GB1443189A - Enhanced production of plasminogen activator - Google Patents
Enhanced production of plasminogen activatorInfo
- Publication number
- GB1443189A GB1443189A GB4919673A GB4919673A GB1443189A GB 1443189 A GB1443189 A GB 1443189A GB 4919673 A GB4919673 A GB 4919673A GB 4919673 A GB4919673 A GB 4919673A GB 1443189 A GB1443189 A GB 1443189A
- Authority
- GB
- United Kingdom
- Prior art keywords
- cells
- oct
- activator
- plasminogen activator
- enhanced production
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 102000001938 Plasminogen Activators Human genes 0.000 title 1
- 108010001014 Plasminogen Activators Proteins 0.000 title 1
- 229940127126 plasminogen activator Drugs 0.000 title 1
- IAKHMKGGTNLKSZ-INIZCTEOSA-N (S)-colchicine Chemical compound C1([C@@H](NC(C)=O)CC2)=CC(=O)C(OC)=CC=C1C1=C2C=C(OC)C(OC)=C1OC IAKHMKGGTNLKSZ-INIZCTEOSA-N 0.000 abstract 2
- 239000012190 activator Substances 0.000 abstract 2
- 238000012258 culturing Methods 0.000 abstract 2
- NNJPGOLRFBJNIW-HNNXBMFYSA-N (-)-demecolcine Chemical compound C1=C(OC)C(=O)C=C2[C@@H](NC)CCC3=CC(OC)=C(OC)C(OC)=C3C2=C1 NNJPGOLRFBJNIW-HNNXBMFYSA-N 0.000 abstract 1
- IPDJRYUVROTJTO-UHFFFAOYSA-N 1,2,3,10-tetramethoxy-6,7-dihydro-5h-benzo[a]heptalen-9-one Chemical compound C1CCC2=CC(=O)C(OC)=CC=C2C2=C1C=C(OC)C(OC)=C2OC IPDJRYUVROTJTO-UHFFFAOYSA-N 0.000 abstract 1
- -1 4-cyanocolchicine Chemical compound 0.000 abstract 1
- HFPMXDMZJUJZBX-AWEZNQCLSA-N Deacetylcolchicine Chemical compound C1([C@@H](N)CC2)=CC(=O)C(OC)=CC=C1C1=C2C=C(OC)C(OC)=C1OC HFPMXDMZJUJZBX-AWEZNQCLSA-N 0.000 abstract 1
- NNJPGOLRFBJNIW-UHFFFAOYSA-N Demecolcine Natural products C1=C(OC)C(=O)C=C2C(NC)CCC3=CC(OC)=C(OC)C(OC)=C3C2=C1 NNJPGOLRFBJNIW-UHFFFAOYSA-N 0.000 abstract 1
- 241000282560 Macaca mulatta Species 0.000 abstract 1
- 241000283973 Oryctolagus cuniculus Species 0.000 abstract 1
- 102000013566 Plasminogen Human genes 0.000 abstract 1
- 108010051456 Plasminogen Proteins 0.000 abstract 1
- JXLYSJRDGCGARV-WWYNWVTFSA-N Vinblastine Natural products O=C(O[C@H]1[C@](O)(C(=O)OC)[C@@H]2N(C)c3c(cc(c(OC)c3)[C@]3(C(=O)OC)c4[nH]c5c(c4CCN4C[C@](O)(CC)C[C@H](C3)C4)cccc5)[C@@]32[C@H]2[C@@]1(CC)C=CCN2CC3)C JXLYSJRDGCGARV-WWYNWVTFSA-N 0.000 abstract 1
- 229930013930 alkaloid Natural products 0.000 abstract 1
- 150000003797 alkaloid derivatives Chemical class 0.000 abstract 1
- 230000002927 anti-mitotic effect Effects 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 229960001338 colchicine Drugs 0.000 abstract 1
- 210000003734 kidney Anatomy 0.000 abstract 1
- 210000004962 mammalian cell Anatomy 0.000 abstract 1
- 239000002609 medium Substances 0.000 abstract 1
- 235000015097 nutrients Nutrition 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 239000003104 tissue culture media Substances 0.000 abstract 1
- 229960003048 vinblastine Drugs 0.000 abstract 1
- JXLYSJRDGCGARV-XQKSVPLYSA-N vincaleukoblastine Chemical compound C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 JXLYSJRDGCGARV-XQKSVPLYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6456—Plasminogen activators
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30005472A | 1972-10-24 | 1972-10-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1443189A true GB1443189A (en) | 1976-07-21 |
Family
ID=23157506
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB4919673A Expired GB1443189A (en) | 1972-10-24 | 1973-10-23 | Enhanced production of plasminogen activator |
