DE2353318A1 - Verbessertes verfahren zur herstellung von plasminogen-aktivator - Google Patents
Verbessertes verfahren zur herstellung von plasminogen-aktivatorInfo
- Publication number
- DE2353318A1 DE2353318A1 DE19732353318 DE2353318A DE2353318A1 DE 2353318 A1 DE2353318 A1 DE 2353318A1 DE 19732353318 DE19732353318 DE 19732353318 DE 2353318 A DE2353318 A DE 2353318A DE 2353318 A1 DE2353318 A1 DE 2353318A1
- Authority
- DE
- Germany
- Prior art keywords
- plasminogen activator
- medium
- cells
- activator
- molar
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
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- 238000000746 purification Methods 0.000 description 1
- 239000012266 salt solution Substances 0.000 description 1
- CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 description 1
- 238000011218 seed culture Methods 0.000 description 1
- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
- 235000011152 sodium sulphate Nutrition 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 229960005202 streptokinase Drugs 0.000 description 1
- 229960005322 streptomycin Drugs 0.000 description 1
- 229960002385 streptomycin sulfate Drugs 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 239000010414 supernatant solution Substances 0.000 description 1
- 229960000103 thrombolytic agent Drugs 0.000 description 1
- 229910052719 titanium Inorganic materials 0.000 description 1
- 239000010936 titanium Substances 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6456—Plasminogen activators
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30005472A | 1972-10-24 | 1972-10-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE2353318A1 true DE2353318A1 (de) | 1974-05-02 |
Family
ID=23157506
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19732353318 Pending DE2353318A1 (de) | 1972-10-24 | 1973-10-24 | Verbessertes verfahren zur herstellung von plasminogen-aktivator |
Country Status (9)
| Country | Link |
|---|---|
| JP (1) | JPS4975794A (enExample) |
| BE (1) | BE806323A (enExample) |
| CH (1) | CH589142A5 (enExample) |
| DE (1) | DE2353318A1 (enExample) |
| FR (1) | FR2203876B1 (enExample) |
| GB (1) | GB1443189A (enExample) |
| IL (1) | IL43343A (enExample) |
| NL (1) | NL7314579A (enExample) |
| SE (2) | SE392618B (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0181465A1 (de) * | 1984-09-21 | 1986-05-21 | BOEHRINGER INGELHEIM INTERNATIONAL GmbH | Blutgerinnungshemmende Proteine, Verfahren zur Herstellung sowie deren Verwendung |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5571496A (en) * | 1978-11-24 | 1980-05-29 | Asahi Chem Ind Co Ltd | Preparation of living substance |
| FI831484L (fi) * | 1982-05-05 | 1983-11-06 | Genentech Inc | Plasminogen aktivator foer maenskovaevnad |
| US4853330A (en) * | 1983-04-07 | 1989-08-01 | Genentech, Inc. | Human tissue plasminogen activator |
| KR840004781A (ko) * | 1982-05-05 | 1984-10-24 | 월터 에이치·드레거 | 인체의 조직 플라스미노겐 활성화제 |
| US5185259A (en) * | 1982-05-05 | 1993-02-09 | Genentech, Inc. | Truncated human tissue plasminogen activator |
| GR79202B (enExample) * | 1982-05-05 | 1984-10-22 | Genentech Inc | |
| IL69664A0 (en) * | 1982-09-15 | 1983-12-30 | Collaborative Res Inc | Medium supplement and method for growing cells in vitro |
| JP2507339B2 (ja) * | 1986-08-11 | 1996-06-12 | 三井東圧化学株式会社 | 粗ｔＰＡの精製方法 |
-
1973
- 1973-09-30 IL IL43343A patent/IL43343A/en unknown
- 1973-10-19 FR FR7337349A patent/FR2203876B1/fr not_active Expired
- 1973-10-22 BE BE1005443A patent/BE806323A/xx unknown
- 1973-10-22 CH CH1484773A patent/CH589142A5/xx not_active IP Right Cessation
- 1973-10-23 SE SE7314381A patent/SE392618B/xx unknown
- 1973-10-23 GB GB4919673A patent/GB1443189A/en not_active Expired
- 1973-10-23 NL NL7314579A patent/NL7314579A/xx not_active Application Discontinuation
- 1973-10-24 JP JP48119815A patent/JPS4975794A/ja active Pending
- 1973-10-24 DE DE19732353318 patent/DE2353318A1/de active Pending
-
1976
- 1976-09-07 SE SE7609880A patent/SE7609880L/xx unknown
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0181465A1 (de) * | 1984-09-21 | 1986-05-21 | BOEHRINGER INGELHEIM INTERNATIONAL GmbH | Blutgerinnungshemmende Proteine, Verfahren zur Herstellung sowie deren Verwendung |
| US4736018A (en) * | 1984-09-21 | 1988-04-05 | Boehringer Ingelheim International Gmbh | Blood coagulation inhibiting proteins, processes for preparing them and their uses |
Also Published As
| Publication number | Publication date |
|---|---|
| FR2203876A1 (enExample) | 1974-05-17 |
| GB1443189A (en) | 1976-07-21 |
| CH589142A5 (enExample) | 1977-06-30 |
| FR2203876B1 (enExample) | 1977-05-27 |
| NL7314579A (enExample) | 1974-04-26 |
| JPS4975794A (enExample) | 1974-07-22 |
| IL43343A0 (en) | 1973-11-28 |
| SE7609880L (sv) | 1976-09-07 |
| SE392618B (sv) | 1977-04-04 |
| BE806323A (fr) | 1974-04-22 |
| IL43343A (en) | 1976-03-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| OHJ | Non-payment of the annual fee |