitol Nutrition 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000008399 tap water Substances 0.000 description 1
- 235000020679 tap water Nutrition 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000004809 thin layer chromatography Methods 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical class [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- VOITXYVAKOUIBA-UHFFFAOYSA-N triethylaluminium Chemical compound CC[Al](CC)CC VOITXYVAKOUIBA-UHFFFAOYSA-N 0.000 description 1
- 238000001665 trituration Methods 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 239000008096 xylene Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0038—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 with an androstane skeleton, including 18- or 19-substituted derivatives, 18-nor derivatives and also derivatives where position 17-beta is substituted by a carbon atom not directly bonded to a further carbon atom and not being part of an amide group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J21/001—Lactones
- C07J21/003—Lactones at position 17
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0036—Nitrogen-containing hetero ring
- C07J71/0042—Nitrogen only
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US31115772A | 1972-12-01 | 1972-12-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE2357250A1 true DE2357250A1 (de) | 1974-06-06 |
Family
ID=23205662
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE2357250A Withdrawn DE2357250A1 (de) | 1972-12-01 | 1973-11-16 | 7 alpha-cyano-17-hydroxy-3-oxo-17 alpha-pregn-4-en-21-carbonsaeure-gamma lacton und verwandte verbindungen, verfahren zu deren herstellung und diese verbindungen enthaltende mittel |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US3773758A (https=) |
| JP (1) | JPS4986358A (https=) |
| CA (1) | CA1020543A (https=) |
| CH (1) | CH603691A5 (https=) |
| DE (1) | DE2357250A1 (https=) |
| ES (1) | ES420665A1 (https=) |
| FR (1) | FR2208665B1 (https=) |
| GB (1) | GB1417808A (https=) |
| NL (1) | NL7315822A (https=) |
| ZA (1) | ZA738806B (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4211701A (en) * | 1979-04-13 | 1980-07-08 | The Upjohn Company | Spironolactone process |
| GB8916636D0 (en) * | 1989-07-20 | 1989-09-06 | Erba Carlo Spa | Steroid ethers |
| US5806111A (en) | 1996-04-12 | 1998-09-15 | Hill-Rom, Inc. | Stretcher controls |
| US6812358B2 (en) * | 2001-06-08 | 2004-11-02 | Bridge Organics Co. | Process for making estra-4,9(10)-diene steroids |
| US7810822B2 (en) | 2006-01-19 | 2010-10-12 | Hill-Rom Services, Inc. | Stretcher having hand actuated caster braking apparatus |
-
1972
- 1972-12-01 US US00311157A patent/US3773758A/en not_active Expired - Lifetime
-
1973
- 1973-11-09 CA CA185,462A patent/CA1020543A/en not_active Expired
- 1973-11-16 ZA ZA00738806A patent/ZA738806B/xx unknown
- 1973-11-16 DE DE2357250A patent/DE2357250A1/de not_active Withdrawn
- 1973-11-19 CH CH1618973A patent/CH603691A5/xx not_active IP Right Cessation
- 1973-11-19 ES ES420665A patent/ES420665A1/es not_active Expired
- 1973-11-19 NL NL7315822A patent/NL7315822A/xx not_active Application Discontinuation
- 1973-11-19 GB GB5363273A patent/GB1417808A/en not_active Expired
- 1973-11-19 FR FR7341131A patent/FR2208665B1/fr not_active Expired
- 1973-11-19 JP JP48130050A patent/JPS4986358A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| ZA738806B (en) | 1975-01-29 |
| FR2208665A1 (https=) | 1974-06-28 |
| AU6241473A (en) | 1975-05-15 |
| ES420665A1 (es) | 1977-01-01 |
| NL7315822A (https=) | 1974-06-05 |
| GB1417808A (en) | 1975-12-17 |
| FR2208665B1 (https=) | 1977-01-28 |
| US3773758A (en) | 1973-11-20 |
| CH603691A5 (https=) | 1978-08-31 |
| CA1020543A (en) | 1977-11-08 |
| JPS4986358A (https=) | 1974-08-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| OD | Request for examination | ||
| OD | Request for examination | ||
| 8130 | Withdrawal |