Country Status (9)
| Country | Link |
|---|---|
| JP (1) | JPS4975794A (enExample) |
| BE (1) | BE806323A (enExample) |
| CH (1) | CH589142A5 (enExample) |
| DE (1) | DE2353318A1 (enExample) |
| FR (1) | FR2203876B1 (enExample) |
| GB (1) | GB1443189A (enExample) |
| IL (1) | IL43343A (enExample) |
| NL (1) | NL7314579A (enExample) |
| SE (2) | SE392618B (enExample) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2119804A (en) * | 1982-05-05 | 1983-11-23 | Genentech Inc | Human tissue plasminogen activator pharmaceutical compositions containing it processes for making it and dna and transformed cell intermediates therefor |
| US4736018A (en) * | 1984-09-21 | 1988-04-05 | Boehringer Ingelheim International Gmbh | Blood coagulation inhibiting proteins, processes for preparing them and their uses |
| US4853330A (en) * | 1983-04-07 | 1989-08-01 | Genentech, Inc. | Human tissue plasminogen activator |
| US5141863A (en) * | 1986-08-11 | 1992-08-25 | Mitsui Toatsu Chemicals, Incorporated | Purification procedure of TPA from crude preparations |
| US5185259A (en) * | 1982-05-05 | 1993-02-09 | Genentech, Inc. | Truncated human tissue plasminogen activator |
| US5587159A (en) * | 1982-05-05 | 1996-12-24 | Genentech, Inc. | Human tissue plasminogen activator |
| US5763253A (en) * | 1982-05-05 | 1998-06-09 | Genentech, Inc. | Methods of preparing tissue plasiminogen activator derivative composition |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5571496A (en) * | 1978-11-24 | 1980-05-29 | Asahi Chem Ind Co Ltd | Preparation of living substance |
| IL69664A0 (en) * | 1982-09-15 | 1983-12-30 | Collaborative Res Inc | Medium supplement and method for growing cells in vitro |
-
1973
- 1973-09-30 IL IL43343A patent/IL43343A/en unknown
- 1973-10-19 FR FR7337349A patent/FR2203876B1/fr not_active Expired
- 1973-10-22 CH CH1484773A patent/CH589142A5/xx not_active IP Right Cessation
- 1973-10-22 BE BE1005443A patent/BE806323A/xx unknown
- 1973-10-23 SE SE7314381A patent/SE392618B/xx unknown
- 1973-10-23 NL NL7314579A patent/NL7314579A/xx not_active Application Discontinuation
- 1973-10-23 GB GB4919673A patent/GB1443189A/en not_active Expired
- 1973-10-24 DE DE19732353318 patent/DE2353318A1/de active Pending
- 1973-10-24 JP JP48119815A patent/JPS4975794A/ja active Pending
-
1976
- 1976-09-07 SE SE7609880A patent/SE7609880L/xx unknown
Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5763253A (en) * | 1982-05-05 | 1998-06-09 | Genentech, Inc. | Methods of preparing tissue plasiminogen activator derivative composition |
| US5185259A (en) * | 1982-05-05 | 1993-02-09 | Genentech, Inc. | Truncated human tissue plasminogen activator |
| US5587159A (en) * | 1982-05-05 | 1996-12-24 | Genentech, Inc. | Human tissue plasminogen activator |
| US5702938A (en) * | 1982-05-05 | 1997-12-30 | Genetech, Inc. | Human tissue plasminogen activator |
| US5728565A (en) * | 1982-05-05 | 1998-03-17 | Genentech, Inc. | Methods of preparing tissue plasminogen activator derivatives |
| US5753486A (en) * | 1982-05-05 | 1998-05-19 | Genentech, Inc. | Human tissue plasminogen activator |
| GB2119804A (en) * | 1982-05-05 | 1983-11-23 | Genentech Inc | Human tissue plasminogen activator pharmaceutical compositions containing it processes for making it and dna and transformed cell intermediates therefor |
