DE2303418A1 - Antibiotisch wirksame substanzen sowie verfahren zum isolieren und reinigen biologisch aktiver substanzen - Google Patents
Antibiotisch wirksame substanzen sowie verfahren zum isolieren und reinigen biologisch aktiver substanzenInfo
- Publication number
- DE2303418A1 DE2303418A1 DE2303418A DE2303418A DE2303418A1 DE 2303418 A1 DE2303418 A1 DE 2303418A1 DE 2303418 A DE2303418 A DE 2303418A DE 2303418 A DE2303418 A DE 2303418A DE 2303418 A1 DE2303418 A1 DE 2303418A1
- Authority
- DE
- Germany
- Prior art keywords
- silica gel
- value
- ethyl acetate
- active substances
- polar solvent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000013543 active substance Substances 0.000 title claims description 9
- 238000000034 method Methods 0.000 title claims description 7
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims description 43
- 239000002253 acid Substances 0.000 claims description 20
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims description 16
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 16
- 239000000741 silica gel Substances 0.000 claims description 16
- 229910002027 silica gel Inorganic materials 0.000 claims description 16
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims description 10
- 238000000855 fermentation Methods 0.000 claims description 10
- 230000004151 fermentation Effects 0.000 claims description 10
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 9
- 230000003115 biocidal effect Effects 0.000 claims description 8
- 238000002329 infrared spectrum Methods 0.000 claims description 8
- XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 claims description 5
- IIEWJVIFRVWJOD-UHFFFAOYSA-N ethyl cyclohexane Natural products CCC1CCCCC1 IIEWJVIFRVWJOD-UHFFFAOYSA-N 0.000 claims description 5
- 239000012454 non-polar solvent Substances 0.000 claims description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 5
- 239000012141 concentrate Substances 0.000 claims description 4
- 239000000284 extract Substances 0.000 claims description 4
- 239000000203 mixture Substances 0.000 claims description 4
- 239000002798 polar solvent Substances 0.000 claims description 4
- 239000002904 solvent Substances 0.000 claims description 4
- FKHIFSZMMVMEQY-UHFFFAOYSA-N talc Chemical compound [Mg+2].[O-][Si]([O-])=O FKHIFSZMMVMEQY-UHFFFAOYSA-N 0.000 claims description 4
- 239000003795 chemical substances by application Substances 0.000 claims description 3
- 239000008030 superplasticizer Substances 0.000 claims description 2
- 150000007513 acids Chemical class 0.000 description 11
- 150000002148 esters Chemical class 0.000 description 8
- 235000010633 broth Nutrition 0.000 description 5
- 230000001408 fungistatic effect Effects 0.000 description 5
- 244000005700 microbiome Species 0.000 description 5
- 238000000746 purification Methods 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 239000003242 anti bacterial agent Substances 0.000 description 2
- 238000004440 column chromatography Methods 0.000 description 2
- 239000000287 crude extract Substances 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 230000000855 fungicidal effect Effects 0.000 description 2
- 239000001963 growth medium Substances 0.000 description 2
- 238000002955 isolation Methods 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 230000000704 physical effect Effects 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 241000222122 Candida albicans Species 0.000 description 1
- YXHKONLOYHBTNS-UHFFFAOYSA-N Diazomethane Chemical compound C=[N+]=[N-] YXHKONLOYHBTNS-UHFFFAOYSA-N 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 241000228404 Histoplasma capsulatum Species 0.000 description 1
- 239000004264 Petrolatum Substances 0.000 description 1
- -1 S acid ester Chemical class 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 239000011149 active material Substances 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 229940095731 candida albicans Drugs 0.000 description 1
- 238000012512 characterization method Methods 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000002024 ethyl acetate extract Substances 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 239000002075 main ingredient Substances 0.000 description 1
- 150000004702 methyl esters Chemical class 0.000 description 1
- 229940066842 petrolatum Drugs 0.000 description 1
- 235000019271 petrolatum Nutrition 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 238000004809 thin layer chromatography Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07G—COMPOUNDS OF UNKNOWN CONSTITUTION
- C07G11/00—Antibiotics
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US00226524A US3804948A (en) | 1972-02-15 | 1972-02-15 | Antifungal substances from polyangium cellulosum var.fulvum |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE2303418A1 true DE2303418A1 (de) | 1973-09-06 |
Family
ID=22849263
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE2303418A Pending DE2303418A1 (de) | 1972-02-15 | 1973-01-24 | Antibiotisch wirksame substanzen sowie verfahren zum isolieren und reinigen biologisch aktiver substanzen |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US3804948A (enExample) |
| JP (1) | JPS4892591A (enExample) |
| CA (1) | CA981607A (enExample) |
| DE (1) | DE2303418A1 (enExample) |
| DK (1) | DK131689C (enExample) |
| GB (1) | GB1349633A (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4001398A (en) * | 1974-06-24 | 1977-01-04 | Warner-Lambert Company | Octahydro and decahydro derivatives of acid S, an antibiotic produced by Polyangium cellulosum var. fulvum |
| US3932620A (en) * | 1974-06-24 | 1976-01-13 | Warner-Lambert Company | Ketones and ketoximes derived from acid S, an antibiotic produced by polyangium cellulosum var. fulvum |
| US3932621A (en) * | 1974-06-24 | 1976-01-13 | Max VON Strandtmann | Triols and acetates thereof derived from antibiotic substance, acid S, produced by polyangium cellulosum var. fulvum |
| US4009261A (en) * | 1975-08-07 | 1977-02-22 | Warner-Lambert Company | 7-Substituted triol derivatives of acid S, an antibiotic produced by polyangium cellulosum var. fulvum |
| US4016257A (en) * | 1975-08-07 | 1977-04-05 | Warner-Lambert Company | Amide derivatives of acids, an antibiotic produced by Polyangium cellulosum var. fulvum |
| US4138550A (en) * | 1976-06-07 | 1979-02-06 | Warner-Lambert Company | Diacyloxyacids derived from acid S, an antibiotic produced by Polyangium cellulosum var. fulvum |
| US4098998A (en) * | 1976-06-10 | 1978-07-04 | Warner-Lambert Company | Aldehyde, oxime and phenylhydrazone derivatives of acid S, an antibiotic produced by Polyangium cellulosum var. fulvum |
| US4107429A (en) * | 1976-06-14 | 1978-08-15 | Warner-Lambert Company | 1-Nor-2-amino carbamates derived from acid S, an antibiotic produced by Polyangium cellulosum var. fulvum |
| US4076940A (en) * | 1977-05-05 | 1978-02-28 | Warner-Lambert Company | Conversion of acid S, produced by the organism Polyangium cellulosum var. fulvum into acid F |
| USRE30339E (en) * | 1978-07-14 | 1980-07-15 | Warner-Lambert Company | Conversion of acid S, produced by the organism Polyangium cellulosum var. fulvum into acid F |
| EP1831204A4 (en) * | 2004-12-16 | 2009-10-21 | Kosan Biosciences Inc | COMPOUNDS AMBRUTICINE VS |
-
1972
- 1972-02-15 US US00226524A patent/US3804948A/en not_active Expired - Lifetime
-
1973
- 1973-01-05 DK DK6873*#A patent/DK131689C/da active
- 1973-01-18 GB GB259173A patent/GB1349633A/en not_active Expired
- 1973-01-24 DE DE2303418A patent/DE2303418A1/de active Pending
- 1973-01-31 CA CA162,549A patent/CA981607A/en not_active Expired
- 1973-02-14 JP JP48018220A patent/JPS4892591A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| DK131689B (da) | 1975-08-18 |
| JPS4892591A (enExample) | 1973-11-30 |
| GB1349633A (en) | 1974-04-10 |
| US3804948A (en) | 1974-04-16 |
| DK131689C (da) | 1976-01-19 |
| CA981607A (en) | 1976-01-13 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE2648121C2 (de) | Dihydro-cyclosporin C, Verfahren zu dessen Herstellung und diese Verbindung enthaltende Arzneimittel | |
| DE2941080C2 (enExample) | ||
| DE2557784C2 (de) | Forskolin, Verfahren zu dessen Gewinnung und diese Verbindung enthaltende pharmazeutische Präparate | |
| DD148517A5 (de) | Verfahren zur herstellung von 6-oxodecahydrochinolinen | |
| DE19638870A1 (de) | Verbindungen mit antimykotischer und cytostatischer Wirkung, Herstellungsverfahren, Mittel und DSM 11 092 | |
| DE3122499A1 (de) | Neue derivate von ml-236b, verfahren zu ihrer herstellung und diese derivate enthaltende arzneimittelzubereitungen | |
| DE2303418A1 (de) | Antibiotisch wirksame substanzen sowie verfahren zum isolieren und reinigen biologisch aktiver substanzen | |
| DE69925459T2 (de) | Verfahren zur herstellung von hochreinen hmg-coa reductase inhibitoren | |
| EP0316650A2 (de) | Verfahren zur Isolierung und Reinigung von Hirudin | |
| US6086889A (en) | Process for the isolation of Z and E gugulsterones from aerial branches of Commiphora wightii (guggul) | |
| DE2623227A1 (de) | Lucknomycin und verfahren zu seiner herstellung | |
| CH637123A5 (en) | Monocyclic peptide, its preparation and use | |
| DE2921085C2 (enExample) | ||
| DE2846210A1 (de) | Neue antileukaemische trichothecin epoxide | |
| DE3041130C2 (enExample) | ||
| Anderson et al. | Nonpolar pentacyclic triterpenes of the medicinal fern Polypodium subpetiolatum | |
| DE1617803A1 (de) | Ein bisher unbekanntes Antibioticum sowie ein Verfahren zu dessen Herstellung | |
| DE1145175B (de) | Verfahren zur Gewinnung von Rescidin aus Pflanzen der Rauwolfiaarten und zur Herstellung von dessen Salzen | |
| WO2010012786A1 (de) | Verfahren zur aufarbeitung von mikrobiologisch hergestellten zyklischen oligopeptiden | |
| DE1593964C3 (de) | Triacetyl-Spiramycin I und Verfahren zu seiner Herstellung | |
| DE918162C (de) | Verfahren zur Gewinnung von antibiotischen Wirkstoffen | |
| DE946005C (de) | Verfahren zur Gewinnung von Vitamin B und anderen LLD- und APF-aktiven Substanzen | |
| KR950010164B1 (ko) | 시볼디아게닌 유도체 및 그 제조방법 | |
| AT363179B (de) | Verfahren zur herstellung neuer antibiotika | |
| EP1529025B1 (de) | Polyisoprenyl-benzophenon-derivate, verfahren zu ihrer herstellung und verwendung derselben |