| US5869314A (en) * | 1982-05-05 | 1999-02-09 | Genentech, Inc. | Tissue plasminogen activators and derivatives thereof as produced by recombinant means |
| US6274335B1 (en) | 1982-05-05 | 2001-08-14 | Genentech, Inc. | Method of treatment using recombinant human tissue plasminogen activator |
| US6284247B1 (en) | 1982-05-05 | 2001-09-04 | Genentech, Inc. | Human tissue plasminogen activators |
| US4853330A (en) * | 1983-04-07 | 1989-08-01 | Genentech, Inc. | Human tissue plasminogen activator |
| US4736018A (en) * | 1984-09-21 | 1988-04-05 | Boehringer Ingelheim International Gmbh | Blood coagulation inhibiting proteins, processes for preparing them and their uses |
| US5141863A (en) * | 1986-08-11 | 1992-08-25 | Mitsui Toatsu Chemicals, Incorporated | Purification procedure of TPA from crude preparations |
Also Published As
| Publication number | Publication date |
|---|---|
| CH589142A5 (enExample) | 1977-06-30 |
| NL7314579A (enExample) | 1974-04-26 |
| DE2353318A1 (de) | 1974-05-02 |
| IL43343A (en) | 1976-03-31 |
| FR2203876B1 (enExample) | 1977-05-27 |
| JPS4975794A (enExample) | 1974-07-22 |
| FR2203876A1 (enExample) | 1974-05-17 |
| SE392618B (sv) | 1977-04-04 |
| SE7609880L (sv) | 1976-09-07 |
| IL43343A0 (en) | 1973-11-28 |
| BE806323A (fr) | 1974-04-22 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES380126A1 (es) | Un procedimiento para la preparacion de un producto enzima-tico que contiene una alfa-amilasa. | |
| GB1443189A (en) | Enhanced production of plasminogen activator | |
| GB1376983A (en) | Enzyme stabilization | |
| GB1387821A (en) | Producing chemical plant metabolites by suspension culture | |
| GB1368903A (en) | Method of producing pullulan | |
| GB1205403A (en) | Preparation of proteolytic enzyme preparations | |
| ES418475A1 (es) | Un proceso para la produccion de pululano. | |
| ES8105384A1 (es) | Procedimiento para la produccion de un material de proteina unicelular | |
| GB1387965A (en) | Process for the production of the antibiotic cephemycin | |
| IE39141B1 (en) | Production of immunological material | |
| GB1526617A (en) | 2 and 3-substituted enkephalins | |
| ES412128A1 (es) | Un procedimiento de produccion de sustancias antibioticas policarbociclicas nitrogenadas. | |
| ES422433A1 (es) | Un procedimiento para la produccion del antibiotico a-287. | |
| GB1133579A (en) | Process for preparing proteases and enzymatic composition prepared thereby | |
| GB1166917A (en) | Process for the biosynthesis of pullulanase by Aerobacter aerogenes | |
| ES382658A1 (es) | Procedimiento de produccion de un nuevo antibiotico. | |
| GB1377339A (en) | Method for producing deacetoxycephalosporin c | |
| GB1461575A (en) | Production of micro-organisms | |
| ATE97958T1 (de) | Zellenzuchtverfahren fuer die produktion von aktiviertem protein-c. | |
| ES8302773A1 (es) | Procedimiento de obtencion de una renina microbial de alta actividad coagulante de leche y baja actividad proteolitica | |
| GB1522756A (en) | Microbiological production of protein | |
| GB1394045A (en) | Method of producing a carrier for serological reactions | |
| GB1420264A (en) | Process for the preparation of protein | |
| GB1359632A (en) | Process for producing citric acid by fermentation | |
| ES452022A1 (es) | Un procedimiento para la produccion de una mezcla antibioti-ca. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |